Gene: DAZL

1618
DAZH|DAZL1|DAZLA|SPGYLA
deleted in azoospermia like
protein-coding
3p24.3
Ensembl:ENSG00000092345 MIM:601486 Vega:OTTHUMG00000157050 UniprotKB:Q92904
NG_023329.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.386e-1 (AD)  4.833e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPO110.691
TMEM950.686
FBXO470.653
MYCL0.64
TMPRSS130.639
CRYBA40.638
CA60.638
GCM10.633
FAM170B0.627
MAFA0.619

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFTPC-0.297
COL20A1-0.249
CHAD-0.241
CRIP3-0.235
GPR17-0.233
FAM186A-0.225
SMOC1-0.214
OMG-0.207
ZNF814-0.206
SNX22-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of DAZL mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of DAZL mRNA22230336
D000082AcetaminophenAcetaminophen results in decreased expression of DAZL mRNA17585979
C011512alpha-naphthoflavone"alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DAZL mRNA]"20562217
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of DAZL mRNA21298039
D001151ArsenicArsenic affects the methylation of DAZL gene25304211
D001280AtrazineAtrazine results in increased expression of DAZL mRNA25929836
C487081belinostatbelinostat results in decreased expression of DAZL mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DAZL mRNA26001963
D004958EstradiolEstradiol results in increased expression of DAZL mRNA24223173
C006780bisphenol Abisphenol A affects the expression of DAZL mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of DAZL mRNA22699882
C006780bisphenol Abisphenol A affects the methylation of DAZL promoter27415467
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DAZL mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of DAZL promoter22457795
D002185CannabidiolCannabidiol results in increased expression of DAZL mRNA29106691
D002220CarbamazepineCarbamazepine affects the expression of DAZL mRNA25979313
C014347decitabinedecitabine results in increased expression of DAZL mRNA19194470|2185625
D013759DronabinolDronabinol affects the expression of DAZL mRNA29106691
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DAZL mRNA"20562217
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of DAZL mRNA"20562217
D0151279,10-Dimethyl-1,2-benzanthracene"AHR protein affects the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DAZL mRNA]"20562217
D0151279,10-Dimethyl-1,2-benzanthracene"alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DAZL mRNA]"20562217
C118739entinostatentinostat results in decreased expression of DAZL mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
D015025ZearalenoneZearalenone results in decreased expression of DAZL mRNA28552778
D004397FonofosFonofos results in increased methylation of DAZL promoter22847954
D008731MethoxychlorMethoxychlor results in decreased expression of DAZL mRNA25048109
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DAZL mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DAZL mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DAZL mRNA"20188158
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of DAZL mRNA28496037
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DAZL mRNA26924002
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of DAZL mRNA26272509
D010278ParathionParathion results in increased methylation of DAZL promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of DAZL mRNA26272509
C009277sodium arsenatesodium arsenate results in decreased expression of DAZL mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of DAZL gene28589171
D012969Sodium FluorideSodium Fluoride results in increased expression of DAZL protein28918527
C012568terbufosterbufos results in increased methylation of DAZL promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DAZL mRNA21570461
D014212TretinoinTretinoin results in decreased expression of DAZL mRNA21934132
D014212TretinoinTretinoin results in increased expression of DAZL mRNA18425777
C012589trichostatin Atrichostatin A results in decreased expression of DAZL mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DAZL mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of DAZL mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DAZL mRNA24383497|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DAZL gene25560391
D015032ZincZinc results in decreased expression of DAZL mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-TAS8968755  
GO:0003730mRNA 3'-UTR binding-IBA21873635  
GO:0005515protein binding-IPI10857750  16001084  
GO:0008494translation activator activity-IBA21873635  
GO:0008494translation activator activity-IDA16001084  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001556oocyte maturation-IEA-  
GO:0007147female meiosis II-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0007281germ cell development-TAS9288969  
GO:0007283spermatogenesis-IEA-  
GO:0045836positive regulation of meiotic nuclear division-IEA-  
GO:0045948positive regulation of translational initiation-IBA21873635  
GO:0045948positive regulation of translational initiation-IDA16001084  
GO:00709353'-UTR-mediated mRNA stabilization-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA11390979  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005844polysome-IEA-  
GO:0032991protein-containing complex-IDA10857750  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16844779Heritable and stable gene knockdown in rats. (2006 Jul 25)Dann CTProc Natl Acad Sci U S A