Gene: CYP27B1

1594
CP2B|CYP1|CYP1alpha|CYP27B|P450c1|PDDR|VDD1|VDDR|VDDRI|VDR
cytochrome P450 family 27 subfamily B member 1
protein-coding
12q14.1
Ensembl:ENSG00000111012 MIM:609506 Vega:OTTHUMG00000170457 UniprotKB:O15528
NG_007076.1
PubMed
0   ANCO-SNPs
ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.451e-2 (AD)  9.946e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C2orf660.612
DCUN1D30.611
MAP2K30.61
ATF7IP20.596
UCP30.592
STK400.586
IPO40.585
CLCF10.584
DOT1L0.581
NOP20.574

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDE11A-0.312
UPK3A-0.256
DIAPH3-0.253
HMGN5-0.248
LPAR3-0.246
ALDH1L1-AS2-0.241
NXNL1-0.216
APOC3-0.212
C16orf96-0.212
GLI1-0.212

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0979491,25-dihydroxyvitamin D"CYP27B1 protein results in increased activity of 1,25-dihydroxyvitamin D"15781002
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CYP27B1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP27B1 mRNA"23146750
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased expression of CYP27B1 mRNA]17699549
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CYP27B1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CYP27B1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CYP27B1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CYP27B1 mRNA"25510870
C10445025-hydroxyvitamin DCYP27B1 gene SNP affects the abundance of 25-hydroxyvitamin D20363324
C10445025-hydroxyvitamin DCYP27B1 protein promotes the reaction [25-hydroxyvitamin D results in increased expression of TRPV6 mRNA]16362534
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CYP27B1 mRNA"20816883
D000082AcetaminophenAcetaminophen results in decreased expression of CYP27B1 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of CYP27B1 mRNA17562736
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of CYP27B1 mRNA19920212
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IFNG protein results in increased expression of CYP27B1 mRNA]"16355272
D013196DihydrotestosteroneDihydrotestosterone affects the expression of CYP27B1 mRNA17659868
D004958EstradiolEstradiol affects the activity of CYP27B1 protein17659868
D004958EstradiolEstradiol affects the expression of CYP27B1 mRNA17659868
D004958EstradiolEstradiol results in increased activity of CYP27B1 protein15795327
C004541biochanin Abiochanin A affects the activity of CYP27B1 protein17659868
C004541biochanin Abiochanin A affects the expression of CYP27B1 mRNA17659868
C004541biochanin Abiochanin A analog affects the expression of CYP27B1 mRNA17659868
C004541biochanin Abiochanin A analog results in increased activity of CYP27B1 protein15795327
C004541biochanin Abiochanin A analog results in increased expression of CYP27B1 mRNA15795327
C004541biochanin Abiochanin A results in increased activity of CYP27B1 protein15795327
C004541biochanin Abiochanin A results in increased expression of CYP27B1 mRNA15795327
C006780bisphenol Abisphenol A results in increased expression of CYP27B1 mRNA22435627
C006780bisphenol Abisphenol A results in decreased expression of CYP27B1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CYP27B1 mRNA23741332
D002118CalciumCalcium affects the expression of CYP27B1 mRNA15913539
D002136Calcium, Dietary"Calcium, Dietary affects the expression of CYP27B1 mRNA"15905206
D002586CesiumCesium results in decreased expression of CYP27B1 mRNA18797846
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CYP27B1 mRNA20971185
D016572CyclosporineCyclosporine results in increased expression of CYP27B1 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of CYP27B1 mRNA21865292
D003907DexamethasoneDexamethasone affects the activity of CYP27B1 protein10694374
D003907DexamethasoneDexamethasone affects the expression of CYP27B1 mRNA10694374
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of CYP27B1 mRNA]27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of CYP27B1 mRNA]27392435
D019422Dietary SucroseDietary Sucrose results in decreased expression of CYP27B1 mRNA18840526
D002117CalcitriolCalcitriol results in increased expression of CYP27B1 mRNA16061850
D002117CalcitriolCYP27B1 gene mutant form results in decreased chemical synthesis of Calcitriol16494812
D002117CalcitriolCYP27B1 protein results in increased chemical synthesis of Calcitriol21542014
D002117CalcitriolCalcitriol affects the expression of CYP27B1 protein11796525
D002117CalcitriolCYP27B1 protein affects the abundance of Calcitriol12846736
D002117CalcitriolGH1 protein affects the reaction [CYP27B1 protein affects the abundance of Calcitriol]11316734
D002117CalcitriolCYP27B1 protein affects the chemical synthesis of Calcitriol15816500
D002117CalcitriolCYP27B1 protein results in increased chemical synthesis of Calcitriol26704532
D002117CalcitriolCYP27B1 results in increased chemical synthesis of Calcitriol16280049
D01565024,25-Dihydroxyvitamin D 3"CYP27B1 protein results in increased chemical synthesis of 24,25-Dihydroxyvitamin D 3"26704532
