Gene: CYP11B2

1585
ALDOS|CPN2|CYP11B|CYP11BL|CYPXIB2|P-450C18|P450C18|P450aldo
cytochrome P450 family 11 subfamily B member 2
protein-coding
8q24.3
Ensembl:ENSG00000179142 MIM:124080 Vega:OTTHUMG00000160254 UniprotKB:P19099
NG_008374.1
PubMed
0   ANCO-SNPs
ND
13   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.883e-1 (AD)  7.138e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR9Q20.65
CD1B0.649
MTRNR2L50.648
OR10A70.647
TAS2R410.642
ZNF7500.637
TAS2R300.637
OR56A40.637
PRDM140.635
PRAMEF170.633

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CENPN-0.275
PIGP-0.248
MRPL30-0.242
PDSS2-0.238
NUDT6-0.237
METTL2A-0.232
GPANK1-0.232
HDDC3-0.23
FAM47E-STBD1-0.229
CCDC112-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C03368918-hydroxycortisolCYP11B2 protein affects the chemical synthesis of 18-hydroxycortisol15356073
C04250918-hydroxydeoxycorticosterone18-hydroxydeoxycorticosterone results in decreased activity of CYP11B2 protein11549669
C04250918-hydroxydeoxycorticosterone18-hydroxydeoxycorticosterone results in increased activity of CYP11B2 protein11549669
C03813518-oxocortisolCYP11B2 protein affects the chemical synthesis of 18-oxocortisol15356073
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with AGT protein] affects the expression of CYP11B2 mRNA"19900470
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B2 mRNA"19900470
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene results in increased expression of CYP11B2 mRNA"19900470
C0337291H,1H,2H,2H-perfluorodecanol"1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B2 mRNA"20615422
C0337291H,1H,2H,2H-perfluorodecanol"1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B2 protein"20615422
C0948592,2',3,3',4,6'-hexachlorobiphenyl"2,2',3,3',4,6'-hexachlorobiphenyl results in increased expression of CYP11B2 mRNA"16396990
C1201292,2',3,4',5',6-hexachlorobiphenyl"2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of CYP11B2 mRNA"16216300
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of CYP11B2 mRNA"18248924
C5112952,2',4,4'-tetrabromodiphenyl ether"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA"25765474
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CYP11B2 mRNA15666830
C0876672,3,3',4,4',5-hexachlorobiphenyl"2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP11B2 mRNA"16396990
C0700552,3',4,4',5-pentachlorobiphenyl"2,3',4,4',5-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA"20574914
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of CYP11B2 mRNA"17447562
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CYP11B2 mRNA"20574914
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA"25765474
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP11B2 mRNA"25765474
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl metabolite results in increased expression of CYP11B2 mRNA"16216300
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA"16216300
C0045542,4,6-tribromophenol"2,4,6-tribromophenol results in decreased expression of CYP11B2 mRNA"17447562
C0139302,4-dibromophenol"2,4-dibromophenol results in increased expression of CYP11B2 mRNA"17447562
C0389642,6-dibromophenol"2,6-dibromophenol results in decreased expression of CYP11B2 mRNA"17447562
C5847872-acetylphenothiazine2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]25617244
C0149532-acetyltributylcitrate2-acetyltributylcitrate results in increased expression of CYP11B2 mRNA28235592
C0327903,3',4,4',5,5'-hexabromobiphenyl"3,3',4,4',5,5'-hexabromobiphenyl results in increased expression of CYP11B2 mRNA"17447562
C0366853,3',4,4'-tetrabromobiphenyl"3,3',4,4'-tetrabromobiphenyl results in increased expression of CYP11B2 mRNA"17447562
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP11B2 mRNA"16396990
C0273093,4,5,3',4',5'-hexachlorobiphenyl"3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP11B2 mRNA"16396990
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP11B2 protein"14962509|1570326
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA"14962509|1570326
C0230353,4,5,3',4'-pentachlorobiphenyl"3',4'-dimethoxyflavone promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA]"16396990
C0230353,4,5,3',4'-pentachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA"25765474
C0230353,4,5,3',4'-pentachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP11B2 mRNA"25765474
C5092883',4'-dimethoxyflavone"3',4'-dimethoxyflavone promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA]"16396990
C5092883',4'-dimethoxyflavone"3',4'-dimethoxyflavone results in increased expression of CYP11B2 mRNA"16396990
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of CYP11B2 mRNA"26751127
