Gene: DBI

1622
ACBD1|ACBP|CCK-RP|EP
diazepam binding inhibitor, acyl-CoA binding protein
protein-coding
2q14.2
Ensembl:ENSG00000155368 MIM:125950 Vega:OTTHUMG00000131403 UniprotKB:P07108
NC_000002.12
PubMed
CD|OD|ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.589e-1 (AD)  6.539e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD630.899
GTF3C60.893
SERF20.877
RHOC0.874
YBX10.874
RPS190.868
FTL0.865
ATP6V0E10.864
DDAH20.863
GSTP10.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.631
OR4F29-0.631
ZNF860-0.412
COL24A1-0.405
TYRP1-0.397
CCDC177-0.394
MCHR2-0.394
C3orf49-0.394
HTR6-0.393
OR14I1-0.393

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01992Coenzyme ASmall Molecule85-61-0Investigational|NutraceuticalTarget
DB03381HexadecanalSmall Molecule629-80-1ExperimentalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of DBI mRNA"16269432
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DBI mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DBI mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DBI mRNA"12376462
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of DBI mRNA"20206263
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in decreased expression of DBI mRNA"16192472
C0185114-dichlorobenzene4-dichlorobenzene results in increased expression of DBI mRNA26975756
D000082AcetaminophenAcetaminophen results in decreased expression of DBI mRNA21420995|2906747
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of DBI mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DBI mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DBI gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of DBI mRNA16963002
D000638AmiodaroneAmiodarone affects the expression of DBI mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DBI mRNA16483693
D001553BenzbromaroneBenzbromarone affects the expression of DBI mRNA19483382
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of DBI mRNA16269432
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of DBI mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DBI mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DBI mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DBI mRNA22228805
D001629BezafibrateBezafibrate results in increased expression of DBI mRNA17118139
C099952bifenthrinbifenthrin analog inhibits the reaction [CGA results in increased expression of DBI mRNA]21871944
C006780bisphenol Abisphenol A results in increased methylation of DBI promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of DBI mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DBI gene28505145
D001761BleomycinBleomycin results in increased expression of DBI protein25933445
C001371boldenone undecylenate[boldenone undecylenate co-treated with estradiol 3-benzoate] results in decreased expression of DBI mRNA16023321
C013418bromfenacoumbromfenacoum results in decreased expression of DBI protein28903499
D002065BuspironeBuspirone results in decreased expression of DBI mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of DBI mRNA15336504
D002104CadmiumCadmium results in decreased expression of DBI mRNA24284285
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of DBI promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DBI mRNA16644059
C100187chloropicrinchloropicrin results in increased expression of DBI mRNA26352163
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of DBI mRNA17585979
D002994ClofibrateClofibrate results in increased expression of DBI mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DBI mRNA]17585979
D002994ClofibrateClofibrate affects the expression of DBI mRNA19483382
D002994ClofibrateClofibrate results in increased expression of DBI mRNA12851107|8499488
D002994ClofibrateClofibrate results in increased expression of DBI protein8499488
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DBI mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of DBI mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of DBI mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of DBI mRNA20971185
D003300CopperCopper deficiency results in increased expression of DBI mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of DBI mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of DBI mRNA16963002
D016572CyclosporineCyclosporine results in decreased expression of DBI mRNA20106945|2556210
D003634DDTDBI protein affects the susceptibility to DDT15118106
D003907DexamethasoneDexamethasone results in increased expression of DBI mRNA25047013
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of DBI mRNA23428407
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DBI mRNA17379624|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of DBI mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of DBI mRNA27392435
D002945CisplatinCisplatin results in increased expression of DBI mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of DBI mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of DBI mRNA18042831
