Gene: ADSS

159
ADEH|ADSS 2
adenylosuccinate synthase
protein-coding
1q44
Ensembl:ENSG00000035687 MIM:103060 Vega:OTTHUMG00000040102 UniprotKB:P30520
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.383e-1 (AD)  4.360e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UCHL50.962
SLC25A460.958
LANCL10.955
ERLEC10.951
KLHL420.948
PJA20.948
NAPG0.946
SRPK20.945
RNMT0.945
ITFG10.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.509
OR4F29-0.482
MTRNR2L10-0.474
CSAG1-0.458
MTRNR2L6-0.454
MTRNR2L9-0.449
EVC2-0.445
MTRNR2L8-0.428
MTRNR2L2-0.428
HVCN1-0.426

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00128L-Aspartic AcidSmall Molecule56-84-8Approved|NutraceuticalTarget
DB05540AlanosineSmall Molecule5854-93-3InvestigationalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ADSS mRNA"21346803
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ADSS mRNA"20816883
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ADSS mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADSS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADSS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADSS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADSS mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ADSS mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of ADSS mRNA17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ADSS mRNA22100608
C006632arsenic trioxidearsenic trioxide results in decreased expression of ADSS protein19364129
C547126AZM551248AZM551248 results in increased expression of ADSS mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ADSS mRNA22342234
D001622BetaineBetaine results in decreased expression of ADSS mRNA26391144
C044887beta-methylcholinebeta-methylcholine affects the expression of ADSS mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ADSS mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of ADSS mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of ADSS protein16470657
D002995Clofibric AcidClofibric Acid affects the expression of ADSS mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADSS mRNA19320972
D016572CyclosporineCyclosporine results in increased expression of ADSS mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ADSS mRNA]27941970
C000944dicrotophosdicrotophos results in decreased expression of ADSS mRNA28302478
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of ADSS mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of ADSS mRNA"21785161
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ADSS protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ADSS mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADSS mRNA17942748
D018120FinasterideFinasteride results in increased expression of ADSS mRNA24136188
D005472FluorouracilFluorouracil results in decreased expression of ADSS mRNA16709241
D005472FluorouracilFluorouracil results in increased expression of ADSS protein15585135|1680352
D005839GentamicinsGentamicins results in increased expression of ADSS mRNA22061828
D005897GlafenineGlafenine results in decreased expression of ADSS mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ADSS mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADSS mRNA25613284
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ADSS protein26558463
D008777MethyltestosteroneMethyltestosterone results in decreased expression of ADSS mRNA29191790
C025256nonylphenolnonylphenol results in increased expression of ADSS mRNA22982499
D017239PaclitaxelPaclitaxel results in decreased expression of ADSS protein15907983
D052638Particulate MatterParticulate Matter results in increased expression of ADSS mRNA24769257
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of ADSS mRNA23602845
D010634PhenobarbitalPhenobarbital affects the expression of ADSS mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ADSS mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ADSS mRNA19482888
D010705PhosgenePhosgene affects the expression of ADSS mRNA16300373
C006253pirinixic acidpirinixic acid results in increased expression of ADSS mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ADSS mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ADSS mRNA22079256
D012715Sesame OilSesame Oil results in increased expression of ADSS mRNA29191790
D012969Sodium FluorideSodium Fluoride results in increased expression of ADSS protein28918527
D013467SulindacSulindac results in increased expression of ADSS mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADSS mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADSS mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADSS mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of ADSS mRNA23409001
D014112ToxapheneToxaphene results in increased expression of ADSS mRNA21220043
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of ADSS gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADSS mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ADSS mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ADSS mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ADSS mRNA"26179874
D014520UrethaneUrethane results in decreased expression of ADSS mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADSS mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ADSS mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of ADSS mRNA17292431|1796380

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004019adenylosuccinate synthase activity-EXP1592113  15786719  
GO:0004019adenylosuccinate synthase activity-IBA21873635  
GO:0004019adenylosuccinate synthase activity-IDA2004783  
GO:0004019adenylosuccinate synthase activity-NAS1592113  
GO:0005515protein binding-IPI23455924  
GO:0005525GTP binding-NAS1592113  15786719  
GO:0042301phosphate ion binding-NAS1592113  15786719  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002376immune system process-NAS15786719  
GO:0006167AMP biosynthetic process-IDA2004783  
GO:0006167AMP biosynthetic process-NAS1592113  15786719  
GO:0006531aspartate metabolic process-IEA-  
GO:0009168purine ribonucleoside monophosphate biosynthetic process-TAS-  
GO:0014074response to purine-containing compound-IEA-  
GO:0044208'de novo' AMP biosynthetic process-IBA21873635  
GO:0044208'de novo' AMP biosynthetic process-IEA-  
GO:0046040IMP metabolic process-IBA21873635  
GO:0060359response to ammonium ion-IEA-  
GO:0071257cellular response to electrical stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00250Alanine, aspartate and glutamate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-73817Purine ribonucleoside monophosphate biosynthesisTAS
R-HSA-8956320Nucleobase biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21896885Vitamin E decreased the activity of acetylcholinesterase and level of lipid peroxidation in brain of rats exposed to aged and diluted sidestream smoke. (2011 Dec)Thome GRNicotine Tob Res