Gene: DAPK1

1612
DAPK|ROCO3
death associated protein kinase 1
protein-coding
9q21.33
Ensembl:ENSG00000196730 MIM:600831 Vega:OTTHUMG00000020150 UniprotKB:P53355
NG_029883.1
PubMed
0   ANCO-SNPs
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.886e-1 (AD)  4.765e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIPA1L10.945
CACNB20.945
ARHGAP320.931
CDK200.929
PIP4K2C0.929
GRAMD1B0.925
ARHGAP260.923
CACNA2D30.922
PDPK10.92
KIAA16710.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.523
KLRB1-0.517
TFPI2-0.512
SGMS2-0.51
CTNNA3-0.51
MYL3-0.503
SH2D1A-0.474
FZD10-0.474
CD2-0.472
TBX21-0.47

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB040695,6-Dihydro-Benzo[H]Cinnolin-3-YlamineSmall MoleculeExperimentalTarget
DB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall MoleculeExperimentalTarget
DB074446-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DAPK1 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DAPK1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of DAPK1 mRNA"19022289
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DAPK1 mRNA"19022289
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DAPK1 mRNA"19576244
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased expression of DAPK1 mRNA"19576244
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DAPK1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,2',4,4'-tetrabromodiphenyl ether co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of DAPK1 mRNA"19022289
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DAPK1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased expression of DAPK1 mRNA"19576244
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DAPK1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DAPK1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DAPK1 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DAPK1 mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of DAPK1 mRNA12419474
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased methylation of DAPK1 promoter15172992
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of DAPK1 mRNA20829426
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]"19477266
D000082Acetaminophen[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of DAPK1 mRNA17093179
D000082AcetaminophenAcetaminophen affects the expression of DAPK1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]19477266
D000393Air PollutantsAir Pollutants analog results in decreased expression of DAPK1 mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of DAPK1 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of DAPK1 mRNA28522335
D001151ArsenicArsenic results in decreased expression of DAPK1 mRNA23872714
D001151ArsenicArsenic results in increased methylation of DAPK1 promoter23872714
C015001arsenitearsenite results in increased methylation of DAPK1 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of DAPK1 mRNA"18687144
D001374AzacitidineAzacitidine affects the methylation of DAPK1 promoter17557868
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DAPK1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DAPK1 mRNA23735875
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DAPK1 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of DAPK1 mRNA16202921
D004958EstradiolEstradiol results in increased expression of DAPK1 mRNA23373633
D001622BetaineBetaine results in decreased expression of DAPK1 mRNA26391144
C006780bisphenol Abisphenol A results in decreased expression of DAPK1 mRNA24066056
C006780bisphenol Abisphenol A results in increased expression of DAPK1 mRNA25181051
C546611brevetoxin 2brevetoxin 2 results in decreased expression of DAPK1 mRNA20498034
D002065BuspironeBuspirone results in decreased expression of DAPK1 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of DAPK1 mRNA12419474|1533650
C018475butyraldehydebutyraldehyde results in decreased expression of DAPK1 mRNA26079696
D002087ButyratesButyrates results in increased expression of DAPK1 mRNA16042588
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DAPK1 mRNA19426795
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DAPK1 mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DAPK1 mRNA27339419
C062047chelidoninechelidonine affects the expression of DAPK1 mRNA25265580
D002737ChloropreneChloroprene results in increased expression of DAPK1 mRNA23125180
D002784Cholesterol"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]"19477266
D002784CholesterolAcetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]19477266
D002784CholesterolCholesterol analog results in increased expression of DAPK1 mRNA19477266
D019327Copper SulfateCopper Sulfate results in decreased expression of DAPK1 mRNA19549813
C030973cupric oxidecupric oxide results in decreased expression of DAPK1 mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of DAPK1 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of DAPK1 mRNA24317228
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of DAPK1 mRNA23640034
C014347decitabinedecitabine affects the expression of DAPK1 mRNA17133271
C014347decitabinedecitabine inhibits the reaction [sodium arsenite results in decreased expression of DAPK1 protein]19577553
C014347decitabinedecitabine results in decreased methylation of DAPK1 promoter17690560
C014347decitabinedecitabine results in increased expression of DAPK1 mRNA15924153|1903799
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DAPK1 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DAPK1 mRNA21266533
