Gene info: ID 1591

Gene: CYP24A1

GENE ID: 1591

Synonyms: CP24|CYP24|HCAI|HCINF1|P450-CC24

Description: cytochrome P450 family 24 subfamily A member 1

Gene type: protein-coding

Location: 20q13.2

dbXrefs: Ensembl:ENSG00000019186 MIM:126065 Vega:OTTHUMG00000032773 UniprotKB:Q07973

RefSeq: NG_008334.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 10

Sherlock p-value : 7.179e-1 (AD) 5.649e-1 (ND) (Frontal_Cortex)

Pascal p-value : 1.548e-1 (AD) 1.762e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HTR4	0.631
HS6ST2	0.617
PAQR9	0.609
IGFBPL1	0.608
COCH	0.607
STRIP2	0.605
HTR2C	0.603
ASCL5	0.602
NETO2	0.596
KNCN	0.596

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC2A4	-0.411
ZIC2	-0.409
TNFRSF10D	-0.385
ITPRIP	-0.38
OTOS	-0.38
TGIF1	-0.376
ZIC5	-0.375
CDKN2C	-0.372
GPR4	-0.367
MAGEA12	-0.366

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB05024	CTA018	Small Molecule	-	Investigational	Target
DB00136	Calcitriol	Small Molecule	32222-06-3	Approved\|Nutraceutical	Enzyme
DB00146	Calcidiol	Small Molecule	19356-17-3	Approved\|Nutraceutical	Enzyme
DB00153	Ergocalciferol	Small Molecule	50-14-6	Approved\|Nutraceutical	Enzyme
DB00910	Paricalcitol	Small Molecule	131918-61-1	Approved\|Investigational	Enzyme
DB01285	Corticotropin	BiotechDrug	12427-33-7	Approved\|Investigational	Enzyme
DB02300	Calcipotriol	Small Molecule	112965-21-6	Approved	Enzyme