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of CYP11B2 mRNA"26751127
D000073AcenaphthenesAcenaphthenes analog results in decreased activity of CYP11B2 protein16246562
D000111AcetylcysteineAcetylcysteine inhibits the reaction [anacetrapib results in increased expression of CYP11B2 mRNA]25617244
D000111AcetylcysteineAcetylcysteine inhibits the reaction [dalcetrapib results in increased expression of CYP11B2 mRNA]25617244
D000111AcetylcysteineAcetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]25617244
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased activity of CYP11B2 protein10822027
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of CYP11B2 mRNA10822027
C006418adrenocorticotropin zincDimethyl Sulfoxide inhibits the reaction [adrenocorticotropin zinc results in decreased expression of CYP11B2 mRNA]10822027
C006418adrenocorticotropin zincDimethyl Sulfoxide promotes the reaction [adrenocorticotropin zinc results in decreased activity of CYP11B2 protein]10822027
C006418adrenocorticotropin zincVitamin E inhibits the reaction [adrenocorticotropin zinc results in decreased expression of CYP11B2 mRNA]10822027
C006418adrenocorticotropin zincVitamin E promotes the reaction [adrenocorticotropin zinc results in decreased activity of CYP11B2 protein]10822027
D000450AldosteroneCYP11B2 protein affects the chemical synthesis of Aldosterone12525251
D000450AldosteroneCYP11B2 protein polymorphism results in increased chemical synthesis of Aldosterone12783697
D000450AldosteroneCYP11B2 protein results in increased chemical synthesis of Aldosterone16054388|1990047
D000450Aldosterone[CYP11B2 protein results in increased hydroxylation of Corticosterone] which results in increased chemical synthesis of Aldosterone21384875
D000450AldosteroneCYP11B2 protein affects the chemical synthesis of Aldosterone15731365
D000450AldosteroneCYP11B2 protein affects the chemical synthesis of Aldosterone16043663
C005197alternariolalternariol results in increased expression of CYP11B2 mRNA23665424
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYP11B2 mRNA16483693
D000658AmoxicillinAmoxicillin results in increased expression of CYP11B217822730
C530884anacetrapibAcetylcysteine inhibits the reaction [anacetrapib results in increased expression of CYP11B2 mRNA]25617244
C530884anacetrapibanacetrapib results in increased expression of CYP11B2 mRNA25617244
C530884anacetrapibGKT137831 inhibits the reaction [anacetrapib results in increased expression of CYP11B2 mRNA]25617244
C530884anacetrapibRotenone inhibits the reaction [anacetrapib results in increased expression of CYP11B2 mRNA]25617244
D000735AndrostenedioneCYP11B2 protein results in increased hydroxylation of Androstenedione12153581
C044946benazeprilCYP11B2 gene polymorphism affects the susceptibility to benazepril16765146
C061004benidipinebenidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B2 mRNA]18331727
D001572BenzofuransBenzofurans results in increased expression of CYP11B2 mRNA17447562
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYP11B2 mRNA15808406
C088060bisindolylmaleimidebisindolylmaleimide results in increased expression of CYP11B2 mRNA9584833
C006780bisphenol Abisphenol A results in decreased expression of CYP11B2 mRNA26751127
C006780bisphenol Abisphenol A results in decreased expression of CYP11B2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CYP11B2 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11B2 mRNA22079614
D002110CaffeineCaffeine results in decreased expression of CYP11B2 mRNA25868845
C031938calmidazoliumcalmidazolium inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA]12193581
C081643candesartanCYP11B2 protein polymorphism affects the susceptibility to candesartan12065207
C081643candesartancandesartan results in decreased expression of CYP11B2 mRNA18796534
C077793candesartan cilexetilcandesartan cilexetil results in decreased expression of CYP11B2 mRNA11086231
D002220CarbamazepineCarbamazepine results in increased expression of CYP11B2 mRNA19566492
D005576ColforsinColforsin results in increased expression of CYP11B2 mRNA9888551
D005576ColforsinNifedipine inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA]9888551
D005576Colforsin"[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B2 mRNA"19900470
D005576ColforsinColforsin results in increased expression of CYP11B2 mRNA16935330|1708040
D005576ColforsinKetoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA]16935330
D005576ColforsinLindane inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA]17080404
D003345CorticosteroneCYP11B2 protein affects the metabolism of Corticosterone16054388
D003345CorticosteroneCYP11B2 protein results in increased chemical synthesis of Corticosterone21384875
