Gene info: ID 1592

Gene: CYP26A1

GENE ID: 1592

Synonyms: CP26|CYP26|P450RAI|P450RAI1

Description: cytochrome P450 family 26 subfamily A member 1

Gene type: protein-coding

Location: 10q23.33

dbXrefs: Ensembl:ENSG00000095596 MIM:602239 Vega:OTTHUMG00000018765 UniprotKB:O43174

RefSeq: NG_008067.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.258e-1 (AD) 4.626e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GALNT14	0.847
GRIK3	0.843
CHRM2	0.831
FOXP2	0.821
ADTRP	0.811
RXFP1	0.809
B3GALT2	0.808
HS3ST4	0.793
RAB3B	0.792
TRABD2A	0.789

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RHOD	-0.531
PARD3B	-0.527
CDC14A	-0.524
STON2	-0.524
IMPA2	-0.523
ASB4	-0.523
RNF135	-0.516
PARD3	-0.515
NBPF10	-0.504
ARHGAP31	-0.504

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00755	Tretinoin	Small Molecule	302-79-4	Approved\|Investigational\|Nutraceutical	Target
DB13083	Talarozole	Small Molecule	201410-53-9	Investigational	Target
DB00162	Vitamin A	Small Molecule	68-26-8	Approved\|Nutraceutical	Enzyme
DB00459	Acitretin	Small Molecule	55079-83-9	Approved	Enzyme
DB00926	Etretinate	Small Molecule	54350-48-0	Withdrawn	Enzyme
DB01026	Ketoconazole	Small Molecule	65277-42-1	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP26A1 mRNA"	21354444\|2269881
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of CYP26A1 mRNA"	21920950
C568513	2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester	"2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]"	21838328
C568513	2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester	"2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester results in decreased activity of CYP26A1 protein"	21838328
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CYP26A1 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of CYP26A1 mRNA"	21346803
C529372	3-((4,6-diphenoxy-1,3,5-triazin-2-yl)amino)benzoic acid	"3-((4,6-diphenoxy-1,3,5-triazin-2-yl)amino)benzoic acid results in increased expression of CYP26A1 protein"	18398471
C038864	4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid	"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of CYP26A1 mRNA"	15589975
C038864	4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid	"AGN 193109 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of CYP26A1 mRNA]"	15589975
C542472	4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid	"4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid inhibits the reaction [Valproic Acid results in increased expression of CYP26A1 mRNA]"	27693483
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CYP26A1 mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CYP26A1 mRNA"	25380136
C064545	4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid	"4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of CYP26A1 mRNA"	10953040
C064545	4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid	"Ro 41-5253 inhibits the reaction [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of CYP26A1 mRNA]"	10953040
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP26A1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CYP26A1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP26A1 mRNA"	27188386
C055506	4-(diethylamino)benzaldehyde	4-(diethylamino)benzaldehyde results in decreased expression of CYP26A1 protein	18398471
C019429	4-hydroxyretinoic acid	4-hydroxyretinoic acid affects the expression of CYP26A1 mRNA	16054125
C019429	4-hydroxyretinoic acid	4-hydroxyretinoic acid results in increased expression of CYP26A1 mRNA	25492813
C019429	4-hydroxyretinoic acid	CYP26A1 mRNA results in increased chemical synthesis of 4-hydroxyretinoic acid	12091498
C019429	4-hydroxyretinoic acid	CYP26A1 protein results in increased chemical synthesis of 4-hydroxyretinoic acid	17460545\|2549281
C019429	4-hydroxyretinoic acid	CYP26A1 protein results in increased metabolism of 4-hydroxyretinoic acid	25492813
C019429	4-hydroxyretinoic acid	[CYP26A1 protein results in increased metabolism of Tretinoin] which results in increased chemical synthesis of 4-hydroxyretinoic acid	25492813
C019429	4-hydroxyretinoic acid	Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-hydroxyretinoic acid]	12091498
C019429	4-hydroxyretinoic acid	[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid	25492813
C019429	4-hydroxyretinoic acid	[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid	25492813
C019429	4-hydroxyretinoic acid	[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid	25492813
C019429	4-hydroxyretinoic acid	[[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid	25492813
