Gene: FBXO39

162517
CT144|Fbx39
F-box protein 39
protein-coding
17p13.1
Ensembl:ENSG00000177294 MIM:609106 Vega:OTTHUMG00000102062 UniprotKB:Q8N4B4
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.428e-1 (AD)  9.755e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOX70.572
DNMBP0.563
BEND70.539
ADAMTSL40.529
ITPR30.524
VSIG100.519
ITGA100.512
MYCBP0.511
FAM114A20.511
NBEAL20.508

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C19orf73-0.256
ASPDH-0.238
GRIFIN-0.238
CPLX3-0.222
NKX2-8-0.207
C16orf95-0.206
SPEF1-0.204
SST-0.198
SOX3-0.197
SAC3D1-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of FBXO39 mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of FBXO39 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FBXO39 mRNA19770486
C015001arsenitearsenite results in increased methylation of FBXO39 promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of FBXO39 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in increased expression of FBXO39 mRNA21139344
D003300CopperCopper deficiency results in increased expression of FBXO39 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of FBXO39 mRNA26033743
C069837fullerene C60fullerene C60 results in increased expression of FBXO39 mRNA19167457
C028473N-acetyl-4-benzoquinoneimineFBXO39 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FBXO39 mRNA19710929
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FBXO39 mRNA19770486
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of FBXO39 mRNA20133372
D014635Valproic AcidValproic Acid affects the expression of FBXO39 mRNA17963808
D014640VancomycinVancomycin results in decreased expression of FBXO39 mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0019005SCF ubiquitin ligase complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24268366Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure. (2014 Jan)Yang TYEnviron Res