D003345CorticosteroneCYP11B2 protein results in increased hydroxylation of Corticosterone21384875
D003345Corticosterone[CYP11B2 protein results in increased hydroxylation of Corticosterone] which results in increased chemical synthesis of Aldosterone21384875
D003345Corticosterone[CYP11B2 protein results in increased hydroxylation of Desoxycorticosterone] which results in increased chemical synthesis of Corticosterone21384875
C020728cyadoxcyadox metabolite affects the expression of CYP11B2 mRNA26802905
C020728cyadoxcyadox metabolite affects the expression of CYP11B2 protein26802905
C020728cyadoxProanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B2 mRNA]26802905
C020728cyadoxProanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B2 protein]26802905
C093628cyproconazolecyproconazole results in decreased expression of CYP11B2 mRNA28454766
C411602dalcetrapibAcetylcysteine inhibits the reaction [dalcetrapib results in increased expression of CYP11B2 mRNA]25617244
C411602dalcetrapibdalcetrapib results in increased expression of CYP11B2 mRNA25617244
C411602dalcetrapibdalcetrapib results in increased expression of CYP11B2 protein25617244
C411602dalcetrapibNSC 74859 inhibits the reaction [dalcetrapib results in increased expression of CYP11B2 mRNA]25617244
D003350CortodoxoneCYP11B2 protein affects the metabolism of Cortodoxone15743198
D003350CortodoxoneCYP11B2 protein results in increased metabolism of Cortodoxone19900470
C007262deoxynivalenoldeoxynivalenol results in increased expression of CYP11B2 mRNA22982764
D000072338Dibenzofurans, Polychlorinated"[Polychlorinated Dibenzodioxins co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in increased expression of CYP11B2 mRNA"16650473
D000072338Dibenzofurans, Polychlorinated"[Polycyclic Aromatic Hydrocarbons co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in increased expression of CYP11B2 mRNA"16650473
D004041Dietary FatsDietary Fats results in increased expression of CYP11B2 mRNA22355066
C012125diisononyl phthalatediisononyl phthalate results in decreased expression of CYP11B2 mRNA22112501
D004121Dimethyl SulfoxideDimethyl Sulfoxide inhibits the reaction [adrenocorticotropin zinc results in decreased expression of CYP11B2 mRNA]10822027
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [adrenocorticotropin zinc results in decreased activity of CYP11B2 protein]10822027
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of CYP11B2 mRNA22112501|2505596
C034171di-n-pentyl phthalate[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B2 mRNA25055962
D000068538DutasterideDutasteride results in increased expression of CYP11B2 mRNA17636412
C100264enniatinsenniatins results in increased expression of CYP11B2 mRNA25625232
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of CYP11B2 mRNA21420147
C109476epoxiconazoleepoxiconazole results in increased expression of CYP11B2 mRNA28454766
D004917ErythromycinErythromycin results in increased expression of CYP11B217822730
D017316FadrozoleFadrozole results in decreased activity of CYP11B2 protein15743198|1577142
D005411Flame RetardantsFlame Retardants metabolite results in increased expression of CYP11B2 mRNA18248924
D005411Flame RetardantsFlame Retardants results in decreased expression of CYP11B2 mRNA17447562
D005411Flame RetardantsFlame Retardants results in increased expression of CYP11B2 mRNA17447562|2244682
C576694GKT137831GKT137831 inhibits the reaction [anacetrapib results in increased expression of CYP11B2 mRNA]25617244
C576694GKT137831GKT137831 inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]25617244
D005947GlucoseGlucose results in decreased expression of CYP11B2 mRNA15017115
D019695Glycyrrhizic AcidGlycyrrhizic Acid results in decreased expression of CYP11B2 mRNA10474021|1179865
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers metabolite results in decreased expression of CYP11B2 mRNA18313098
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers metabolite results in increased expression of CYP11B2 mRNA18248924|1831309
C089796hexabromocyclododecane"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA"25765474
C072551HS 142-1HS 142-1 results in increased expression of CYP11B2 mRNA12591748
D006843Hydrocarbons, Chlorinated"[Polychlorinated Dibenzodioxins co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in increased expression of CYP11B2 mRNA"16650473
D006843Hydrocarbons, Chlorinated"[Polycyclic Aromatic Hydrocarbons co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in increased expression of CYP11B2 mRNA"16650473
D006852HydrochlorothiazideHydrochlorothiazide results in increased expression of CYP11B2 mRNA18796534
