Gene info: ID 1586

Gene: CYP17A1

GENE ID: 1586

Synonyms: CPT7|CYP17|P450C17|S17AH

Description: cytochrome P450 family 17 subfamily A member 1

Gene type: protein-coding

Location: 10q24.32

dbXrefs: Ensembl:ENSG00000148795 MIM:609300 Vega:OTTHUMG00000018969 UniprotKB:P05093

RefSeq: NG_007955.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.199e-1 (AD) 1.228e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HSD3B2	0.766
CYP11B1	0.749
OR51A2	0.624
SULT2A1	0.561
ZP2	0.511
AMELY	0.491
FGF3	0.482
MUC7	0.462
PRAMEF7	0.461
OR6S1	0.461

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
S100A12	-0.277
FCGR3B	-0.27
RELL1	-0.245
CEP152	-0.237
SIX4	-0.233
MMP9	-0.233
BACE2	-0.232
PLA1A	-0.231
CXCR1	-0.23
ACER2	-0.229

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB00396	Progesterone	Small Molecule	57-83-0	Approved	Target
DB05812	Abiraterone	Small Molecule	154229-19-3	Approved	Target
DB00396	Progesterone	Small Molecule	57-83-0	Approved	Enzyme
DB01233	Metoclopramide	Small Molecule	364-62-5	Approved\|Investigational	Enzyme
DB01234	Dexamethasone	Small Molecule	50-02-2	Approved\|Investigational	Enzyme
DB01424	Aminophenazone	Small Molecule	58-15-1	Approved\|Withdrawn	Enzyme
DB02901	Stanolone	Small Molecule	521-18-6	Illicit\|Investigational	Enzyme
DB04630	Aldosterone	Small Molecule	52-39-1	Experimental\|Investigational	Enzyme
DB09061	Cannabidiol	Small Molecule	13956-29-1	Approved\|Investigational	Enzyme
DB13951	Stanolone acetate	Small Molecule	1164-91-6	Experimental	Enzyme

ID	Drug Name	Action	PubMed
C495657	1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane	"1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane results in decreased expression of CYP17A1 mRNA"	20840852
C003582	11-hydroxyandrostenedione	11-hydroxyandrostenedione results in decreased expression of CYP17A1 mRNA	15858796
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of CYP17A1 mRNA"	19162173
C583463	1,3,4-oxadiazole	"1,3,4-oxadiazole analog results in decreased activity of CYP17A1 protein"	25993309
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP17A1 mRNA"	27413110
C018975	16-hydroxyprogesterone	[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 16-hydroxyprogesterone	17194026
C410803	17-(5'-isoxazolyl)androsta-4,16-dien-3-one	"17-(5'-isoxazolyl)androsta-4,16-dien-3-one results in decreased activity of CYP17A1 protein"	11118046
C055238	1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene	"[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with LHB protein] results in decreased expression of CYP17A1 mRNA"	23333615
C033729	1H,1H,2H,2H-perfluorodecanol	"1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP17A1 mRNA"	20615422
C033729	1H,1H,2H,2H-perfluorodecanol	"1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP17A1 protein"	20615422
C116515	20-hydroximino-4,16-pregnadien-3-one	"20-hydroximino-4,16-pregnadien-3-one results in decreased activity of CYP17A1 protein"	11118046
C483839	2,2',3,4,4',5',6-heptabromodiphenyl ether	"2,2',3,4,4',5',6-heptabromodiphenyl ether results in decreased activity of CYP17A1 protein"	16828825
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP17A1 mRNA"	25510870
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased activity of CYP17A1 protein"	16828825
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether metabolite results in decreased expression of CYP17A1 mRNA"	18248924
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein]]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone results in decreased expression of CYP17A1 mRNA"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone results in decreased expression of CYP17A1 protein"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"THRA mutant form inhibits the reaction [2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]]"	21726595
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of CYP17A1 mRNA	15817663
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Lactones results in decreased activity of CYP17A1 protein]	19913079
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased activity of CYP17A1 protein	17138841\|1991307
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CYP17A1 mRNA	17138841
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	pioglitazone inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased activity of CYP17A1 protein]	17138841
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	pioglitazone inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CYP17A1 mRNA]	17138841
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of CYP17A1 protein"	24451217
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of CYP17A1 mRNA"	11509743
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of CYP17A1 mRNA"	11509743
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of CYP17A1 protein"	24451217
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CYP17A1 mRNA"	19114083
C038890	2,3,4,7,8-pentachlorodibenzofuran	"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of CYP17A1 mRNA"	21724226
C066841	2,3,7,8-tetrabromodibenzo-4-dioxin	"2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of CYP17A1 mRNA"	17447562
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of CYP17A1 mRNA"	21724226
C547124	2,3-dibromopropyl-2,4,6-tribromophenyl ether	"2,3-dibromopropyl-2,4,6-tribromophenyl ether analog results in decreased expression of CYP17A1 mRNA"	25818047
C547124	2,3-dibromopropyl-2,4,6-tribromophenyl ether	"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of CYP17A1 mRNA"	25818047
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP17A1 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP17A1 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP17A1 mRNA"	25510870
C004554	2,4,6-tribromophenol	"2,4,6-tribromophenol affects the expression of CYP17A1 mRNA"	19931292
C004554	2,4,6-tribromophenol	"2,4,6-tribromophenol results in decreased expression of CYP17A1 mRNA"	17447562
C013930	2,4-dibromophenol	"2,4-dibromophenol results in increased expression of CYP17A1 mRNA"	17447562
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CYP17A1 mRNA"	21346803
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP17A1 mRNA"	25510870
C104450	25-hydroxyvitamin D	25-hydroxyvitamin D deficiency results in decreased expression of CYP17A1 protein	28655646
C038964	2,6-dibromophenol	"2,6-dibromophenol results in decreased expression of CYP17A1 mRNA"	17447562
C014953	2-acetyltributylcitrate	2-acetyltributylcitrate results in decreased expression of CYP17A1 mRNA	28235592
C032038	2-bromophenol	2-bromophenol results in increased expression of CYP17A1 mRNA	17447562
C032790	3,3',4,4',5,5'-hexabromobiphenyl	"3,3',4,4',5,5'-hexabromobiphenyl results in increased expression of CYP17A1 mRNA"	17447562
C036685	3,3',4,4'-tetrabromobiphenyl	"3,3',4,4'-tetrabromobiphenyl results in increased expression of CYP17A1 mRNA"	17447562
C041525	3,3',4,5'-tetrahydroxystilbene	"3,3',4,5'-tetrahydroxystilbene results in decreased activity of CYP17A1 protein"	24610083
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in increased expression of CYP17A1 mRNA"	27092574
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP17A1 protein"	15703266
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP17A1 mRNA"	15703266
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA"	16216300
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA"	12781204
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA"	20959002
C017906	3-dinitrobenzene	3-dinitrobenzene results in decreased expression of CYP17A1 mRNA	22841810
C439677	3-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene	"3-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene results in decreased activity of CYP17A1 protein"	15555909
C500627	3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene	"3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene results in decreased activity of CYP17A1 protein"	15828836
C500627	3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene	"3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene results in decreased activity of CYP17A1 protein"	18985049\|2109275
C495960	3-hydroxy-17-(imidazol-1-yl)androsta-5,16-diene	"3-hydroxy-17-(imidazol-1-yl)androsta-5,16-diene results in decreased activity of CYP17A1 protein"	15555909
C003524	4,16-androstadien-3-one	"4,16-androstadien-3-one analog results in decreased activity of CYP17A1 protein"	11118046
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of CYP17A1 mRNA"	26751127
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in decreased expression of CYP17A1 mRNA"	25723718
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in decreased expression of CYP17A1 mRNA"	26751127
C494060	4-nitro-3-phenylphenol	[4-nitro-3-phenylphenol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of CYP17A1 protein	18336853
C041594	4-nonylphenol	4-nonylphenol results in decreased expression of CYP17A1 mRNA	29029336
C041594	4-nonylphenol	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA	29029336
C080417	4-octylphenol	4-octylphenol results in decreased expression of CYP17A1 protein	9361775
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of CYP17A1 mRNA	17696135
C105260	4-tert-octylphenol	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA	29029336
C521334	5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate	5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of CYP17A1 mRNA	20932894
C046094	7-chlorobenz(a)anthracene	7-chlorobenz(a)anthracene results in increased expression of CYP17A1 mRNA	23358148
C037112	9-deoxy-delta-9-prostaglandin D2	9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]	11889176
C089740	abiraterone	abiraterone analog results in decreased activity of CYP17A1 protein	17194026
