Gene: CYP27A1

1593
CP27|CTX|CYP27
cytochrome P450 family 27 subfamily A member 1
protein-coding
2q35
Ensembl:ENSG00000135929 MIM:606530 Vega:OTTHUMG00000048238 UniprotKB:Q02318
NG_007959.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.192e-1 (AD)  5.592e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PMP220.907
GSN0.898
VWA10.893
EFHD10.893
DDR10.875
PREX10.874
MAL0.869
LGALS3BP0.866
GLTP0.861
RHOG0.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HS6ST3-0.511
FREM3-0.474
CNTN5-0.472
KCNH5-0.47
GPR26-0.469
PRSS12-0.465
CDH7-0.463
FBLN7-0.46
KCNH1-0.452
SERTM1-0.45

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]"19196849
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]"19196849
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 mRNA]19035488
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 protein]19035488
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CYP27A1 mRNA"21346803
C04456324-hydroxycholesterolCYP27A1 protein results in decreased abundance of 24-hydroxycholesterol12119285
C04456324-hydroxycholesterol[CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 24-hydroxycholesterol8443234
C00799725-hydroxycholesterol[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 25-hydroxycholesterol8078928
C00799725-hydroxycholesterolCYP27A1 protein results in increased chemical synthesis of 25-hydroxycholesterol17890683
C00799725-hydroxycholesterol[CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 25-hydroxycholesterol8443234
C07699627-hydroxycholesterolCYP27A1 protein results in increased abundance of 27-hydroxycholesterol12119285
C07699627-hydroxycholesterolCYP27A1 protein results in increased chemical synthesis of 27-hydroxycholesterol11714861|1253190
C07699627-hydroxycholesterol[CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol9660774
C07699627-hydroxycholesterol[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol11408283|9215552
C07699627-hydroxycholesterol[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein11408283
C07699627-hydroxycholesterol[CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid9660774
C07699627-hydroxycholesterol[TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol15708352
C07699627-hydroxycholesterol[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol8496670
C07699627-hydroxycholesterol[CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol8443234
C07699627-hydroxycholesterolCYP27A1 protein results in increased chemical synthesis of 27-hydroxycholesterol18817892|1967183
C07699627-hydroxycholesterol[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol19158428
C07699627-hydroxycholesterol[CYP27A1 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol11514559
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of CYP27A1 mRNA]23041272
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of CYP27A1 protein]23041272
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide results in decreased expression of CYP27A1 mRNA23041272
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide results in decreased expression of CYP27A1 protein23041272
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CYP27A1 mRNA]"19467301
C0294353-hydroxy-5-cholestenoic acidCYP27A1 protein results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid14622972
C0294353-hydroxy-5-cholestenoic acid[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid8078928|9215552
C0294353-hydroxy-5-cholestenoic acid[CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid9660774
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CYP27A1 mRNA"18648102
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of CYP27A1 mRNA15982314
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of CYP27A1 mRNA20932894
C0030017-ketocholesterolCYP27A1 protein results in increased metabolism of 7-ketocholesterol10869358
D000082AcetaminophenAcetaminophen results in decreased expression of CYP27A1 mRNA21420995|2570463
D000082AcetaminophenAcetaminophen affects the expression of CYP27A1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYP27A1 mRNA27153756
C103303alitretinoinalitretinoin results in decreased expression of CYP27A1 mRNA15982314
C103303alitretinoinalitretinoin results in increased expression of CYP27A1 mRNA15964820
C103303alitretinoinDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CYP27A1 mRNA]15964820
C103303alitretinoinperiodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CYP27A1 mRNA]]15964820
C103505AM 251AM 251 inhibits the reaction [Ethanol results in increased expression of CYP27A1 mRNA]23894352
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYP27A1 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of CYP27A1 mRNA16715494
D001151ArsenicArsenic affects the methylation of CYP27A1 gene25304211
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of CYP27A1 mRNA16386711
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of CYP27A1 protein16386711
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of CYP27A1 mRNA25278499
D001280AtrazineAtrazine results in decreased expression of CYP27A1 mRNA25929836
D001280AtrazineAtrazine results in increased expression of CYP27A1 mRNA22378314
D001548Benzalkonium CompoundsBenzalkonium Compounds results in decreased expression of CYP27A1 mRNA20713136
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CYP27A1 mRNA20127859
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYP27A1 mRNA22228805
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of CYP27A1 mRNA28392238
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of CYP27A1 mRNA28392238