D004040Dietary Carbohydrates[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of DAPK1 mRNA17093179
D004041Dietary FatsDietary Fats affects the expression of DAPK1 mRNA19680557
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of DAPK1 protein20970405
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of DAPK1 promoter20970405
D002117CalcitriolCalcitriol results in decreased expression of DAPK1 mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of DAPK1 mRNA21592394
C025034doxifluridineDAPK1 protein results in increased susceptibility to doxifluridine16734730
D004317DoxorubicinDoxorubicin results in decreased expression of DAPK1 mRNA26873546
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of DAPK1 mRNA12628509
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of DAPK1 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DAPK1 mRNA22079256
D005472FluorouracilFluorouracil affects the expression of DAPK1 mRNA20421339
D005485FlutamideFlutamide results in decreased expression of DAPK1 mRNA24136188
D006830HydralazineHydralazine results in decreased methylation of DAPK1 promoter15862127
D006830HydralazineHydralazine results in increased expression of DAPK1 mRNA15862127
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DAPK1 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of DAPK1 mRNA12419474
D006918HydroxyureaHydroxyurea results in increased expression of DAPK1 mRNA27208086
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DAPK1 mRNA25613284
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of DAPK1 mRNA12832151
D007854LeadLead affects the splicing of DAPK1 mRNA28903495
C008261lead acetatelead acetate results in increased expression of DAPK1 mRNA21829687
C013598methoxyacetic acidmethoxyacetic acid affects the expression of DAPK1 mRNA20421339
D008731MethoxychlorMethoxychlor affects the expression of DAPK1 mRNA20829426
D008731MethoxychlorMethoxychlor results in increased methylation of DAPK1 gene23303685
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of DAPK1 mRNA23519560
D008748Methylcholanthrene[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of DAPK1 protein20970405
D008748Methylcholanthrene[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of DAPK1 promoter20970405
D008752Methylene ChlorideMethylene Chloride results in increased methylation of DAPK1 promoter15172992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DAPK1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DAPK1 mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of DAPK1 mRNA25270620
D016685MitomycinMitomycin results in increased expression of DAPK1 mRNA25270620
D008942MitoxantroneDAPK1 protein affects the susceptibility to Mitoxantrone16217747
C028577monobutyl phthalatemonobutyl phthalate affects the expression of DAPK1 mRNA20421339
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of DAPK1 mRNA"29244179
C064769N-acetylsphingosineN-acetylsphingosine results in increased activity of DAPK1 protein17087515
C064769N-acetylsphingosineN-acetylsphingosine results in increased activity of DAPK1 protein17087515
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DAPK1 mRNA"25554681|2562005
C038541N-benzyloxycarbonylprolylprolinalN-benzyloxycarbonylprolylprolinal results in decreased expression of DAPK1 mRNA21487212
D019829NevirapineNevirapine metabolite results in increased expression of DAPK1 mRNA23947594
D009532NickelNickel results in decreased expression of DAPK1 mRNA23195993
C028007nickel monoxidenickel monoxide results in increased expression of DAPK1 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of DAPK1 mRNA22714537
C012655nimesulidenimesulide results in decreased expression of DAPK1 mRNA24136188
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of DAPK1 mRNA"22937105
C016340o,p'-DDT"o,p'-DDT results in increased expression of DAPK1 mRNA"22937105
D008939MitotaneMitotane results in increased expression of DAPK1 mRNA23485034
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DAPK1 mRNA25729387
D010269ParaquatParaquat results in increased expression of DAPK1 mRNA18836921
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DAPK1 mRNA"25510870
C046012pentanalpentanal results in decreased expression of DAPK1 mRNA26079696
D010656PhenylephrinePhenylephrine results in decreased expression of DAPK1 mRNA18158353
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DAPK1 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DAPK1 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DAPK1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DAPK1 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of DAPK1 mRNA21632981
C059514resveratrolresveratrol results in increased activity of DAPK1 protein23800064
C059514resveratrolresveratrol results in increased expression of DAPK1 mRNA23800064
C059514resveratrolresveratrol results in increased expression of DAPK1 protein23800064
D012402RotenoneRotenone results in decreased expression of DAPK1 mRNA23186747
C017947sodium arsenitedecitabine inhibits the reaction [sodium arsenite results in decreased expression of DAPK1 protein]19577553
C017947sodium arseniteLCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of DAPK1 mRNA]24570342
C017947sodium arsenitesodium arsenite results in decreased expression of DAPK1 mRNA22714537
C017947sodium arsenitesodium arsenite results in decreased expression of DAPK1 protein19577553
C017947sodium arsenitesodium arsenite results in increased expression of DAPK1 mRNA10910055|2457034