C002202	4-oxoretinoic acid	4-oxoretinoic acid affects the expression of CYP26A1 mRNA	16054125
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of CYP26A1 mRNA	25492813
C002202	4-oxoretinoic acid	CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid	12091498
C002202	4-oxoretinoic acid	CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid	12091498
C002202	4-oxoretinoic acid	CYP26A1 protein results in increased chemical synthesis of 4-oxoretinoic acid	17460545\|2549281
C002202	4-oxoretinoic acid	CYP26A1 protein results in increased metabolism of 4-oxoretinoic acid	25492813
C002202	4-oxoretinoic acid	Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]	12091498
C002202	4-oxoretinoic acid	Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]	12091498
C002202	4-oxoretinoic acid	[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid	25492813
C002202	4-oxoretinoic acid	[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid	25492813
C002202	4-oxoretinoic acid	[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid	25492813
C002202	4-oxoretinoic acid	[[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid	25492813
C041819	4-oxoretinol	CYP26A1 protein affects the chemical synthesis of 4-oxoretinol	10557354
C521334	5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate	5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of CYP26A1 mRNA	20932894
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP26A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CYP26A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP26A1 mRNA"	27188386
C483321	6-bromoindirubin-3'-oxime	[Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] affects the expression of CYP26A1 mRNA	27693483
D000082	Acetaminophen	Acetaminophen results in decreased expression of CYP26A1 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of CYP26A1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CYP26A1 mRNA	21641981
C096920	AGN 193109	"AGN 193109 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of CYP26A1 mRNA]"	15589975
C096920	AGN 193109	AGN 193109 inhibits the reaction [Aldrin results in increased expression of CYP26A1 mRNA]	15589975
C096920	AGN 193109	AGN 193109 inhibits the reaction [Chlordan results in increased expression of CYP26A1 mRNA]	15589975
C096920	AGN 193109	AGN 193109 inhibits the reaction [Dieldrin results in increased expression of CYP26A1 mRNA]	15589975
C096920	AGN 193109	AGN 193109 inhibits the reaction [Endosulfan results in increased expression of CYP26A1 mRNA]	15589975
C096920	AGN 193109	AGN 193109 inhibits the reaction [Endrin results in increased expression of CYP26A1 mRNA]	15589975
D000447	Aldehydes	Aldehydes results in increased expression of CYP26A1 mRNA	25014914
D000452	Aldrin	AGN 193109 inhibits the reaction [Aldrin results in increased expression of CYP26A1 mRNA]	15589975
D000452	Aldrin	Aldrin results in increased expression of CYP26A1 mRNA	15589975
C103303	alitretinoin	alitretinoin results in increased expression of CYP26A1 mRNA	16194896
C103303	alitretinoin	alitretinoin results in increased expression of CYP26A1 mRNA	16688765
C103303	alitretinoin	alitretinoin results in increased expression of CYP26A1 mRNA	28689802
D013196	Dihydrotestosterone	[Retinaldehyde co-treated with Dihydrotestosterone] results in increased expression of CYP26A1 mRNA	17526768
C068073	Am 580	Am 580 results in increased expression of CYP26A1 mRNA	10953040
C068073	Am 580	Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA]	10953040
D000638	Amiodarone	Amiodarone results in increased expression of CYP26A1 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CYP26A1 mRNA	16483693
D000841	Anisomycin	Anisomycin inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	16038797
D001151	Arsenic	Arsenic affects the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	18288313
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	15688020
C487081	belinostat	belinostat results in increased expression of CYP26A1 mRNA	26272509
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP26A1 mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CYP26A1 mRNA	21839799
D019207	beta Carotene	beta Carotene results in increased expression of CYP26A1 mRNA	16186334\|2254275
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of CYP26A1 mRNA	20660070
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of CYP26A1 mRNA	17404688
D004958	Estradiol	[Promegestone co-treated with Estradiol] results in increased expression of CYP26A1 mRNA	16955405
