| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| KNDC1 | 0.784 |
| MGAT5B | 0.783 |
| KCNC4 | 0.77 |
| ZBTB7A | 0.758 |
| PPFIA4 | 0.757 |
| SLC45A4 | 0.756 |
| PLEKHG5 | 0.756 |
| GNG13 | 0.756 |
| KCNQ4 | 0.754 |
| DENND1A | 0.753 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| SGMS2 | -0.579 |
| C9orf135 | -0.522 |
| VRK2 | -0.513 |
| WIPF1 | -0.5 |
| BST1 | -0.489 |
| RAI14 | -0.488 |
| HAS2 | -0.476 |
| LAYN | -0.475 |
| SH2D1A | -0.473 |
| GDNF | -0.466 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB00126 | Vitamin C | Small Molecule | 50-81-7 | Approved|Nutraceutical | Target |
| DB00822 | Disulfiram | Small Molecule | 97-77-8 | Approved | Target |
| DB00988 | Dopamine | Small Molecule | 51-61-6 | Approved | Target |
| DB00550 | Propylthiouracil | Small Molecule | 51-52-5 | Approved|Investigational | Enzyme |
| DB00988 | Dopamine | Small Molecule | 51-61-6 | Approved | Enzyme |
| DB05394 | Corticorelin | Small Molecule | 86784-80-7 | Investigational | Enzyme |
| DB06774 | Capsaicin | Small Molecule | 404-86-4 | Approved | Enzyme |
| DB09130 | Copper | Small Molecule | 7440-50-8 | Approved|Investigational | Enzyme |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C008745 | 4,4'-bisphenol F | "4,4'-bisphenol F results in decreased expression of DBH mRNA" | 26186136 |
| C032538 | 4-cresol | 4-cresol results in decreased activity of DBH protein | 2306476 |
| D000082 | Acetaminophen | Acetaminophen results in decreased expression of DBH mRNA | 29067470 |
| D000535 | Aluminum | Aluminum results in decreased activity of DBH protein | 11787979 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of DBH mRNA | 16483693 |
| C006632 | arsenic trioxide | arsenic trioxide results in decreased expression of DBH mRNA | 23392890|2351822 |
| C006632 | arsenic trioxide | Taurine inhibits the reaction [arsenic trioxide results in decreased expression of DBH mRNA] | 23392890 |
| C039726 | artesunate | DBH mRNA results in increased susceptibility to artesunate | 20144594 |
| D001280 | Atrazine | Atrazine results in decreased expression of DBH mRNA | 22378314 |
| D001280 | Atrazine | Atrazine results in decreased expression of DBH protein | 14550852 |
| D001280 | Atrazine | Colforsin inhibits the reaction [Atrazine results in decreased expression of DBH protein] | 14550852 |
| D001280 | Atrazine | Dexamethasone inhibits the reaction [Atrazine results in decreased expression of DBH protein] | 14550852 |
| C547126 | AZM551248 | AZM551248 results in increased expression of DBH mRNA | 22323515 |
| C044887 | beta-methylcholine | beta-methylcholine affects the expression of DBH mRNA | 21179406 |
| C543008 | bis(4-hydroxyphenyl)sulfone | bis(4-hydroxyphenyl)sulfone results in decreased expression of DBH mRNA | 26186136 |
| D005406 | Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide | Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide results in decreased activity of DBH protein | 413140|4854165 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of DBH mRNA | 25181051 |
| D001971 | Bromocriptine | Bromocriptine results in decreased activity of DBH protein | 501350 |
| D016642 | Bupropion | DBH protein results in increased susceptibility to Bupropion | 15148402 |
| D002104 | Cadmium | Cadmium results in increased expression of DBH mRNA | 23256528 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in increased expression of DBH mRNA | 19031917 |
| D002246 | Carbon Disulfide | Carbon Disulfide results in decreased activity of DBH protein | 9072070 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in increased expression of DBH mRNA | 17452286|1881221 |
| D015283 | Citalopram | DBH protein promotes the reaction [Citalopram results in increased abundance of Serotonin] | 15148402 |
| D003042 | Cocaine | DBH gene polymorphism results in increased susceptibility to Cocaine | 10673769|1255523 |
| D003042 | Cocaine | DBH gene mutant form results in decreased susceptibility to Cocaine | 18083142 |
| D005576 | Colforsin | Colforsin inhibits the reaction [Atrazine results in decreased expression of DBH protein] | 14550852 |
| D005576 | Colforsin | Colforsin inhibits the reaction [Simazine results in decreased expression of DBH protein] | 14550852 |
| D005576 | Colforsin | Colforsin results in increased expression of DBH protein | 14550852 |