C017947sodium arsenitesodium arsenite results in increased methylation of DAPK1 promoter17683884|1957755
C017947sodium arseniteU 0126 inhibits the reaction [sodium arsenite results in decreased expression of DAPK1 protein]19577553
D012969Sodium FluorideSodium Fluoride results in decreased expression of DAPK1 mRNA27862939
D018038Sodium SeleniteSodium Selenite results in decreased expression of DAPK1 mRNA16705456|1817575
D012999SomanSoman results in decreased expression of DAPK1 mRNA19281266
D013311StreptozocinStreptozocin results in decreased expression of DAPK1 mRNA25905778
C013698tallowtallow affects the expression of DAPK1 mRNA19680557
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of DAPK1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of DAPK1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DAPK1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DAPK1 mRNA15972635|1993321
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of DAPK1 mRNA10910055
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of DAPK1 mRNA23519560
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DAPK1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of DAPK1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DAPK1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of DAPK1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of DAPK1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of DAPK1 mRNA16249480
D014212TretinoinTretinoin affects the expression of DAPK1 mRNA20421339
D014212TretinoinTretinoin results in increased expression of DAPK1 mRNA20488242
C012589trichostatin Atrichostatin A results in increased expression of DAPK1 mRNA16865256
C057693troglitazonetroglitazone results in decreased expression of DAPK1 mRNA28973697
C080163trovafloxacintrovafloxacin results in decreased expression of DAPK1 mRNA24136188
C113580U 0126U 0126 inhibits the reaction [sodium arsenite results in decreased expression of DAPK1 protein]19577553
D014635Valproic AcidValproic Acid affects the expression of DAPK1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DAPK1 mRNA24383497|2493525
D014635Valproic AcidValproic Acid affects the expression of DAPK1 mRNA20421339
C025643vinclozolinvinclozolin affects the expression of DAPK1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of DAPK1 mRNA23034163
C017963vinyl carbamatevinyl carbamate results in increased methylation of DAPK1 promoter15172992
C111237vorinostatvorinostat results in decreased expression of DAPK1 mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of DAPK1 mRNA19036117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA7828849  12730201  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-TAS16756490  
GO:0004683calmodulin-dependent protein kinase activity-IDA10629061  
GO:0005515protein binding-IPI15616583  16132846  19180116  19712061  20389280  21725354  
25241761  
GO:0005516calmodulin binding-IDA10629061  
GO:0005524ATP binding-IBA21873635  
GO:0005524ATP binding-IDA10629061  
GO:0005525GTP binding-IEA-  
GO:0017075syntaxin-1 binding-IPI12730201  
GO:0042802identical protein binding-IPI19180116  19712061  21738225  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IDA10629061  
GO:0006468protein phosphorylation-TAS16756490  
GO:0006915apoptotic process-IGI7828849  
GO:0006915apoptotic process-IMP10629061  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-IEA-  
GO:0010506regulation of autophagy-TAS16756490  
GO:0010508positive regulation of autophagy-IMP22095288  
GO:0017148negative regulation of translation-IDA18995835  
GO:0035556intracellular signal transduction-IDA10629061  
GO:0042981regulation of apoptotic process-TAS16756490  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA16132846  
GO:0046777protein autophosphorylation-IDA10629061  12730201  
GO:0046777protein autophosphorylation-TAS16756490  
GO:0071346cellular response to interferon-gamma-IDA18995835  
GO:0071447cellular response to hydroperoxide-IMP22095288  
GO:0097190apoptotic signaling pathway-IMP7828849  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-IEA-  
GO:2000310regulation of NMDA receptor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IDA12730201  
GO:0005886plasma membrane-IDA12730201  
GO:0015629actin cytoskeleton-IDA10629061  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05219Bladder cancer
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisIEA
R-HSA-418889Ligand-independent caspase activation via DCCIEA
R-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathwayIEA
R-HSA-5357801Programmed Cell DeathIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25813726Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits. (2015 Feb)Ottini LMutat Res Genet Toxicol Environ Mutagen
19506903RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. (2009 Dec)Lin QJ Cancer Res Clin Oncol
22217548Similar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposure. (2012 Jul)Scesnaite AMutagenesis
18349282DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. (2008 Mar)Feng QCancer Epidemiol Biomarkers Prev
21507233Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC). (2011 Apr 20)Ji MBMC Cancer
23066440Tumor-suppressor Gene Promoter Hypermethylation in Saliva of Head and Neck Cancer Patients. (2012 Oct)Ovchinnikov DATransl Oncol
25569158IGSF4 methylation as an independent marker of human papillomavirus-positive oropharyngeal squamous cell carcinoma. (2015 Mar)Chen KMJAMA Otolaryngol Head Neck Surg
28421310Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. (2017 Aug)Strzelczyk JKBiochem Genet