D019422Dietary SucroseDietary Sucrose results in increased expression of DBI mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of DBI mRNA19245819|1985064
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of DBI mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DBI mRNA17602206
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DBI mRNA"12376462
C067311docetaxel[docetaxel co-treated with Doxorubicin] results in increased expression of DBI protein20457137
D004317Doxorubicin[docetaxel co-treated with Doxorubicin] results in increased expression of DBI protein20457137
C074283estradiol 3-benzoate[boldenone undecylenate co-treated with estradiol 3-benzoate] results in decreased expression of DBI mRNA16023321
C074283estradiol 3-benzoate[Testosterone co-treated with estradiol 3-benzoate] results in decreased expression of DBI mRNA16023321
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DBI mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DBI mRNA17108234
D005001EthionineEthionine affects the expression of DBI mRNA19483382
C024565ethylene dichlorideethylene dichloride results in decreased expression of DBI mRNA28189721
D011345FenofibrateFenofibrate results in increased expression of DBI mRNA17118139
D018120FinasterideFinasteride results in increased expression of DBI mRNA24136188
D005944GlucosamineGlucosamine results in increased expression of DBI mRNA17178593
D005947GlucoseGlucose results in increased expression of DBI mRNA17178593
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of DBI mRNA17183730
C016517indole-3-carbinolindole-3-carbinol results in decreased expression of DBI mRNA16192472
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of DBI mRNA25613284
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of DBI mRNA23428407
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of DBI mRNA27392435
C544151jinfukangjinfukang results in increased expression of DBI mRNA27392435
C410337K 7174K 7174 results in decreased expression of DBI mRNA24086573
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of DBI mRNA18386188
D008727MethotrexateMethotrexate affects the expression of DBI mRNA18502557
C030667methylazoxymethanolmethylazoxymethanol results in increased expression of DBI mRNA17107856
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DBI mRNA23649840
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of DBI mRNA16525678
C044361M-VAC protocol[DBI co-treated with GGH] results in increased susceptibility to M-VAC protocol19815704
C044361M-VAC protocolDBI protein results in increased susceptibility to M-VAC protocol15814643
C044361M-VAC protocolDBI results in increased susceptibility to M-VAC protocol19815704
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of DBI protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DBI mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DBI mRNA"25620056
C022838nickel chloridenickel chloride affects the expression of DBI mRNA22110744
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of DBI mRNA20971185
D009853OmeprazoleOmeprazole affects the expression of DBI mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DBI mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of DBI mRNA18042831
D010269ParaquatParaquat results in decreased expression of DBI mRNA15458575
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of DBI mRNA18386188
D010433PentylenetetrazolePentylenetetrazole affects the expression of DBI mRNA21503142
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of DBI mRNA8499488
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of DBI protein8499488
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of DBI mRNA28558994
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of DBI mRNA28558994
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of DBI mRNA28558994
C076994perfluorooctane sulfonic acidPPARA protein affects the reaction [perfluorooctane sulfonic acid results in increased expression of DBI mRNA]28558994
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of DBI mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DBI mRNA17681415|2855899
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DBI mRNA8499488
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DBI protein8499488
D010795Phthalic AcidsPhthalic Acids results in decreased expression of DBI mRNA15728792
C006253pirinixic acidpirinixic acid results in increased expression of DBI mRNA17118139|1742611
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of DBI mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of DBI mRNA19483382
C006253pirinixic acidpirinixic acid promotes the reaction [[PPARA protein binds to MDM2 protein] which binds to DBI promoter]19103650
C006253pirinixic acidpirinixic acid results in increased expression of DBI mRNA19162173