C089740	abiraterone	abiraterone results in decreased activity of CYP17A1 protein	29100959
C089740	abiraterone	[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone	29100959
C089740	abiraterone	[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone	29100959
C089740	abiraterone	[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone	29100959
C089740	abiraterone	[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone	29100959
C089740	abiraterone	abiraterone results in decreased activity of CYP17A1 protein	25993309
D000069501	Abiraterone Acetate	Abiraterone Acetate results in decreased activity of CYP17A1 protein	18985049\|2109275
D000079	Acetaldehyde	[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of CYP17A1 mRNA	22285649
D000079	Acetaldehyde	CYP17A1 protein results in increased abundance of Acetaldehyde	22285649
D000082	Acetaminophen	Acetaminophen affects the expression of CYP17A1 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of CYP17A1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP17A1 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in decreased expression of CYP17A1 mRNA	17202762
D000082	Acetaminophen	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CYP17A1 mRNA	25607892
C033116	acetyl methyl tetramethyl tetralin	[acetyl methyl tetramethyl tetralin co-treated with Cyclic AMP] results in decreased activity of CYP17A1 protein	23084589
C033116	acetyl methyl tetramethyl tetralin	[acetyl methyl tetramethyl tetralin co-treated with Cyclic AMP] results in increased activity of CYP17A1 protein	23084589
C033116	acetyl methyl tetramethyl tetralin	acetyl methyl tetramethyl tetralin results in increased activity of CYP17A1 protein	23084589
D000242	Cyclic AMP	[acetyl methyl tetramethyl tetralin co-treated with Cyclic AMP] results in decreased activity of CYP17A1 protein	23084589
D000242	Cyclic AMP	[acetyl methyl tetramethyl tetralin co-treated with Cyclic AMP] results in increased activity of CYP17A1 protein	23084589
D000242	Cyclic AMP	[galaxolide co-treated with Cyclic AMP] results in decreased activity of CYP17A1 protein	23084589
D000242	Cyclic AMP	[galaxolide co-treated with Cyclic AMP] results in increased activity of CYP17A1 protein	23084589
D000242	Cyclic AMP	Cyclic AMP results in increased expression of CYP17A1 mRNA	25576683
D000324	Adrenocorticotropic Hormone	Adrenocorticotropic Hormone results in increased expression of CYP17A1 mRNA	15625562
D000324	Adrenocorticotropic Hormone	CYP17A1 protein affects the abundance of Adrenocorticotropic Hormone	18645707
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CYP17A1 mRNA	19770486
D000420	Albuterol	Albuterol results in increased expression of CYP17A1	17822730
D043582	5-alpha-Dihydroprogesterone	CYP17A1 protein results in increased hydroxylation of 5-alpha-Dihydroprogesterone	14522586
D006907	17-alpha-Hydroxypregnenolone	[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone	29100959
D006907	17-alpha-Hydroxypregnenolone	CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxypregnenolone	16030167
D006907	17-alpha-Hydroxypregnenolone	CYP17A1 protein affects the metabolism of 17-alpha-Hydroxypregnenolone	16030167
D006907	17-alpha-Hydroxypregnenolone	CYP17A1 protein results in decreased acetylation of 17-alpha-Hydroxypregnenolone	15562394
D006907	17-alpha-Hydroxypregnenolone	[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone	17194026\|2910095
D006907	17-alpha-Hydroxypregnenolone	CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone	29100959
D006907	17-alpha-Hydroxypregnenolone	[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone	29100959
D006907	17-alpha-Hydroxypregnenolone	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]	29100959
D006907	17-alpha-Hydroxypregnenolone	Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]	29100959
D006907	17-alpha-Hydroxypregnenolone	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]	29100959
D006907	17-alpha-Hydroxypregnenolone	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]	29100959
D006907	17-alpha-Hydroxypregnenolone	Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]	29100959
D006907	17-alpha-Hydroxypregnenolone	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]	29100959
D006907	17-alpha-Hydroxypregnenolone	CYP17A1 protein results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone	22285649
C011512	alpha-naphthoflavone	alpha-naphthoflavone results in decreased expression of CYP17A1 mRNA	24875446
C005197	alternariol	alternariol results in increased expression of CYP17A1 mRNA	23665424
D000616	Aminoglutethimide	Aminoglutethimide results in decreased expression of CYP17A1 mRNA	16935330
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CYP17A1 mRNA	16483693
D000726	Androgen Antagonists	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CYP17A1 mRNA	25607892
D000728	Androgens	CYP17A1 protein affects the chemical synthesis of Androgens	15761033
D000728	Androgens	CYP17A1 protein affects the chemical synthesis of Androgens	14624484
D000728	Androgens	CYP17A1 protein affects the chemical synthesis of Androgens	15862817
C030419	andrographolide	[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CYP17A1 mRNA	19737545
C000152	androsta-5,16-dien-3 beta-ol	"androsta-5,16-dien-3 beta-ol analog results in decreased activity of CYP17A1 protein"	11118046
C000152	androsta-5,16-dien-3 beta-ol	"CYP17A1 protein affects the chemical synthesis of androsta-5,16-dien-3 beta-ol"	12631293
C000152	androsta-5,16-dien-3 beta-ol	"CYP17A1 protein affects the chemical synthesis of androsta-5,16-dien-3 beta-ol"	12631293
D000735	Androstenedione	Androstenedione results in decreased expression of CYP17A1 mRNA	15625562
D000735	Androstenedione	[DAX1 protein results in decreased expression of CYP17A1 mRNA] which results in decreased abundance of Androstenedione	18409030
D000735	Androstenedione	FSHB protein inhibits the reaction [[[NR0B1 protein binds to CYP17A1 promoter] which results in increased expression of CYP17A1 mRNA] which results in increased abundance of Androstenedione]	22155568\|2215556
D000735	Androstenedione	FSHB protein promotes the reaction [[[GATA6 protein binds to CYP17A1 promoter] which results in increased expression of CYP17A1 mRNA] which results in increased abundance of Androstenedione]	22155568\|2215556
D000735	Androstenedione	FSHB protein promotes the reaction [[[NR5A1 protein binds to CYP17A1 promoter] which results in increased expression of CYP17A1 mRNA] which results in increased abundance of Androstenedione]	22155568\|2215556
D000735	Androstenedione	[LHB protein results in increased expression of CYP17A1 mRNA] which results in increased abundance of Androstenedione	22155568
D000735	Androstenedione	Androstenedione results in decreased expression of CYP17A1 mRNA	15625562
D000735	Androstenedione	CYP17A1 protein affects the abundance of Androstenedione	21427057
D000735	Androstenedione	CYP17A1 protein affects the chemical synthesis of Androstenedione	14522586\|1556239
D000735	Androstenedione	[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione	29100959
D000735	Androstenedione	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]	29100959
D000735	Androstenedione	TNF protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Androstenedione]	16030167
D000735	Androstenedione	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]	29100959
D000735	Androstenedione	CYP17A1 protein affects the chemical synthesis of Androstenedione	15555913
D000735	Androstenedione	CYP17A1 protein affects the chemical synthesis of Androstenedione	15640159
D000735	Androstenedione	CYP17A1 protein results in increased abundance of Androstenedione	24451217
D000738	Androsterone	CYP17A1 protein affects the chemical synthesis of Androsterone	14522586
C103016	antalarmin	antalarmin results in decreased expression of CYP17A1 mRNA	16014403
D047310	Apigenin	Apigenin inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	23370353
D001151	Arsenic	CYP17A1 protein affects the metabolism of Arsenic	18682255
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CYP17A1 mRNA	18630931
C104416	astressin	astressin results in decreased expression of CYP17A1 mRNA	16014403
D001280	Atrazine	Atrazine results in increased expression of CYP17A1 mRNA	25929836
D001280	Atrazine	Atrazine results in increased expression of CYP17A1 protein	23358194
D001280	Atrazine	Atrazine results in decreased expression of CYP17A1 mRNA	23376530\|2359156
D001280	Atrazine	[Atrazine co-treated with Bucladesine] results in increased expression of CYP17A1 mRNA	23200735
D001280	Atrazine	Atrazine results in decreased expression of CYP17A1 mRNA	19541795
D001280	Atrazine	Atrazine results in increased expression of CYP17A1 mRNA	20667998\|2320073
D001280	Atrazine	Atrazine results in increased expression of CYP17A1 protein	20667998
D001280	Atrazine	Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of CYP17A1 mRNA]	23200735
D001280	Atrazine	Quercetin inhibits the reaction [Atrazine results in increased expression of CYP17A1 mRNA]	23200735
D001542	Benomyl	Benomyl results in decreased expression of and results in decreased activity of CYP17A1 protein	25324206
D001542	Benomyl	Benomyl results in decreased expression of CYP17A1 mRNA	25324206
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of CYP17A1 mRNA	26377693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CYP17A1 mRNA	27858113
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of CYP17A1 mRNA	23358148
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CYP17A1 mRNA	27858113
D019324	beta-Naphthoflavone	[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CYP17A1 mRNA	19737545
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CYP17A1 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CYP17A1 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of CYP17A1 mRNA	22960446