ID	Drug Name	Action	PubMed
C013721	1,24,25-trihydroxyvitamin D3	"1,24,25-trihydroxyvitamin D3 results in increased expression of CYP24A1 mRNA"	7530193
C063087	1,24-dihydroxyvitamin D2	"1,24-dihydroxyvitamin D2 results in increased expression of CYP24A1 mRNA"	10927029
C087630	1,25-dihydroxy-16-ene-vitamin D3	"1,25-dihydroxy-16-ene-vitamin D3 results in increased expression of CYP24A1 mRNA"	7530193
C083610	1,25-dihydroxy-19-norvitamin D3	"1,25-dihydroxy-19-norvitamin D3 analog affects the activity of CYP24A1 promoter"	10828308
C046127	1,25-dihydroxy-26,27-dimethylcholecalciferol	"[1,25-dihydroxy-26,27-dimethylcholecalciferol binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA"	20153625
C046127	1,25-dihydroxy-26,27-dimethylcholecalciferol	"1,25-dihydroxy-26,27-dimethylcholecalciferol results in increased expression of CYP24A1 protein"	20153625
C003564	1,25-dihydroxyergocalciferol	"1,25-dihydroxyergocalciferol results in increased expression of CYP24A1 protein"	22751936
C097949	1,25-dihydroxyvitamin D	"U 0126 inhibits the reaction [1,25-dihydroxyvitamin D results in increased expression of CYP24A1 mRNA]"	15331595
C097949	1,25-dihydroxyvitamin D	"U 0126 promotes the reaction [1,25-dihydroxyvitamin D results in increased expression of CYP24A1 mRNA]"	15331595
C097949	1,25-dihydroxyvitamin D	"CYP24A1 protein results in increased degradation of 1,25-dihydroxyvitamin D"	15781002
C539020	1alpha,20-dihydroxyvitamin D3	"1alpha,20-dihydroxyvitamin D3 results in increased expression of CYP24A1 mRNA"	19000766
C023850	1 alpha,24-dihydroxyvitamin D3	"1 alpha,24-dihydroxyvitamin D3 results in increased expression of CYP24A1 mRNA"	26704532
C023850	1 alpha,24-dihydroxyvitamin D3	"1 alpha,24-dihydroxyvitamin D3 results in increased expression of CYP24A1 mRNA"	10927029
C533599	24a-homo-1,15-dihydroxyergocalciferol	"24a-homo-1,15-dihydroxyergocalciferol results in increased expression of CYP24A1 protein"	22751936
C461658	(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid	"(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of CYP24A1 mRNA]"	21815645
C065250	4-hydroxy-equilenin	4-hydroxy-equilenin results in decreased expression of CYP24A1 mRNA	15135645
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of CYP24A1 mRNA"	26238291
D000082	Acetaminophen	Acetaminophen affects the expression of CYP24A1 mRNA	25064622
D000082	Acetaminophen	Acetaminophen affects the expression of CYP24A1 mRNA	25704631
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of CYP24A1 mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CYP24A1 protein	20106945
C008088	alfacalcidol	alfacalcidol results in increased expression of CYP24A1 mRNA	16824767
C008088	alfacalcidol	[Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA	16824767
C008088	alfacalcidol	alfacalcidol results in increased expression of CYP24A1 mRNA	18180267\|1958139
C008088	alfacalcidol	alfacalcidol results in increased expression of CYP24A1 mRNA	8410379
C008088	alfacalcidol	alfacalcidol results in increased expression of CYP24A1 protein	8410379
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of CYP24A1 mRNA	28522335
D013196	Dihydrotestosterone	Dihydrotestosterone inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]	16524720
D013196	Dihydrotestosterone	Dihydrotestosterone inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	15538745
D017962	alpha-Linolenic Acid	alpha-Linolenic Acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19667161
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]]	19244278
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	19244278
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Cycloheximide promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	19244278
D000638	Amiodarone	Amiodarone affects the expression of CYP24A1 mRNA	25064622
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CYP24A1 mRNA	16483693
D000667	Ampicillin	Ampicillin results in decreased expression of CYP24A1 mRNA	21632981
C526219	apple polyphenol extract	apple polyphenol extract results in increased expression of CYP24A1 mRNA	18351577
D016718	Arachidonic Acid	Arachidonic Acid results in decreased expression of CYP24A1 mRNA	16623957
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of CYP24A1 mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of CYP24A1 mRNA	23912714
D001152	Arsenicals	Arsenicals results in increased expression of CYP24A1 mRNA	28625800
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [Cholecalciferol results in increased expression of CYP24A1 mRNA]	16184197
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CYP24A1	15781666
C006632	arsenic trioxide	[arsenic trioxide results in decreased expression of CYP24A1] which results in increased activity of paricalcitol	15781666
C015001	arsenite	arsenite results in increased methylation of CYP24A1 promoter	19716837\|2397400
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of CYP24A1 mRNA"	20831825
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of CYP24A1 mRNA"	20831825
D001507	Beclomethasone	Beclomethasone results in increased expression of CYP24A1 mRNA	23656298
D001564	Benzo(a)pyrene	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]]	19244278
D001564	Benzo(a)pyrene	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	19244278
D001564	Benzo(a)pyrene	Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]]	19244278
D001564	Benzo(a)pyrene	Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]	19244278
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19244278
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [CYP24A1 protein results in increased degradation of Calcitriol]	19244278
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]	19244278
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CYP24A1 mRNA	20106945\|2163298
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CYP24A1 mRNA"	26238291
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of CYP24A1 mRNA	20660070
D004958	Estradiol	Estradiol results in increased expression of CYP24A1 mRNA	20106945\|2163298
D001629	Bezafibrate	Bezafibrate inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19667161
C006780	bisphenol A	bisphenol A affects the expression of CYP24A1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of CYP24A1 mRNA	25181051
