Gene: GRASP

160622
TAMALIN
general receptor for phosphoinositides 1 associated scaffold protein
protein-coding
12q13.13
Ensembl:ENSG00000161835 MIM:612027 Vega:OTTHUMG00000169595 UniprotKB:Q7Z6J2
NG_050572.1
PubMed
0   ANCO-SNPs
CD|ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.202e-1 (AD)  4.283e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MMP170.838
FMNL10.834
TESC0.82
SH3GL10.812
VIPR10.809
SYT120.807
CACNA1A0.804
ST8SIA50.799
CACNB10.797
BRSK20.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.513
OR4F29-0.489
PHEX-0.413
MBNL3-0.373
TRDN-0.368
PARD3B-0.366
C5orf38-0.362
ZNF114-0.359
HMX2-0.358
PDE11A-0.358

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of GRASP mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRASP mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of GRASP mRNA"23829299
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of GRASP mRNA]"19467301
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of GRASP mRNA"23195993
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GRASP mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRASP mRNA16483693
D001151ArsenicArsenic results in decreased expression of GRASP mRNA27838757
C006632arsenic trioxidearsenic trioxide results in decreased expression of GRASP mRNA19128835
D001280AtrazineAtrazine results in increased expression of GRASP mRNA22982499
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of GRASP mRNA]22228805
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GRASP promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of GRASP mRNA25181051
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of GRASP mRNA25270620
D002994ClofibrateClofibrate results in increased expression of GRASP mRNA25270620
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of GRASP mRNA24690739
D019327Copper SulfateCopper Sulfate results in decreased expression of GRASP mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GRASP mRNA21266533
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GRASP promoter23359474
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of GRASP mRNA28962523
D004026DieldrinDieldrin results in increased expression of GRASP mRNA20584760
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of GRASP mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of GRASP mRNA18042831|1946730
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GRASP promoter23359474
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of GRASP mRNA24690739
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GRASP mRNA23550701
D006534Heptachlor EpoxideHeptachlor Epoxide results in increased expression of GRASP mRNA25270620
D017313FenretinideFenretinide results in increased expression of GRASP mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GRASP mRNA23086925
D009532NickelNickel results in increased expression of GRASP mRNA23195993
D000073878Palm OilPalm Oil results in increased expression of GRASP mRNA18042831
C410127PCB 180PCB 180 results in increased expression of GRASP mRNA23829299
C009277sodium arsenatesodium arsenate results in decreased expression of GRASP mRNA23922661
D016559TacrolimusTacrolimus results in increased expression of GRASP mRNA25270620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRASP mRNA21570461
D014520UrethaneUrethane results in decreased expression of GRASP mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of GRASP gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030165PDZ domain binding-IEA-  
GO:0030306ADP-ribosylation factor binding-IEA-  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0008104protein localization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0045211postsynaptic membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27758088The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations. (2017 Jan)Barrie ESHum Mutat
25249428A phase II study of erlotinib monotherapy in pre-treated non-small cell lung cancer without EGFR gene mutation who have never/light smoking history: re-evaluation of EGFR gene status (NEJ006/TCOG0903). (2014 Nov)Matsumoto YLung Cancer
16881528[Epidemiology, treatment and prevention of attention deficit/hyperactivity disorder: a review]. (2006 Jun)Yoshimasu KNihon Koshu Eisei Zasshi