D003900DesoxycorticosteroneCYP11B2 protein affects the metabolism of Desoxycorticosterone15985365
D003900DesoxycorticosteroneCYP11B2 protein results in increased hydroxylation of Desoxycorticosterone21384875
D003900Desoxycorticosterone[CYP11B2 protein results in increased hydroxylation of Desoxycorticosterone] which results in increased chemical synthesis of Corticosterone21384875
C065166imidaprilCYP11B2 gene polymorphism affects the susceptibility to imidapril16765146
D007189IndansIndans results in decreased activity of CYP11B2 protein15743198
C081309irbesartanCYP11B2 gene SNP results in increased susceptibility to irbesartan12022239
D007654KetoconazoleKetoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA]16935330
D007654KetoconazoleKetoconazole results in decreased activity of CYP11B2 protein15743198
D007654KetoconazoleKetoconazole results in increased expression of CYP11B2 mRNA16935330
C072105KN 93KN 93 inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA]12193581
D001556LindaneLindane inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA]17080404
C545385MequindoxMequindox metabolite results in decreased expression of CYP11B2 mRNA26802905
C545385MequindoxMequindox metabolite results in decreased expression of CYP11B2 protein26802905
C545385MequindoxMequindox results in decreased expression of CYP11B2 protein26802905
C545385MequindoxProanthocyanidins affects the reaction [Mequindox metabolite results in decreased expression of CYP11B2 protein]26802905
C545385MequindoxProanthocyanidins inhibits the reaction [Mequindox metabolite results in decreased expression of CYP11B2 mRNA]26802905
C545385MequindoxMequindox results in decreased expression of CYP11B2 mRNA19733641
D008696MethandrostenoloneCYP11B2 protein results in increased chemical synthesis of Methandrostenolone analog22885098
D008696MethandrostenoloneCYP11B2 protein results in increased metabolism of Methandrostenolone22885098
C004925methylmercuric chloride"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA"25765474
D008797MetyraponeMetyrapone results in increased expression of CYP11B2 protein9832454
D020748MibefradilMibefradil inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]18331727
D009183MycotoxinsMycotoxins results in increased expression of CYP11B2 mRNA23665424
C005274naringinnaringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]22798349
D009543NifedipineNifedipine inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA]9888551
D009543NifedipineNifedipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B2 mRNA]9584833
D009543NifedipineNifedipine inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA]9888551
D005996NitroglycerinNitroglycerin results in decreased expression of CYP11B2 mRNA12102619
C520337NSC 74859NSC 74859 inhibits the reaction [dalcetrapib results in increased expression of CYP11B2 mRNA]25617244
C520337NSC 74859NSC 74859 inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]25617244
C118580octylmethoxycinnamateoctylmethoxycinnamate results in increased expression of CYP11B2 mRNA28235592
D008939MitotaneMitotane results in decreased expression of CYP11B2 protein23696597
C005290oxybenzoneoxybenzone results in decreased expression of CYP11B2 mRNA22721600
C098189pentabromophenolpentabromophenol results in increased expression of CYP11B2 mRNA17447562
C003072perflubronperflubron results in increased expression of CYP11B2 mRNA25871633
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CYP11B2 mRNA23074026|2576547
C076994perfluorooctane sulfonic acid"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA"25765474
C076994perfluorooctane sulfonic acid"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP11B2 mRNA"25765474
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CYP11B2 mRNA23399300
C023036perfluorooctanoic acid[perfluorooctanoic acid co-treated with PPARA] results in increased expression of CYP11B2 mRNA20118188
D010656PhenylephrinePhenylephrine results in increased expression of CYP11B2 mRNA19966502
D011078Polychlorinated Biphenyls"[Polychlorinated Dibenzodioxins co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in increased expression of CYP11B2 mRNA"16650473
D011078Polychlorinated Biphenyls"[Polycyclic Aromatic Hydrocarbons co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in increased expression of CYP11B2 mRNA"16650473
D000072317Polychlorinated Dibenzodioxins"[Polychlorinated Dibenzodioxins co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in increased expression of CYP11B2 mRNA"16650473
D011084Polycyclic Aromatic Hydrocarbons"[Polycyclic Aromatic Hydrocarbons co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in increased expression of CYP11B2 mRNA"16650473
