Gene: AP2A2

161
ADTAB|CLAPA2|HIP-9|HIP9|HYPJ
adaptor related protein complex 2 subunit alpha 2
protein-coding
11p15.5
Ensembl:ENSG00000183020 MIM:607242 Vega:OTTHUMG00000165627 UniprotKB:O94973
NC_000011.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.852e-1 (AD)  6.952e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09906169chr11:1005993AP2A2Gene body5.077e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPI0.968
HK10.968
ATG9A0.964
CLSTN10.964
DHX300.963
AP2A10.962
ATP6V0A10.961
ATP6V0D10.961
MAPK8IP30.96
ZFYVE270.959

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.66
OR4F29-0.609
RAI14-0.408
TFPI2-0.397
MBNL3-0.392
REST-0.389
ASB4-0.384
YES1-0.383
KLRB1-0.372
IL18RAP-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AP2A2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AP2A2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of AP2A2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of AP2A2 protein"25670856
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AP2A2 mRNA16483693
D001151ArsenicArsenic affects the methylation of AP2A2 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AP2A2 mRNA26238291
C006780bisphenol Abisphenol A results in decreased expression of AP2A2 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of AP2A2 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AP2A2 mRNA17484886
D003976DiazinonDiazinon results in increased methylation of AP2A2 gene22964155
D002945CisplatinCisplatin results in decreased expression of AP2A2 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of AP2A2 mRNA28302478
D004237DiuronDiuron results in decreased expression of AP2A2 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AP2A2 mRNA22079256
C082360fipronilfipronil results in decreased expression of AP2A2 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of AP2A2 mRNA24793618
D005839GentamicinsGentamicins results in decreased expression of AP2A2 mRNA22061828
D006220HaloperidolHaloperidol results in decreased expression of AP2A2 mRNA15860345
D017313FenretinideFenretinide results in decreased expression of AP2A2 mRNA28973697
D048628KetolidesKetolides analog results in increased expression of AP2A2 mRNA24967691
D007657Ketone BodiesKetone Bodies results in decreased expression of AP2A2 mRNA16807920
C002385linsidominelinsidomine results in increased oxidation of AP2A2 protein28086193
D008628MercuryMercury results in decreased expression of AP2A2 mRNA19937285
C004925methylmercuric chloridemethylmercuric chloride affects the expression of AP2A2 protein27012723
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of AP2A2 mRNA"20188158
C006253pirinixic acidpirinixic acid results in increased expression of AP2A2 mRNA16985257
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AP2A2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AP2A2 mRNA22079256
C059514resveratrolresveratrol results in decreased expression of AP2A2 protein25505154
D012643SeleniumSelenium results in increased expression of AP2A2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of AP2A2 mRNA19073995
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AP2A2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AP2A2 mRNA21354282
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AP2A2 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of AP2A2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of AP2A2 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of AP2A2 mRNA15799026
D014810Vitamin EVitamin E results in increased expression of AP2A2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI16902404  22323290  
GO:0008289lipid binding-IEA-  
GO:0019901protein kinase binding-ISS-  
GO:0035615clathrin adaptor activitycontributes_toTAS12121421  
GO:0097718disordered domain specific binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IEA-  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0032802low-density lipoprotein particle receptor catabolic process-TAS-  
GO:0034383low-density lipoprotein particle clearance-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0050690regulation of defense response to virus by virus-TAS-  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-TAS-  
GO:0061024membrane organization-TAS-  
GO:0072583clathrin-dependent endocytosis-TAS12121421  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0030122AP-2 adaptor complex-TAS12121421  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030667secretory granule membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0031410cytoplasmic vesicle-ISS-  
GO:0036020endolysosome membrane-TAS-  
GO:0045334clathrin-coated endocytic vesicle-NAS25898166  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1643685DiseaseTAS
R-HSA-164938Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adaptersTAS
R-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesisTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-166520Signaling by NTRKsTAS
R-HSA-167590Nef Mediated CD4 Down-regulationTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-177504Retrograde neurotrophin signallingIEA
R-HSA-177504Retrograde neurotrophin signallingTAS
R-HSA-182218Nef Mediated CD8 Down-regulationTAS
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-195721Signaling by WNTTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-416993Trafficking of GluR2-containing AMPA receptorsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-437239Recycling pathway of L1TAS
R-HSA-437239Recycling pathway of L1IEA
R-HSA-5099900WNT5A-dependent internalization of FZD4TAS
R-HSA-5140745WNT5A-dependent internalization of FZD2, FZD5 and ROR2TAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8866427VLDLR internalisation and degradationTAS
R-HSA-8964038LDL clearanceTAS
R-HSA-8964043Plasma lipoprotein clearanceTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25241909Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. (2014 Sep 21)Lee JHRespir Res
29532581Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway. (2018 Mar 13)Hallfors JAddict Biol