Gene info: ID 1622

Gene: DBI

GENE ID: 1622

Synonyms: ACBD1|ACBP|CCK-RP|EP

Description: diazepam binding inhibitor, acyl-CoA binding protein

Gene type: protein-coding

Location: 2q14.2

dbXrefs: Ensembl:ENSG00000155368 MIM:125950 Vega:OTTHUMG00000131403 UniprotKB:P07108

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.589e-1 (AD) 6.539e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CD63	0.899
GTF3C6	0.893
SERF2	0.877
RHOC	0.874
YBX1	0.874
RPS19	0.868
FTL	0.865
ATP6V0E1	0.864
DDAH2	0.863
GSTP1	0.863

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.631
OR4F29	-0.631
ZNF860	-0.412
COL24A1	-0.405
TYRP1	-0.397
CCDC177	-0.394
MCHR2	-0.394
C3orf49	-0.394
HTR6	-0.393
OR14I1	-0.393

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01992	Coenzyme A	Small Molecule	85-61-0	Investigational\|Nutraceutical	Target
DB03381	Hexadecanal	Small Molecule	629-80-1	Experimental	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of DBI mRNA"	16269432
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DBI mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of DBI mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DBI mRNA"	12376462
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of DBI mRNA"	20206263
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in decreased expression of DBI mRNA"	16192472
C018511	4-dichlorobenzene	4-dichlorobenzene results in increased expression of DBI mRNA	26975756
D000082	Acetaminophen	Acetaminophen results in decreased expression of DBI mRNA	21420995\|2906747
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of DBI mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DBI mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of DBI gene	27153756
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of DBI mRNA	16963002
D000638	Amiodarone	Amiodarone affects the expression of DBI mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DBI mRNA	16483693
D001553	Benzbromarone	Benzbromarone affects the expression of DBI mRNA	19483382
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of DBI mRNA	16269432
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of DBI mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DBI mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DBI mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DBI mRNA	22228805
D001629	Bezafibrate	Bezafibrate results in increased expression of DBI mRNA	17118139
C099952	bifenthrin	bifenthrin analog inhibits the reaction [CGA results in increased expression of DBI mRNA]	21871944
C006780	bisphenol A	bisphenol A results in increased methylation of DBI promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of DBI mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of DBI gene	28505145
D001761	Bleomycin	Bleomycin results in increased expression of DBI protein	25933445
C001371	boldenone undecylenate	[boldenone undecylenate co-treated with estradiol 3-benzoate] results in decreased expression of DBI mRNA	16023321
C013418	bromfenacoum	bromfenacoum results in decreased expression of DBI protein	28903499
D002065	Buspirone	Buspirone results in decreased expression of DBI mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of DBI mRNA	15336504
D002104	Cadmium	Cadmium results in decreased expression of DBI mRNA	24284285
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of DBI promoter	22457795
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of DBI mRNA	16644059
C100187	chloropicrin	chloropicrin results in increased expression of DBI mRNA	26352163
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of DBI mRNA	17585979
D002994	Clofibrate	Clofibrate results in increased expression of DBI mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DBI mRNA]	17585979
D002994	Clofibrate	Clofibrate affects the expression of DBI mRNA	19483382
D002994	Clofibrate	Clofibrate results in increased expression of DBI mRNA	12851107\|8499488
D002994	Clofibrate	Clofibrate results in increased expression of DBI protein	8499488
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DBI mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of DBI mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of DBI mRNA	24386269
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of DBI mRNA	20971185
D003300	Copper	Copper deficiency results in increased expression of DBI mRNA	26033743
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of DBI mRNA	19549813
D003345	Corticosterone	Corticosterone results in increased expression of DBI mRNA	16963002
D016572	Cyclosporine	Cyclosporine results in decreased expression of DBI mRNA	20106945\|2556210
D003634	DDT	DBI protein affects the susceptibility to DDT	15118106
D003907	Dexamethasone	Dexamethasone results in increased expression of DBI mRNA	25047013
D003907	Dexamethasone	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of DBI mRNA	23428407
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DBI mRNA	17379624\|2126653
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of DBI mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of DBI mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of DBI mRNA	27594783
C000944	dicrotophos	dicrotophos results in decreased expression of DBI mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of DBI mRNA	18042831
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of DBI mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DBI mRNA	19245819\|1985064
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of DBI mRNA]	19850644
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DBI mRNA	17602206
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DBI mRNA"	12376462
C067311	docetaxel	[docetaxel co-treated with Doxorubicin] results in increased expression of DBI protein	20457137
D004317	Doxorubicin	[docetaxel co-treated with Doxorubicin] results in increased expression of DBI protein	20457137
C074283	estradiol 3-benzoate	[boldenone undecylenate co-treated with estradiol 3-benzoate] results in decreased expression of DBI mRNA	16023321
C074283	estradiol 3-benzoate	[Testosterone co-treated with estradiol 3-benzoate] results in decreased expression of DBI mRNA	16023321
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DBI mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of DBI mRNA	17108234
D005001	Ethionine	Ethionine affects the expression of DBI mRNA	19483382