C095105bexarotenebexarotene results in increased expression of CYP27A1 mRNA16648578
D001647Bile Acids and SaltsCYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts16477808
D001647Bile Acids and Salts[CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol]16477808
D001647Bile Acids and Salts[CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] which results in increased expression of and results in increased activity of HMGCR protein16477808
D001647Bile Acids and Salts[CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] which results in increased expression of LDLR mRNA16477808
D001647Bile Acids and SaltsCYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts12368294
D001647Bile Acids and SaltsCYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts12029625
D001647Bile Acids and Salts[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Bile Acids and Salts18817892
C006780bisphenol Abisphenol A results in increased expression of CYP27A1 mRNA27685785|2927551
C006780bisphenol Abisphenol A results in increased expression of CYP27A1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CYP27A1 mRNA22079614
D002065BuspironeBuspirone results in increased expression of CYP27A1 mRNA24136188
C027561butylbenzyl phthalatebutylbenzyl phthalate results in increased expression of CYP27A1 mRNA26472102
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CYP27A1 mRNA17484886|2438101
D002586CesiumCesium results in increased activity of CYP27A1 protein20173315
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of CYP27A1 mRNA25582706
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of CYP27A1 mRNA7832767
D004083CholestanolCYP27A1 protein results in increased secretion of Cholestanol12117727
D002784CholesterolCYP27A1 protein promotes the reaction [APOA1 protein results in increased secretion of Cholesterol]12531903
D002784CholesterolCYP27A1 protein results in decreased chemical synthesis of Cholesterol12531903
D002784Cholesterol[CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol]16477808
D002784CholesterolCYP27A1 protein results in increased hydroxylation of and results in decreased abundance of Cholesterol11714861
D002784Cholesterol[CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol9660774
D002784Cholesterol[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 25-hydroxycholesterol8078928
D002784Cholesterol[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol11408283|9215552
D002784Cholesterol[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein11408283
D002784Cholesterol[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid8078928|9215552
D002784CholesterolCYP27A1 protein results in increased secretion of Cholesterol12117727
D002784Cholesterol[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of CYP27A1 mRNA18356535
D002784Cholesterol[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol8496670
D002784Cholesterol[CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 24-hydroxycholesterol8443234
D002784Cholesterol[CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 25-hydroxycholesterol8443234
D002784Cholesterol[CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol8443234
D002784Cholesterol[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol19158428
D002784Cholesterol[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of Bile Acids and Salts18817892
D002784CholesterolCYP27A1 protein results in increased oxidation of Cholesterol15148325
D002784Cholesterol[CYP27A1 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol11514559
D019826Cholic AcidCholic Acid results in decreased expression of CYP27A1 mRNA25582706
D019826Cholic AcidCholic Acid results in decreased expression of CYP27A1 mRNA7832767
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of CYP27A1 mRNA27344345
D002793Cholic Acids[Cyclosporine results in decreased expression of CYP27A1 protein] which affects the abundance of Cholic Acids26198044
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of CYP27A1 mRNA27344345
D002793Cholic Acids[Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP27A1 mRNA27344345
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYP27A1 mRNA22872676
D002922CiguatoxinsCiguatoxins affects the expression of CYP27A1 mRNA18353800
D002995Clofibric AcidClofibric Acid affects the expression of CYP27A1 mRNA17602206
D019327Copper SulfateCopper Sulfate results in decreased expression of CYP27A1 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of CYP27A1 mRNA17211630
D003471CuprizoneCuprizone results in decreased expression of CYP27A1 mRNA26577399
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of CYP27A1 mRNA27344345
D016572Cyclosporine[Cyclosporine co-treated with Sirolimus] results in decreased activity of CYP27A1 protein17516993
D016572CyclosporineCyclosporine results in decreased activity of CYP27A1 protein17516993
D016572CyclosporineCyclosporine results in decreased expression of CYP27A1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of CYP27A1 protein26198044
D016572Cyclosporine[Cyclosporine results in decreased expression of CYP27A1 protein] which affects the abundance of Cholic Acids26198044
D003561CytarabineCytarabine results in decreased expression of CYP27A1 mRNA21198554
D003897DesmosterolCYP27A1 protein results in increased metabolism of Desmosterol14622972
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of CYP27A1 mRNA21914718|2558270
D003840Deoxycholic AcidSLCO1A1 protein affects the susceptibility to [Deoxycholic Acid results in decreased expression of CYP27A1 mRNA]21914718
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of CYP27A1 mRNA7832767