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CYP17A1 mRNA	21737371
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CYP17A1 protein	21737371
D001599	Berberine	Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA]	20462044
C075388	beta-damascenone	beta-damascenone results in increased expression of CYP17A1 mRNA	22982537
D004958	Estradiol	bisphenol A promotes the reaction [Estradiol results in increased expression of CYP17A1 mRNA]	28476547
D004958	Estradiol	bisphenol A promotes the reaction [Estradiol results in increased expression of CYP17A1 protein]	28476547
D004958	Estradiol	ESR1 protein affects the reaction [Estradiol results in decreased expression of CYP17A1 mRNA]	17158782
D004958	Estradiol	"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of CYP17A1 mRNA"	11509743
D004958	Estradiol	[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of CYP17A1 mRNA	11509743
D004958	Estradiol	Estradiol results in decreased expression of CYP17A1 mRNA	11509743\|1715878
D004958	Estradiol	Estradiol results in decreased expression of CYP17A1 protein	28476547
D004958	Estradiol	Estradiol results in increased expression of CYP17A1 mRNA	18281260\|2368455
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of CYP17A1 mRNA	26496021
D004958	Estradiol	Estradiol results in decreased expression of CYP17A1 mRNA	20144698
D004958	Estradiol	Estradiol results in decreased expression of CYP17A1 protein	20144698
C095105	bexarotene	[bexarotene co-treated with Tamoxifen] results in increased expression of CYP17A1 mRNA	17630414
D001629	Bezafibrate	Bezafibrate results in increased expression of CYP17A1 mRNA	21703979
C099952	bifenthrin	bifenthrin results in increased expression of CYP17A1 mRNA	24938463
C099952	bifenthrin	bifenthrin results in decreased expression of CYP17A1 mRNA	23994515\|2444916
C099952	bifenthrin	bifenthrin results in increased expression of CYP17A1 mRNA	26071804
D001688	Biological Products	Biological Products results in decreased expression of CYP17A1 mRNA	26055946
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of CYP17A1 mRNA	26751127
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of CYP17A1 mRNA	25576683
C006780	bisphenol A	bisphenol A affects the expression of CYP17A1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of CYP17A1 mRNA	28765074
C006780	bisphenol A	bisphenol A results in increased expression of CYP17A1 mRNA	27855330
C006780	bisphenol A	bisphenol A affects the expression of CYP17A1 mRNA	28501544
C006780	bisphenol A	bisphenol A affects the methylation of CYP17A1 gene	28501544
C006780	bisphenol A	bisphenol A results in increased expression of CYP17A1 mRNA	22710023
C006780	bisphenol A	bisphenol A results in decreased activity of CYP17A1 protein	21427057\|2192525
C006780	bisphenol A	bisphenol A results in decreased expression of CYP17A1 mRNA	26751127
C006780	bisphenol A	bisphenol A affects the expression of CYP17A1 mRNA	28476547
C006780	bisphenol A	bisphenol A affects the expression of CYP17A1 protein	28476547
C006780	bisphenol A	bisphenol A promotes the reaction [Estradiol results in increased expression of CYP17A1 mRNA]	28476547
C006780	bisphenol A	bisphenol A promotes the reaction [Estradiol results in increased expression of CYP17A1 protein]	28476547
C006780	bisphenol A	bisphenol A results in decreased expression of CYP17A1 mRNA	21182934\|2402436
C006780	bisphenol A	bisphenol A results in increased expression of CYP17A1 mRNA	17706920\|2674610
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CYP17A1 mRNA	25607892
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of CYP17A1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased activity of CYP17A1 protein	21925253
C006780	bisphenol A	bisphenol A results in decreased expression of CYP17A1 mRNA	15901920\|2014469
C006780	bisphenol A	bisphenol A results in decreased expression of CYP17A1 protein	14605012\|2014469
C006780	bisphenol A	[bisphenol A results in decreased expression of CYP17A1 protein] which results in decreased abundance of Testosterone	14605012
C006780	bisphenol A	bisphenol A results in increased expression of CYP17A1 mRNA	18191889
C006780	bisphenol A	[bisphenol A results in increased expression of CYP17A1 mRNA] which affects the abundance of Testosterone	18191889
C006780	bisphenol A	"[Gonadotropins, Equine co-treated with bisphenol A] results in increased expression of CYP17A1 mRNA"	28648634
C000611646	bisphenol F	bisphenol F results in decreased expression of CYP17A1 mRNA	28741210
C584056	BMS-764459	BMS-764459 results in decreased expression of CYP17A1 mRNA	23831372
D015124	8-Bromo Cyclic Adenosine Monophosphate	[4-nitro-3-phenylphenol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of CYP17A1 protein	18336853
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA	22079614\|2254648
D015124	8-Bromo Cyclic Adenosine Monophosphate	Mitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]	22546480
D015124	8-Bromo Cyclic Adenosine Monophosphate	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein]]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA	21726595\|2401464
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP17A1 mRNA	21610156
D015124	8-Bromo Cyclic Adenosine Monophosphate	"THRA mutant form inhibits the reaction [2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein]	21726595
C027561	butylbenzyl phthalate	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA	29029336
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of CYP17A1 mRNA	26472102
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CYP17A1 mRNA	25607892
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CYP17A1 mRNA	23741332
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CYP17A1 mRNA	19897027\|2498288
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CYP17A1 protein	19897027
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CYP17A1 mRNA	25993096
D002110	Caffeine	Caffeine results in increased expression of CYP17A1 mRNA	25868845
D002220	Carbamazepine	Carbamazepine results in decreased activity of CYP17A1 protein	15730543
D002220	Carbamazepine	Carbamazepine results in decreased expression of CYP17A1 mRNA	19566492
C010059	carbamylhydrazine	carbamylhydrazine analog results in decreased expression of CYP17A1 mRNA	28834696
C062876	cetrorelix	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP17A1 mRNA	18160741
C062876	cetrorelix	[cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP17A1 mRNA	18160741
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased expression of CYP17A1 mRNA	22961653
D002635	Chenodeoxycholic Acid	NR1H4 protein promotes the reaction [Chenodeoxycholic Acid results in decreased expression of CYP17A1 mRNA]	22961653
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP17A1 mRNA	29208485
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP17A1 protein	29208485
D002738	Chloroquine	Chloroquine results in decreased expression of CYP17A1 mRNA	19393257
D002784	Cholesterol	CYP17A1 protein affects the chemical synthesis of Cholesterol	15761033
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CYP17A1 mRNA	27858113
C029010	cinnamic acid	cinnamic acid analog results in decreased activity of CYP17A1 protein	15072549
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of CYP17A1 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of CYP17A1 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP17A1 mRNA]	17585979
D002994	Clofibrate	Clofibrate results in increased expression of CYP17A1 mRNA	15033592
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CYP17A1 mRNA	17602206
D003022	Clotrimazole	Clotrimazole results in increased expression of CYP17A1 mRNA	22564764
D003022	Clotrimazole	Clotrimazole results in increased expression of CYP17A1 protein	22564764
D003033	Coal Tar	Coal Tar results in decreased expression of CYP17A1 mRNA	27858113
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CYP17A1 mRNA	22816610
D005576	Colforsin	Colforsin results in increased expression of CYP17A1 mRNA	15625562
D005576	Colforsin	Apigenin inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	23370353
D005576	Colforsin	Colforsin results in increased expression of CYP17A1 mRNA	15625562\|1588625
D005576	Colforsin	Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	16935330
D005576	Colforsin	Lindane inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	17080404
D005576	Colforsin	Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	16935330
D005576	Colforsin	TGFB1 protein inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	15625562
D005576	Colforsin	Valproic Acid inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	20726872
D005576	Colforsin	AGT protein inhibits the reaction [Colforsin results in increased expression of CYP17A1 protein]	15666819
D005576	Colforsin	Colforsin results in increased expression of CYP17A1 protein	15666819
D005576	Colforsin	Tetradecanoylphorbol Acetate inhibits the reaction [Colforsin results in increased expression of CYP17A1 protein]	15666819
D005576	Colforsin	AGT protein inhibits the reaction [Colforsin results in increased expression of CYP17A1 protein]	15666819
D005576	Colforsin	Colforsin results in increased expression of CYP17A1 protein	15666819
D005576	Colforsin	Tetradecanoylphorbol Acetate inhibits the reaction [Colforsin results in increased expression of CYP17A1 protein]	15666819
D005576	Colforsin	Colforsin results in increased expression of CYP17A1 mRNA	22461451
D003314	Corn Oil	Corn Oil affects the expression of CYP17A1 mRNA	16360708
C029892	cupric chloride	cupric chloride results in increased expression of CYP17A1 mRNA	24650576
D003484	Cyanamide	Cyanamide inhibits the reaction [CGA protein results in increased expression of CYP17A1 mRNA]	22285649