D011188PotassiumNifedipine inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA]9888551
D011188PotassiumPotassium results in increased expression of CYP11B2 mRNA9888551
D011188Potassiumcalmidazolium inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA]12193581
D011188PotassiumKN 93 inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA]12193581
D011188PotassiumPotassium results in increased expression of CYP11B2 mRNA12193581|9139807
D011188PotassiumPotassium results in increased expression of CYP11B2 mRNA14642076
D011189Potassium ChlorideNifedipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B2 mRNA]9584833
D011189Potassium ChloridePotassium Chloride results in increased expression of CYP11B2 mRNA9584833
D011189Potassium Chloridebenidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B2 mRNA]18331727
D011189Potassium ChloridePotassium Chloride results in increased expression of CYP11B2 mRNA18331727
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CYP11B2 mRNA23608068
D044945ProanthocyanidinsProanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B2 mRNA]26802905
D044945ProanthocyanidinsProanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B2 protein]26802905
D044945ProanthocyanidinsProanthocyanidins affects the reaction [Mequindox metabolite results in decreased expression of CYP11B2 protein]26802905
D044945ProanthocyanidinsProanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B2 protein]26802905
D044945ProanthocyanidinsProanthocyanidins inhibits the reaction [Mequindox metabolite results in decreased expression of CYP11B2 mRNA]26802905
D044945ProanthocyanidinsProanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of CYP11B2 mRNA]26802905
D011441PropylthiouracilPropylthiouracil results in decreased expression of CYP11B2 mRNA24780913
D0014983-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of CYP11B2 mRNA"9139807
C502851quinocetoneProanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B2 protein]26802905
C502851quinocetoneProanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of CYP11B2 mRNA]26802905
C502851quinocetonequinocetone metabolite affects the expression of CYP11B2 protein26802905
C502851quinocetonequinocetone metabolite results in decreased expression of CYP11B2 mRNA26802905
D012402RotenoneRotenone inhibits the reaction [anacetrapib results in increased expression of CYP11B2 mRNA]25617244
D012402RotenoneRotenone inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]25617244
D019821Simvastatin[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B2 mRNA25055962
D012964SodiumCYP11B2 protein polymorphism affects the susceptibility to Sodium12624609
C017947sodium arsenitesodium arsenite affects the methylation of CYP11B2 gene28589171
D012965Sodium ChlorideSodium Chloride results in increased activity of CYP11B2 protein15134804
D012965Sodium ChlorideSodium Chloride results in increased expression of CYP11B2 mRNA15134804
D012982Sodium, Dietary"Sodium, Dietary results in decreased expression of CYP11B2 mRNA"12865309
D013148SpironolactoneSpironolactone results in increased expression of CYP11B2 mRNA15218317
D013311StreptozocinStreptozocin results in increased expression of CYP11B2 mRNA16043663
D013311StreptozocinStreptozocin results in increased expression of CYP11B2 protein16043663
D013739TestosteroneCYP11B2 protein polymorphism results in increased chemical synthesis of Testosterone12783697
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA"25765474
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP11B2 mRNA"25765474
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP11B2 mRNA16962184
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of CYP11B2 mRNA15666830
D013764TetrahydronaphthalenesTetrahydronaphthalenes results in decreased activity of CYP11B2 protein15743198
C483909torcetrapib2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]25617244
C483909torcetrapibAcetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]25617244
C483909torcetrapibGKT137831 inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]25617244
C483909torcetrapibNSC 74859 inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]25617244
C483909torcetrapibRotenone inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]25617244
C483909torcetrapibtorcetrapib results in increased expression of CYP11B2 mRNA19164467|2049861
C483909torcetrapibtorcetrapib results in increased expression of CYP11B2 protein25617244
C026116torsemidetorsemide affects the expression of CYP11B2 protein18001696
C533760tribromodiphenyl ether 28tribromodiphenyl ether 28 metabolite results in increased expression of CYP11B2 mRNA18248924
C011559tributyltin"[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA"25765474