C095105	bexarotene	bexarotene results in increased expression of CYP26A1 mRNA	17178900
C095105	bexarotene	[bexarotene co-treated with Tamoxifen] results in increased expression of CYP26A1 mRNA	17630414
C006780	bisphenol A	bisphenol A results in increased expression of CYP26A1 mRNA	22281776
C006780	bisphenol A	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CYP26A1 promoter	23359474
C006780	bisphenol A	bisphenol A results in increased expression of CYP26A1 mRNA	25181051
C402892	BMS453	BMS453 inhibits the reaction [retinol acetate results in increased expression of CYP26A1 mRNA]	16322074
C018475	butyraldehyde	butyraldehyde results in increased expression of CYP26A1 mRNA	26079696
D002104	Cadmium	Cadmium results in decreased expression of CYP26A1 mRNA	19556237
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CYP26A1 mRNA	23741332
D002220	Carbamazepine	Carbamazepine affects the expression of CYP26A1 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CYP26A1 mRNA	27339419
C099555	CD 437	CD 437 results in increased expression of CYP26A1 mRNA	10953040
D002706	Chlordan	AGN 193109 inhibits the reaction [Chlordan results in increased expression of CYP26A1 mRNA]	15589975
D002706	Chlordan	Chlordan results in increased expression of CYP26A1 mRNA	15589975
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of CYP26A1 mRNA	21356183
D002922	Ciguatoxins	Ciguatoxins affects the expression of CYP26A1 mRNA	18353800
C019304	ciprofibrate	ciprofibrate results in decreased expression of CYP26A1 mRNA	12771043
D002994	Clofibrate	Clofibrate results in decreased expression of CYP26A1 mRNA	17585979
D003042	Cocaine	Cocaine affects the expression of CYP26A1 mRNA	20187946
C057862	cyanoginosin LR	cyanoginosin LR results in decreased expression of CYP26A1 mRNA	17383702
C093628	cyproconazole	cyproconazole affects the expression of CYP26A1 mRNA	21621602
C093628	cyproconazole	cyproconazole results in increased expression of CYP26A1 mRNA	22664269
C014347	decitabine	decitabine affects the expression of CYP26A1 mRNA	23300844
D003671	DEET	[fipronil co-treated with DEET] results in increased expression of CYP26A1 mRNA	27091632
D003993	Dibutyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CYP26A1 promoter	23359474
D002945	Cisplatin	Cisplatin affects the expression of CYP26A1 mRNA	23300844
D002945	Cisplatin	CYP26A1 protein results in decreased susceptibility to Cisplatin	15703382
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of CYP26A1 mRNA	16707153
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of CYP26A1 protein	16707153
D004008	Diclofenac	Diclofenac results in decreased expression of CYP26A1 mRNA	26934552
D004026	Dieldrin	AGN 193109 inhibits the reaction [Dieldrin results in increased expression of CYP26A1 mRNA]	15589975
D004026	Dieldrin	Dieldrin results in increased expression of CYP26A1 mRNA	15589975
D004041	Dietary Fats	[Dietary Fats co-treated with sodium arsenite] results in decreased expression of CYP26A1 mRNA	28283972
D004041	Dietary Fats	Dietary Fats results in decreased expression of CYP26A1 mRNA	28283972
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of CYP26A1 mRNA	19245819
D004051	Diethylhexyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CYP26A1 promoter	23359474
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of CYP26A1 mRNA	12771043\|2453584
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP26A1 mRNA	18164116
D002117	Calcitriol	Calcitriol results in increased expression of CYP26A1 mRNA	27107558
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of CYP26A1 mRNA	25380136
D011397	Promegestone	[Promegestone co-treated with Estradiol] results in increased expression of CYP26A1 mRNA	16955405
D011397	Promegestone	Promegestone results in increased expression of CYP26A1 mRNA	16955405
D004147	Dioxins	Dioxins affects the expression of CYP26A1 mRNA	20463971
D004726	Endosulfan	AGN 193109 inhibits the reaction [Endosulfan results in increased expression of CYP26A1 mRNA]	15589975
D004726	Endosulfan	Endosulfan results in increased expression of CYP26A1 mRNA	15589975\|2661514
D004732	Endrin	AGN 193109 inhibits the reaction [Endrin results in increased expression of CYP26A1 mRNA]	15589975
D004732	Endrin	Endrin results in increased expression of CYP26A1 mRNA	15589975
C118739	entinostat	entinostat results in increased expression of CYP26A1 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP26A1 mRNA"	27188386
D000431	Ethanol	Ethanol results in increased expression of CYP26A1 mRNA	19167417
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CYP26A1 mRNA	23550701