D016572	Cyclosporine	Cyclosporine results in decreased expression of CYP17A1 mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in decreased expression of CYP17A1 mRNA	19770486
C017160	cypermethrin	cypermethrin results in decreased expression of CYP17A1 mRNA	21397294\|2156030
C017160	cypermethrin	cypermethrin results in decreased expression of CYP17A1 protein	24810582
D065607	Cytochrome P-450 Enzyme Inhibitors	Cytochrome P-450 Enzyme Inhibitors analog results in decreased activity of CYP17A1 protein	17194026
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid affects the expression of CYP17A1 mRNA"	26838045
D003634	DDT	DDT results in increased expression of CYP17A1 mRNA	23684557
D003634	DDT	fulvestrant inhibits the reaction [DDT results in increased expression of CYP17A1 mRNA]	23684557
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased activity of CYP17A1 protein	18495385
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in decreased expression of CYP17A1 mRNA	15625562
D003687	Dehydroepiandrosterone	CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosterone	15562394\|1603016
D003687	Dehydroepiandrosterone	[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone	29100959
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in decreased expression of CYP17A1 mRNA	15625562
D003687	Dehydroepiandrosterone	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]	29100959
D003687	Dehydroepiandrosterone	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]	29100959
D003687	Dehydroepiandrosterone	CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosterone	15666818
D003687	Dehydroepiandrosterone	CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosterone	15934942
D003687	Dehydroepiandrosterone	CYP17A1 protein affects the metabolism of Dehydroepiandrosterone	15261307
D003687	Dehydroepiandrosterone	CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosterone	15640159
D003687	Dehydroepiandrosterone	CYP17A1 protein results in increased chemical synthesis of Dehydroepiandrosterone	22285649
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CYP17A1 mRNA	22982764
D017135	Desogestrel	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP17A1 mRNA	18160741
D003907	Dexamethasone	Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA]	20462044
D003907	Dexamethasone	Dexamethasone results in increased expression of CYP17A1 mRNA	20462044
D003907	Dexamethasone	[Dexamethasone co-treated with Dibutyl Phthalate] results in decreased expression of CYP17A1 mRNA	22615892
D003907	Dexamethasone	Dexamethasone results in increased expression of CYP17A1	19852296
C526766	diaminochlorotriazine	diaminochlorotriazine results in decreased expression of CYP17A1 mRNA	24632104
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of CYP17A1 mRNA	23656968
C088674	dibromoacetic acid	dibromoacetic acid results in decreased expression of CYP17A1 mRNA	21046364
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CYP17A1 mRNA	22511013
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CYP17A1 mRNA	25765776
D003993	Dibutyl Phthalate	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA	29029336
D003993	Dibutyl Phthalate	[Dexamethasone co-treated with Dibutyl Phthalate] results in decreased expression of CYP17A1 mRNA	22615892
D003993	Dibutyl Phthalate	Dibutyl Phthalate inhibits the reaction [CEBPB binds to CYP17A1 promoter]	17884934
D003993	Dibutyl Phthalate	Dibutyl Phthalate inhibits the reaction [NR5A1 binds to CYP17A1 promoter]	17884934
D003993	Dibutyl Phthalate	Dibutyl Phthalate inhibits the reaction [NR5A1 protein binds to CYP17A1 promoter]	23358192
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CYP17A1 mRNA	14617579\|1514109
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CYP17A1 protein	14617579\|1514109
D003994	Bucladesine	[Atrazine co-treated with Bucladesine] results in increased expression of CYP17A1 mRNA	23200735
D003994	Bucladesine	Bucladesine results in decreased expression of CYP17A1 mRNA	21693180
D003994	Bucladesine	Bucladesine results in increased expression of CYP17A1 mRNA	21458522
D003994	Bucladesine	Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of CYP17A1 mRNA]	23200735
D004008	Diclofenac	Diclofenac results in increased expression of CYP17A1 mRNA	26934552
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in decreased expression of CYP17A1 mRNA	26924002
D004041	Dietary Fats	Dietary Fats affects the expression of CYP17A1 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in increased expression of CYP17A1 mRNA	25016146
D004042	Dietary Fats, Unsaturated	"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of CYP17A1 mRNA]"	23626681
D004051	Diethylhexyl Phthalate	[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA	29029336
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of CYP17A1 mRNA	25701202\|2597599
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of CYP17A1 protein	27405655
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of CYP17A1 mRNA	26472102
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CYP17A1 mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CYP17A1 mRNA	17602206
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased activity of CYP17A1 protein	12112309
D004052	Diethylnitrosamine	[nodularin co-treated with Diethylnitrosamine] results in decreased activity of CYP17A1 protein	12112309
C007379	diethyl phthalate	diethyl phthalate inhibits the reaction [NR5A1 binds to CYP17A1 promoter]	17884934
D004054	Diethylstilbestrol	Diethylstilbestrol affects the expression of CYP17A1 mRNA	15196701
D004054	Diethylstilbestrol	Diethylstilbestrol affects the expression of CYP17A1 protein	15196701
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CYP17A1 mRNA	22615892
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CYP17A1 protein	9361775
C089799	diheptyl phthalate	diheptyl phthalate results in decreased expression of CYP17A1 mRNA	22112501
C025605	diisobutyl phthalate	diisobutyl phthalate results in decreased expression of CYP17A1 mRNA	22112501\|2865564
C012125	diisononyl phthalate	diisononyl phthalate results in decreased expression of CYP17A1 mRNA	22112501\|2544572
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of CYP17A1 mRNA	17072980
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of CYP17A1 mRNA	26924002
C027387	di-n-hexyl phthalate	di-n-hexyl phthalate results in decreased expression of CYP17A1 mRNA	22112501\|2693418
C027387	di-n-hexyl phthalate	di-n-hexyl phthalate results in decreased expression of CYP17A1 protein	26934186
C034171	di-n-pentyl phthalate	di-n-pentyl phthalate results in decreased activity of CYP17A1 protein	6829050
C034171	di-n-pentyl phthalate	di-n-pentyl phthalate results in decreased expression of CYP17A1 mRNA	22112501\|2505596
C034171	di-n-pentyl phthalate	[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP17A1 mRNA	25055962
D004221	Disulfiram	Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]	22285649
C035144	drospirenone	[Ethinyl Estradiol co-treated with drospirenone] results in decreased activity of CYP17A1 protein	17418832
D000068736	Duloxetine Hydrochloride	Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]	29100959
D000068736	Duloxetine Hydrochloride	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]	29100959
D000068736	Duloxetine Hydrochloride	Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]	29100959
D000068736	Duloxetine Hydrochloride	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]	29100959
D000068736	Duloxetine Hydrochloride	Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]	29100959
D000068736	Duloxetine Hydrochloride	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]	29100959
D000068736	Duloxetine Hydrochloride	Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]	29100959
D000068736	Duloxetine Hydrochloride	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]	29100959
D000068736	Duloxetine Hydrochloride	Duloxetine Hydrochloride results in decreased activity of CYP17A1 protein	29100959
C100264	enniatins	enniatins results in decreased expression of CYP17A1 mRNA	25625232
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of CYP17A1 mRNA	21420147
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CYP17A1 mRNA	25607892
C579439	epiallopregnanolone sulfate	epiallopregnanolone sulfate results in decreased expression of CYP17A1 mRNA	22961653
C579439	epiallopregnanolone sulfate	NR1H4 protein promotes the reaction [epiallopregnanolone sulfate results in decreased expression of CYP17A1 mRNA]	22961653
D060754	Equol	Equol results in decreased expression of CYP17A1 mRNA	26876617
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in decreased expression of CYP17A1 protein	24752506
D004967	Estrogens	CYP17A1 promoter polymorphism affects the metabolism of Estrogens	16850246
D004967	Estrogens	CYP17A1 protein affects the chemical synthesis of Estrogens	15341023
D002393	Estrogens, Catechol	"CYP17A1 protein polymorphism results in increased chemical synthesis of Estrogens, Catechol"	15288375
D004970	Estrone	CYP17A1 protein affects the abundance of Estrone	21427057
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CYP17A1 mRNA	22710023
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with drospirenone] results in decreased activity of CYP17A1 protein	17418832
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CYP17A1 mRNA	14976129
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CYP17A1 mRNA	12072388
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CYP17A1 mRNA	26379055
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CYP17A1 mRNA	15858796
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CYP17A1 mRNA	17222921
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CYP17A1 mRNA	12655037\|1583489