D003907DexamethasoneDexamethasone promotes the reaction [NR3C1 protein binds to CYP27A1 promoter]18817892
D003907DexamethasoneDexamethasone results in increased expression of CYP27A1 mRNA18817892
C053316di-(2-ethylhexyl) terephthalatedi-(2-ethylhexyl) terephthalate results in increased expression of CYP27A1 mRNA26472102
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CYP27A1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CYP27A1 mRNA26472102
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of CYP27A1 mRNA28392238
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of CYP27A1 mRNA28392238
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CYP27A1 mRNA]"19467301
D004041Dietary Fats[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of CYP27A1 mRNA18356535
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP27A1 mRNA28433925
D004041Dietary FatsDietary Fats results in increased expression of CYP27A1 mRNA19467301
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYP27A1 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CYP27A1 mRNA26472102
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CYP27A1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CYP27A1 mRNA20360939
D002117CalcitriolCalcitriol results in decreased expression of CYP27A1 mRNA26485663
D002117CalcitriolCalcitriol results in increased expression of CYP27A1 protein8164439
D002117CalcitriolCYP27A1 protein affects the chemical synthesis of Calcitriol15816500
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CYP27A1 mRNA]15964820
D004121Dimethyl Sulfoxideperiodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CYP27A1 mRNA]]15964820
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in increased expression of CYP27A1 mRNA26472102
D004237DiuronDiuron results in increased expression of CYP27A1 mRNA21551480
D004603Elements, Radioactive"Elements, Radioactive results in increased activity of CYP27A1 protein"20173315
D004642EmodinEmodin results in decreased expression of CYP27A1 mRNA28161596
C007630estradiol 17 beta-cypionate[estradiol 17 beta-cypionate co-treated with Progesterone] results in increased activity of CYP27A1 protein8696951
C007630estradiol 17 beta-cypionate[estradiol 17 beta-cypionate co-treated with Progesterone] results in increased expression of CYP27A1 mRNA8696951
C007630estradiol 17 beta-cypionateestradiol 17 beta-cypionate results in increased activity of CYP27A1 protein8696951
C007630estradiol 17 beta-cypionateestradiol 17 beta-cypionate results in increased expression of CYP27A1 mRNA8696951
D000431EthanolAM 251 inhibits the reaction [Ethanol results in increased expression of CYP27A1 mRNA]23894352
D000431EthanolEthanol results in increased expression of CYP27A1 mRNA23894352
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of CYP27A1 mRNA27344345
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYP27A1 mRNA16174780|1710823
D005054EugenolEugenol results in decreased expression of CYP27A1 mRNA20713136
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated results in decreased expression of CYP27A1 mRNA"18356535
D005485FlutamideFlutamide results in decreased expression of CYP27A1 mRNA24136188|2479361
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYP27A1 mRNA22872676
C069837fullerene C60fullerene C60 results in decreased expression of CYP27A1 mRNA19167457
D005897GlafenineGlafenine results in decreased expression of CYP27A1 mRNA24136188
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]23894352
C094503glyceryl 2-arachidonateglyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]23894352
C094503glyceryl 2-arachidonateglyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA23894352
C094503glyceryl 2-arachidonateINS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]]23894352
C094503glyceryl 2-arachidonateINS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]23894352
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]23894352
C094503glyceryl 2-arachidonateglyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA23894352
C412815GW 4064GW 4064 results in increased expression of CYP27A1 mRNA27609522
C000625836HFPO4 compoundHFPO4 compound results in decreased expression of CYP27A1 mRNA27553808
D002112CalcifediolCYP27A1 protein results in increased chemical synthesis of Calcifediol26704532
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased expression of CYP27A1 mRNA17572062
D007213IndomethacinIndomethacin results in increased expression of CYP27A1 mRNA18299717
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CYP27A1 mRNA25613284
C051890irinotecanirinotecan affects the expression of CYP27A1 mRNA20097248
D007810LanosterolCYP27A1 protein results in increased metabolism of Lanosterol14622972
C008261lead acetatelead acetate results in decreased expression of CYP27A1 mRNA21829687
D064704LevofloxacinLevofloxacin results in increased expression of CYP27A1 mRNA24136188
D008095Lithocholic Acid"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]"19196849
D008095Lithocholic AcidLithocholic Acid results in decreased expression of CYP27A1 mRNA19196849|2035947
D008095Lithocholic Acid"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]"19196849
D008095Lithocholic AcidNR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]19196849
D008095Lithocholic AcidPhenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]19196849
D008694MethamphetamineMethamphetamine results in decreased expression of CYP27A1 mRNA19149911
D008694MethamphetamineValproic Acid inhibits the reaction [Methamphetamine results in decreased expression of CYP27A1 mRNA]19149911