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of DBI mRNA	28189721
D011345	Fenofibrate	Fenofibrate results in increased expression of DBI mRNA	17118139
D018120	Finasteride	Finasteride results in increased expression of DBI mRNA	24136188
D005944	Glucosamine	Glucosamine results in increased expression of DBI mRNA	17178593
D005947	Glucose	Glucose results in increased expression of DBI mRNA	17178593
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of DBI mRNA	17183730
C016517	indole-3-carbinol	indole-3-carbinol results in decreased expression of DBI mRNA	16192472
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of DBI mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of DBI mRNA	23428407
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of DBI mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of DBI mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of DBI mRNA	24086573
D008344	Maneb	[Paraquat co-treated with Maneb] results in decreased expression of DBI mRNA	18386188
D008727	Methotrexate	Methotrexate affects the expression of DBI mRNA	18502557
C030667	methylazoxymethanol	methylazoxymethanol results in increased expression of DBI mRNA	17107856
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of DBI mRNA	23649840
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of DBI mRNA	16525678
C044361	M-VAC protocol	[DBI co-treated with GGH] results in increased susceptibility to M-VAC protocol	19815704
C044361	M-VAC protocol	DBI protein results in increased susceptibility to M-VAC protocol	15814643
C044361	M-VAC protocol	DBI results in increased susceptibility to M-VAC protocol	19815704
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of DBI protein"	21135415
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of DBI mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of DBI mRNA"	25620056
C022838	nickel chloride	nickel chloride affects the expression of DBI mRNA	22110744
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of DBI mRNA	20971185
D009853	Omeprazole	Omeprazole affects the expression of DBI mRNA	19483382
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of DBI mRNA	25729387
D000073878	Palm Oil	Palm Oil results in decreased expression of DBI mRNA	18042831
D010269	Paraquat	Paraquat results in decreased expression of DBI mRNA	15458575
D010269	Paraquat	[Paraquat co-treated with Maneb] results in decreased expression of DBI mRNA	18386188
D010433	Pentylenetetrazole	Pentylenetetrazole affects the expression of DBI mRNA	21503142
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in increased expression of DBI mRNA	8499488
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in increased expression of DBI protein	8499488
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of DBI mRNA	28558994
C584865	perfluorononanoic acid	perfluorononanoic acid results in increased expression of DBI mRNA	28558994
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of DBI mRNA	28558994
C076994	perfluorooctane sulfonic acid	PPARA protein affects the reaction [perfluorooctane sulfonic acid results in increased expression of DBI mRNA]	28558994
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of DBI mRNA	18281256
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of DBI mRNA	17681415\|2855899
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of DBI mRNA	8499488
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of DBI protein	8499488
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of DBI mRNA	15728792
C006253	pirinixic acid	pirinixic acid results in increased expression of DBI mRNA	17118139\|1742611
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of DBI mRNA]	20059764
C006253	pirinixic acid	pirinixic acid affects the expression of DBI mRNA	19483382
C006253	pirinixic acid	pirinixic acid promotes the reaction [[PPARA protein binds to MDM2 protein] which binds to DBI promoter]	19103650
C006253	pirinixic acid	pirinixic acid results in increased expression of DBI mRNA	19162173
C035988	procymidone	procymidone results in decreased expression of DBI mRNA	15686871
D011374	Progesterone	Progesterone affects the expression of DBI mRNA	17251523
D011374	Progesterone	Progesterone results in increased expression of DBI mRNA	19690047
D011441	Propylthiouracil	Propylthiouracil affects the expression of DBI mRNA	19483382
D015474	Isotretinoin	Isotretinoin results in decreased expression of DBI mRNA	20436886
C017947	sodium arsenite	sodium arsenite results in increased expression of DBI mRNA	28595984
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of DBI protein	28918527
D018038	Sodium Selenite	Sodium Selenite results in increased expression of DBI mRNA	18175754
C040349	S-tetradecanoyl-coenzyme A	S-tetradecanoyl-coenzyme A binds to DBI protein	17044054
D013739	Testosterone	[Testosterone co-treated with estradiol 3-benzoate] results in decreased expression of DBI mRNA	16023321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DBI mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DBI mRNA	17942748
D013752	Tetracycline	Tetracycline results in decreased expression of DBI mRNA	16917069
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of DBI mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of DBI mRNA	22378314
D013853	Thioacetamide	Thioacetamide affects the expression of DBI mRNA	19483382
C009495	titanium dioxide	titanium dioxide results in decreased expression of DBI mRNA	23557971
D014050	Toluene	Toluene results in decreased expression of DBI mRNA	22967744
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of DBI mRNA	25729387
C011559	tributyltin	tributyltin results in increased expression of DBI mRNA	23428407
C057693	troglitazone	troglitazone results in increased expression of DBI mRNA	12732648
D014415	Tunicamycin	Tunicamycin results in decreased expression of DBI mRNA	22378314
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of DBI mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of DBI mRNA	17292431
C025643	vinclozolin	vinclozolin results in decreased expression of DBI mRNA	15686871
C025643	vinclozolin	vinclozolin results in increased expression of DBI mRNA	23034163
D024483	Vitamin K 3	Vitamin K 3 affects the expression of DBI mRNA	20044591
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of DBI mRNA"	25475078