C024565	ethylene dichloride	ethylene dichloride affects the expression of CYP17A1 mRNA	28973639
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of CYP17A1 mRNA	27776689
C026098	etiracetam	etiracetam results in decreased expression of CYP17A1 mRNA	19566492
D015025	Zearalenone	Zearalenone results in decreased expression of CYP17A1 mRNA	24512812
D017316	Fadrozole	Fadrozole results in decreased activity of CYP17A1 protein	15743198\|1577142
C004808	farnesyl pyrophosphate	farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]	21918126
C033789	fenarimol	fenarimol results in increased expression of CYP17A1 mRNA	21722721
C033789	fenarimol	fenarimol results in increased expression of CYP17A1 protein	21722721
C017690	fenvalerate	fenvalerate results in decreased expression of CYP17A1 mRNA	20063364\|2013895
C017690	fenvalerate	fenvalerate results in decreased expression of CYP17A1 protein	20063364\|2013895
D005411	Flame Retardants	Flame Retardants results in increased expression of CYP17A1 mRNA	22446829
D005411	Flame Retardants	Flame Retardants metabolite results in decreased expression of CYP17A1 mRNA	18248924
D005411	Flame Retardants	Flame Retardants metabolite results in increased expression of CYP17A1 mRNA	18248924
D005411	Flame Retardants	Flame Retardants results in decreased expression of CYP17A1 mRNA	17447562\|2244682
D005411	Flame Retardants	Flame Retardants results in increased expression of CYP17A1 mRNA	17447562
D005411	Flame Retardants	Flame Retardants results in decreased activity of CYP17A1 protein	18243468
D005485	Flutamide	Flutamide results in decreased expression of CYP17A1 mRNA	21126777
D005485	Flutamide	Flutamide results in increased expression of CYP17A1 mRNA	11509743
D005485	Flutamide	Flutamide affects the expression of CYP17A1 mRNA	17222921
D005485	Flutamide	Flutamide results in decreased expression of CYP17A1 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of CYP17A1 mRNA	14967917\|1929941
C069837	fullerene C60	fullerene C60 results in decreased expression of CYP17A1 mRNA	19167457
C070081	fulvestrant	fulvestrant inhibits the reaction [DDT results in increased expression of CYP17A1 mRNA]	23684557
C070081	fulvestrant	fulvestrant results in increased expression of CYP17A1 mRNA	17158782
C056933	fumonisin B1	fumonisin B1 results in decreased expression of CYP17A1 mRNA	16221962
C033119	galaxolide	[galaxolide co-treated with Cyclic AMP] results in decreased activity of CYP17A1 protein	23084589
C033119	galaxolide	[galaxolide co-treated with Cyclic AMP] results in increased activity of CYP17A1 protein	23084589
C033119	galaxolide	galaxolide results in decreased activity of CYP17A1 protein	23084589
C033119	galaxolide	galaxolide results in increased activity of CYP17A1 protein	23084589
C001277	geldanamycin	geldanamycin results in increased expression of CYP17A1 mRNA	15711029
D019833	Genistein	Genistein results in decreased expression of CYP17A1 mRNA	21624456\|2679261
D019833	Genistein	Genistein results in increased expression of CYP17A1 mRNA	18281260
D019833	Genistein	Genistein results in decreased expression of CYP17A1 mRNA	15901920
D005839	Gentamicins	Gentamicins results in decreased expression of CYP17A1 mRNA	22061828
C002963	geranylgeranyl pyrophosphate	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]	21918126
D005897	Glafenine	Glafenine results in decreased expression of CYP17A1 mRNA	24136188
D012739	Gonadal Steroid Hormones	CYP17A1 protein affects the chemical synthesis of Gonadal Steroid Hormones	16045239
D006064	Gonadotropins, Equine	"[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of CYP17A1 mRNA"	28648634
D006064	Gonadotropins, Equine	"[Gonadotropins, Equine co-treated with bisphenol A] results in increased expression of CYP17A1 mRNA"	28648634
D006064	Gonadotropins, Equine	"Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP17A1 mRNA]"	19276399
D055768	Halogenated Diphenyl Ethers	Halogenated Diphenyl Ethers metabolite results in decreased expression of CYP17A1 mRNA	18313098
D055768	Halogenated Diphenyl Ethers	Halogenated Diphenyl Ethers metabolite results in increased expression of CYP17A1 mRNA	18313098
D055768	Halogenated Diphenyl Ethers	[Halogenated Diphenyl Ethers co-treated with hexabromocyclododecane] results in decreased expression of CYP17A1 mRNA	26607716
D006063	Chorionic Gonadotropin	"[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of CYP17A1 mRNA"	28648634
D006063	Chorionic Gonadotropin	Chorionic Gonadotropin results in increased expression of CYP17A1 mRNA	15930178
C089796	hexabromocyclododecane	[Halogenated Diphenyl Ethers co-treated with hexabromocyclododecane] results in decreased expression of CYP17A1 mRNA	26607716
D006581	Hexachlorobenzene	Hexachlorobenzene results in decreased expression of CYP17A1 protein	21296658
C012351	HT-2 toxin	HT-2 toxin results in decreased expression of CYP17A1 mRNA	22982764
C029424	hydrazine	hydrazine results in increased expression of CYP17A1 mRNA	15370871
D019326	17-alpha-Hydroxyprogesterone	[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone	29100959
D019326	17-alpha-Hydroxyprogesterone	CYP17A1 protein affects the abundance of 17-alpha-Hydroxyprogesterone	21427057
D019326	17-alpha-Hydroxyprogesterone	CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxyprogesterone	16030167
D019326	17-alpha-Hydroxyprogesterone	CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone	16030167
D019326	17-alpha-Hydroxyprogesterone	[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone	17194026\|2910095
D019326	17-alpha-Hydroxyprogesterone	CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone	29100959
D019326	17-alpha-Hydroxyprogesterone	[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione	29100959
D019326	17-alpha-Hydroxyprogesterone	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]	29100959
D019326	17-alpha-Hydroxyprogesterone	Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]	29100959
D019326	17-alpha-Hydroxyprogesterone	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]	29100959
D019326	17-alpha-Hydroxyprogesterone	TNF protein inhibits the reaction [CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone]	16030167
D019326	17-alpha-Hydroxyprogesterone	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]	29100959
D019326	17-alpha-Hydroxyprogesterone	Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]	29100959
D019326	17-alpha-Hydroxyprogesterone	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]	29100959
D006908	Hydroxyprogesterones	CYP17A1 protein results in decreased acetylation of Hydroxyprogesterones	15562394
C082359	imidacloprid	imidacloprid results in decreased expression of CYP17A1 mRNA	27782041
C011582	IMOL S-140	IMOL S-140 results in increased expression of CYP17A1 mRNA	22446829
D007189	Indans	Indans results in decreased activity of CYP17A1 protein	15743198
D007220	Industrial Waste	Industrial Waste results in decreased expression of CYP17A1 mRNA	26055946
D007529	Isoflavones	Isoflavones results in increased activity of CYP17A1 protein	15698548
C040920	isoliquiritigenin	isoliquiritigenin results in decreased expression of CYP17A1 mRNA	27773742
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	16935330
D007654	Ketoconazole	Ketoconazole results in decreased activity of CYP17A1 protein	11118046\|1574319
D007654	Ketoconazole	Ketoconazole results in decreased expression of CYP17A1 mRNA	16935330
D007654	Ketoconazole	Ketoconazole results in decreased expression of CYP17A1 mRNA	18423573
D007654	Ketoconazole	Ketoconazole results in increased expression of CYP17A1 mRNA	17571688
D007654	Ketoconazole	Ketoconazole results in decreased activity of CYP17A1 protein	15934942\|2599330
D007654	Ketoconazole	Ketoconazole results in decreased activity of CYP17A1 protein	18985049\|2109275
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of CYP17A1 mRNA	15469884
D007783	Lactones	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Lactones results in decreased activity of CYP17A1 protein]	19913079
D007783	Lactones	Lactones results in decreased activity of CYP17A1 protein	19913079
D007783	Lactones	Lactones results in increased metabolism of CYP17A1 protein	19913079
C047781	lamotrigine	lamotrigine results in decreased activity of CYP17A1 protein	15730543
C008261	lead acetate	lead acetate results in increased expression of CYP17A1 mRNA	21335049
C045463	leflunomide	leflunomide results in decreased expression of CYP17A1 mRNA	24136188
D001556	Lindane	Lindane inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	17080404
D008044	Linuron	Linuron results in decreased expression of CYP17A1 mRNA	28007637\|2870577
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of CYP17A1 mRNA"	24972896
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CYP17A1 mRNA	8828518
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CYP17A1 protein	8828518
D008070	Lipopolysaccharides	[Lipopolysaccharides results in decreased expression of CYP17A1 protein] which results in decreased abundance of Testosterone	8828518
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CYP17A1 mRNA	27339419
D008687	Metformin	Metformin results in decreased expression of CYP17A1 mRNA	23166782
D008727	Methotrexate	Methotrexate affects the expression of CYP17A1 mRNA	18502557
C013598	methoxyacetic acid	methoxyacetic acid results in increased expression of CYP17A1 mRNA	18486176
D008731	Methoxychlor	[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of CYP17A1 mRNA	11509743
D008731	Methoxychlor	Methoxychlor metabolite results in decreased expression of CYP17A1 mRNA	11509743
D008731	Methoxychlor	Methoxychlor results in decreased expression of CYP17A1 mRNA	21514315
C005219	methyl cellosolve	methyl cellosolve results in decreased expression of CYP17A1 mRNA	21061450
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CYP17A1 mRNA	26011545