C402892	BMS453	BMS453 inhibits the reaction [Tretinoin inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	16289102
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of CYP24A1 mRNA	23410634
C584509	C646 compound	C646 compound results in decreased expression of CYP24A1 mRNA	26191083
D002104	Cadmium	Cadmium results in decreased expression of CYP24A1 mRNA	24376830
C055085	calcipotriene	calcipotriene results in increased expression of CYP24A1 mRNA	7530193
D002118	Calcium	Calcium affects the expression of CYP24A1 mRNA	15913539
D002118	Calcium	[Calcium co-treated with Calcitriol] affects the expression of CYP24A1 mRNA	15913539
D002136	Calcium, Dietary	"Calcium, Dietary affects the expression of CYP24A1 mRNA"	15905206
C505748	CD4528	CD4528 results in increased expression of CYP24A1 mRNA	15860548
D002509	Cephaloridine	Cephaloridine results in decreased expression of CYP24A1 mRNA	18500788
D002746	Chlorpromazine	Chlorpromazine affects the expression of CYP24A1 mRNA	25064622
D002922	Ciguatoxins	Ciguatoxins affects the expression of CYP24A1 mRNA	18353800
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CYP24A1 mRNA	19376846
D003300	Copper	Copper results in decreased expression of CYP24A1 mRNA	25646894
D019327	Copper Sulfate	Copper Sulfate results in increased expression of CYP24A1 mRNA	19549813
D003474	Curcumin	[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA	20153625
D003474	Curcumin	Curcumin results in increased expression of CYP24A1 protein	20153625
D003513	Cycloheximide	alpha-naphthoflavone inhibits the reaction [Cycloheximide promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	19244278
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19244278
D016572	Cyclosporine	Cyclosporine affects the expression of CYP24A1 mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in increased expression of CYP24A1 mRNA	20106945\|2163298
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CYP24A1 mRNA	24317228
C010902	decabromobiphenyl ether	decabromobiphenyl ether analog results in decreased expression of CYP24A1 mRNA	26854739
D003907	Dexamethasone	Dexamethasone affects the activity of CYP24A1 protein	10694374
D003907	Dexamethasone	Dexamethasone affects the expression of CYP24A1 mRNA	10694374
D003907	Dexamethasone	Dexamethasone results in increased expression of CYP24A1 mRNA	15630458
D002945	Cisplatin	Cisplatin results in decreased expression of CYP24A1 mRNA	27392435
C000944	dicrotophos	dicrotophos results in increased expression of CYP24A1 mRNA	28302478
D002117	Calcitriol	Calcitriol promotes the reaction [Ketoconazole results in increased expression of CYP24A1 mRNA]	17302875
D002117	Calcitriol	Calcitriol results in increased expression of CYP24A1 mRNA	17302875
D002117	Calcitriol	Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	17302875
D002117	Calcitriol	Calcitriol results in increased expression of CYP24A1 mRNA	15992766
D002117	Calcitriol	alpha-Linolenic Acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19667161
D002117	Calcitriol	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]]	19244278
D002117	Calcitriol	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	19244278
D002117	Calcitriol	alpha-naphthoflavone inhibits the reaction [Cycloheximide promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	19244278
D002117	Calcitriol	Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]]	19244278
D002117	Calcitriol	Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]	19244278
D002117	Calcitriol	Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19244278
D002117	Calcitriol	Benzo(a)pyrene promotes the reaction [CYP24A1 protein results in increased degradation of Calcitriol]	19244278
D002117	Calcitriol	Bezafibrate inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19667161
D002117	Calcitriol	BMS453 inhibits the reaction [Tretinoin inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	16289102
D002117	Calcitriol	Calcitriol analog results in increased expression of CYP24A1	19667147
D002117	Calcitriol	[Calcitriol binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA	15489543\|1818026
D002117	Calcitriol	[Calcitriol co-treated with NR1I2 protein] results in increased expression of CYP24A1 mRNA	21115105
D002117	Calcitriol	[Calcitriol co-treated with VDR protein] results in increased expression of CYP24A1 mRNA	21115105
D002117	Calcitriol	Calcitriol inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]	21917910
D002117	Calcitriol	Calcitriol promotes the reaction [HNF4A protein binds to CYP24A1 mRNA]	20371703
D002117	Calcitriol	Calcitriol promotes the reaction [NCOA1 protein binds to CYP24A1 promoter]	21917910
D002117	Calcitriol	Calcitriol promotes the reaction [NCOR1 protein binds to CYP24A1 mRNA]	20371703
D002117	Calcitriol	Calcitriol promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]	20371703
D002117	Calcitriol	Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 mRNA]	20371703
D002117	Calcitriol	Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]	19244278\|2191791
D002117	Calcitriol	Calcitriol promotes the reaction [VDR protein binds to CYP24A1 mRNA]	20371703
D002117	Calcitriol	Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]	15919092\|1924427
D002117	Calcitriol	Calcitriol promotes the reaction [[VDR protein binds to MED1 protein] which binds to CYP24A1 promoter]	15919092
D002117	Calcitriol	Calcitriol promotes the reaction [[VDR protein binds to NCOA3 protein] which binds to CYP24A1 promoter]	15919092
D002117	Calcitriol	Calcitriol promotes the reaction [[VDR protein binds to RXRA protein] which binds to CYP24A1 promoter]	15919092
D002117	Calcitriol	Calcitriol results in increased activity of CYP24A1 protein	15955619
D002117	Calcitriol	[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA	20371703
D002117	Calcitriol	Calcitriol results in increased expression of CYP24A1	16039846
D002117	Calcitriol	Calcitriol results in increased expression of CYP24A1 mRNA	14996990\|1553874
D002117	Calcitriol	Calcitriol results in increased expression of CYP24A1 protein	22751936
D002117	Calcitriol	CSK protein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	20371703
D002117	Calcitriol	Cycloheximide inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19244278
D002117	Calcitriol	CYP24A1 gene mutant form results in decreased metabolism of and results in increased abundance of Calcitriol	22337913
