Gene info: ID 160728

Gene: SLC5A8

GENE ID: 160728

Synonyms: AIT|SMCT|SMCT1

Description: solute carrier family 5 member 8

Gene type: protein-coding

Location: 12q23.1-q23.2

dbXrefs: Ensembl:ENSG00000256870 MIM:608044 Vega:OTTHUMG00000170499 UniprotKB:Q8N695

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.771e-1 (AD) 3.850e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg18841298	chr12:101604258	SLC5A8	Promoter	2.316e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC26A4	0.658
SLIT2	0.655
GPLD1	0.651
PHTF1	0.649
GRIK2	0.649
AFF2	0.642
ARMCX4	0.637
ZNF233	0.631
TBC1D30	0.631
SOWAHB	0.63

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AKR1C3	-0.4
ROM1	-0.388
RAB13	-0.385
BCL7C	-0.373
HEY2	-0.366
SYDE1	-0.358
COPZ2	-0.356
LRAT	-0.355
TMEM102	-0.351
TMEM176A	-0.35

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00627	Niacin	Small Molecule	59-67-6	Approved\|Investigational\|Nutraceutical	Transporter
DB01762	Acetoacetic Acid	Small Molecule	541-50-4	Experimental	Transporter
DB08872	Gabapentin Enacarbil	Small Molecule	478296-72-9	Approved\|Investigational	Transporter
DB08949	Inositol nicotinate	Small Molecule	6556-11-2	Approved\|Withdrawn	Transporter

ID	Drug Name	Action	PubMed
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of SLC5A8 mRNA"	18648102
C015001	arsenite	arsenite results in increased methylation of SLC5A8 promoter	23974009
D001280	Atrazine	Atrazine results in decreased expression of SLC5A8 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SLC5A8 mRNA	22316170
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of SLC5A8 gene	28505145
C006780	bisphenol A	bisphenol A results in increased expression of SLC5A8 mRNA	27257137
D002087	Butyrates	SLC5A8 protein results in increased transport of [Butyrates co-treated with Sodium]	15090606
C584509	C646 compound	C646 compound results in increased expression of SLC5A8 mRNA	26191083
D002264	Carboxylic Acids	SLC5A8 protein results in increased transport of [Carboxylic Acids co-treated with Sodium]	15090606
D002922	Ciguatoxins	Ciguatoxins affects the expression of SLC5A8 mRNA	18353800
C014347	decitabine	[decitabine affects the methylation of SLC5A8 gene] which affects the expression of SLC5A8 mRNA	18559491\|1855949
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of SLC5A8 mRNA	26924002
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of SLC5A8 mRNA	26924002
D005232	Fatty Acids, Volatile	"SLC5A8 protein results in increased transport of [Fatty Acids, Volatile co-treated with Sodium]"	15090606
D004397	Fonofos	Fonofos results in increased methylation of SLC5A8 promoter	22847954
C039281	furan	furan results in decreased methylation of SLC5A8 gene	27387713
C039281	furan	furan results in increased expression of SLC5A8 mRNA	27387713
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of SLC5A8 gene	28505145
C029424	hydrazine	hydrazine results in decreased expression of SLC5A8 mRNA	15282401
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of SLC5A8 mRNA	21179406
D007052	Ibuprofen	Ibuprofen results in decreased activity of SLC5A8 protein	15090606\|1667019
C492448	ICG 001	ICG 001 results in increased expression of SLC5A8 mRNA	26191083
D019344	Lactic Acid	SLC5A8 protein results in increased transport of [Lactic Acid co-treated with Sodium]	15090606
C008261	lead acetate	lead acetate results in decreased expression of SLC5A8 mRNA	21829687
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of SLC5A8 mRNA	26011545
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of SLC5A8 mRNA	26924002
D009539	Nicotinic Acids	SLC5A8 protein results in increased transport of [Nicotinic Acids co-treated with Sodium]	15090606
D010278	Parathion	Parathion results in increased methylation of SLC5A8 promoter	22847954
C006253	pirinixic acid	pirinixic acid results in decreased expression of SLC5A8 mRNA	17426115
D011339	Probenecid	Probenecid results in decreased activity of SLC5A8 protein	15090606
D011374	Progesterone	Progesterone results in decreased expression of SLC5A8 protein	21360409
D011422	Propionates	SLC5A8 protein results in increased transport of [Propionates co-treated with Sodium]	15090606
D012964	Sodium	SLC5A8 protein results in increased transport of [Butyrates co-treated with Sodium]	15090606
D012964	Sodium	SLC5A8 protein results in increased transport of [Carboxylic Acids co-treated with Sodium]	15090606
D012964	Sodium	"SLC5A8 protein results in increased transport of [Fatty Acids, Volatile co-treated with Sodium]"	15090606
D012964	Sodium	SLC5A8 protein results in increased transport of [Lactic Acid co-treated with Sodium]	15090606
D012964	Sodium	SLC5A8 protein results in increased transport of [Nicotinic Acids co-treated with Sodium]	15090606
D012964	Sodium	SLC5A8 protein results in increased transport of [Propionates co-treated with Sodium]	15090606
D012964	Sodium	SLC5A8 protein results in increased transport of [Valerates co-treated with Sodium]	15090606
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of SLC5A8 mRNA	27257137
C012568	terbufos	terbufos results in increased methylation of SLC5A8 promoter	22847954
D013739	Testosterone	Testosterone results in increased expression of SLC5A8 mRNA	20589576
D013739	Testosterone	Testosterone results in increased expression of SLC5A8 mRNA	27684650
C009495	titanium dioxide	titanium dioxide results in decreased expression of SLC5A8 mRNA	23557971
D014631	Valerates	SLC5A8 protein results in increased transport of [Valerates co-treated with Sodium]	15090606
D014635	Valproic Acid	Valproic Acid affects the expression of SLC5A8 mRNA	17963808
D014640	Vancomycin	Vancomycin results in increased expression of SLC5A8 mRNA	18930951

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008028	monocarboxylic acid transmembrane transporter activity	-	TAS	-
GO:0015129	lactate transmembrane transporter activity	-	IEA	-
GO:0015552	propionate transmembrane transporter activity	-	IEA	-
GO:0022803	passive transmembrane transporter activity	-	TAS	-
GO:0140161	monocarboxylate:sodium symporter activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006811	ion transport	-	TAS	-
GO:0006814	sodium ion transport	-	IEA	-
GO:0006915	apoptotic process	-	IEA	-
GO:0015730	propanoate transport	-	IEA	-
GO:0015913	short-chain fatty acid import	-	IEA	-
GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway	-	TAS	-
GO:0035873	lactate transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0016324	apical plasma membrane	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-196807	Nicotinate metabolism	TAS
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	TAS
R-HSA-196854	Metabolism of vitamins and cofactors	TAS
R-HSA-197264	Nicotinamide salvaging	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS
R-HSA-428643	Organic anion transporters	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25657825	Identification and validation of the methylation biomarkers of non-small cell lung cancer (NSCLC). (2015)	Guo S	Clin Epigenetics
22649395	Association of Cigarette Smoking with Aberrant Methylation of the Tumor Suppressor Gene RARbeta2 in Papillary Thyroid Cancer. (2011)	Kiseljak-Vassiliades K	Front Endocrinol (Lausanne)