D008797	Metyrapone	Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	16935330
D008797	Metyrapone	Metyrapone results in increased expression of CYP17A1 mRNA	15265784
D015735	Mifepristone	Mifepristone results in decreased expression of CYP17A1 mRNA	19439560
D008901	Mineralocorticoids	CYP17A1 protein affects the abundance of Mineralocorticoids	18645707
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate affects the expression of CYP17A1	19560483
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of CYP17A1 mRNA	16809437\|2208726
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of CYP17A1 protein	22087261
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of CYP17A1 mRNA	16809437
C028577	monobutyl phthalate	monobutyl phthalate results in decreased expression of CYP17A1 mRNA	22511013
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of CYP17A1 mRNA	20024957
C517284	monomethyl phthalate	monomethyl phthalate results in decreased expression of CYP17A1 mRNA	26924002
C500085	muraglitazar	muraglitazar results in increased expression of CYP17A1 mRNA	21515302
D009183	Mycotoxins	Mycotoxins results in increased expression of CYP17A1 mRNA	23665424
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CYP17A1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of CYP17A1 mRNA"	25620056
D009281	Naphthalenes	Naphthalenes analog results in decreased activity of CYP17A1 protein	15449729
C026385	n-hexane	n-hexane affects the expression of CYP17A1 mRNA	26410608
C026385	n-hexane	n-hexane affects the expression of CYP17A1 protein	26410608
C026385	n-hexane	n-hexane affects the methylation of CYP17A1 promoter	26410608
C028007	nickel monoxide	nickel monoxide results in decreased expression of CYP17A1 mRNA	19167457
D009538	Nicotine	Nicotine results in decreased expression of CYP17A1 mRNA	24709674
D009538	Nicotine	Nicotine results in decreased expression of CYP17A1 mRNA	27782041\|2898617
D009538	Nicotine	Nicotine results in decreased expression of CYP17A1 protein	28986172
C063998	nodularin	[nodularin co-treated with Diethylnitrosamine] results in decreased activity of CYP17A1 protein	12112309
D016912	Levonorgestrel	[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of CYP17A1 mRNA	19074003
C118580	octylmethoxycinnamate	octylmethoxycinnamate results in decreased expression of CYP17A1 mRNA	28235592
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CYP17A1 mRNA	25607892
D000069463	Olive Oil	Olive Oil analog affects the expression of CYP17A1 mRNA	17349074
C016340	o,p'-DDT	"o,p'-DDT affects the expression of CYP17A1 mRNA"	18925944
C016340	o,p'-DDT	"o,p'-DDT affects the expression of CYP17A1 mRNA"	17984292
C571806	orteronel	orteronel results in decreased activity of CYP17A1 protein	21092758
D008939	Mitotane	Mitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]	22546480
D008939	Mitotane	Mitotane results in decreased expression of CYP17A1 mRNA	23254310
D010098	Oxycodone	Oxycodone affects the expression of CYP17A1 mRNA	20487198
D010098	Oxycodone	Oxycodone results in increased expression of CYP17A1 mRNA	23439660
D010100	Oxygen	Oxygen deficiency results in increased expression of CYP17A1 mRNA	22816610
D010126	Ozone	Ozone results in decreased expression of CYP17A1 mRNA	16183385
D000073878	Palm Oil	Palm Oil affects the expression of CYP17A1 mRNA	19680557
D052638	Particulate Matter	Particulate Matter results in increased expression of CYP17A1 mRNA	18449530\|2286100
D052638	Particulate Matter	Particulate Matter results in decreased expression of CYP17A1 protein	22712718
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CYP17A1 mRNA"	25510870
C517827	pentabrominated diphenyl ether 100	pentabrominated diphenyl ether 100 results in increased expression of CYP17A1 protein	21871953
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased activity of CYP17A1 protein	18243468
C098189	pentabromophenol	pentabromophenol results in increased expression of CYP17A1 mRNA	17447562
C003060	pentachlorobenzene	pentachlorobenzene results in increased expression of CYP17A1 protein	21296658
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of CYP17A1 mRNA	21296122
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of CYP17A1 mRNA	23892564
D010457	Peptidoglycan	Peptidoglycan results in decreased expression of CYP17A1 mRNA	24727680
C003072	perflubron	perflubron results in increased expression of CYP17A1 mRNA	25871633
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of CYP17A1 mRNA	17400581
C584865	perfluorononanoic acid	perfluorononanoic acid results in increased expression of CYP17A1 mRNA	25543169
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CYP17A1 mRNA	23074026
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CYP17A1 mRNA	23074026
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CYP17A1 mRNA	16221955\|1869254
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CYP17A1 mRNA	23399300
C023036	perfluorooctanoic acid	"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of CYP17A1 mRNA]"	23626681
C023036	perfluorooctanoic acid	[perfluorooctanoic acid co-treated with PPARA] results in increased expression of CYP17A1 mRNA	20118188
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CYP17A1 mRNA	20118188\|2171208
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CYP17A1 protein	21712084
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CYP17A1 mRNA	17681415
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CYP17A1 mRNA	16221955\|1916217
D010575	Pesticides	CYP17A1 gene polymorphism affects the susceptibility to Pesticides	25064838
D015232	Dinoprostone	Dinoprostone results in increased expression of CYP17A1 mRNA	19001523
D010634	Phenobarbital	Phenobarbital results in increased expression of CYP17A1 mRNA	19270015\|2309116
D010634	Phenobarbital	Phenobarbital results in increased expression of CYP17A1 mRNA	19162173
D010795	Phthalic Acids	Phthalic Acids inhibits the reaction [LHB protein results in increased expression of CYP17A1 mRNA]	19699292
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of CYP17A1 mRNA	21061450
C060836	pioglitazone	pioglitazone inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased activity of CYP17A1 protein]	17138841
C060836	pioglitazone	pioglitazone inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CYP17A1 mRNA]	17138841
C060836	pioglitazone	pioglitazone results in decreased activity of CYP17A1 protein	15072549\|1713884
C060836	pioglitazone	pioglitazone results in decreased expression of CYP17A1 mRNA	17138841
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in decreased expression of CYP17A1 mRNA	22484513
C006253	pirinixic acid	pirinixic acid results in increased expression of CYP17A1 mRNA	18301758\|2005976
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of CYP17A1 mRNA]	20059764
C006253	pirinixic acid	pirinixic acid promotes the reaction [PPARA protein binds to CYP17A1 promoter]	23358192
C006253	pirinixic acid	pirinixic acid results in increased expression of CYP17A1 mRNA	19162173\|2211250
D010936	Plant Extracts	Plant Extracts results in decreased expression of CYP17A1 mRNA	23557933
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Pregnenolone binds to CYP17A1 protein]	15666820
D011075	Polybrominated Biphenyls	Polybrominated Biphenyls analog results in decreased activity of CYP17A1 protein	16828825
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in decreased expression of CYP17A1 mRNA	20924025
D011280	Pregnanolone	CYP17A1 protein results in increased hydroxylation of Pregnanolone analog	14522586
D011284	Pregnenolone	CYP17A1 protein results in increased hydroxylation of Pregnenolone	15459122
D011284	Pregnenolone	CYP17A1 protein affects the metabolism of Pregnenolone	15993106
D011284	Pregnenolone	[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone	29100959
D011284	Pregnenolone	[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone	29100959
D011284	Pregnenolone	CYP17A1 protein affects the metabolism of Pregnenolone	16030167\|1605438
D011284	Pregnenolone	CYP17A1 protein mutant form results in increased hydroxylation of Pregnenolone	15844475
D011284	Pregnenolone	CYP17A1 protein results in increased hydroxylation of Pregnenolone	15562394\|1584447
D011284	Pregnenolone	[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone	17194026\|2910095
D011284	Pregnenolone	Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]	29100959
D011284	Pregnenolone	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]	29100959
D011284	Pregnenolone	Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]	29100959
D011284	Pregnenolone	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]	29100959
D011284	Pregnenolone	Pregnenolone analog results in decreased activity of CYP17A1 protein	11836100
D011284	Pregnenolone	CYP17A1 protein results in increased hydroxylation of Pregnenolone	15459122
D011284	Pregnenolone	Plant Extracts inhibits the reaction [Pregnenolone binds to CYP17A1 protein]	15666820
D011284	Pregnenolone	CYP17A1 protein results in increased hydroxylation of Pregnenolone	15640159
D011284	Pregnenolone	CYP17A1 protein results in increased metabolism of Pregnenolone	22285649
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of CYP17A1 mRNA	19162173
C045362	prochloraz	prochloraz results in increased expression of CYP17A1 mRNA	21158436
C045362	prochloraz	prochloraz results in decreased activity of CYP17A1 protein	19733639
C045362	prochloraz	prochloraz results in decreased expression of and results in decreased activity of CYP17A1 protein	25324206
C045362	prochloraz	prochloraz results in decreased expression of CYP17A1 mRNA	19733639\|2532420
C045362	prochloraz	prochloraz results in increased expression of CYP17A1 mRNA	19767443
C045362	prochloraz	prochloraz results in decreased activity of CYP17A1 protein	16375936\|1723464