C024565	ethylene dichloride	ethylene dichloride results in increased expression of CYP26A1 mRNA	28189721
D005047	Etoposide	CYP26A1 protein results in decreased susceptibility to Etoposide	15703382
C033789	fenarimol	fenarimol results in increased expression of CYP26A1 mRNA	28970091
C082360	fipronil	[fipronil co-treated with DEET] results in increased expression of CYP26A1 mRNA	27091632
C082360	fipronil	fipronil results in increased expression of CYP26A1 mRNA	27091632
C000591741	Firemaster 550	Firemaster 550 results in decreased expression of CYP26A1 mRNA	27957850
D015725	Fluconazole	Fluconazole results in increased expression of CYP26A1 mRNA	19429397
C061365	flusilazole	flusilazole affects the expression of CYP26A1 mRNA	21621602
C061365	flusilazole	flusilazole results in increased expression of CYP26A1 mRNA	22382673\|2266426
C061365	flusilazole	flusilazole results in increased expression of CYP26A1 mRNA	22664269\|2709437
D004397	Fonofos	Fonofos results in increased methylation of CYP26A1 promoter	22847954
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in increased expression of CYP26A1 mRNA	25270620
D017313	Fenretinide	Fenretinide results in increased expression of CYP26A1 mRNA	15291358
D017313	Fenretinide	Fenretinide results in increased expression of CYP26A1 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CYP26A1 mRNA	26846883
D006861	Hydrogen Peroxide	CYP26A1 protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]	15703382
D006861	Hydrogen Peroxide	CYP26A1 protein inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]	15703382
D006861	Hydrogen Peroxide	CYP26A1 protein inhibits the reaction [[Tretinoin co-treated with Hydrogen Peroxide] results in increased expression of CDKN1A protein]	15703382
D006861	Hydrogen Peroxide	CYP26A1 protein inhibits the reaction [Tretinoin promotes the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]]	15703382
D006861	Hydrogen Peroxide	CYP26A1 protein results in decreased susceptibility to Hydrogen Peroxide	15703382
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-hydroxyretinoic acid]	12091498
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]	12091498
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]	12091498
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of Tretinoin]	12091498
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]	15703382
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]	15703382
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]]	15703382
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of and results in decreased susceptibility to Tretinoin]	15703382
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of Tretinoin]	21906690
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP26A1 results in increased metabolism of Tretinoin]	14532297
D007654	Ketoconazole	Ketoconazole results in decreased activity of CYP26A1	14532297
D007654	Ketoconazole	Ketoconazole results in decreased activity of CYP26A1 protein	25492813
D007654	Ketoconazole	[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid	25492813
D007654	Ketoconazole	[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid	25492813
D007654	Ketoconazole	[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin	25492813
D007654	Ketoconazole	[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid	25492813
D007654	Ketoconazole	[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid	25492813
D007654	Ketoconazole	Ketoconazole results in decreased susceptibility to CYP26A1 protein	18059332
D007654	Ketoconazole	Ketoconazole results in increased expression of CYP26A1 mRNA	28263823
C061121	liarozole	[liarozole co-treated with Tretinoin] results in increased expression of CYP26A1 mRNA	21428449
C061121	liarozole	liarozole promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	21838328
C061121	liarozole	liarozole results in decreased activity of CYP26A1 protein	15597402\|1627977
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	17185629
D008095	Lithocholic Acid	Lithocholic Acid promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	18059332
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of CYP26A1 mRNA	18059332
D015122	Mercaptopurine	Mercaptopurine results in increased expression of CYP26A1 mRNA	23358152
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CYP26A1 mRNA	23179753\|2627250
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of CYP26A1 mRNA	20864626
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CYP26A1 mRNA	26011545