| D003276 | Contraceptives, Oral | "Contraceptives, Oral results in increased activity of DBH protein" | 1122595 |
| D019327 | Copper Sulfate | Copper Sulfate results in increased expression of DBH mRNA | 19789285 |
| C007168 | cyanazine | cyanazine results in increased expression of DBH protein | 14550852 |
| D015084 | 2,4-Dichlorophenoxyacetic Acid | "2,4-Dichlorophenoxyacetic Acid results in decreased expression of DBH protein" | 16931444 |
| D003891 | Desipramine | DBH protein results in increased susceptibility to Desipramine | 15148402 |
| D003907 | Dexamethasone | Dexamethasone inhibits the reaction [Atrazine results in decreased expression of DBH protein] | 14550852 |
| D003907 | Dexamethasone | Dexamethasone inhibits the reaction [Simazine results in decreased expression of DBH protein] | 14550852 |
| D003907 | Dexamethasone | Dexamethasone results in decreased expression of DBH mRNA | 20032058 |
| D003907 | Dexamethasone | Dexamethasone results in increased expression of DBH protein | 14550852 |
| D003907 | Dexamethasone | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of DBH mRNA] | 20032058 |
| D003976 | Diazinon | Diazinon results in decreased expression of DBH mRNA | 18812211 |
| D003976 | Diazinon | Diazinon results in increased expression of DBH mRNA | 17452286 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in increased expression of DBH mRNA | 21266533 |
| D004006 | Dichlorvos | Dichlorvos results in increased activity of DBH protein | 12186780 |
| D004006 | Dichlorvos | Nimodipine inhibits the reaction [Dichlorvos results in increased activity of DBH protein] | 12186780 |
| D004026 | Dieldrin | Dieldrin results in decreased expression of DBH mRNA | 18812211 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in decreased expression of DBH mRNA | 15620428 |
| D004221 | Disulfiram | DBH gene SNP affects the susceptibility to Disulfiram | 19462300 |
| D004221 | Disulfiram | Disulfiram results in decreased activity of DBH protein | 90468 |
| D004221 | Disulfiram | DBH gene polymorphism affects the susceptibility to Disulfiram | 16163519 |
| D004221 | Disulfiram | Disulfiram metabolite results in decreased activity of DBH protein | 17414256 |
| D004221 | Disulfiram | Disulfiram results in decreased activity of DBH protein | 16163519|2742552 |
| D004280 | Dobutamine | DBH protein affects the susceptibility to Dobutamine | 10338466 |
| D007980 | Levodopa | Levodopa results in decreased activity of DBH protein | 501350 |
| D004298 | Dopamine | DBH gene polymorphism affects the abundance of Dopamine | 16163519 |
| D004298 | Dopamine | DBH protein affects the reaction [Dopamine binds to DRD2 protein] | 15716360 |
| D004298 | Dopamine | DBH protein affects the abundance of Dopamine | 9072070 |
| D004298 | Dopamine | DBH protein affects the metabolism of Dopamine | 17414256|4854165 |
| D004298 | Dopamine | DBH protein results in increased metabolism of Dopamine | 16163519|1693144 |
| D004837 | Epinephrine | DBH gene polymorphism affects the abundance of Epinephrine | 16163519 |
| D005038 | Ethylnitrosourea | Ethylnitrosourea results in increased mutagenesis of DBH gene | 16495775 |
| C011251 | ferbam | ferbam results in decreased activity of DBH protein | 6420938 |
| D005473 | Fluoxetine | DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin] | 15148402 |
| D005473 | Fluoxetine | DBH protein results in increased susceptibility to Fluoxetine | 15148402 |
| D005473 | Fluoxetine | Fluoxetine results in increased expression of DBH mRNA | 20626387 |
| D005492 | Folic Acid | Folic Acid results in increased expression of DBH mRNA | 25006883 |
| C069837 | fullerene C60 | fullerene C60 results in decreased expression of DBH mRNA | 19167457 |
| D005669 | Fusaric Acid | Fusaric Acid results in decreased activity of DBH protein | 2724147 |
| D005669 | Fusaric Acid | Fusaric Acid results in decreased activity of DBH protein | 63668 |
| D012701 | Serotonin | DBH protein promotes the reaction [Citalopram results in increased abundance of Serotonin] | 15148402 |
| D012701 | Serotonin | DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin] | 15148402 |
| C047781 | lamotrigine | DBH protein results in increased susceptibility to lamotrigine | 20021991 |