D002117	Calcitriol	CYP24A1 protein results in increased degradation of Calcitriol	15955619
D002117	Calcitriol	CYP24A1 protein results in increased metabolism of and results in decreased susceptibility to Calcitriol	15867263
D002117	Calcitriol	CYP24A1 protein results in increased metabolism of Calcitriol	26038696
D002117	Calcitriol	Dihydrotestosterone inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	15538745
D002117	Calcitriol	Docosahexaenoic Acids promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19667161
D002117	Calcitriol	Genistein inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]	15955619
D002117	Calcitriol	Genistein inhibits the reaction [CYP24A1 protein results in increased degradation of Calcitriol]	15955619
D002117	Calcitriol	Genistein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	15955619
D002117	Calcitriol	GW 501516 inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19667161
D002117	Calcitriol	HR protein inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	22466564
D002117	Calcitriol	Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	20206692
D002117	Calcitriol	[Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA	16824767
D002117	Calcitriol	lactacystin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	24792400
D002117	Calcitriol	Methylcholanthrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19244278
D002117	Calcitriol	NCOR1 protein inhibits the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]	20371703
D002117	Calcitriol	NCOR2 protein inhibits the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]	20371703
D002117	Calcitriol	PPARGC1A protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]	20371703
D002117	Calcitriol	RELA protein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	20206692
D002117	Calcitriol	saracatinib inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	20371703
D002117	Calcitriol	tamibarotene inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	16289102
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA	21592394
D002117	Calcitriol	Tetrachlorodibenzodioxin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19244278
D002117	Calcitriol	Tetradecanoylphorbol Acetate promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	20206692
D002117	Calcitriol	Tretinoin inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	16289102
D002117	Calcitriol	trichostatin A promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	20206692\|2111510
D002117	Calcitriol	trichostatin A promotes the reaction [Valproic Acid promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	21115105
D002117	Calcitriol	U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]]	20371703
D002117	Calcitriol	U 0126 inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 mRNA]]	20371703
D002117	Calcitriol	Valproic Acid promotes the reaction [[Calcitriol co-treated with VDR protein] results in increased expression of CYP24A1 mRNA]	21115105
D002117	Calcitriol	Valproic Acid promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	21115105
D002117	Calcitriol	Calcitriol affects the expression of and affects the activity of CYP24A1 protein	17244627
D002117	Calcitriol	Calcitriol affects the expression of CYP24A1 mRNA	17244627
D002117	Calcitriol	Calcitriol affects the expression of CYP24A1 protein	11796525
D002117	Calcitriol	Calcitriol promotes the reaction [CREBBP protein binds to CYP24A1 promoter]	15647825
D002117	Calcitriol	Calcitriol promotes the reaction [EP300 protein binds to CYP24A1 promoter]	15647825
D002117	Calcitriol	Calcitriol promotes the reaction [MED1 protein binds to CYP24A1 promoter]	15647825
D002117	Calcitriol	Calcitriol promotes the reaction [NCOA1 protein binds to CYP24A1 promoter]	15647825
D002117	Calcitriol	Calcitriol promotes the reaction [NCOA2 protein binds to CYP24A1 promoter]	15647825
D002117	Calcitriol	Calcitriol promotes the reaction [NCOA3 protein binds to CYP24A1 promoter]	15647825
D002117	Calcitriol	Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]	15647825
D002117	Calcitriol	Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]	15647825
D002117	Calcitriol	Calcitriol results in increased activity of CYP24A1 protein	10694374
D002117	Calcitriol	Calcitriol results in increased expression of CYP24A1 mRNA	10694374\|1703533
D002117	Calcitriol	CYP24A1 protein results in increased susceptibility to Calcitriol	17244627
D002117	Calcitriol	Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	18840526
D002117	Calcitriol	Calcitriol results in increased activity of CYP24A1 protein	16483768
D002117	Calcitriol	Calcitriol results in increased expression of CYP24A1 mRNA	10927029
D002117	Calcitriol	Calcitriol results in increased expression of CYP24A1 protein	8164439
D002117	Calcitriol	[Calcium co-treated with Calcitriol] affects the expression of CYP24A1 mRNA	15913539
D002117	Calcitriol	CYP24A1 protein affects the abundance of Calcitriol	12846736
D002117	Calcitriol	[Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA	16483768
D002117	Calcitriol	Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]	16483768
D002117	Calcitriol	Calcitriol analog results in increased activity of CYP24A1 protein	8533897
D002117	Calcitriol	Calcitriol promotes the reaction [[VDR protein binds to RXRA protein] which binds to CYP24A1 promoter]	15992766
D002117	Calcitriol	CYP24A1 protein results in increased hydroxylation of Calcitriol	26704532
D015650	24,25-Dihydroxyvitamin D 3	"CYP24A1 gene mutant form results in decreased abundance of 24,25-Dihydroxyvitamin D 3"	22337913
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19667161
C547512	eldecalcitol	CYP24A1 protein results in increased metabolism of eldecalcitol metabolite	26038696
C118739	entinostat	entinostat results in increased expression of CYP24A1 mRNA	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of CYP24A1 mRNA	24534155
D000431	Ethanol	Ethanol promotes the reaction [Vitamin D results in increased expression of CYP24A1 mRNA]	22892342
D000431	Ethanol	Ethanol results in increased expression of CYP24A1 mRNA	22892342
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CYP24A1 mRNA	25064622
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP24A1 mRNA	17942748
D005480	Flurbiprofen	Flurbiprofen results in decreased expression of CYP24A1 mRNA	16949054
