Gene: CYP21A2

1589
CA21H|CAH1|CPS1|CYP21|CYP21B|P450c21B
cytochrome P450 family 21 subfamily A member 2
protein-coding
6p21.33
Ensembl:ENSG00000231852 MIM:613815 Vega:OTTHUMG00000031069 UniprotKB:P08686
NG_007941.3
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03239580chr6:31973051CYP21A23.620e-9Maternal smoking in pregnancy27040690
cg19154116chr6:32005786CYP21A27.250e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC10.663
DLEC10.632
ATOH80.623
TEP10.595
SLC52A30.587
TRAF3IP20.587
TMCO40.584
IL1R10.582
PXN0.578
MMEL10.573

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.417
KIT-0.409
HAPLN1-0.405
VWC2-0.404
GAD2-0.398
NXPH1-0.397
LHX6-0.395
ZNF385D-0.393
DLX1-0.389
TAC1-0.389

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01026KetoconazoleSmall Molecule65277-42-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene results in decreased expression of CYP21A2 mRNA"19900470
C0326681-nitropyrene1-nitropyrene results in decreased expression of CYP21A2 mRNA19041380
C1201292,2',3,4',5',6-hexachlorobiphenyl"2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of CYP21A2 mRNA"16216300
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of CYP21A2 mRNA"17447562
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl metabolite results in increased expression of CYP21A2 mRNA"16216300
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl results in increased expression of CYP21A2 mRNA"16216300
C0045542,4,6-tribromophenol"2,4,6-tribromophenol results in decreased expression of CYP21A2 mRNA"17447562
C0389642,6-dibromophenol"2,6-dibromophenol results in decreased expression of CYP21A2 mRNA"17447562
C0149532-acetyltributylcitrate2-acetyltributylcitrate results in increased expression of CYP21A2 mRNA28235592
C0327903,3',4,4',5,5'-hexabromobiphenyl"3,3',4,4',5,5'-hexabromobiphenyl results in increased expression of CYP21A2 mRNA"17447562
C0366853,3',4,4'-tetrabromobiphenyl"3,3',4,4'-tetrabromobiphenyl results in increased expression of CYP21A2 mRNA"17447562
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in decreased expression of CYP21A2 mRNA"24610083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP21A2 protein"15703266
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP21A2 mRNA"15703266|1621630
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of CYP21A2 mRNA"26751127
D000082AcetaminophenAcetaminophen results in decreased expression of CYP21A2 mRNA21420995|2906747
C033116acetyl methyl tetramethyl tetralinacetyl methyl tetramethyl tetralin results in decreased expression of CYP21A223084589
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CYP21A2 mRNA21641981
D047310ApigeninApigenin inhibits the reaction [Colforsin results in increased expression of CYP21A2 mRNA]23370353
D001572BenzofuransBenzofurans results in decreased expression of CYP21A2 mRNA17447562
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYP21A2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CYP21A2 gene25435355
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in increased expression of CYP21A2 protein24464499
D001688Biological ProductsBiological Products results in decreased expression of CYP21A2 mRNA26055946
C006780bisphenol Abisphenol A results in decreased expression of CYP21A2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP21A2 mRNA22079614|2254648
D0151248-Bromo Cyclic Adenosine MonophosphateMitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP21A2 mRNA]22546480
D002110CaffeineCaffeine results in decreased expression of CYP21A2 mRNA24717552
D004002Clodronic AcidClodronic Acid results in decreased activity of CYP21A2 protein12208672
D005576ColforsinApigenin inhibits the reaction [Colforsin results in increased expression of CYP21A2 mRNA]23370353
D005576Colforsin[Colforsin co-treated with Ketoconazole] results in decreased expression of CYP21A2 mRNA16935330
D005576ColforsinColforsin results in increased expression of CYP21A2 mRNA16935330|2072687
D005576Colforsindaidzein inhibits the reaction [Colforsin results in increased expression of CYP21A2 mRNA]23370353
