Gene info: ID 160335

SNP ID	Position	Alleles	Trait	Variation Type
rs4620789	chr12:82714616 (GRCh38.p7)	G>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs12579483	chr12:82695652 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg00418163	chr12:83476631	TMTC2		1.770e-8	Maternal smoking in pregnancy	27040690

Gene Symbol	Pearson Correlation Coefficient
COL4A5	0.904
PLEKHH1	0.882
FRYL	0.874
PPP2R3A	0.873
TTYH2	0.869
PHLDB1	0.868
SEMA6A	0.864
TMEM144	0.86
PSEN1	0.86
LAMP2	0.853

Gene Symbol	Pearson Correlation Coefficient
PRTN3	-0.354
SHISA8	-0.343
PAX2	-0.336
CHRNA2	-0.33
WTIP	-0.319
OR4F29	-0.311
GPR153	-0.306
EPPIN	-0.305
CALB2	-0.304
OR4F5	-0.303

DrugBank
CTD

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of TMTC2 mRNA"	26377693
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TMTC2 mRNA"	19167446
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TMTC2 mRNA]"	19467301
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of TMTC2 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of TMTC2 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of TMTC2 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TMTC2 mRNA	19770486
D000638	Amiodarone	Amiodarone results in increased expression of TMTC2 mRNA	24535564
D001151	Arsenic	Arsenic results in decreased expression of TMTC2 mRNA	19654921
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TMTC2 mRNA	26705709
D001280	Atrazine	Atrazine results in decreased expression of TMTC2 mRNA	22378314
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of TMTC2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TMTC2 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TMTC2 mRNA	19770486\|2171566
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TMTC2 mRNA	22228805
C006780	bisphenol A	bisphenol A results in increased expression of TMTC2 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of TMTC2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of TMTC2 gene	28505145
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TMTC2 mRNA	25596134
D002737	Chloroprene	Chloroprene results in decreased expression of TMTC2 mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TMTC2 mRNA	20938992
C059262	cidofovir	cidofovir results in decreased expression of TMTC2 mRNA	25596134
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TMTC2 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of TMTC2 mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of TMTC2 mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of TMTC2 mRNA	25596134
D016572	Cyclosporine	Cyclosporine results in increased expression of TMTC2 mRNA	20106945
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TMTC2 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TMTC2 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of TMTC2 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of TMTC2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of TMTC2 mRNA	21603599\|2559613
D002945	Cisplatin	Cisplatin results in decreased expression of TMTC2 mRNA	25270620
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TMTC2 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of TMTC2 mRNA	19467301\|2501614
D002117	Calcitriol	Calcitriol results in decreased expression of TMTC2 mRNA	16002434
C118739	entinostat	entinostat results in decreased expression of TMTC2 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC2 mRNA"	27188386
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of TMTC2 mRNA	28189721
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TMTC2 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of TMTC2 mRNA	23649840
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of TMTC2 mRNA	18951874
D007069	Ifosfamide	Ifosfamide results in decreased expression of TMTC2 mRNA	25596134
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of TMTC2 mRNA	27392435
D007854	Lead	Lead results in increased expression of TMTC2 mRNA	19921347
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of TMTC2 mRNA"	24972896
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TMTC2 mRNA	20938992
C005219	methyl cellosolve	methyl cellosolve results in increased expression of TMTC2 mRNA	21061450
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [AHR protein binds to TMTC2 promoter]	20348232
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TMTC2 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of TMTC2 mRNA	23649840
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TMTC2 mRNA"	25620056
D010100	Oxygen	Oxygen deficiency results in increased expression of TMTC2 mRNA	25596134
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of TMTC2 mRNA	28558994
C584865	perfluorononanoic acid	perfluorononanoic acid results in increased expression of TMTC2 mRNA	28558994
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of TMTC2 mRNA	28558994
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TMTC2 mRNA	28558994
C023036	perfluorooctanoic acid	PPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of TMTC2 mRNA]	28558994
D010634	Phenobarbital	Phenobarbital results in increased expression of TMTC2 mRNA	19270015
D010795	Phthalic Acids	Phthalic Acids results in increased expression of TMTC2 mRNA	21061450
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TMTC2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of TMTC2 mRNA	18301758\|2081375
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TMTC2 mRNA	24780913
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of TMTC2 mRNA	19167446
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of TMTC2 mRNA	25895662
D012906	Smoke	Smoke results in decreased expression of TMTC2 mRNA	21095227
C017947	sodium arsenite	sodium arsenite affects the methylation of TMTC2 gene	28589171
D053260	Soot	Soot results in decreased expression of TMTC2 mRNA	26551751
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TMTC2 mRNA	22903824
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TMTC2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of TMTC2 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TMTC2 mRNA	28922406
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of TMTC2 mRNA	28973375
C009495	titanium dioxide	titanium dioxide results in increased expression of TMTC2 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TMTC2 mRNA	20133372
D014241	Trichloroethylene	Trichloroethylene results in increased expression of TMTC2 mRNA	25549359
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC2 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of TMTC2 mRNA	24935251\|2627250
D014635	Valproic Acid	Valproic Acid results in decreased expression of TMTC2 mRNA	24935251\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of TMTC2 mRNA	24535564
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of TMTC2 gene	25560391
C088658	zoledronic acid	zoledronic acid results in increased expression of TMTC2 mRNA	20977926

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005783	endoplasmic reticulum	-	IDA	-
GO:0005789	endoplasmic reticulum membrane	-	IDA	24764305
GO:0016021	integral component of membrane	-	IEA	-

Gene: TMTC2

ANCO-SNPs

DNA Methylation

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

There is no DrugBank record for this gene !

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)