C408042	fullerol C60(OH)24	fullerol C60(OH)24 results in decreased expression of CYP24A1 mRNA	21513982
C056507	gemcitabine	gemcitabine results in decreased expression of CYP24A1 mRNA	17039268
D019833	Genistein	Genistein inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]	15955619
D019833	Genistein	Genistein inhibits the reaction [CYP24A1 protein results in increased degradation of Calcitriol]	15955619
D019833	Genistein	Genistein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	15955619
D019833	Genistein	Genistein results in decreased activity of CYP24A1 protein	15955619
D019833	Genistein	[Genistein co-treated with vinclozolin] results in increased expression of CYP24A1 mRNA	23160963
C412815	GW 4064	GW 4064 results in increased expression of CYP24A1 mRNA	26655953
C425931	GW 501516	GW 501516 inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19667161
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CYP24A1 mRNA	26846883
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CYP24A1 mRNA	23410634
D002112	Calcifediol	Calcifediol promotes the reaction [Ketoconazole results in increased expression of CYP24A1 mRNA]	17302875
D002112	Calcifediol	Calcifediol results in increased expression of CYP24A1 mRNA	16289102\|1652472
D002112	Calcifediol	Dihydrotestosterone inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]	16524720
D002112	Calcifediol	Tretinoin inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]	16289102
D002112	Calcifediol	Calcifediol results in increased expression of CYP24A1 mRNA	18840526
D002112	Calcifediol	Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]	18840526
C001654	hyperforin	hyperforin results in increased expression of CYP24A1 mRNA	15630458
C492448	ICG 001	ICG 001 results in decreased expression of CYP24A1 mRNA	26191083
D058085	Iron Compounds	Iron Compounds results in decreased expression of CYP24A1 mRNA	28483490
D017964	Itraconazole	Itraconazole results in decreased activity of CYP24A1 protein	15328084
D017964	Itraconazole	Itraconazole results in decreased activity of CYP24A1 protein	15328084
C544151	jinfukang	jinfukang results in increased expression of CYP24A1 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CYP24A1 mRNA	26752646
D007654	Ketoconazole	Calcifediol promotes the reaction [Ketoconazole results in increased expression of CYP24A1 mRNA]	17302875
D007654	Ketoconazole	Calcitriol promotes the reaction [Ketoconazole results in increased expression of CYP24A1 mRNA]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [seocalcitol analog results in increased expression of CYP24A1 mRNA]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [seocalcitol results in increased expression of CYP24A1 mRNA]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [Vitamin D analog results in increased expression of CYP24A1 mRNA]	17302875
D007654	Ketoconazole	Ketoconazole results in increased expression of CYP24A1 mRNA	17302875
D007654	Ketoconazole	seocalcitol analog promotes the reaction [Ketoconazole results in increased expression of CYP24A1 mRNA]	17302875
D007654	Ketoconazole	seocalcitol promotes the reaction [Ketoconazole results in increased expression of CYP24A1 protein]	17302875
D007654	Ketoconazole	Vitamin D analog promotes the reaction [Ketoconazole results in increased expression of CYP24A1 mRNA]	17302875
D007654	Ketoconazole	Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	20206692
D007654	Ketoconazole	Ketoconazole results in decreased activity of CYP24A1 protein	26485663
D007654	Ketoconazole	[Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA	16824767
D007654	Ketoconazole	[Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA	16824767
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]	18840526
D007654	Ketoconazole	Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	18840526
D007654	Ketoconazole	[Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA	16483768
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]	16483768
D007654	Ketoconazole	Ketoconazole results in decreased activity of CYP24A1 protein	16483768
C067713	lactacystin	lactacystin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	24792400
C045463	leflunomide	leflunomide results in increased expression of CYP24A1 mRNA	28988120
D008095	Lithocholic Acid	Benzo(a)pyrene promotes the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]	19244278
D008095	Lithocholic Acid	HR protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]	22466564
D008095	Lithocholic Acid	[Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA	18180267
D008095	Lithocholic Acid	[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA	15489543\|1818026
D008095	Lithocholic Acid	Lithocholic Acid inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]	21917910
D008095	Lithocholic Acid	Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of CYP24A1 mRNA]	20055894
D008095	Lithocholic Acid	Lithocholic Acid promotes the reaction [VDR protein binds to CYP24A1 promoter]	21917910
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of CYP24A1 mRNA	19244278\|2005589
D008095	Lithocholic Acid	Lithocholic Acid analog results in increased expression of CYP24A1 mRNA	18180267
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of CYP24A1 mRNA	15489543
D008095	Lithocholic Acid	[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA	21311750
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of CYP24A1 mRNA	17535892
D008095	Lithocholic Acid	Vitamin D inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]	17535892
D008095	Lithocholic Acid	Lithocholic Acid promotes the reaction [[VDR protein binds to RXRA protein] which binds to CYP24A1 promoter]	15992766
C502354	lithocholic acid acetate	lithocholic acid acetate analog results in increased expression of CYP24A1 mRNA	18180267
C502354	lithocholic acid acetate	[lithocholic acid acetate binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA	15489543\|1818026
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [HNF4A protein binds to CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [NCOR1 protein binds to CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [RXRA protein binds to CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [VDR protein binds to CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate results in increased expression of CYP24A1 mRNA	20371703
