Gene: DAB2

1601
DOC-2|DOC2
DAB2, clathrin adaptor protein
protein-coding
5p13.1
Ensembl:ENSG00000153071 MIM:601236 Vega:OTTHUMG00000162043 UniprotKB:P98082
NG_030312.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.589e-1 (AD)  7.393e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM129A0.841
ELK30.831
ADPRH0.827
MYOF0.82
CARD60.817
CTSC0.814
NOD10.814
TGFBR20.811
PLCG20.81
SP1000.81

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.377
ARSF-0.36
HES5-0.352
HAGHL-0.346
LYPD8-0.342
KCNIP3-0.337
SLC25A10-0.329
C9orf24-0.328
C19orf73-0.327
GAL3ST3-0.325

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DAB2 mRNA"15215175
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of DAB2 mRNA16788091
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of DAB2 mRNA14610520
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DAB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DAB2 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of DAB2 mRNA28959563
D000393Air PollutantsAir Pollutants analog results in decreased expression of DAB2 mRNA21757418
D000450AldosteroneAGT protein affects the reaction [DAB2 protein results in increased secretion of Aldosterone]17303656
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DAB2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DAB2 mRNA24449571
D001149ArsenatesArsenates results in decreased expression of DAB2 mRNA12773770
C006632arsenic trioxidearsenic trioxide affects the expression of DAB2 mRNA28786057
C006632arsenic trioxidearsenic trioxide results in decreased expression of DAB2 mRNA22521957
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of DAB2 mRNA"25351596
D001205Ascorbic AcidAscorbic Acid results in decreased expression of DAB2 mRNA15305145
C547126AZM551248AZM551248 results in increased expression of DAB2 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of DAB2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DAB2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DAB2 mRNA20713471|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DAB2 mRNA"19150397|2001819
D004958EstradiolEstradiol affects the expression of DAB2 mRNA22574217
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DAB2 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of DAB2 mRNA28711546
D004958EstradiolEstradiol results in increased expression of DAB2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of DAB2 mRNA19484750
C095105bexarotenebexarotene results in decreased expression of DAB2 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of DAB2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of DAB2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of DAB2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DAB2 gene28505145
D002065BuspironeBuspirone results in decreased expression of DAB2 mRNA24136188
D002104CadmiumCadmium results in increased expression of DAB2 mRNA24376830
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNA12634122
D002737ChloropreneChloroprene results in decreased expression of DAB2 mRNA23125180
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNA12634122
D002922CiguatoxinsCiguatoxins affects the expression of DAB2 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of DAB2 mRNA19320972
D003471CuprizoneCuprizone results in increased expression of DAB2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of DAB2 mRNA27989131
D003561CytarabineCytarabine results in decreased expression of DAB2 mRNA21198554
D002945CisplatinDAB2 protein results in decreased susceptibility to Cisplatin16734730
D002945CisplatinCisplatin results in increased expression of DAB2 mRNA21151649
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of DAB2 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of DAB2 mRNA18042831|2501614
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of DAB2 mRNA19638242
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of DAB2 mRNA"27840820
C024629dimethyl phthalatedimethyl phthalate affects the expression of DAB2 mRNA26924002
D004237DiuronDiuron results in decreased expression of DAB2 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DAB2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DAB2 mRNA17351261
D005047EtoposideDAB2 protein affects the susceptibility to Etoposide16217747
C056516exemestaneexemestane results in increased expression of DAB2 mRNA17254854
C540355fenamidonefenamidone results in increased expression of DAB2 mRNA27029645
C082360fipronilfipronil results in increased expression of DAB2 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of DAB2 mRNA24793618
C039281furanfuran results in increased expression of DAB2 mRNA27387713
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of DAB2 mRNA22634610
D017313FenretinideFenretinide results in increased expression of DAB2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DAB2 mRNA20044591
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DAB2 protein18951874
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of DAB2 mRNA16849584
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of DAB2 mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DAB2 mRNA25613284
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of DAB2 protein17337753
C005134juglonejuglone affects the phosphorylation of DAB2 protein12881709
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNA12634122
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of DAB2 mRNA21641980
D019216Metals, Heavy"Metals, Heavy results in decreased expression of DAB2 mRNA"12773770
D008727MethotrexateMethotrexate affects the expression of DAB2 mRNA18502557
D008748MethylcholanthreneMethylcholanthrene results in increased expression of DAB2 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DAB2 mRNA26011545
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of DAB2 mRNA12634122|1277377
D008774MethylphenidateMethylphenidate results in increased expression of DAB2 mRNA22470460
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of DAB2 protein24625837
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DAB2 mRNA26924002
C523799MRK 003DAB2 results in increased susceptibility to MRK 00319903844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of DAB2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DAB2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DAB2 mRNA"25620056
D009532NickelNickel results in increased expression of DAB2 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in decreased expression of DAB2 mRNA17312168
C028007nickel monoxidenickel monoxide results in increased expression of DAB2 mRNA19167457
C012655nimesulidenimesulide results in decreased expression of DAB2 mRNA24136188
C024713n-tetradecanen-tetradecane results in decreased expression of DAB2 protein17337753
D019319Okadaic AcidOkadaic Acid affects the phosphorylation of DAB2 protein12881709