D005576ColforsinValproic Acid inhibits the reaction [Colforsin results in increased expression of CYP21A2 mRNA]20726872
D016572CyclosporineCyclosporine results in decreased expression of CYP21A2 mRNA27989131
D065607Cytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme Inhibitors analog results in decreased activity of CYP21A2 protein17194026
C004742daidzeindaidzein inhibits the reaction [Colforsin results in increased expression of CYP21A2 mRNA]23370353
D003671DEET[fipronil co-treated with DEET] results in increased expression of CYP21A2 mRNA27091632
C007262deoxynivalenoldeoxynivalenol results in increased expression of CYP21A2 mRNA22982764
D000072338Dibenzofurans, Polychlorinated"[Polychlorinated Dibenzodioxins co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of CYP21A2 mRNA"16650473
D000072338Dibenzofurans, Polychlorinated"[Polycyclic Aromatic Hydrocarbons co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of CYP21A2 mRNA"16650473
C100264enniatinsenniatins results in increased expression of CYP21A2 mRNA25625232
C082360fipronil[fipronil co-treated with DEET] results in increased expression of CYP21A2 mRNA27091632
C082360fipronilfipronil results in increased expression of CYP21A2 mRNA27091632
D005411Flame RetardantsFlame Retardants results in decreased expression of CYP21A2 mRNA17447562
D005411Flame RetardantsFlame Retardants results in increased expression of CYP21A2 mRNA17447562
C033119galaxolidegalaxolide results in decreased expression of CYP21A223084589
C033119galaxolide[galaxolide results in decreased expression of [HSD3B2 co-treated with CYP21A2]] which results in decreased chemical synthesis of Hydrocortisone23084589
C033119galaxolide[galaxolide results in decreased expression of [HSD3B2 co-treated with CYP21A2]] which results in decreased chemical synthesis of Progesterone23084589
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers metabolite results in increased expression of CYP21A2 mRNA18313098
C012351HT-2 toxinHT-2 toxin results in increased expression of CYP21A2 mRNA22982764
D006843Hydrocarbons, Chlorinated"[Polychlorinated Dibenzodioxins co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of CYP21A2 mRNA"16650473
D006843Hydrocarbons, Chlorinated"[Polycyclic Aromatic Hydrocarbons co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of CYP21A2 mRNA"16650473
D006854Hydrocortisone[galaxolide results in decreased expression of [HSD3B2 co-treated with CYP21A2]] which results in decreased chemical synthesis of Hydrocortisone23084589
D01932617-alpha-HydroxyprogesteroneCYP21A2 protein mutant form results in decreased metabolism of 17-alpha-Hydroxyprogesterone18445671
D01932617-alpha-HydroxyprogesteroneCYP21A2 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone18445671
D003900Desoxycorticosterone[CYP21A2 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of Desoxycorticosterone17194026
D003900Desoxycorticosterone[Ketoconazole results in increased activity of CYP21A2 protein] which results in increased chemical synthesis of Desoxycorticosterone17194026
D007220Industrial WasteIndustrial Waste results in decreased expression of CYP21A2 mRNA26055946
D007654Ketoconazole[Colforsin co-treated with Ketoconazole] results in decreased expression of CYP21A2 mRNA16935330
D007654KetoconazoleKetoconazole results in decreased expression of CYP21A2 mRNA16935330
D007654KetoconazoleKetoconazole results in increased activity of CYP21A2 protein17194026
D007654Ketoconazole[Ketoconazole results in increased activity of CYP21A2 protein] which results in increased chemical synthesis of Desoxycorticosterone17194026
D008797MetyraponeMetyrapone results in increased expression of CYP21A2 protein9832454
C063855microcystin RRmicrocystin RR results in decreased expression of CYP21A2 protein19111056
C464660obeticholic acidobeticholic acid results in decreased expression of CYP21A2 mRNA27939613
C118580octylmethoxycinnamateoctylmethoxycinnamate results in increased expression of CYP21A2 mRNA28235592
D008939MitotaneMitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP21A2 mRNA]22546480