| C025340 | manganese chloride | manganese chloride results in increased methylation of DBH gene | 27913844 |
| D008353 | Mannitol | Mannitol results in increased expression of DBH mRNA | 25270620 |
| D008694 | Methamphetamine | Methamphetamine results in decreased expression of DBH protein | 28661099 |
| D008713 | Methimazole | Methimazole results in increased expression of DBH protein | 11521740 |
| D008731 | Methoxychlor | Methoxychlor results in increased methylation of DBH gene | 19589859 |
| C054634 | methyllycaconitine | [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] | 17498763 |
| D015655 | 1-Methyl-4-phenylpyridinium | 1-Methyl-4-phenylpyridinium affects the expression of DBH mRNA | 12710931 |
| D015655 | 1-Methyl-4-phenylpyridinium | 1-Methyl-4-phenylpyridinium results in decreased expression of DBH protein | 26558463 |
| D008777 | Methyltestosterone | Methyltestosterone results in increased expression of DBH mRNA | 29191790 |
| D009151 | Mustard Gas | Mustard Gas results in increased expression of DBH mRNA | 15674843 |
| C109487 | nepicastat | nepicastat results in decreased activity of DBH protein | 18329701 |
| D009538 | Nicotine | [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] | 17498763 |
| D009538 | Nicotine | Nicotine results in increased expression of DBH mRNA | 17498763 |
| D009553 | Nimodipine | Nimodipine inhibits the reaction [Dichlorvos results in increased activity of DBH protein] | 12186780 |
| D009638 | Norepinephrine | DBH gene polymorphism affects the abundance of Norepinephrine | 16163519 |
| D009638 | Norepinephrine | DBH mutant form results in decreased abundance of Norepinephrine | 18329701 |
| D009638 | Norepinephrine | DBH protein results in increased abundance of Norepinephrine | 15148402 |
| D009638 | Norepinephrine | DBH protein affects the abundance of Norepinephrine | 17414256|9072070 |
| D009638 | Norepinephrine | DBH protein results in increased abundance of Norepinephrine | 4854165 |
| D009638 | Norepinephrine | DBH protein results in increased chemical synthesis of Norepinephrine | 16163519|1693144 |
| D010293 | Pargyline | DBH protein results in increased susceptibility to Pargyline | 15148402 |
| D017374 | Paroxetine | DBH protein results in increased susceptibility to Paroxetine | 15148402 |
| C031181 | phenanthrene | phenanthrene results in increased expression of DBH mRNA | 19457238 |
| D010936 | Plant Extracts | Plant Extracts results in decreased expression of DBH mRNA | 23557933 |
| C035988 | procymidone | procymidone results in increased expression of DBH mRNA | 15686871 |
| D011441 | Propylthiouracil | Propylthiouracil affects the expression of DBH mRNA | 24780913 |
| C074679 | reboxetine | DBH protein results in increased susceptibility to reboxetine | 15148402 |
| D012110 | Reserpine | Reserpine results in decreased activity of DBH protein | 7984052 |
| D012110 | Reserpine | Reserpine results in increased activity of DBH protein | 7984052 |
| D012110 | Reserpine | Reserpine results in increased expression of DBH mRNA | 1359376|2325165| |
| D012110 | Reserpine | Reserpine results in increased stability of DBH protein | 7984052 |
| D012524 | Sarin | Sarin results in decreased expression of DBH mRNA | 19522546 |
| D020280 | Sertraline | DBH protein results in increased susceptibility to Sertraline | 15148402 |
| D012839 | Simazine | Colforsin inhibits the reaction [Simazine results in decreased expression of DBH protein] | 14550852 |
| D012839 | Simazine | Dexamethasone inhibits the reaction [Simazine results in decreased expression of DBH protein] | 14550852 |
| D012839 | Simazine | Simazine results in decreased expression of DBH protein | 14550852 |
| D013654 | Taurine | Taurine inhibits the reaction [arsenic trioxide results in decreased expression of DBH mRNA] | 23392890 |
| D013739 | Testosterone | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of DBH mRNA] | 20032058 |
| D013893 | Thiram | Thiram results in decreased activity of DBH protein | 6420938 |
| D014212 | Tretinoin | Tretinoin results in decreased expression of DBH mRNA | 23724009 |
| D014227 | Triazines | Triazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of DBH mRNA] | 27469509 |
| C013320 | tris(2-butoxyethyl) phosphate | tris(2-butoxyethyl) phosphate affects the expression of DBH mRNA | 29024780 |
