Gene: CCDC63

160762
ODA5
coiled-coil domain containing 63
protein-coding
12q24.11
Ensembl:ENSG00000173093 MIM:617969 Vega:OTTHUMG00000169534 UniprotKB:Q8NA47
NC_000012.12
PubMed|SNP Mapped
5   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.742e-1 (AD)  3.072e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10774610chr12:110902439 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1858881chr12:110896313 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10849915chr12:110895818 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs11065750chr12:110893212 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2238149chr12:110874125 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BOLL0.553
OLIG30.536
TCP100.495
DMP10.48
TMCO5A0.473
DMBX10.472
MMP130.471
ENAM0.465
DMRT10.463
IL17A0.461

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFTPC-0.245
OMG-0.229
TOMM20L-0.221
SESN1-0.218
C17orf100-0.214
MYBPHL-0.208
FRAT1-0.201
TUBA3D-0.2
CCP110-0.2
ZNF681-0.199

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in increased expression of CCDC63 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCDC63 mRNA22316170
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of CCDC63 mRNA25270620
C006780bisphenol Abisphenol A results in decreased expression of CCDC63 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CCDC63 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CCDC63 promoter22457795
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CCDC63 mRNA27392435
D002945CisplatinCisplatin results in increased expression of CCDC63 mRNA27392435
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CCDC63 mRNA27392435
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CCDC63 mRNA19710929
D012969Sodium FluorideSodium Fluoride results in increased expression of CCDC63 protein28918527

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0003341cilium movement-IBA21873635  
GO:0007286spermatid development-ISS-  
GO:0036158outer dynein arm assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005930axoneme-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21270382Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (2011 Apr)Baik IAm J Clin Nutr
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. (2014 Mar)Quillen EEAm J Med Genet B Neuropsychiatr Genet