Gene: ALDH1L2

160428
mtFDH
aldehyde dehydrogenase 1 family member L2
protein-coding
12q23.3
Ensembl:ENSG00000136010 MIM:613584 Vega:OTTHUMG00000169823 UniprotKB:Q3SY69
NG_012748.1
PubMed
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.519e-1 (AD)  5.557e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNPC30.832
MPHOSPH90.831
USP490.83
SMG10.829
MLLT100.819
UHRF1BP10.815
ZNF5500.813
CHD60.809
ZNF5190.806
SPIN30.803

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBP1-0.385
BCL7C-0.376
S100A1-0.364
PLA2G5-0.353
HPR-0.346
MDFI-0.328
METRN-0.311
PINLYP-0.303
OR4F5-0.297
SLC22A6-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C01016110-formyltetrahydropteroylglutamic acidALDH1L2 protein results in increased metabolism of 10-formyltetrahydropteroylglutamic acid21238436
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ALDH1L2 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ALDH1L2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ALDH1L2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ALDH1L2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ALDH1L2 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ALDH1L2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
C0303715,6,7,8-tetrahydrofolic acid"ALDH1L2 protein results in increased chemical synthesis of 5,6,7,8-tetrahydrofolic acid"21238436
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ALDH1L2 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ALDH1L2 mRNA21298039
D000968Antimycin AAntimycin A results in increased expression of ALDH1L2 mRNA19304788
D001151ArsenicArsenic affects the methylation of ALDH1L2 gene25304211
C015001arsenitearsenite affects the expression of ALDH1L2 mRNA22959463
C547126AZM551248AZM551248 results in increased expression of ALDH1L2 mRNA22323515
C006780bisphenol Abisphenol A results in increased expression of ALDH1L2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ALDH1L2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ALDH1L2 gene28505145
D002104CadmiumCadmium results in increased expression of ALDH1L2 mRNA21120746
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ALDH1L2 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALDH1L2 mRNA20938992
C041167chromium nitratechromium nitrate results in increased expression of ALDH1L2 protein22144121
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of ALDH1L2 mRNA18078969
C018021cobaltous chloridecobaltous chloride results in increased expression of ALDH1L2 mRNA24386269
D003471CuprizoneCuprizone results in increased expression of ALDH1L2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in increased expression of ALDH1L2 mRNA19159671|2556210
D000069439DasatinibDasatinib results in increased expression of ALDH1L2 mRNA20579391
D003907DexamethasoneDexamethasone results in decreased expression of ALDH1L2 mRNA22733784
D004008DiclofenacDiclofenac results in decreased expression of ALDH1L2 mRNA26934552
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ALDH1L2 mRNA25380136
C118739entinostatentinostat results in increased expression of ALDH1L2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of ALDH1L2 mRNA27776689
C000499ferric oxideferric oxide analog results in decreased expression of ALDH1L2 mRNA25086211
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALDH1L2 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of ALDH1L2 mRNA27664576
D005839GentamicinsGentamicins results in decreased expression of ALDH1L2 mRNA22061828
D007213IndomethacinIndomethacin results in increased expression of ALDH1L2 mRNA17401462
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of ALDH1L2 mRNA16835149
C008261lead acetatelead acetate results in increased expression of ALDH1L2 mRNA25270620
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ALDH1L2 mRNA"24972896
D008154LucanthoneLucanthone results in decreased expression of ALDH1L2 mRNA21148553
C042720mercuric bromidemercuric bromide results in increased expression of ALDH1L2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALDH1L2 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ALDH1L2 mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ALDH1L2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ALDH1L2 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ALDH1L2 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ALDH1L2 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ALDH1L2 mRNA25380136
C029938nickel sulfatenickel sulfate results in decreased expression of ALDH1L2 mRNA22714537
D008939MitotaneMitotane results in increased expression of ALDH1L2 mRNA22966885
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ALDH1L2 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ALDH1L2 mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ALDH1L2 mRNA26705709
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ALDH1L2 mRNA17560707
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ALDH1L2 protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ALDH1L2 mRNA26272509
D011137PolystyrenesPolystyrenes analog results in increased expression of ALDH1L2 mRNA25102311
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ALDH1L2 mRNA22714537
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ALDH1L2 protein22144121
D011441PropylthiouracilPropylthiouracil results in increased expression of ALDH1L2 mRNA24780913
C059514resveratrolresveratrol results in increased expression of ALDH1L2 protein25505154
D012402RotenoneRotenone results in increased expression of ALDH1L2 mRNA19304788
D012822Silicon DioxideSilicon Dioxide analog affects the expression of ALDH1L2 mRNA23806026
C016104sodium bichromatesodium bichromate results in decreased expression of ALDH1L2 mRNA25993096
D012999SomanSoman results in increased expression of ALDH1L2 mRNA19281266
C016766sulforafansulforafan results in decreased expression of ALDH1L2 mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALDH1L2 mRNA21570461
D013853ThioacetamideThioacetamide results in decreased expression of ALDH1L2 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of ALDH1L2 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ALDH1L2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ALDH1L2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ALDH1L2 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of ALDH1L2 mRNA24935251
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of ALDH1L2 mRNA18078969
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1L2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ALDH1L2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of ALDH1L2 mRNA17963808
C025643vinclozolinvinclozolin results in decreased expression of ALDH1L2 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of ALDH1L2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004029aldehyde dehydrogenase (NAD) activity-EXP20498374  21238436  
GO:0004029aldehyde dehydrogenase (NAD) activity-IBA21873635  
GO:0016742hydroxymethyl-, formyl- and related transferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006730one-carbon metabolic process-IEA-  
GO:0009058biosynthetic process-IEA-  
GO:000925810-formyltetrahydrofolate catabolic process-IEA-  
GO:0046655folic acid metabolic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00670One carbon pool by folate
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196757Metabolism of folate and pterinesTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23857790Genome-wide DNA methylation patterns in discordant sib pairs with alcohol dependence. (2013 Mar)Zhao RAsia Pac Psychiatry