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYP27A1 mRNA22872676
D008727MethotrexateMethotrexate inhibits the reaction [IFNG protein results in decreased expression of CYP27A1 mRNA]19035488
D008727MethotrexateMethotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 mRNA]19035488
D008727MethotrexateMethotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 protein]19035488
D008727MethotrexateMethotrexate results in increased expression of CYP27A1 mRNA19035488|2123209
D008727MethotrexateZM 241385 inhibits the reaction [Methotrexate inhibits the reaction [IFNG protein results in decreased expression of CYP27A1 mRNA]]19035488
D008727MethotrexateZM 241385 inhibits the reaction [Methotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 mRNA]]19035488
D008727MethotrexateZM 241385 inhibits the reaction [Methotrexate results in increased expression of CYP27A1 mRNA]19035488
D008730MethoxsalenMethoxsalen results in decreased expression of CYP27A1 mRNA28552422
D008777Methyltestosterone[Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP27A1 mRNA27344345
D009020MorphineMorphine results in increased expression of CYP27A1 mRNA20144693
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 mRNA]19035488
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 protein]19035488
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideMethotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 mRNA]19035488
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideMethotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 protein]19035488
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 mRNA19035488
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 protein19035488
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideZM 241385 inhibits the reaction [Methotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 mRNA]]19035488
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CYP27A1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYP27A1 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CYP27A1 mRNA25655198
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CYP27A1 mRNA24120425
D009532NickelNickel results in decreased expression of CYP27A1 mRNA25583101
C022838nickel chloridenickel chloride affects the expression of CYP27A1 mRNA22110744
C028007nickel monoxidenickel monoxide results in decreased expression of CYP27A1 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of CYP27A1 mRNA20713136
C029938nickel sulfatenickel sulfate results in increased expression of CYP27A1 mRNA22714537
C012655nimesulidenimesulide results in decreased expression of CYP27A1 mRNA24136188
C464660obeticholic acidobeticholic acid results in decreased expression of CYP27A1 mRNA27939613
D009828Oleanolic AcidOleanolic Acid results in decreased expression of CYP27A1 mRNA23948738
D010098OxycodoneOxycodone results in increased expression of CYP27A1 mRNA23439660
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of CYP27A1 mRNA27344344
C036567perfluorodecanoic acidPPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA]27344344
C584865perfluorononanoic acidperfluorononanoic acid results in decreased expression of CYP27A1 mRNA29112762
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CYP27A1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYP27A1 mRNA17681415|1942940
C027579periodate-oxidized adenosineperiodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CYP27A1 mRNA]]15964820
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]19196849
D010634PhenobarbitalPhenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]19196849
D010634PhenobarbitalPhenobarbital results in decreased expression of CYP27A1 mRNA19162173
C008905physcionephyscione results in decreased expression of CYP27A1 mRNA28161596
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of CYP27A1 mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of CYP27A1 mRNA17950772|2381119
C006253pirinixic acidpirinixic acid results in increased expression of CYP27A1 mRNA17426115
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CYP27A1 mRNA28903501
D011374ProgesteroneCYP27A1 protein affects the metabolism of and affects the abundance of Progesterone19671838
D011374ProgesteroneCYP27A1 protein affects the metabolism of and affects the abundance of Progesterone19671838
D011374ProgesteroneProgesterone results in increased expression of CYP27A1 mRNA22238285
D011374Progesterone[estradiol 17 beta-cypionate co-treated with Progesterone] results in increased activity of CYP27A1 protein8696951
D011374Progesterone[estradiol 17 beta-cypionate co-treated with Progesterone] results in increased expression of CYP27A1 mRNA8696951
D011441PropylthiouracilPropylthiouracil results in decreased expression of CYP27A1 mRNA24780913
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of CYP27A1 mRNA26100227
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of CYP27A1 mRNA16079270
C059514resveratrol2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of CYP27A1 mRNA]23041272
C059514resveratrol2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of CYP27A1 protein]23041272
C059514resveratrolADORA2A protein promotes the reaction [resveratrol results in increased expression of CYP27A1 protein]23041272
C059514resveratrolPPARG protein promotes the reaction [resveratrol results in increased expression of CYP27A1 mRNA]23041272
C059514resveratrolPPARG protein promotes the reaction [resveratrol results in increased expression of CYP27A1 protein]23041272
C059514resveratrolresveratrol results in increased expression of CYP27A1 mRNA23041272