D004317DoxorubicinDoxorubicin results in increased expression of CYP27B1 mRNA17716971
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CYP27B1 mRNA22079256
D000431Ethanol[Ethanol co-treated with Vitamin D] results in decreased expression of CYP27B1 mRNA22892342
D005047EtoposideEtoposide results in increased expression of CYP27B1 mRNA17716971
D005419FlavonoidsFlavonoids results in increased expression of CYP27B1 mRNA18035473
D019833GenisteinGenistein affects the activity of CYP27B1 protein17659868
D019833GenisteinGenistein affects the expression of CYP27B1 mRNA17659868
D019833GenisteinGenistein results in increased activity of CYP27B1 protein15795327
D019833GenisteinGenistein results in increased expression of CYP27B1 mRNA15795327
D002112CalcifediolCYP27B1 protein affects the metabolism of Calcifediol16061850
D002112CalcifediolCYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL mRNA]21542014
D002112CalcifediolCYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL protein]21542014
D002112CalcifediolCYP27B1 protein promotes the reaction [Calcifediol results in increased expression of IBSP mRNA]21542014
D002112CalcifediolCYP27B1 protein promotes the reaction [Calcifediol results in increased expression of RUNX2 mRNA]21542014
D002112CalcifediolCYP27B1 protein results in increased hydroxylation of Calcifediol21542014
D002112CalcifediolCYP27B1 protein affects the metabolism of Calcifediol16061850
D002112CalcifediolCYP27B1 protein results in increased hydroxylation of Calcifediol26704532
D002112CalcifediolCYP27B1 results in increased hydroxylation of Calcifediol16280049
C492448ICG 001ICG 001 results in decreased expression of CYP27B1 mRNA26191083
D017964ItraconazoleItraconazole results in decreased activity of CYP27B1 protein15328084
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of CYP27B1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of CYP27B1 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of CYP27B1 mRNA27392435
D007654KetoconazoleKetoconazole results in decreased activity of CYP27B1 protein16483768
C008261lead acetatelead acetate results in decreased expression of CYP27B1 mRNA22609695
D008070LipopolysaccharidesIFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of CYP27B1 mRNA]16355272
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CYP27B1 mRNA16355272
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CYP27B128430709
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of CYP27B1 mRNA20843944
D008558MelphalanMelphalan results in increased expression of CYP27B1 mRNA22363485
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CYP27B1 mRNA26011545
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of CYP27B1 mRNA21843606
D009532NickelNickel results in increased expression of CYP27B1 mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CYP27B1 mRNA20971185
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CYP27B1 mRNA"25510870
C506614PD 0325901PD 0325901 results in increased expression of CYP27B1 mRNA21976371
C023036perfluorooctanoic acid[perfluorooctanoic acid co-treated with PPARA] results in increased expression of CYP27B1 mRNA20118188
D010710PhosphatesPhosphates affects the activity of CYP27B1 protein15265826
D010710PhosphatesPhosphates affects the expression of CYP27B1 mRNA15265826
D010710PhosphatesPhosphates affects the expression of CYP27B1 protein15265826
D010758PhosphorusPhosphorus affects the reaction [FGF23 protein results in decreased expression of CYP27B1 mRNA]17699549
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the activity of CYP27B1 protein"12865326
D016226Phosphorus, Dietary"Phosphorus, Dietary results in increased expression of CYP27B1 mRNA"16123154
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the expression of CYP27B1 mRNA"11316734|1587786
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the expression of CYP27B1 protein"11316734
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CYP27B1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CYP27B1 mRNA22079256
C482452pramiconazolepramiconazole results in decreased activity of CYP27B1 protein15328084
D011374ProgesteroneProgesterone results in decreased expression of CYP27B1 mRNA17404688
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors results in increased expression of CYP27B1 mRNA21976371
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of CYP27B1 mRNA19297354
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in increased expression of CYP27B1 mRNA26100227
D011794QuercetinQuercetin results in increased expression of CYP27B1 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of CYP27B1 mRNA15795327
C093642SB 203580SB 203580 inhibits the reaction [IFNG protein results in increased expression of CYP27B1 mRNA]16355272
C078903seocalcitolseocalcitol results in increased expression of CYP27B1 mRNA21843606
D012460SulfasalazineSulfasalazine results in decreased expression of CYP27B1 mRNA15243130