D008939MitotaneMitotane results in decreased expression of CYP21A2 mRNA22546480|2296688
C098189pentabromophenolpentabromophenol results in increased expression of CYP21A2 mRNA17447562
C003072perflubronperflubron results in increased expression of CYP21A2 mRNA25871633
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CYP21A2 mRNA23074026
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CYP21A2 mRNA23399300
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP21A2 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of CYP21A2 mRNA23557933
D011078Polychlorinated Biphenyls"[Polychlorinated Dibenzodioxins co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of CYP21A2 mRNA"16650473
D011078Polychlorinated Biphenyls"[Polycyclic Aromatic Hydrocarbons co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of CYP21A2 mRNA"16650473
D000072317Polychlorinated Dibenzodioxins"[Polychlorinated Dibenzodioxins co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of CYP21A2 mRNA"16650473
D011084Polycyclic Aromatic Hydrocarbons"[Polycyclic Aromatic Hydrocarbons co-treated with Polychlorinated Biphenyls co-treated with Hydrocarbons, Chlorinated co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of CYP21A2 mRNA"16650473
C045362prochlorazprochloraz results in decreased activity of CYP21A2 protein19733639
C045362prochlorazprochloraz results in decreased expression of CYP21A2 mRNA19733639
D011374ProgesteroneCYP21A2 protein mutant form results in decreased metabolism of Progesterone18445671
D011374ProgesteroneCYP21A2 protein results in increased hydroxylation of Progesterone17194026
D011374Progesterone[CYP21A2 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of Desoxycorticosterone17194026
D011374ProgesteroneCYP21A2 protein results in increased metabolism of Progesterone18445671
D011374Progesterone[galaxolide results in decreased expression of [HSD3B2 co-treated with CYP21A2]] which results in decreased chemical synthesis of Progesterone23084589
C502851quinocetonequinocetone results in increased expression of CYP21A2 mRNA27046791
C502851quinocetonequinocetone results in decreased expression of CYP21A2 mRNA26296292
C059514resveratrolresveratrol results in decreased expression of CYP21A2 mRNA24875446
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in increased expression of CYP21A2 protein24464499
D013605T-2 ToxinT-2 Toxin results in increased expression of CYP21A2 mRNA22982764
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CYP21A2 mRNA18313098
C483909torcetrapibtorcetrapib results in increased expression of CYP21A2 mRNA28235592
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of CYP21A2 mRNA29024780
D014520UrethaneUrethane results in decreased expression of CYP21A2 mRNA28818685
D014635Valproic AcidValproic Acid inhibits the reaction [Colforsin results in increased expression of CYP21A2 mRNA]20726872
D014635Valproic AcidValproic Acid results in decreased expression of CYP21A2 mRNA19566492|2915479
D015034Zinc OxideZinc Oxide analog results in decreased expression of CYP21A2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004509steroid 21-monooxygenase activity-IDA25855791  
GO:0004509steroid 21-monooxygenase activity-TAS-  
GO:0005496steroid binding-IEA-  
GO:0005506iron ion binding-IEA-  
GO:0008395steroid hydroxylase activity-IMP16984992  
GO:0020037heme binding-IDA25855791  
GO ID GO Term Qualifier Evidence PubMed
GO:0006694steroid biosynthetic process-IDA25855791  
GO:0006704glucocorticoid biosynthetic process-TAS-  
GO:0006705mineralocorticoid biosynthetic process-TAS-  
GO:0008202steroid metabolic process-IMP16984992  
GO:0016125sterol metabolic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-193993Mineralocorticoid biosynthesisTAS
R-HSA-194002Glucocorticoid biosynthesisTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5579021Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23197595Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)O'Shaughnessy PJMol Hum Reprod
29429410The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. (2018 Feb 12)Johnston ZCBMC Med