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in increased expression of CYP11B2 mRNA22446829
D014635Valproic AcidValproic Acid results in increased expression of CYP11B2 mRNA19566492
D014635Valproic AcidValproic Acid results in increased methylation of CYP11B2 gene29154799
D000068756ValsartanValsartan results in decreased expression of CYP11B2 mRNA16043663
D000068756ValsartanValsartan results in decreased expression of CYP11B2 protein16043663
D014810Vitamin EVitamin E inhibits the reaction [adrenocorticotropin zinc results in decreased expression of CYP11B2 mRNA]10822027
D014810Vitamin EVitamin E promotes the reaction [adrenocorticotropin zinc results in decreased activity of CYP11B2 protein]10822027
D014810Vitamin EVitamin E results in decreased expression of CYP11B2 mRNA28923436
C574123walrycin Awalrycin A results in increased expression of CYP11B2 mRNA22314385

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004507steroid 11-beta-monooxygenase activity-IBA21873635  
GO:0004507steroid 11-beta-monooxygenase activity-IDA1741400  2256920  23322723  
GO:0004507steroid 11-beta-monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0008395steroid hydroxylase activity-TAS-  
GO:0020037heme binding-IC2256920  
GO:0020037heme binding-IDA23322723  
GO:0047783corticosterone 18-monooxygenase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002017regulation of blood volume by renal aldosterone-IMP14614232  
GO:0003091renal water homeostasis-IC2256920  
GO:0006700C21-steroid hormone biosynthetic process-IBA21873635  
GO:0006700C21-steroid hormone biosynthetic process-IDA2256920  
GO:0006704glucocorticoid biosynthetic process-IBA21873635  
GO:0006705mineralocorticoid biosynthetic process-TAS-  
GO:0008203cholesterol metabolic process-IBA21873635  
GO:0016125sterol metabolic process-TAS-  
GO:0032342aldosterone biosynthetic process-IBA21873635  
GO:0032342aldosterone biosynthetic process-IDA1741400  2256920  23322723  
GO:0032342aldosterone biosynthetic process-IMP19342457  
GO:0032870cellular response to hormone stimulus-IEP19342457  
GO:0034650cortisol metabolic process-IBA21873635  
GO:0034651cortisol biosynthetic process-IMP19342457  
GO:0034651cortisol biosynthetic processNOTIMP9703385  
GO:0035865cellular response to potassium ion-IEP19342457  
GO:0055075potassium ion homeostasis-IMP9838244  
GO:0055078sodium ion homeostasis-IMP9838244  
GO:0055114oxidation-reduction process-IEA-  
GO:0071375cellular response to peptide hormone stimulus-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA1741400  2256920  
GO:0005743mitochondrial inner membrane-IBA21873635  
GO:0005743mitochondrial inner membrane-IC2256920  
GO:0005743mitochondrial inner membrane-TAS-  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-193993Mineralocorticoid biosynthesisTAS
R-HSA-194002Glucocorticoid biosynthesisTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5579009Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10577993Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction. (1999 Nov 30)Hautanen ACirculation
22508051Renin-angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions. (2012)Jia EZCell Physiol Biochem
15135254The -344T>C promoter variant of the gene for aldosterone synthase (CYP11B2) is not associated with cardiovascular risk in a prospective study of UK healthy men. (2004 May)Payne JRAtherosclerosis
12627873A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study. (2003 Feb)Kikuya MHypertens Res
10701812Analysis of promoter region polymorphism in the aldosterone synthase gene (CYP11B2) as a risk factor for myocardial infarction. (2000 Feb)Patel SAm J Hypertens
28078278Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension. (2016)Gu TBiomed Res Int
15055249CYP11B2 polymorphisms and home blood pressure in a population-based cohort in Japanese: the Ohasama study. (2004 Jan)Matsubara MHypertens Res
11725161Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: the Ohasama Study. (2001 Dec)Matsubara MJ Hypertens
22969879Association between cytochrome P450 promoter polymorphisms and ischemic stroke. (2012 Feb)Kim SKExp Ther Med
22307319Angiotensin converting enzyme gene polymorphism is associated with severity of coronary artery disease in men with high total cholesterol levels. (2012 May)Borzyszkowska JJ Appl Genet
29429410The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. (2018 Feb 12)Johnston ZCBMC Med
9494027Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. (1998 Feb 17)Kupari MCirculation
20193392[Associations of the genetic polymorphisms in CYP11B2 gene with nonfamilial structural atrial fibrillation]. (2009 Oct)Cao FFZhonghua Liu Xing Bing Xue Za Zhi