C028577	monobutyl phthalate	monobutyl phthalate affects the expression of CYP26A1 mRNA	19162170
C500085	muraglitazar	muraglitazar results in increased expression of CYP26A1 mRNA	21515302
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of CYP26A1 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CYP26A1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of CYP26A1 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of CYP26A1 mRNA	25380136
D009538	Nicotine	Nicotine results in decreased expression of CYP26A1 mRNA	21371177
D009538	Nicotine	Nicotine results in decreased expression of CYP26A1 protein	21371177
D010278	Parathion	Parathion results in increased methylation of CYP26A1 promoter	22847954
C046012	pentanal	pentanal results in increased expression of CYP26A1 mRNA	26079696
D010634	Phenobarbital	Phenobarbital results in increased expression of CYP26A1 mRNA	19270015\|1948288
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CYP26A1 mRNA"	27188386
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CYP26A1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of CYP26A1 mRNA	23811191
D010936	Plant Extracts	Plant Extracts results in decreased expression of CYP26A1 mRNA	23557933
C531249	Poly(amidoamine)	Poly(amidoamine) analog affects the expression of CYP26A1	27193728
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of CYP26A1 mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of CYP26A1 mRNA	28903501
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of CYP26A1 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of CYP26A1 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of CYP26A1 mRNA	17404688
D011374	Progesterone	Progesterone affects the expression of CYP26A1 mRNA	17251523
D011374	Progesterone	[Progesterone results in increased activity of PGR protein] which results in increased expression of CYP26A1 mRNA	15845616
D011374	Progesterone	Progesterone results in decreased expression of CYP26A1	17510236
C045950	propiconazole	propiconazole results in increased expression of CYP26A1 mRNA	21278054
C045950	propiconazole	propiconazole results in increased expression of CYP26A1 mRNA	28970091
C005556	propionaldehyde	propionaldehyde results in increased expression of CYP26A1 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of CYP26A1 mRNA	24780913
D011691	Puromycin	[Tretinoin co-treated with Puromycin] results in increased expression of CYP26A1 mRNA	15977162
C406527	R 115866	R 115866 results in decreased activity of CYP26A1 protein	25492813
C406527	R 115866	[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid	25492813
C406527	R 115866	[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid	25492813
C406527	R 115866	[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin	25492813
C406527	R 115866	[[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid	25492813
C406527	R 115866	[[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid	25492813
C406527	R 115866	R 115866 binds to and results in decreased activity of CYP26A1 protein	20580668
C406527	R 115866	[R 115866 co-treated with Vitamin A] results in increased expression of CYP26A1 mRNA	17510468
C406527	R 115866	[R 115866 results in decreased activity of CYP26A1 protein] which results in increased abundance of Tretinoin	17510468
C406527	R 115866	R 115866 results in increased expression of CYP26A1 mRNA	20580668
C450682	R116010	[R116010 co-treated with Tretinoin] results in increased expression of CYP26A1 mRNA	21428449
C450682	R116010	R116010 promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	21838328
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of CYP26A1 mRNA	25905778
D012172	Retinaldehyde	[Retinaldehyde co-treated with Dihydrotestosterone] results in increased expression of CYP26A1 mRNA	17526768
D012172	Retinaldehyde	Retinaldehyde results in increased expression of CYP26A1 mRNA	17526768
D015474	Isotretinoin	Isotretinoin results in increased expression of CYP26A1 mRNA	16194896\|1748613
C009166	retinol acetate	BMS453 inhibits the reaction [retinol acetate results in increased expression of CYP26A1 mRNA]	16322074
C009166	retinol acetate	retinol acetate results in increased expression of CYP26A1 mRNA	16322074
C013672	riddelliine	riddelliine results in increased expression of CYP26A1 mRNA	18047727
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of CYP26A1 mRNA	21127053
C084904	Ro 41-5253	"Ro 41-5253 inhibits the reaction [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of CYP26A1 mRNA]"	10953040
C084904	Ro 41-5253	Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA]	10953040