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of DAB2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of DAB2 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of DAB2 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of DAB2 mRNA24642059
D010476PerfumePerfume results in increased expression of DAB2 mRNA24768652
D010634PhenobarbitalPhenobarbital affects the expression of DAB2 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DAB2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DAB2 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of DAB2 mRNA15728792
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DAB2 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DAB2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DAB2 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of DAB2 mRNA23018184
D011441PropylthiouracilPropylthiouracil results in decreased expression of DAB2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of DAB2 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of DAB2 mRNA21632981
C488333Ro 65-7199Ro 65-7199 results in decreased expression of DAB2 mRNA14610520
C104586roscovitineroscovitine results in decreased phosphorylation of DAB2 protein12881709
C104586roscovitineroscovitine results in decreased phosphorylation of DAB2 protein12881709
D012822Silicon DioxideSilicon Dioxide results in increased expression of DAB2 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of DAB2 mRNA22431001
D012834SilverSilver results in decreased expression of DAB2 mRNA27131904
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNA12634122
C016104sodium bichromatesodium bichromate results in decreased expression of DAB2 mRNA17685462
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary affects the expression of DAB2 mRNA alternative form"17303656
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary affects the expression of DAB2 protein alternative form"17303656
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of DAB2 mRNA21641980
C004648testosterone enanthatetestosterone enanthate affects the expression of DAB2 mRNA17440010
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DAB2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DAB2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DAB2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DAB2 mRNA18691609|1993321
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DAB2 mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DAB2 protein18951874
C009495titanium dioxidetitanium dioxide results in increased expression of DAB2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of DAB2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of DAB2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of DAB2 mRNA18230668
D014212TretinoinTretinoin results in increased expression of DAB2 mRNA17138961|2193413
D014212TretinoinTretinoin results in increased expression of DAB2 mRNA16788091
C012589trichostatin Atrichostatin A results in decreased expression of DAB2 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of DAB2 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of DAB2 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of DAB2 mRNA29024780
C022884undecaneundecane results in increased expression of DAB2 protein17337753
D014520UrethaneUrethane results in decreased expression of DAB2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of DAB2 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of DAB2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DAB2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of DAB2 mRNA24896083
D014638VanadatesVanadates results in increased expression of DAB2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DAB2 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of DAB2 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of DAB2 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11387212  11967127  12805222  15247260  17474147  20936779  
22491013  
GO:0008022protein C-terminus binding-IPI15837803  
GO:0035615clathrin adaptor activity-IMP16984970  
GO:0038024cargo receptor activity-IMP16984970  
GO:0046332SMAD binding-IDA11387212  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IMP12805222  
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0007229integrin-mediated signaling pathwayNOTIMP19581412  
GO:0007275multicellular organism development-IEA-  
GO:0008283cell proliferation-TAS9620555  
GO:0010718positive regulation of epithelial to mesenchymal transition-IDA15734730  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IDA11387212  
GO:0015031protein transport-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030335positive regulation of cell migration-IMP19581412  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IDA11387212  
GO:0032091negative regulation of protein binding-IMP12805222  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IMP12805222  
GO:0035026leading edge cell differentiation-IMP19581412  
GO:0043066negative regulation of apoptotic process-IDA15734730  
GO:0045807positive regulation of endocytosis-IMP19581412  21995445  
GO:0045892negative regulation of transcription, DNA-templated-IMP12805222  
GO:0045893positive regulation of transcription, DNA-templated-IMP12805222  
GO:0060391positive regulation of SMAD protein signal transduction-IDA11387212  
GO:0060766negative regulation of androgen receptor signaling pathway-IMP16267015  
GO:0061024membrane organization-TAS-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP12805222  
GO:0090090negative regulation of canonical Wnt signaling pathway-ISS-  
GO:1903077negative regulation of protein localization to plasma membrane-IMP19581412  
GO:2000096positive regulation of Wnt signaling pathway, planar cell polarity pathway-IMP12805222  
GO:2000370positive regulation of clathrin-dependent endocytosis-IMP16984970  
GO:2000643positive regulation of early endosome to late endosome transport-IMP21995445  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005765lysosomal membrane-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005905clathrin-coated pit-IDA12857860  
GO:0005925focal adhesion-HDA21423176  
GO:0030136clathrin-coated vesicle-IDA19581412  
GO:0030665clathrin-coated vesicle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070022transforming growth factor beta receptor complexcolocalizes_withIDA11387212  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-157858Gap junction trafficking and regulationTAS
R-HSA-190828Gap junction traffickingTAS
R-HSA-190873Gap junction degradationTAS
R-HSA-196025Formation of annular gap junctionsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24608456The expression of disabled-2 is common reduced in meningiomas. (2014 Jan-Feb)Zhang ZNeurol India