C502354	lithocholic acid acetate	NCOR1 protein inhibits the reaction [[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	NCOR2 protein inhibits the reaction [[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	PPARGC1A protein promotes the reaction [[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	saracatinib inhibits the reaction [lithocholic acid acetate results in increased expression of CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	U 0126 inhibits the reaction [lithocholic acid acetate promotes the reaction [NCOR1 protein binds to CYP24A1 mRNA]]	20371703
C502354	lithocholic acid acetate	U 0126 inhibits the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to CYP24A1 mRNA]]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate results in increased expression of CYP24A1 mRNA	15489543\|1818026
C051883	maxacalcitol	maxacalcitol results in increased expression of CYP24A1 mRNA	7530193
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19244278
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CYP24A1 mRNA	23458150
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of CYP24A1 mRNA	16966085
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of CYP24A1 mRNA	22108045
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased methylation of CYP24A1 promoter	19716837
D009532	Nickel	Nickel affects the expression of CYP24A1 mRNA	14575637
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of CYP24A1 mRNA]	14575637
D010269	Paraquat	Paraquat affects the expression of CYP24A1 mRNA	25064622
C084656	paricalcitol	[arsenic trioxide results in decreased expression of CYP24A1] which results in increased activity of paricalcitol	15781666
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in increased expression of CYP24A1 mRNA	17715259
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in increased expression of CYP24A1 mRNA	17715259
C506614	PD 0325901	PD 0325901 results in decreased expression of CYP24A1 mRNA	21976371
C506614	PD 0325901	PD 0325901 results in increased expression of CYP24A1 mRNA	23872713
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CYP24A1 protein	26879310
D010634	Phenobarbital	Phenobarbital results in increased expression of CYP24A1 mRNA	19084549
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in increased expression of CYP24A1 mRNA	17715259
D010758	Phosphorus	Phosphorus affects the reaction [FGF23 protein results in increased expression of CYP24A1 mRNA]	17699549
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in increased expression of CYP24A1 mRNA	17715259
D016226	Phosphorus, Dietary	"Phosphorus, Dietary results in increased expression of CYP24A1 mRNA"	16123154
D016226	Phosphorus, Dietary	"Phosphorus, Dietary affects the expression of CYP24A1 mRNA"	15166007
D016226	Phosphorus, Dietary	"Phosphorus, Dietary affects the expression of CYP24A1 mRNA"	15877868
D010936	Plant Extracts	Plant Extracts results in increased expression of CYP24A1 mRNA	18351577
C482452	pramiconazole	pramiconazole results in decreased activity of CYP24A1 protein	15328084
C482452	pramiconazole	pramiconazole results in decreased activity of CYP24A1 protein	15328084
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of CYP24A1 mRNA	15630458
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of CYP24A1 mRNA	20660070
C045950	propiconazole	propiconazole results in increased expression of CYP24A1 mRNA	16730040
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors results in decreased expression of CYP24A1 mRNA	21976371
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of CYP24A1 mRNA	19297354
D011794	Quercetin	Quercetin results in decreased expression of CYP24A1 mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of CYP24A1 mRNA	26366751
D011794	Quercetin	VDR promotes the reaction [Quercetin results in increased expression of CYP24A1 mRNA]	26366751
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of CYP24A1 mRNA	21632981
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP24A1 mRNA	19059307
D012293	Rifampin	NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP24A1 mRNA]	21127053
D012293	Rifampin	Rifampin promotes the reaction [NR1I2 protein binds to CYP24A1 promoter]	15630458
D012293	Rifampin	Rifampin results in increased activity of CYP24A1 protein	15630458
D012293	Rifampin	Rifampin results in increased expression of CYP24A1 mRNA	15630458\|2112705
C515233	saracatinib	saracatinib inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	20371703
C515233	saracatinib	saracatinib inhibits the reaction [lithocholic acid acetate results in increased expression of CYP24A1 mRNA]	20371703
C078903	seocalcitol	Ketoconazole promotes the reaction [seocalcitol analog results in increased expression of CYP24A1 mRNA]	17302875
C078903	seocalcitol	Ketoconazole promotes the reaction [seocalcitol results in increased expression of CYP24A1 mRNA]	17302875
C078903	seocalcitol	seocalcitol analog promotes the reaction [Ketoconazole results in increased expression of CYP24A1 mRNA]	17302875
C078903	seocalcitol	seocalcitol analog results in increased expression of CYP24A1 mRNA	17302875
C078903	seocalcitol	seocalcitol promotes the reaction [Ketoconazole results in increased expression of CYP24A1 protein]	17302875
C078903	seocalcitol	seocalcitol results in increased expression of CYP24A1 mRNA	17302875
C078903	seocalcitol	seocalcitol results in increased expression of CYP24A1 mRNA	12040012\|7530193
C078903	seocalcitol	seocalcitol results in increased expression of CYP24A1 mRNA	26704532
C078903	seocalcitol	seocalcitol affects the expression of CYP24A1 mRNA	21843606
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of CYP24A1 mRNA	25351596
D012834	Silver	Silver results in increased expression of CYP24A1 mRNA	26014281
C017947	sodium arsenite	sodium arsenite affects the methylation of CYP24A1 gene	28589171
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CYP24A1 mRNA	27862939
D014284	Triiodothyronine	"(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of CYP24A1 mRNA]"	21815645
D014284	Triiodothyronine	Triiodothyronine results in increased expression of CYP24A1 mRNA	21815645
C061133	tamibarotene	tamibarotene inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	16289102
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP24A1 mRNA	19059307
D013739	Testosterone	Testosterone affects the expression of CYP24A1 mRNA	21592394
