Gene: DBT

1629
BCATE2|BCKAD-E2|BCKADE2|BCOADC-E2|E2|E2B
dihydrolipoamide branched chain transacylase E2
protein-coding
1p21.2
Ensembl:ENSG00000137992 MIM:248610 Vega:OTTHUMG00000010921 UniprotKB:P11182
NG_011852.2
PubMed
0   ANCO-SNPs
OD|ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.597e-1 (AD)  3.983e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17746819chr1:100715586DBTPromoter1.013e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1920.888
MEGF90.871
NCOA20.869
MUT0.861
CLIP40.859
CLCN30.858
FAM199X0.856
DCUN1D10.854
SNX130.847
BBS100.847

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.575
OR4F29-0.534
KLRK1-0.327
CETP-0.309
CSAG1-0.305
TBX21-0.297
SPINK8-0.292
KLRB1-0.292
IL2RB-0.287
MTRNR2L6-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0127962-butenal2-butenal results in decreased expression of DBT mRNA20471460
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DBT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DBT mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of DBT mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of DBT mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of DBT mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of DBT mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DBT mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DBT mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of DBT protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DBT mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of DBT mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of DBT mRNA"24160326
D001280AtrazineAtrazine results in decreased expression of DBT mRNA22378314
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of DBT mRNA]22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DBT mRNA"20018196
C044887beta-methylcholinebeta-methylcholine affects the expression of DBT mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of DBT mRNA25181051
C034939cadmium sulfide[cadmium telluride co-treated with cadmium sulfide] results in decreased expression of DBT mRNA20596552
C028337cadmium telluride[cadmium telluride co-treated with cadmium sulfide] results in decreased expression of DBT mRNA20596552
D002220CarbamazepineCarbamazepine affects the expression of DBT mRNA24752500
C041167chromium nitratechromium nitrate results in increased expression of DBT protein22144121
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of DBT mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DBT mRNA]17585979
C029892cupric chloridecupric chloride results in decreased expression of DBT protein19616320
D016572CyclosporineCyclosporine results in decreased expression of DBT mRNA20106945|2556210
C093628cyproconazolecyproconazole results in decreased expression of DBT mRNA22334560
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of DBT mRNA23914054
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DBT mRNA]27941970
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of DBT mRNA26873546
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DBT mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DBT mRNA21266533
D004008DiclofenacDiclofenac affects the expression of DBT mRNA24752500
D004041Dietary FatsDietary Fats results in decreased expression of DBT mRNA15238619
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of DBT mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of DBT mRNA]19850644
D004147DioxinsDioxins affects the expression of DBT mRNA20463971
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of DBT mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of DBT mRNA26873546
C109476epoxiconazoleepoxiconazole results in decreased expression of DBT mRNA22334560
D005419FlavonoidsFlavonoids results in decreased expression of DBT mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of DBT mRNA23649840
D017313FenretinideFenretinide results in decreased expression of DBT mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DBT mRNA25613284
D008627Mercuric Chloride"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DBT mRNA"27188386
D008713MethimazoleMethimazole results in decreased expression of DBT mRNA22504374
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DBT mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DBT mRNA23179753
D009532NickelNickel results in decreased expression of DBT mRNA25583101
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of DBT protein19716841
D010098OxycodoneOxycodone results in increased expression of DBT mRNA23439660
D010634PhenobarbitalPhenobarbital affects the expression of DBT mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DBT mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of DBT mRNA23811191
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of DBT protein22144121
C045950propiconazolepropiconazole results in decreased expression of DBT mRNA21278054|2233456
D011441PropylthiouracilPropylthiouracil results in decreased expression of DBT mRNA22504374
C059514resveratrolresveratrol results in increased expression of DBT mRNA22610192
D015474IsotretinoinIsotretinoin results in decreased expression of DBT mRNA20436886
D013311StreptozocinStreptozocin affects the expression of DBT mRNA18583417
D013501Surface-Active AgentsSurface-Active Agents results in increased expression of DBT mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DBT mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DBT mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DBT mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of DBT mRNA26217789
C483909torcetrapibtorcetrapib results in increased expression of DBT mRNA23228038
D014415TunicamycinTunicamycin results in increased expression of DBT mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of DBT mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DBT mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of DBT gene29154799
D014640VancomycinVancomycin results in increased expression of DBT mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DBT gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of DBT mRNA26682919
D015032ZincZinc deficiency results in increased expression of DBT mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016407acetyltransferase activity-IBA21873635  
GO:0031405lipoic acid binding-IBA21873635  
GO:0031625ubiquitin protein ligase binding-IPI19725078  
GO:0043754dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006637acyl-CoA metabolic process-IBA21873635  
GO:0008152metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0005947mitochondrial alpha-ketoglutarate dehydrogenase complex-TAS1429740  
GO:0042645mitochondrial nucleoid-IDA18063578  
KEGG ID KEGG Term
hsa00280Valine, leucine and isoleucine degradation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-389661Glyoxylate metabolism and glycine degradationTAS
R-HSA-70895Branched-chain amino acid catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2818751Vagal neuropathy in chronic alcoholics: relation to ethanol consumption. (1989)Villalta JAlcohol Alcohol
23520400Association of placenta organotin concentrations with congenital cryptorchidism and reproductive hormone levels in 280 newborn boys from Denmark and Finland. (2013 Jun)Rantakokko PHum Reprod