C045362	prochloraz	[prochloraz results in decreased activity of CYP17A1 protein] which results in decreased chemical synthesis of Testosterone	17234647\|1736919
C045362	prochloraz	prochloraz results in increased expression of CYP17A1 mRNA	16375936
C045362	prochloraz	prochloraz results in increased expression of CYP17A1 protein	16375936
C045362	prochloraz	prochloraz results in decreased activity of CYP17A1 protein	26781511
C024273	profenofos	profenofos results in increased expression of CYP17A1 mRNA	17569032
D011374	Progesterone	FSHB protein inhibits the reaction [[[NR0B1 protein binds to CYP17A1 promoter] which results in increased expression of CYP17A1 mRNA] which results in increased abundance of Progesterone]	22155568\|2215556
D011374	Progesterone	FSHB protein promotes the reaction [[[GATA6 protein binds to CYP17A1 promoter] which results in increased expression of CYP17A1 mRNA] which results in increased abundance of Progesterone]	22155568\|2215556
D011374	Progesterone	FSHB protein promotes the reaction [[[NR5A1 protein binds to CYP17A1 promoter] which results in increased expression of CYP17A1 mRNA] which results in increased abundance of Progesterone]	22155568\|2215556
D011374	Progesterone	[LHB protein results in increased expression of CYP17A1 mRNA] which results in increased abundance of Progesterone	22155568
D011374	Progesterone	[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone	29100959
D011374	Progesterone	[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone	29100959
D011374	Progesterone	CYP17A1 protein affects the metabolism of Progesterone	16030167\|1605438
D011374	Progesterone	CYP17A1 protein binds to and affects the metabolism of Progesterone	14522586
D011374	Progesterone	CYP17A1 protein results in increased hydroxylation of Progesterone	15562394\|1719402
D011374	Progesterone	[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 16-hydroxyprogesterone	17194026
D011374	Progesterone	[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone	17194026\|2910095
D011374	Progesterone	Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]	29100959
D011374	Progesterone	Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]	29100959
D011374	Progesterone	Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]	29100959
D011374	Progesterone	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]	29100959
D011374	Progesterone	CYP17A1 protein affects the metabolism of Progesterone	15261307
D011374	Progesterone	CYP17A1 protein results in increased hydroxylation of Progesterone	15640159
D011374	Progesterone	CYP17A1 protein results in increased metabolism of Progesterone	24451217
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of CYP17A1 mRNA]	16269825
C432165	pyrazolanthrone	pyrazolanthrone results in increased expression of CYP17A1 mRNA	16269825
C031280	pyrazole	pyrazole results in decreased expression of CYP17A1 mRNA	17945193
C030984	pyrene	pyrene results in decreased expression of CYP17A1 mRNA	23656968
D019289	Pyruvic Acid	Pyruvic Acid promotes the reaction [CTBP1 protein binds to CYP17A1 promoter]	18184656
D019289	Pyruvic Acid	Pyruvic Acid promotes the reaction [CTBP2 protein binds to CYP17A1 promoter]	18184656
D019289	Pyruvic Acid	Pyruvic Acid promotes the reaction [NR5A1 protein binds to CYP17A1 promoter]	18184656
D019289	Pyruvic Acid	Pyruvic Acid results in increased expression of CYP17A1 mRNA	18184656
D011794	Quercetin	Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of CYP17A1 mRNA]	23200735
D011794	Quercetin	Quercetin inhibits the reaction [Atrazine results in increased expression of CYP17A1 mRNA]	23200735
C502851	quinocetone	quinocetone results in increased expression of CYP17A1 mRNA	27046791
C059514	resveratrol	resveratrol analog results in decreased activity of CYP17A1 protein	24610083
C059514	resveratrol	resveratrol analog results in decreased expression of CYP17A1 mRNA	24610083
C059514	resveratrol	resveratrol results in decreased activity of CYP17A1 protein	24610083
C059514	resveratrol	resveratrol results in decreased expression of CYP17A1 mRNA	24610083\|2487544
C059514	resveratrol	resveratrol promotes the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]	24524197
C059514	resveratrol	resveratrol results in decreased expression of CYP17A1 mRNA	22719052\|2452419
C059514	resveratrol	Simvastatin promotes the reaction [resveratrol results in decreased expression of CYP17A1 mRNA]	24524197
D012176	Retinoids	Retinoids results in increased expression of CYP17A1 mRNA	15914525
C089730	rosiglitazone	rosiglitazone results in decreased activity of CYP17A1 protein	15072549
C089730	rosiglitazone	rosiglitazone results in increased expression of CYP17A1 mRNA	21515302
C541923	sandostatinLAR	sandostatinLAR results in decreased expression of CYP17A1 mRNA	17210224
D019821	Simvastatin	farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]	21918126
D019821	Simvastatin	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]	21918126
D019821	Simvastatin	resveratrol promotes the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]	24524197
D019821	Simvastatin	[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP17A1 mRNA	25055962
D019821	Simvastatin	Simvastatin promotes the reaction [resveratrol results in decreased expression of CYP17A1 mRNA]	24524197
D019821	Simvastatin	Simvastatin results in decreased expression of CYP17A1 mRNA	21918126\|2452419
C017947	sodium arsenite	sodium arsenite results in decreased expression of CYP17A1 mRNA	28414027
C017947	sodium arsenite	sodium arsenite results in decreased expression of CYP17A1 protein	28414027
C016104	sodium bichromate	sodium bichromate results in increased expression of CYP17A1 mRNA	25993096
D013110	Sphingosine	Sphingosine results in increased expression of CYP17A1 mRNA	15666826
C060506	sphingosine 1-phosphate	sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA	15666826
D013259	Steroids, Fluorinated	"Steroids, Fluorinated analog results in decreased activity of CYP17A1 protein"	11836100
D014284	Triiodothyronine	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]]"	21726595
D014284	Triiodothyronine	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein]]"	21726595
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]	21726595
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein]	21726595
D013605	T-2 Toxin	[T-2 Toxin co-treated with CGA protein] results in decreased activity of CYP17A1 protein	25962641
C013698	tallow	tallow affects the expression of CYP17A1 mRNA	19680557
D013629	Tamoxifen	CYP17A1 gene polymorphism results in increased susceptibility to Tamoxifen	15706422
D013629	Tamoxifen	Tamoxifen affects the expression of CYP17A1 mRNA	20937368
D013629	Tamoxifen	Tamoxifen results in decreased expression of CYP17A1 mRNA	25123088
D013629	Tamoxifen	[bexarotene co-treated with Tamoxifen] results in increased expression of CYP17A1 mRNA	17630414
C037565	terbutylazine	terbutylazine results in decreased expression of CYP17A1 mRNA	23591565
C501413	tesaglitazar	tesaglitazar results in increased expression of CYP17A1 mRNA	21515302
D013739	Testosterone	Testosterone results in decreased expression of CYP17A1 mRNA	15625562
D013739	Testosterone	CYP17A1 protein affects the abundance of Testosterone	21427057
D013739	Testosterone	Testosterone results in decreased expression of CYP17A1 mRNA	15625562
D013739	Testosterone	AMH protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Testosterone]	14630719
D013739	Testosterone	CYP17A1 protein affects the chemical synthesis of Testosterone	15932923
D013739	Testosterone	Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]	22285649
D013739	Testosterone	[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA	22285649
D013739	Testosterone	[Lipopolysaccharides results in decreased expression of CYP17A1 protein] which results in decreased abundance of Testosterone	8828518
D013739	Testosterone	Testosterone results in decreased expression of CYP17A1 mRNA	20600201\|2166921
D013739	Testosterone	[[titanium dioxide results in decreased expression of CYP17A1 mRNA] co-treated with [titanium dioxide results in decreased expression of HSD17B10 mRNA]] results in increased chemical synthesis of Testosterone	24241477
D013739	Testosterone	Tretinoin inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]	22285649
D013739	Testosterone	[bisphenol A results in decreased expression of CYP17A1 protein] which results in decreased abundance of Testosterone	14605012
D013739	Testosterone	[bisphenol A results in increased expression of CYP17A1 mRNA] which affects the abundance of Testosterone	18191889
D013739	Testosterone	[prochloraz results in decreased activity of CYP17A1 protein] which results in decreased chemical synthesis of Testosterone	17234647\|1736919
C004648	testosterone enanthate	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP17A1 mRNA	18160741
C004648	testosterone enanthate	[cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP17A1 mRNA	18160741
C004648	testosterone enanthate	testosterone enanthate results in decreased expression of CYP17A1 mRNA	21427060\|2560346
D043343	Testosterone Propionate	Testosterone Propionate results in decreased expression of CYP17A1 mRNA	15601916
C010792	testosterone undecanoate	[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of CYP17A1 mRNA	19074003
C010792	testosterone undecanoate	testosterone undecanoate results in decreased expression of CYP17A1 mRNA	19074003
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of CYP17A1 mRNA	24014645
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of CYP17A1 mRNA	26988606
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CYP17A1 mRNA	28922406
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP17A1 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP17A1 mRNA	19770486\|2135428