C059514resveratrolresveratrol results in increased expression of CYP27A1 protein23041272
C059514resveratrolZM 241385 inhibits the reaction [resveratrol results in increased expression of CYP27A1 protein]23041272
C059514resveratrolresveratrol results in increased expression of CYP27A1 mRNA22610192
D015474IsotretinoinIsotretinoin results in decreased expression of CYP27A1 mRNA15982314
D012293RifampinRifampin promotes the reaction [[NR1I2 protein binds to NCOA1 protein] which binds to CYP27A1 gene]17088262
D012293RifampinRifampin results in increased expression of CYP27A1 mRNA17088262
C089730rosiglitazonerosiglitazone results in decreased expression of CYP27A1 mRNA21515302
C009238senkirkinesenkirkine results in decreased expression of CYP27A1 mRNA26100227
D020123Sirolimus[Cyclosporine co-treated with Sirolimus] results in decreased activity of CYP27A1 protein17516993
D020123SirolimusSirolimus results in decreased activity of CYP27A1 protein17516993
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in decreased expression of CYP27A1 mRNA12815608
D013656Taurocholic AcidTaurocholic Acid results in decreased expression of CYP27A1 mRNA7832767
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of CYP27A1 mRNA15885361
C501413tesaglitazartesaglitazar results in decreased expression of CYP27A1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP27A1 mRNA12377990
D013749Tetrachlorodibenzodioxin[NFE2L2 gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of CYP27A1 mRNA21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYP27A1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP27A1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP27A1 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP27A1 mRNA21215274|2172422
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of CYP27A1 mRNA28973375
D013752TetracyclineTetracycline results in decreased expression of CYP27A1 mRNA24489787
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CYP27A1 mRNA25613284
D013806TheophyllineTheophylline results in decreased expression of CYP27A1 protein26851681
D013853ThioacetamideThioacetamide results in decreased expression of CYP27A1 mRNA26222700
C423915TO-901317TO-901317 results in increased expression of CYP27A1 mRNA19665519
C009564trilinoleintrilinolein results in decreased expression of CYP27A1 mRNA18356535
C101314trilinolenintrilinolenin results in decreased expression of CYP27A1 mRNA18356535
D014304TrioleinTriolein results in decreased expression of CYP27A1 mRNA18356535
D014501UraniumUranium results in decreased activity of CYP27A1 protein16502312
D014501UraniumUranium results in decreased expression of CYP27A1 mRNA17118558
D014501UraniumUranium results in increased activity of CYP27A1 protein16231126|1650231
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of CYP27A1 mRNA25582706
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of CYP27A1 mRNA16764892
D014635Valproic AcidValproic Acid affects the expression of CYP27A1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CYP27A1 mRNA29154799
D014635Valproic AcidValproic Acid inhibits the reaction [Methamphetamine results in decreased expression of CYP27A1 mRNA]19149911
D014640VancomycinVancomycin results in increased expression of CYP27A1 mRNA18930951
C025643vinclozolinvinclozolin affects the expression of CYP27A1 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of CYP27A1 mRNA22570695
D014800VitalliumVitallium analog results in increased expression of CYP27A1 mRNA23825117
D002762CholecalciferolCholecalciferol affects the expression of CYP27A1 mRNA21843606
D002762CholecalciferolCYP27A1 protein affects the metabolism of Cholecalciferol15816500
D002762CholecalciferolCYP27A1 protein results in increased hydroxylation of Cholecalciferol26704532
D015032ZincZinc deficiency results in decreased expression of CYP27A1 mRNA15671213
C097270ZM 241385ZM 241385 inhibits the reaction [Methotrexate inhibits the reaction [IFNG protein results in decreased expression of CYP27A1 mRNA]]19035488
C097270ZM 241385ZM 241385 inhibits the reaction [Methotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 mRNA]]19035488
C097270ZM 241385ZM 241385 inhibits the reaction [Methotrexate results in increased expression of CYP27A1 mRNA]19035488
C097270ZM 241385ZM 241385 inhibits the reaction [resveratrol results in increased expression of CYP27A1 protein]23041272
C015582zymosterolCYP27A1 protein results in increased metabolism of zymosterol14622972

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005506iron ion binding-IEA-  
GO:0008395steroid hydroxylase activity-TAS-  
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen-IEA-  
GO:0020037heme binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006699bile acid biosynthetic process-TAS-  
GO:0016125sterol metabolic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0031966mitochondrial membrane-IEA-  
KEGG ID KEGG Term
hsa00120Primary bile acid biosynthesis
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-192105Synthesis of bile acids and bile saltsTAS
R-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolTAS
R-HSA-193775Synthesis of bile acids and bile salts via 24-hydroxycholesterolTAS
R-HSA-193807Synthesis of bile acids and bile salts via 27-hydroxycholesterolTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5578996Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29250167Associations between abnormal vitamin D metabolism pathway function and non-small cell lung cancer. (2017 Dec)Ge NOncol Lett
22155603Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. (2011 Oct)Morrison MAHum Genomics