C089730	rosiglitazone	rosiglitazone results in increased expression of CYP26A1 mRNA	21515302
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CYP26A1 mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in increased expression of CYP26A1 mRNA	28595984
C017947	sodium arsenite	[Dietary Fats co-treated with sodium arsenite] results in decreased expression of CYP26A1 mRNA	28283972
C017947	sodium arsenite	sodium arsenite results in decreased expression of CYP26A1 mRNA	28283972
C017947	sodium arsenite	sodium arsenite results in increased methylation of CYP26A1 gene	24118411
C016104	sodium bichromate	sodium bichromate results in decreased expression of CYP26A1 mRNA	24612858
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of CYP26A1 mRNA	25905778
D014284	Triiodothyronine	Triiodothyronine results in increased expression of CYP26A1 mRNA	22281776
D013629	Tamoxifen	Tamoxifen affects the expression of CYP26A1 mRNA	14699072
D013629	Tamoxifen	Tamoxifen affects the expression of CYP26A1 mRNA	20937368
D013629	Tamoxifen	[bexarotene co-treated with Tamoxifen] results in increased expression of CYP26A1 mRNA	17630414
C087114	tebuconazole	tebuconazole results in increased expression of CYP26A1 mRNA	28970091
C012568	terbufos	terbufos results in increased methylation of CYP26A1 promoter	22847954
C501413	tesaglitazar	tesaglitazar results in increased expression of CYP26A1 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP26A1 mRNA	16443690
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CYP26A1 mRNA	28922406
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP26A1 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP26A1 mRNA	19770486\|2821309
D013752	Tetracycline	Tetracycline results in decreased expression of CYP26A1 mRNA	16917069
D013893	Thiram	Thiram results in increased expression of CYP26A1 mRNA	20530235
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]	17035595
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]	17035595
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]	17035595
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]	17035595
D014212	Tretinoin	CYP26A1 protein results in increased degradation of Tretinoin	17035595
D014212	Tretinoin	[Tretinoin co-treated with Puromycin] results in increased expression of CYP26A1 mRNA	15977162
D014212	Tretinoin	Tretinoin results in increased expression of CYP26A1 mRNA	15977162
D014212	Tretinoin	Tretinoin affects the expression of CYP26A1 mRNA	16054125
D014212	Tretinoin	Tretinoin results in increased expression of CYP26A1 mRNA	16885356\|1716442
D014212	Tretinoin	Tretinoin results in increased expression of CYP26A1 protein	18398471
D014212	Tretinoin	"2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]"	21838328
D014212	Tretinoin	Arsenic affects the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	18288313
D014212	Tretinoin	CYP26A1 exon SNP results in decreased metabolism of Tretinoin	17460545
D014212	Tretinoin	CYP26A1 mRNA results in increased metabolism of Tretinoin	12091498
D014212	Tretinoin	CYP26A1 protein binds to and results in increased metabolism of Tretinoin	21906690
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [[Tretinoin co-treated with Hydrogen Peroxide] results in increased expression of CDKN1A protein]	15703382
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin promotes the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]]	15703382
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in decreased expression of BCL2L1 protein]	15703382
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]	15703382
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]	15703382
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]	15703382
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in increased cleavage of CASP3 protein]	15703382
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]	15703382
D014212	Tretinoin	CYP26A1 protein polymorphism results in decreased metabolism of Tretinoin	17460545
D014212	Tretinoin	CYP26A1 protein results in decreased abundance of Tretinoin	18059332
D014212	Tretinoin	CYP26A1 protein results in increased metabolism of and results in decreased susceptibility to Tretinoin	15703382
D014212	Tretinoin	CYP26A1 protein results in increased metabolism of Tretinoin	16194896\|1746054
D014212	Tretinoin	CYP26A1 protein results in increased metabolism of Tretinoin metabolite	25492813
D014212	Tretinoin	[CYP26A1 protein results in increased metabolism of Tretinoin] which results in increased chemical synthesis of 4-hydroxyretinoic acid	25492813
