Gene: LGI4

163175
AMCNMY|LGIL3
leucine rich repeat LGI family member 4
protein-coding
19q13.12|19q13.11
Ensembl:ENSG00000153902 MIM:608303 Vega:OTTHUMG00000044558 UniprotKB:Q8N135
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.351e-1 (AD)  2.724e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEMA4B0.868
CLU0.85
BCAT20.847
LRRC8A0.843
ACADVL0.843
CD810.841
UNG0.822
WFS10.821
PC0.816
GPT20.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.617
OR4F29-0.595
FER1L6-0.404
CETP-0.396
SCARA5-0.394
GADL1-0.365
TSHR-0.344
IBSP-0.335
GALR1-0.325
WDR72-0.325

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of LGI4 mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LGI4 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LGI4 mRNA"23196670
D000082AcetaminophenAcetaminophen results in increased expression of LGI4 mRNA22230336|2906747
C000188alachloralachlor affects the expression of LGI4 mRNA19425180
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of LGI4 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LGI4 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of LGI4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LGI4 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of LGI4 mRNA26079696
D004041Dietary FatsDietary Fats results in decreased expression of LGI4 mRNA25016146
C039281furanfuran results in increased methylation of LGI4 gene22079235
D017313FenretinideFenretinide results in decreased expression of LGI4 mRNA28973697
D007649KetamineKetamine results in increased expression of LGI4 mRNA20080153
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LGI4 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LGI4 mRNA"25554681
D009532NickelNickel results in decreased expression of LGI4 mRNA25583101
C464660obeticholic acidobeticholic acid results in increased expression of LGI4 mRNA27939613
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LGI4 mRNA19710929
D028321Plant PreparationsPlant Preparations results in decreased expression of LGI4 mRNA26945725
D011192Potassium DichromatePotassium Dichromate results in increased expression of LGI4 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of LGI4 mRNA24780913
D012834SilverSilver results in increased expression of LGI4 mRNA27131904
D012999SomanSoman results in increased expression of LGI4 mRNA19281266
D014284TriiodothyronineTriiodothyronine results in increased expression of LGI4 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LGI4 mRNA24680724
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LGI4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0008344adult locomotory behavior-IEA-  
GO:0014009glial cell proliferation-IEA-  
GO:0022011myelination in peripheral nervous system-IEA-  
GO:0031641regulation of myelination-IMP28318499  
GO:0042551neuron maturation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-5682910LGI-ADAM interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27814717Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations. (2016 Nov 5)Busch RRespir Res