Gene: FSIP1

161835
HSD10
fibrous sheath interacting protein 1
protein-coding
15q14
Ensembl:ENSG00000150667 MIM:615795 Vega:OTTHUMG00000172456 UniprotKB:Q8NA03
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.403e-1 (AD)  3.305e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03316752chr15:40069497FSIP14.900e-9Smoking27651444
cg14428590chr15:40076065FSIP17.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPGRIP1L0.766
KHDRBS20.759
CAMK40.752
TENM20.747
UBXN100.746
MPPED20.744
ZNF5440.743
ARL60.74
RSPH30.74
MRPS300.738

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFB3-0.475
ROM1-0.459
CSAG1-0.451
OTOS-0.43
MYL3-0.427
PPBP-0.426
GNG8-0.422
KIF1C-0.415
CNN2-0.411
PXDC1-0.409

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of FSIP1 mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FSIP1 mRNA"23196670
C496492abrineabrine results in increased expression of FSIP1 mRNA22595364
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of FSIP1 protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of FSIP1 protein26597043
D001151ArsenicFSIP1 gene SNP results in increased susceptibility to Arsenic21947419
D001241AspirinFSIP1 SNP affects the susceptibility to Aspirin20513247
D001280AtrazineAtrazine results in increased expression of FSIP1 mRNA25929836
C006780bisphenol Abisphenol A affects the expression of FSIP1 mRNA22574217
C006780bisphenol Abisphenol A results in increased methylation of FSIP1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of FSIP1 mRNA25181051
D004390ChlorpyrifosChlorpyrifos results in decreased expression of FSIP1 mRNA21356183
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of FSIP1 mRNA20971185
D016572CyclosporineCyclosporine results in increased expression of FSIP1 mRNA20106945|2798913
D003561CytarabineCytarabine results in increased expression of FSIP1 mRNA21198554
D004041Dietary FatsDietary Fats results in increased expression of FSIP1 mRNA25016146
C039281furanfuran results in increased expression of FSIP1 mRNA25539665
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FSIP1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FSIP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FSIP1 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of FSIP1 mRNA20971185
D011441PropylthiouracilPropylthiouracil results in increased expression of FSIP1 mRNA24780913
D013853ThioacetamideThioacetamide results in increased expression of FSIP1 mRNA23411599
C009495titanium dioxidetitanium dioxide affects the expression of FSIP1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of FSIP1 gene26756918
D014635Valproic AcidValproic Acid affects the expression of FSIP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of FSIP1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of FSIP1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FSIP1 gene25560391
C111237vorinostatvorinostat results in increased expression of FSIP1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20513247Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. (2010 Jun 1)Kim JYBMC Pulm Med