D014212	Tretinoin	CYP26A1 results in increased metabolism of Tretinoin	14532297
D014212	Tretinoin	Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of Tretinoin]	12091498
D014212	Tretinoin	Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]	15703382
D014212	Tretinoin	Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]	15703382
D014212	Tretinoin	Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]]	15703382
D014212	Tretinoin	Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of and results in decreased susceptibility to Tretinoin]	15703382
D014212	Tretinoin	Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of Tretinoin]	21906690
D014212	Tretinoin	Ketoconazole inhibits the reaction [CYP26A1 results in increased metabolism of Tretinoin]	14532297
D014212	Tretinoin	[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin	25492813
D014212	Tretinoin	[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid	25492813
D014212	Tretinoin	[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid	25492813
D014212	Tretinoin	[liarozole co-treated with Tretinoin] results in increased expression of CYP26A1 mRNA	21428449
D014212	Tretinoin	liarozole promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	21838328
D014212	Tretinoin	Lithocholic Acid promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	18059332
D014212	Tretinoin	[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin	25492813
D014212	Tretinoin	[[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid	25492813
D014212	Tretinoin	[[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid	25492813
D014212	Tretinoin	[R116010 co-treated with Tretinoin] results in increased expression of CYP26A1 mRNA	21428449
D014212	Tretinoin	R116010 promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	21838328
D014212	Tretinoin	RARA protein affects the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	16194896
D014212	Tretinoin	SUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	24819975
D014212	Tretinoin	[Tretinoin co-treated with CXCL8 protein] results in increased expression of CYP26A1 mRNA	17218384
D014212	Tretinoin	[Tretinoin co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA	17244623
D014212	Tretinoin	Tretinoin metabolite results in increased expression of CYP26A1 mRNA	25492813
D014212	Tretinoin	Tretinoin results in increased expression of CYP26A1 mRNA	10953040\|1287065
D014212	Tretinoin	Anisomycin inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	16038797
D014212	Tretinoin	arsenic trioxide inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	15688020
D014212	Tretinoin	CYP26A1 protein affects the degradation of Tretinoin	16688765
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in decreased expression of FGF8 mRNA]	12588859
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in decreased expression of WNT3A mRNA]	12588859
D014212	Tretinoin	CYP26A1 protein results in decreased susceptibility to Tretinoin	12588859
D014212	Tretinoin	CYP26A1 protein results in increased degradation of Tretinoin	12588859
D014212	Tretinoin	CYP26A1 protein results in increased metabolism of Tretinoin	19010342
D014212	Tretinoin	[DHRS3 gene mutant form results in increased abundance of Tretinoin] which results in increased expression of CYP26A1 mRNA	24005908
D014212	Tretinoin	RARA protein affects the reaction [Tretinoin affects the expression of CYP26A1 mRNA]	16261163
D014212	Tretinoin	Tretinoin promotes the reaction [[RARG protein binds to RXRA protein] which binds to CYP26A1 promoter]	16053444
D014212	Tretinoin	Tretinoin results in increased expression of CYP26A1	10862743
D014212	Tretinoin	Tretinoin results in increased expression of CYP26A1 mRNA	15688020\|1603879
D014212	Tretinoin	Lipopolysaccharides inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]	17185629
D014212	Tretinoin	[R 115866 results in decreased activity of CYP26A1 protein] which results in increased abundance of Tretinoin	17510468
D014212	Tretinoin	Tretinoin results in increased expression of CYP26A1 mRNA	17185629\|1751046
D014212	Tretinoin	CYP26A1 protein results in increased metabolism of Tretinoin	16979153
D014212	Tretinoin	Tretinoin results in increased expression of CYP26A1 mRNA	28689802
D014212	Tretinoin	CYP26A1 protein results in increased degradation of Tretinoin	17510468
D014212	Tretinoin	CYP26A1 protein results in increased metabolism of and results in decreased activity of Tretinoin	16933217
D014212	Tretinoin	CYP26A1 protein results in increased metabolism of and results in increased degradation of Tretinoin	10862743