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008289	lipid binding	-	IEA	-
GO:0030156	benzodiazepine receptor binding	-	TAS	3020548
GO:0036042	long-chain fatty acyl-CoA binding	-	IDA	21079819
GO:0046983	protein dimerization activity	-	IDA	21079819

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006637	acyl-CoA metabolic process	-	TAS	-
GO:0018345	protein palmitoylation	NOT	IDA	21079819
GO:0036151	phosphatidylcholine acyl-chain remodeling	-	IDA	21079819

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005794	Golgi apparatus	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	20458337 23533145

KEGG ID	KEGG Term
hsa03320	PPAR signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation	TAS
R-HSA-8978868	Fatty acid metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24818357	Relationship between alcohol dependence and the DBI rs2276596 (C/A) polymorphism in Japanese. (2014 Feb)	Yoshihara E	Nihon Arukoru Yakubutsu Igakkai Zasshi
15764844	Functional proteins involved in regulation of intracellular Ca(2+) for drug development: chronic nicotine treatment upregulates L-type high voltage-gated calcium channels. (2005 Mar)	Katsura M	J Pharmacol Sci
18240651	The relationship between alcoholism and DBI gene polymorphism in Japanese--genotyping of the +529A/T in DBI gene polymorphism based on PCR. (2007 Dec)	Waga C	Nihon Arukoru Yakubutsu Igakkai Zasshi
3220589	Finger systolic pressure during local cooling in normal subjects aged 20 to 60 years: reference values for the assessment of digital vasospasm in Raynaud's phenomenon of occupational origin. (1988)	Bovenzi M	Int Arch Occup Environ Health
15950760	Conditioned place preference associates with the mRNA expression of diazepam binding inhibitor in brain regions of the addicted rat during withdrawal. (2005 Jun 13)	Liu X	Brain Res Mol Brain Res
28545471	Decisional Balance Inventory (DBI) Adolescent Form for Smoking: Psychometric Properties of the Persian Version. (2017 May 25)	Khazaee-Pool M	BMC Public Health
8529966	[Functional significance of diazepam binding inhibitor (DBI) in establishment of alcohol dependence]. (1995 Sep)	Katsura M	Nihon Yakurigaku Zasshi
7791128	Increase of diazepam binding inhibitor mRNA levels in the brains of chronically ethanol-treated and -withdrawn mice. (1995 Jun)	Katsura M	J Pharmacol Exp Ther
7188002	A Quantitative Inventory of Alcohol Disorders (QIAD): a severity scale for alcohol abuse. (1982-1983)	Stinnett JL	Am J Drug Alcohol Abuse
26277529	Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry. (2016 Jan 4)	Levran O	Prog Neuropsychopharmacol Biol Psychiatry
21226341	[Relationship between GSK-3 beta -50T/C and DBI +529A/T polymorphisms in Japanese alcoholics]. (2010 Oct)	Kurihara K	Nihon Arukoru Yakubutsu Igakkai Zasshi