D013749	Tetrachlorodibenzodioxin	"Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP17A1 mRNA]"	19276399
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CYP17A1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP17A1 mRNA	16254025\|1696003
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP17A1 protein	17291543\|1927639
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYP17A1 mRNA	20959002
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of CYP17A1 mRNA	28973375
D013752	Tetracycline	Tetracycline results in decreased expression of CYP17A1 mRNA	16917069
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [Colforsin results in increased expression of CYP17A1 protein]	15666819
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of CYP17A1 protein	15666819
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [Colforsin results in increased expression of CYP17A1 protein]	15666819
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of CYP17A1 protein	15666819
D013764	Tetrahydronaphthalenes	Tetrahydronaphthalenes results in decreased activity of CYP17A1 protein	15743198
C020809	tetrathiomolybdate	tetrathiomolybdate results in increased expression of CYP17A1 mRNA	16731777
C009495	titanium dioxide	titanium dioxide results in decreased expression of CYP17A1 mRNA	24241477
C009495	titanium dioxide	[[titanium dioxide results in decreased expression of CYP17A1 mRNA] co-treated with [titanium dioxide results in decreased expression of HSD17B10 mRNA]] results in increased chemical synthesis of Testosterone	24241477
C009495	titanium dioxide	titanium dioxide results in decreased expression of CYP17A1 protein	24241477
C009495	titanium dioxide	titanium dioxide results in increased expression of CYP17A1 mRNA	23131501
C052342	topiramate	topiramate results in decreased activity of CYP17A1 protein	15730543
C483909	torcetrapib	torcetrapib results in increased expression of CYP17A1 mRNA	28235592
D014147	Tramadol	Tramadol results in decreased activity of CYP17A1 protein	29100959
D014212	Tretinoin	Tretinoin results in increased expression of CYP17A1 mRNA	16621909
D014212	Tretinoin	Tretinoin inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]	22285649
D014212	Tretinoin	Tretinoin results in decreased expression of CYP17A1 mRNA	14960491
C072782	tri-(2-chloroisopropyl)phosphate	tri-(2-chloroisopropyl)phosphate results in decreased expression of CYP17A1 mRNA	22446829
C533760	tribromodiphenyl ether 28	tribromodiphenyl ether 28 metabolite results in increased expression of CYP17A1 mRNA	18248924
C012589	trichostatin A	trichostatin A results in decreased expression of CYP17A1 mRNA	15901671
D014260	Triclosan	Triclosan results in decreased expression of CYP17A1 mRNA	19118620
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of CYP17A1 mRNA	26898711
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of CYP17A1 mRNA	22446829\|2360314
C005445	triphenyl phosphate	triphenyl phosphate inhibits the reaction [CGB3 protein results in increased expression of CYP17A1 mRNA]	26049154
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of CYP17A1 mRNA	26049154\|2618380
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYP17A1 mRNA"	22446829\|2360314
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in decreased expression of CYP17A1 mRNA	26547027
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of CYP17A1 mRNA	27912163
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in decreased expression of CYP17A1 mRNA	29024780
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate inhibits the reaction [CGB3 protein results in increased expression of CYP17A1 mRNA]	26049154
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in decreased expression of CYP17A1 mRNA	26049154\|2618380
C057693	troglitazone	troglitazone results in decreased activity of CYP17A1 protein	15072549
C057693	troglitazone	troglitazone results in increased expression of CYP17A1 mRNA	21515302
C057693	troglitazone	troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]	11889176
C057693	troglitazone	troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 protein modified form]	11889176
D014501	Uranium	Uranium analog results in decreased expression of CYP17A1 mRNA	27544493
C406224	valdecoxib	valdecoxib results in decreased expression of CYP17A1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYP17A1 mRNA	23152920
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYP17A1 mRNA	15901671
D014635	Valproic Acid	Valproic Acid inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]	20726872
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYP17A1 mRNA	19566492
D014635	Valproic Acid	Valproic Acid results in increased expression of CYP17A1 mRNA	14576182
D014635	Valproic Acid	Valproic Acid results in increased expression of CYP17A1 protein	14576182
D014635	Valproic Acid	Valproic Acid affects the expression of CYP17A1 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CYP17A1 mRNA	18449530\|2286100
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of CYP17A1 protein	22712718
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]	29100959
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]	29100959
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]	29100959
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]	29100959
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]	29100959
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]	29100959
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]	29100959
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]	29100959
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride results in decreased activity of CYP17A1 protein	29100959
C025643	vinclozolin	vinclozolin results in increased expression of CYP17A1 mRNA	14967917\|2316096
D014753	Vinyl Compounds	Vinyl Compounds analog results in decreased activity of CYP17A1 protein	11836100
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical analog results in increased expression of CYP17A1 mRNA"	21932247
D015039	Ziram	Ziram results in decreased activity of CYP17A1 protein	28973382
D015039	Ziram	Ziram results in decreased expression of CYP17A1 mRNA	28973382
D015039	Ziram	Ziram results in decreased expression of CYP17A1 protein	28973382

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004508	steroid 17-alpha-monooxygenase activity	-	IBA	21873635
GO:0004508	steroid 17-alpha-monooxygenase activity	-	IDA	22266943
GO:0004508	steroid 17-alpha-monooxygenase activity	-	IMP	22170710 24140098
GO:0004508	steroid 17-alpha-monooxygenase activity	-	TAS	-
GO:0005506	iron ion binding	-	IEA	-
GO:0019825	oxygen binding	-	TAS	2808364
GO:0020037	heme binding	-	IDA	22266943
GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	-	IBA	21873635
GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	-	IMP	24140098

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006694	steroid biosynthetic process	-	TAS	3500022
GO:0006702	androgen biosynthetic process	-	TAS	-
GO:0006704	glucocorticoid biosynthetic process	-	TAS	-
GO:0007548	sex differentiation	-	TAS	9326943
GO:0008202	steroid metabolic process	-	IDA	22266943
GO:0016125	sterol metabolic process	-	TAS	-
GO:0042446	hormone biosynthetic process	-	IBA	21873635
GO:0042446	hormone biosynthetic process	-	IDA	22266943
GO:0042448	progesterone metabolic process	-	IBA	21873635
GO:0042448	progesterone metabolic process	-	IDA	22266943
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005783	endoplasmic reticulum	-	NAS	9326943
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0030424	axon	-	IEA	-
GO:0043025	neuronal cell body	-	IEA	-

KEGG ID	KEGG Term
hsa00140	Steroid hormone biosynthesis
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1643685	Disease	TAS
R-HSA-193048	Androgen biosynthesis	TAS
R-HSA-194002	Glucocorticoid biosynthesis	TAS
R-HSA-196071	Metabolism of steroid hormones	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211897	Cytochrome P450 - arranged by substrate type	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-211976	Endogenous sterols	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5579028	Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)	TAS
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	TAS
R-HSA-5668914	Diseases of metabolism	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23197595	Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)	O'Shaughnessy PJ	Mol Hum Reprod
26414697	Polymorphisms in genes in the androgen pathway and risk of Barrett's esophagus and esophageal adenocarcinoma. (2016 Mar 1)	Ek WE	Int J Cancer
15654505	Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (2005)	Liu Y	J Hum Genet
25064838	CYP17A1 gene polymorphisms and environmental exposure to organochlorine pesticides contribute to the risk of small for gestational age. (2014 Sep)	Chand S	Eur J Obstet Gynecol Reprod Biol
25030786	Risk for estrogen-dependent diseases in relation to phthalate exposure and polymorphisms of CYP17A1 and estrogen receptor genes. (2014 Dec)	Huang PC	Environ Sci Pollut Res Int
19642097	Genetic variation in CYP17A1 and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California. (2010 Feb 1)	Duell EJ	Int J Cancer
29162857	Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads. (2017 Nov 21)	Mamsen LS	Sci Rep
22969879	Association between cytochrome P450 promoter polymorphisms and ischemic stroke. (2012 Feb)	Kim SK	Exp Ther Med
20171624	Solitary and multiple uterine leiomyomas among Caucasian women: two different disorders? (2010 Nov)	Pakiz M	Fertil Steril
27165211	Association of the CYP17-34T/C Polymorphism with Pancreatic Cancer Risk. (2016)	Hussain S	Asian Pac J Cancer Prev
29429410	The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. (2018 Feb 12)	Johnston ZC	BMC Med