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of CYP24A1 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP24A1 mRNA	26854739
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	19244278
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYP24A1 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP24A1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYP24A1 mRNA	16267337
D013752	Tetracycline	Tetracycline affects the expression of CYP24A1 mRNA	25064622
C582340	tetradecabromodiphenoxybenzene	tetradecabromodiphenoxybenzene analog results in decreased expression of CYP24A1 mRNA	26854739
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	20206692
D013853	Thioacetamide	Thioacetamide affects the expression of CYP24A1 mRNA	25064622
C009495	titanium dioxide	titanium dioxide results in decreased expression of CYP24A1 mRNA	21513982
D014212	Tretinoin	BMS453 inhibits the reaction [Tretinoin inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	16289102
D014212	Tretinoin	Tretinoin inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]	16289102
D014212	Tretinoin	Tretinoin inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	16289102
D014212	Tretinoin	Tretinoin results in increased expression of CYP24A1 mRNA	16249480
C032910	triadimefon	triadimefon results in increased expression of CYP24A1 mRNA	26790661
C032910	triadimefon	triadimefon results in increased expression of CYP24A1 mRNA	16730040
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of CYP24A1 mRNA]	14575637
C012589	trichostatin A	trichostatin A promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	20206692\|2111510
C012589	trichostatin A	trichostatin A promotes the reaction [Valproic Acid promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	21115105
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYP24A1 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in decreased expression of CYP24A1 mRNA	26562049
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of CYP24A1 mRNA	29024780
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of CYP24A1 mRNA	27776230
C113580	U 0126	"U 0126 inhibits the reaction [1,25-dihydroxyvitamin D results in increased expression of CYP24A1 mRNA]"	15331595
C113580	U 0126	U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 mRNA]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [lithocholic acid acetate promotes the reaction [NCOR1 protein binds to CYP24A1 mRNA]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to CYP24A1 mRNA]]	20371703
C113580	U 0126	"U 0126 promotes the reaction [1,25-dihydroxyvitamin D results in increased expression of CYP24A1 mRNA]"	15331595
D014501	Uranium	Uranium results in decreased expression of CYP24A1 mRNA	17118558
D014520	Urethane	Urethane results in decreased expression of CYP24A1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of CYP24A1 mRNA	25064622
D014635	Valproic Acid	trichostatin A promotes the reaction [Valproic Acid promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]	21115105
D014635	Valproic Acid	[Valproic Acid co-treated with NR1I2 protein] results in increased expression of CYP24A1 mRNA	21115105
D014635	Valproic Acid	[Valproic Acid co-treated with VDR protein] results in increased expression of CYP24A1 mRNA	21115105
D014635	Valproic Acid	Valproic Acid promotes the reaction [[Calcitriol co-treated with VDR protein] results in increased expression of CYP24A1 mRNA]	21115105
D014635	Valproic Acid	Valproic Acid promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]	21115105
D014635	Valproic Acid	Valproic Acid results in increased expression of CYP24A1 mRNA	21115105\|2317975
D014635	Valproic Acid	Valproic Acid affects the expression of CYP24A1 mRNA	17292431
C025643	vinclozolin	[Genistein co-treated with vinclozolin] results in increased expression of CYP24A1 mRNA	23160963
D014807	Vitamin D	Ketoconazole promotes the reaction [Vitamin D analog results in increased expression of CYP24A1 mRNA]	17302875
D014807	Vitamin D	Vitamin D analog promotes the reaction [Ketoconazole results in increased expression of CYP24A1 mRNA]	17302875
D014807	Vitamin D	Vitamin D analog results in increased expression of CYP24A1 mRNA	17302875
D014807	Vitamin D	Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of CYP24A1 mRNA]	20055894
D014807	Vitamin D	Vitamin D analog inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]	21917910
D014807	Vitamin D	Vitamin D analog inhibits the reaction [VDR protein binds to CYP24A1 promoter]	21917910
D014807	Vitamin D	Vitamin D analog promotes the reaction [NCOR2 protein binds to CYP24A1 promoter]	21917910
D014807	Vitamin D	Vitamin D analog promotes the reaction [[NCOR2 protein binds to VDR protein] which binds to CYP24A1 promoter]	21917910
D014807	Vitamin D	Vitamin D analog promotes the reaction [RXRA protein binds to CYP24A1 promoter]	21917910
D014807	Vitamin D	Vitamin D analog results in increased expression of CYP24A1 mRNA	21917910
D014807	Vitamin D	Vitamin D results in increased expression of CYP24A1 mRNA	20055894
D014807	Vitamin D	Ethanol promotes the reaction [Vitamin D results in increased expression of CYP24A1 mRNA]	22892342
D014807	Vitamin D	Vitamin D results in increased expression of CYP24A1 mRNA	22892342
D014807	Vitamin D	Vitamin D deficiency results in decreased expression of CYP24A1 protein	8410379
D014807	Vitamin D	Vitamin D inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]	17535892
D014807	Vitamin D	CYP24A1 protein affects the metabolism of and results in decreased activity of Vitamin D metabolite	15630458
D014807	Vitamin D	CYP24A1 protein results in increased degradation of Vitamin D	21976371
D014807	Vitamin D	CYP24A1 protein results in increased metabolism of Vitamin D	16886663
D002762	Cholecalciferol	arsenic trioxide inhibits the reaction [Cholecalciferol results in increased expression of CYP24A1 mRNA]	16184197
D002762	Cholecalciferol	Cholecalciferol results in increased expression of CYP24A1 mRNA	16184197\|1620782
D002762	Cholecalciferol	Cholecalciferol affects the expression of CYP24A1 mRNA	21843606
D024483	Vitamin K 3	Vitamin K 3 affects the expression of CYP24A1 mRNA	23410634
D015032	Zinc	Zinc deficiency results in increased expression of CYP24A1 mRNA	18356318
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of CYP24A1 mRNA	27504894