D014212	Tretinoin	CYP26A1 protein results in increased metabolism of Tretinoin	16837774\|1695540
C032910	triadimefon	triadimefon results in increased expression of CYP26A1 mRNA	26790661
C032910	triadimefon	triadimefon results in increased expression of CYP26A1 mRNA	19010342
C032910	triadimefon	triadimefon results in increased expression of CYP26A1 mRNA	22664269\|2826382
C032910	triadimefon	triadimefon results in increased expression of CYP26A1 mRNA	16875885\|2127263
C011559	tributyltin	tributyltin results in increased expression of CYP26A1 mRNA	27614199
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of CYP26A1 mRNA	25055964
C012589	trichostatin A	trichostatin A results in decreased expression of CYP26A1 mRNA	24935251
C012589	trichostatin A	trichostatin A results in increased expression of CYP26A1 mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CYP26A1 mRNA"	26179874
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of CYP26A1 mRNA	27776230
C057693	troglitazone	troglitazone results in increased expression of CYP26A1 mRNA	21515302
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of CYP26A1 mRNA	15885361
D014635	Valproic Acid	Valproic Acid affects the expression of CYP26A1 protein	25111975
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP26A1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of CYP26A1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYP26A1 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of CYP26A1 mRNA	26272509
D014635	Valproic Acid	"4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid inhibits the reaction [Valproic Acid results in increased expression of CYP26A1 mRNA]"	27693483
D014635	Valproic Acid	Valproic Acid affects the expression of CYP26A1 mRNA	27693483
D014635	Valproic Acid	[Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] affects the expression of CYP26A1 mRNA	27693483
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYP26A1 mRNA	19136453\|2054688
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of CYP26A1 gene	25560391
D014801	Vitamin A	Vitamin A results in increased expression of CYP26A1 mRNA	16230703
D014801	Vitamin A	[Vitamin A co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA	17244623
D014801	Vitamin A	Vitamin A results in increased expression of CYP26A1 mRNA	16194896\|2254275
D014801	Vitamin A	CYP26A1 protein affects the metabolism of Vitamin A	10557354
D014801	Vitamin A	[R 115866 co-treated with Vitamin A] results in increased expression of CYP26A1 mRNA	17510468
D002762	Cholecalciferol	Cholecalciferol results in increased expression of CYP26A1 mRNA	17170073
C111237	vorinostat	vorinostat results in decreased expression of CYP26A1 mRNA	27188386
C574123	walrycin A	walrycin A results in increased expression of CYP26A1 mRNA	22314385
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of CYP26A1 mRNA"	22326570

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001972	retinoic acid binding	-	IDA	10823918
GO:0005506	iron ion binding	-	IEA	-
GO:0008401	retinoic acid 4-hydroxylase activity	-	IDA	9228017 9716180 10823918
GO:0008401	retinoic acid 4-hydroxylase activity	-	TAS	-
GO:0016491	oxidoreductase activity	-	IBA	21873635
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	-	IDA	26937021
GO:0019825	oxygen binding	-	TAS	9228017
GO:0020037	heme binding	-	NAS	9228017

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006766	vitamin metabolic process	-	TAS	-
GO:0006805	xenobiotic metabolic process	-	IDA	26937021
GO:0016125	sterol metabolic process	-	IBA	21873635
GO:0032526	response to retinoic acid	-	IEA	-
GO:0033189	response to vitamin A	-	IEA	-
GO:0034653	retinoic acid catabolic process	-	IDA	10823918
GO:0042573	retinoic acid metabolic process	-	IDA	9716180
GO:0048387	negative regulation of retinoic acid receptor signaling pathway	-	TAS	14532297
GO:0055114	oxidation-reduction process	-	IBA	21873635
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0031090	organelle membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00830	Retinol metabolism

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211897	Cytochrome P450 - arranged by substrate type	TAS
R-HSA-211916	Vitamins	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-5362517	Signaling by Retinoic Acid	TAS
R-HSA-5365859	RA biosynthesis pathway	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22300446	Cocaine decreases expression of neurogranin via alterations in thyroid receptor/retinoid X receptor signaling. (2012 Apr)	Kovalevich J	J Neurochem