Gene info: ID 160428

Gene: ALDH1L2

GENE ID: 160428

Synonyms: mtFDH

Description: aldehyde dehydrogenase 1 family member L2

Gene type: protein-coding

Location: 12q23.3

dbXrefs: Ensembl:ENSG00000136010 MIM:613584 Vega:OTTHUMG00000169823 UniprotKB:Q3SY69

RefSeq: NG_012748.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.519e-1 (AD) 5.557e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RNPC3	0.832
MPHOSPH9	0.831
USP49	0.83
SMG1	0.829
MLLT10	0.819
UHRF1BP1	0.815
ZNF550	0.813
CHD6	0.809
ZNF519	0.806
SPIN3	0.803

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RBP1	-0.385
BCL7C	-0.376
S100A1	-0.364
PLA2G5	-0.353
HPR	-0.346
MDFI	-0.328
METRN	-0.311
PINLYP	-0.303
OR4F5	-0.297
SLC22A6	-0.293

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C010161	10-formyltetrahydropteroylglutamic acid	ALDH1L2 protein results in increased metabolism of 10-formyltetrahydropteroylglutamic acid	21238436
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ALDH1L2 mRNA"	25614096
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ALDH1L2 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ALDH1L2 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ALDH1L2 mRNA"	21346803
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of ALDH1L2 mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of ALDH1L2 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
C030371	5,6,7,8-tetrahydrofolic acid	"ALDH1L2 protein results in increased chemical synthesis of 5,6,7,8-tetrahydrofolic acid"	21238436
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ALDH1L2 mRNA	19770486
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of ALDH1L2 mRNA	21298039
D000968	Antimycin A	Antimycin A results in increased expression of ALDH1L2 mRNA	19304788
D001151	Arsenic	Arsenic affects the methylation of ALDH1L2 gene	25304211
C015001	arsenite	arsenite affects the expression of ALDH1L2 mRNA	22959463
C547126	AZM551248	AZM551248 results in increased expression of ALDH1L2 mRNA	22323515
C006780	bisphenol A	bisphenol A results in increased expression of ALDH1L2 mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of ALDH1L2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ALDH1L2 gene	28505145
D002104	Cadmium	Cadmium results in increased expression of ALDH1L2 mRNA	21120746
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ALDH1L2 mRNA	27339419
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALDH1L2 mRNA	20938992
C041167	chromium nitrate	chromium nitrate results in increased expression of ALDH1L2 protein	22144121
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in decreased expression of ALDH1L2 mRNA	18078969
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ALDH1L2 mRNA	24386269
D003471	Cuprizone	Cuprizone results in increased expression of ALDH1L2 mRNA	26577399\|2752363
D016572	Cyclosporine	Cyclosporine results in increased expression of ALDH1L2 mRNA	19159671\|2556210
D000069439	Dasatinib	Dasatinib results in increased expression of ALDH1L2 mRNA	20579391
D003907	Dexamethasone	Dexamethasone results in decreased expression of ALDH1L2 mRNA	22733784
D004008	Diclofenac	Diclofenac results in decreased expression of ALDH1L2 mRNA	26934552
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of ALDH1L2 mRNA	25380136
C118739	entinostat	entinostat results in increased expression of ALDH1L2 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of ALDH1L2 mRNA	27776689
C000499	ferric oxide	ferric oxide analog results in decreased expression of ALDH1L2 mRNA	25086211
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALDH1L2 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of ALDH1L2 mRNA	27664576
D005839	Gentamicins	Gentamicins results in decreased expression of ALDH1L2 mRNA	22061828
D007213	Indomethacin	Indomethacin results in increased expression of ALDH1L2 mRNA	17401462
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of ALDH1L2 mRNA	16835149
C008261	lead acetate	lead acetate results in increased expression of ALDH1L2 mRNA	25270620
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of ALDH1L2 mRNA"	24972896
D008154	Lucanthone	Lucanthone results in decreased expression of ALDH1L2 mRNA	21148553
C042720	mercuric bromide	mercuric bromide results in increased expression of ALDH1L2 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALDH1L2 mRNA	20938992
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of ALDH1L2 mRNA	18804290
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ALDH1L2 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of ALDH1L2 mRNA	26011545
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of ALDH1L2 mRNA	24810058
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ALDH1L2 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of ALDH1L2 mRNA	25380136
C029938	nickel sulfate	nickel sulfate results in decreased expression of ALDH1L2 mRNA	22714537
D008939	Mitotane	Mitotane results in increased expression of ALDH1L2 mRNA	22966885
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of ALDH1L2 mRNA	25729387
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of ALDH1L2 mRNA	26272509
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of ALDH1L2 mRNA	26705709
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of ALDH1L2 mRNA	17560707
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ALDH1L2 protein	26879310
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of ALDH1L2 mRNA	26272509
D011137	Polystyrenes	Polystyrenes analog results in increased expression of ALDH1L2 mRNA	25102311
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of ALDH1L2 mRNA	22714537
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of ALDH1L2 protein	22144121
D011441	Propylthiouracil	Propylthiouracil results in increased expression of ALDH1L2 mRNA	24780913
C059514	resveratrol	resveratrol results in increased expression of ALDH1L2 protein	25505154
D012402	Rotenone	Rotenone results in increased expression of ALDH1L2 mRNA	19304788
D012822	Silicon Dioxide	Silicon Dioxide analog affects the expression of ALDH1L2 mRNA	23806026
C016104	sodium bichromate	sodium bichromate results in decreased expression of ALDH1L2 mRNA	25993096
D012999	Soman	Soman results in increased expression of ALDH1L2 mRNA	19281266
C016766	sulforafan	sulforafan results in decreased expression of ALDH1L2 mRNA	26833863
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ALDH1L2 mRNA	21570461
D013853	Thioacetamide	Thioacetamide results in decreased expression of ALDH1L2 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in decreased expression of ALDH1L2 mRNA	27760801
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of ALDH1L2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of ALDH1L2 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of ALDH1L2 mRNA	23724009
C012589	trichostatin A	trichostatin A results in increased expression of ALDH1L2 mRNA	24935251
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in decreased expression of ALDH1L2 mRNA	18078969
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of ALDH1L2 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid affects the expression of ALDH1L2 mRNA	17963808
C025643	vinclozolin	vinclozolin results in decreased expression of ALDH1L2 mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of ALDH1L2 mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004029	aldehyde dehydrogenase (NAD) activity	-	EXP	20498374 21238436
GO:0004029	aldehyde dehydrogenase (NAD) activity	-	IBA	21873635
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006730	one-carbon metabolic process	-	IEA	-
GO:0009058	biosynthetic process	-	IEA	-
GO:0009258	10-formyltetrahydrofolate catabolic process	-	IEA	-
GO:0046655	folic acid metabolic process	-	TAS	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	-
GO:0005739	mitochondrion	-	IDA	-
GO:0005759	mitochondrial matrix	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa00670	One carbon pool by folate

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-196757	Metabolism of folate and pterines	TAS
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	TAS
R-HSA-196854	Metabolism of vitamins and cofactors	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23857790	Genome-wide DNA methylation patterns in discordant sib pairs with alcohol dependence. (2013 Mar)	Zhao R	Asia Pac Psychiatry