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005506	iron ion binding	-	IEA	-
GO:0008403	25-hydroxycholecalciferol-24-hydroxylase activity	-	IEA	-
GO:0016491	oxidoreductase activity	-	NAS	7632726
GO:0020037	heme binding	-	TAS	8506296
GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	-	IDA	8506296
GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001649	osteoblast differentiation	-	IEP	17023519
GO:0006766	vitamin metabolic process	-	TAS	-
GO:0033280	response to vitamin D	-	IDA	16720713
GO:0042359	vitamin D metabolic process	-	TAS	-
GO:0042369	vitamin D catabolic process	-	NAS	16720713
GO:0055114	oxidation-reduction process	-	IDA	8506296
GO:0070561	vitamin D receptor signaling pathway	-	NAS	16720713

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	-
GO:0005654	nucleoplasm	-	IDA	-
GO:0005739	mitochondrion	-	IDA	-
GO:0005741	mitochondrial outer membrane	-	TAS	-
GO:0005886	plasma membrane	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1643685	Disease	TAS
R-HSA-196791	Vitamin D (calciferol) metabolism	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211897	Cytochrome P450 - arranged by substrate type	TAS
R-HSA-211916	Vitamins	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5579010	Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)	TAS
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	TAS
R-HSA-5668914	Diseases of metabolism	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27513734	1,25-Dihydroxyvitamin D Modulates Antibacterial and Inflammatory Response in Human Cigarette Smoke-Exposed Macrophages. (2016)	Heulens N	PLoS One
18508622	Expression of cytochrome P450 in non-small cell lung cancer. (2008 May 1)	Oyama T	Front Biosci
22155603	Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. (2011 Oct)	Morrison MA	Hum Genomics
22797725	Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. (2012 Jul 15)	Dong J	Nat Genet
29528271	Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke. (2018 May)	Turkanoglu Ozcelik A	Neurol Res
26275945	Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study. (2016 Nov)	Brouwer-Brolsma EM	J Steroid Biochem Mol Biol
28009432	Genetic polymorphisms of vitamin D receptor (VDR), CYP27B1 and CYP24A1 genes and the risk of colorectal cancer. (2017 May 4)	Vidigal VM	Int J Biol Markers
19244278	The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages. (2009 May)	Matsunawa M	Toxicol Sci
29250167	Associations between abnormal vitamin D metabolism pathway function and non-small cell lung cancer. (2017 Dec)	Ge N	Oncol Lett
27669215	Vitamin D-Related Gene Polymorphisms, Plasma 25-Hydroxy-Vitamin D, Cigarette Smoke and Non-Small Cell Lung Cancer (NSCLC) Risk. (2016 Sep 22)	Wu X	Int J Mol Sci