| D014520 | Urethane | Urethane results in decreased expression of DBH mRNA | 28818685 |
| D014635 | Valproic Acid | Valproic Acid affects the expression of DBH mRNA | 25979313 |
| D014635 | Valproic Acid | Valproic Acid results in increased methylation of DBH gene | 29154799 |
| D001335 | Vehicle Emissions | Vehicle Emissions results in increased methylation of DBH gene | 25560391 |
| C025643 | vinclozolin | vinclozolin results in increased expression of DBH mRNA | 15686871 |
| D015034 | Zinc Oxide | Zinc Oxide analog results in decreased expression of DBH mRNA | 27215404 |
| D019287 | Zinc Sulfate | Zinc Sulfate results in decreased expression of DBH mRNA | 27215404 |
| D015039 | Ziram | Ziram results in decreased activity of DBH protein | 6420938 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0003824 | catalytic activity | - | TAS | 3443096 |
| GO:0004500 | dopamine beta-monooxygenase activity | - | IBA | 21873635 |
| GO:0004500 | dopamine beta-monooxygenase activity | - | IDA | 3443096 7961964 |
| GO:0004500 | dopamine beta-monooxygenase activity | - | TAS | - |
| GO:0005507 | copper ion binding | - | IBA | 21873635 |
| GO:0005507 | copper ion binding | - | IDA | 7961964 27152332 |
| GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen | - | IBA | 21873635 |
| GO:0031418 | L-ascorbic acid binding | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0001816 | cytokine production | - | IEA | - |
| GO:0001974 | blood vessel remodeling | - | IEA | - |
| GO:0001975 | response to amphetamine | - | IEA | - |
| GO:0002443 | leukocyte mediated immunity | - | IEA | - |
| GO:0006589 | octopamine biosynthetic process | - | IBA | 21873635 |
| GO:0007268 | chemical synaptic transmission | - | TAS | 2880016 |
| GO:0007613 | memory | - | IEA | - |
| GO:0007626 | locomotory behavior | - | IEA | - |
| GO:0008542 | visual learning | - | IEA | - |
| GO:0042127 | regulation of cell proliferation | - | IEA | - |
| GO:0042309 | homoiothermy | - | IEA | - |
| GO:0042420 | dopamine catabolic process | - | IBA | 21873635 |
| GO:0042420 | dopamine catabolic process | - | IDA | 3443096 7961964 |
| GO:0042421 | norepinephrine biosynthetic process | - | IBA | 21873635 |
| GO:0042421 | norepinephrine biosynthetic process | - | IEA | - |
| GO:0042421 | norepinephrine biosynthetic process | - | IMP | 27148966 |
| GO:0042423 | catecholamine biosynthetic process | - | TAS | - |
| GO:0042593 | glucose homeostasis | - | IEA | - |
| GO:0042596 | fear response | - | IEA | - |
| GO:0042711 | maternal behavior | - | IEA | - |
| GO:0045907 | positive regulation of vasoconstriction | - | IEA | - |
| GO:0048149 | behavioral response to ethanol | - | IEA | - |
| GO:0048265 | response to pain | - | IEA | - |
| GO:0050900 | leukocyte migration | - | IEA | - |
| GO:0055114 | oxidation-reduction process | - | IEA | - |
| GO:2001236 | regulation of extrinsic apoptotic signaling pathway | - | IEA | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005576 | extracellular region | - | NAS | 14718574 |
| GO:0005615 | extracellular space | - | IBA | 21873635 |
| GO:0005615 | extracellular space | - | IDA | 7961964 |
| GO:0005737 | cytoplasm | - | IBA | 21873635 |
| GO:0005737 | cytoplasm | - | TAS | 3443096 |
| GO:0005783 | endoplasmic reticulum | - | IDA | - |
| GO:0005815 | microtubule organizing center | - | IDA | - |
| GO:0016020 | membrane | - | TAS | 3443096 |
| GO:0016021 | integral component of membrane | - | IEA | - |
| GO:0030658 | transport vesicle membrane | - | IEA | - |
| GO:0030667 | secretory granule membrane | - | IBA | 21873635 |
| GO:0030667 | secretory granule membrane | - | IDA | 7961964 |
| GO:0034466 | chromaffin granule lumen | - | IEA | - |
| GO:0034774 | secretory granule lumen | - | IDA | 7961964 |
| GO:0034774 | secretory granule lumen | - | TAS | - |
| GO:0042584 | chromaffin granule membrane | - | IEA | - |
| GO:0043231 | intracellular membrane-bounded organelle | - | IDA | - |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-1430728 | Metabolism | TAS |
| R-HSA-209776 | Amine-derived hormones | TAS |
| R-HSA-209905 | Catecholamine biosynthesis | TAS |
| R-HSA-71291 | Metabolism of amino acids and derivatives | TAS |
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