C035988procymidoneprocymidone results in decreased expression of DBI mRNA15686871
D011374ProgesteroneProgesterone affects the expression of DBI mRNA17251523
D011374ProgesteroneProgesterone results in increased expression of DBI mRNA19690047
D011441PropylthiouracilPropylthiouracil affects the expression of DBI mRNA19483382
D015474IsotretinoinIsotretinoin results in decreased expression of DBI mRNA20436886
C017947sodium arsenitesodium arsenite results in increased expression of DBI mRNA28595984
D012969Sodium FluorideSodium Fluoride results in decreased expression of DBI protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of DBI mRNA18175754
C040349S-tetradecanoyl-coenzyme AS-tetradecanoyl-coenzyme A binds to DBI protein17044054
D013739Testosterone[Testosterone co-treated with estradiol 3-benzoate] results in decreased expression of DBI mRNA16023321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DBI mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DBI mRNA17942748
D013752TetracyclineTetracycline results in decreased expression of DBI mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of DBI mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of DBI mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of DBI mRNA19483382
C009495titanium dioxidetitanium dioxide results in decreased expression of DBI mRNA23557971
D014050TolueneToluene results in decreased expression of DBI mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DBI mRNA25729387
C011559tributyltintributyltin results in increased expression of DBI mRNA23428407
C057693troglitazonetroglitazone results in increased expression of DBI mRNA12732648
D014415TunicamycinTunicamycin results in decreased expression of DBI mRNA22378314
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of DBI mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of DBI mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of DBI mRNA15686871
C025643vinclozolinvinclozolin results in increased expression of DBI mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of DBI mRNA20044591
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of DBI mRNA"25475078

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008289lipid binding-IEA-  
GO:0030156benzodiazepine receptor binding-TAS3020548  
GO:0036042long-chain fatty acyl-CoA binding-IDA21079819  
GO:0046983protein dimerization activity-IDA21079819  
GO ID GO Term Qualifier Evidence PubMed
GO:0006637acyl-CoA metabolic process-TAS-  
GO:0018345protein palmitoylationNOTIDA21079819  
GO:0036151phosphatidylcholine acyl-chain remodeling-IDA21079819  
GO ID GO Term Qualifier Evidence PubMed
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005794Golgi apparatus-IEA-  
GO:0070062extracellular exosome-HDA20458337  23533145  
KEGG ID KEGG Term
hsa03320PPAR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-77289Mitochondrial Fatty Acid Beta-OxidationTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24818357Relationship between alcohol dependence and the DBI rs2276596 (C/A) polymorphism in Japanese. (2014 Feb)Yoshihara ENihon Arukoru Yakubutsu Igakkai Zasshi
15764844Functional proteins involved in regulation of intracellular Ca(2+) for drug development: chronic nicotine treatment upregulates L-type high voltage-gated calcium channels. (2005 Mar)Katsura MJ Pharmacol Sci
18240651The relationship between alcoholism and DBI gene polymorphism in Japanese--genotyping of the +529A/T in DBI gene polymorphism based on PCR. (2007 Dec)Waga CNihon Arukoru Yakubutsu Igakkai Zasshi
3220589Finger systolic pressure during local cooling in normal subjects aged 20 to 60 years: reference values for the assessment of digital vasospasm in Raynaud's phenomenon of occupational origin. (1988)Bovenzi MInt Arch Occup Environ Health
15950760Conditioned place preference associates with the mRNA expression of diazepam binding inhibitor in brain regions of the addicted rat during withdrawal. (2005 Jun 13)Liu XBrain Res Mol Brain Res
28545471Decisional Balance Inventory (DBI) Adolescent Form for Smoking: Psychometric Properties of the Persian Version. (2017 May 25)Khazaee-Pool MBMC Public Health
8529966[Functional significance of diazepam binding inhibitor (DBI) in establishment of alcohol dependence]. (1995 Sep)Katsura MNihon Yakurigaku Zasshi
7791128Increase of diazepam binding inhibitor mRNA levels in the brains of chronically ethanol-treated and -withdrawn mice. (1995 Jun)Katsura MJ Pharmacol Exp Ther
7188002A Quantitative Inventory of Alcohol Disorders (QIAD): a severity scale for alcohol abuse. (1982-1983)Stinnett JLAm J Drug Alcohol Abuse
26277529Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry. (2016 Jan 4)Levran OProg Neuropsychopharmacol Biol Psychiatry
21226341[Relationship between GSK-3 beta -50T/C and DBI +529A/T polymorphisms in Japanese alcoholics]. (2010 Oct)Kurihara KNihon Arukoru Yakubutsu Igakkai Zasshi