C446685systhanesysthane results in increased expression of CYP27B1 mRNA16643972
D016559TacrolimusTacrolimus results in increased expression of CYP27B1 mRNA21865292
D013629TamoxifenTamoxifen results in decreased expression of CYP27B1 mRNA15590111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP27B119367694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP27B1 mRNA28213091
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of CYP27B1 mRNA28973375
D013853ThioacetamideThioacetamide results in increased expression of CYP27B1 mRNA23411599
C032910triadimefontriadimefon results in increased expression of CYP27B1 mRNA16643972
D014501UraniumUranium results in increased expression of CYP27B1 mRNA16502312
D014520UrethaneUrethane results in decreased expression of CYP27B1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of CYP27B1 gene29154799
D014640VancomycinVancomycin results in decreased expression of CYP27B1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CYP27B1 gene25560391
D014807Vitamin D[Ethanol co-treated with Vitamin D] results in decreased expression of CYP27B1 mRNA22892342
D014807Vitamin DVitamin D deficiency results in increased expression of CYP27B1 protein8410379
D014807Vitamin DCYP27B1 protein results in increased activity of Vitamin D21976371
D002762CholecalciferolCholecalciferol results in increased expression of CYP27B1 mRNA21843606
D002762CholecalciferolCYP27B1 protein affects the metabolism of Cholecalciferol15816500

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004498calcidiol 1-monooxygenase activity-IDA9415400  15795327  16549446  17023519  
GO:0004498calcidiol 1-monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0020037heme binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006766vitamin metabolic process-TAS-  
GO:0006816calcium ion transport-ISS-  
GO:0008285negative regulation of cell proliferation-IDA16549446  
GO:0010956negative regulation of calcidiol 1-monooxygenase activity-IDA16549446  
GO:0010980positive regulation of vitamin D 24-hydroxylase activity-IDA16549446  
GO:0030282bone mineralization-IEP17023519  
GO:0030308negative regulation of cell growth-IMP12496369  
GO:0030500regulation of bone mineralization-IMP9415400  
GO:0032496response to lipopolysaccharide-IDA12855575  
GO:0033280response to vitamin D-IDA16549446  
GO:0034341response to interferon-gamma-IDA9282826  
GO:0036378calcitriol biosynthetic process from calciol-IDA9415400  15795327  16549446  17023519  
GO:0042359vitamin D metabolic process-IDA9415400  
GO:0042359vitamin D metabolic process-TAS-  
GO:0042369vitamin D catabolic process-IEA-  
GO:0043627response to estrogen-IEP15795327  
GO:0045618positive regulation of keratinocyte differentiation-IMP12496369  
GO:0046697decidualization-IEP16720713  
GO:0055074calcium ion homeostasis-IMP9415400  
GO:0055114oxidation-reduction process-IEA-  
GO:0070314G1 to G0 transition-IMP12496369  
GO:0070564positive regulation of vitamin D receptor signaling pathway-IDA16549446  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA15589699  16720713  
GO:0005739mitochondrion-ISS-  
GO:0005739mitochondrion-TAS9333115  
GO:0005741mitochondrial outer membrane-TAS-  
KEGG ID KEGG Term
hsa00100Steroid biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-196791Vitamin D (calciferol) metabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211916VitaminsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5579014Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19154546Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship. (2009 Apr)Hypponen EAllergy
275137341,25-Dihydroxyvitamin D Modulates Antibacterial and Inflammatory Response in Human Cigarette Smoke-Exposed Macrophages. (2016)Heulens NPLoS One
23483715Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis. (2013 Mar)Pierrot-Deseilligny CTher Adv Neurol Disord
22155603Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. (2011 Oct)Morrison MAHum Genomics
21916886Calcium homeostasis and body composition in patients with palmoplantar pustulosis: a case-control study. (2012 Jan)Hagforsen EBr J Dermatol
28883932Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial. (2017)Vargas Buonfiglio LGBMJ Open Respir Res
28009432Genetic polymorphisms of vitamin D receptor (VDR), CYP27B1 and CYP24A1 genes and the risk of colorectal cancer. (2017 May 4)Vidigal VMInt J Biol Markers
29250167Associations between abnormal vitamin D metabolism pathway function and non-small cell lung cancer. (2017 Dec)Ge NOncol Lett
24568525Lack of associations between Vitamin D metabolism-related gene variants and risk of colorectal cancer. (2014)Mahmoudi TAsian Pac J Cancer Prev
27669215Vitamin D-Related Gene Polymorphisms, Plasma 25-Hydroxy-Vitamin D, Cigarette Smoke and Non-Small Cell Lung Cancer (NSCLC) Risk. (2016 Sep 22)Wu XInt J Mol Sci
28029444Associations between Serum Vitamin D and Genetic Variants in Vitamin D Pathways and Age-Related Macular Degeneration in the European Eye Study. (2017 Jan)McKay GJOphthalmology