Gene: ACE

1636
ACE1|CD143|DCP|DCP1
angiotensin I converting enzyme
protein-coding
17q23.3
Ensembl:ENSG00000159640 MIM:106180 Vega:OTTHUMG00000154927 UniprotKB:P12821
NG_011648.1
PubMed
CD|OD|ND|AD
522   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.520e-1 (AD)  2.802e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPHA100.812
RASGRP20.795
RNF1230.794
CAND20.794
SPTB0.794
SLC29A10.791
TRIM170.788
TRANK10.787
TMEM120B0.782
LMO70.781

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.474
YES1-0.462
RAB13-0.457
PMP2-0.45
ROM1-0.445
ZNF114-0.432
PHEX-0.429
BEST3-0.428
MTRNR2L10-0.408
MTRNR2L6-0.407

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00178RamiprilSmall Molecule87333-19-5ApprovedTarget
DB00492FosinoprilSmall Molecule98048-97-6ApprovedTarget
DB00519TrandolaprilSmall Molecule87679-37-6ApprovedTarget
DB00542BenazeprilSmall Molecule86541-75-5Approved|InvestigationalTarget
DB00584EnalaprilSmall Molecule75847-73-3ApprovedTarget
DB00616CandoxatrilSmall Molecule123122-55-4ExperimentalTarget
DB00691MoexiprilSmall Molecule103775-10-6ApprovedTarget
DB00722LisinoprilSmall Molecule76547-98-3Approved|InvestigationalTarget
DB00790PerindoprilSmall Molecule82834-16-0ApprovedTarget
DB00881QuinaprilSmall Molecule85441-61-8Approved|InvestigationalTarget
DB00886OmapatrilatSmall Molecule167305-00-2InvestigationalTarget
DB01180RescinnamineSmall Molecule24815-24-5ApprovedTarget
DB01197CaptoprilSmall Molecule62571-86-2ApprovedTarget
DB01340CilazaprilSmall Molecule88768-40-5ApprovedTarget
DB01348SpiraprilSmall Molecule83647-97-6ApprovedTarget
DB020321-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidSmall MoleculeExperimentalTarget
DB03740N-acetyl-alpha-D-glucosamineSmall Molecule10036-64-3ExperimentalTarget
DB08836TemocaprilSmall Molecule111902-57-9Experimental|InvestigationalTarget
DB09477EnalaprilatSmall Molecule76420-72-9ApprovedTarget
DB13166ZofenoprilSmall Molecule81872-10-8ExperimentalTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in decreased expression of ACE mRNA"19502547
C04678214,15-epoxy-5,8,11-eicosatrienoic acid"14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein"27428043
C5812861,4-bisdesoxyquinocetone"1,4-bisdesoxyquinocetone results in increased expression of ACE mRNA"26296292
C0181001-methylimidazole1-methylimidazole analog results in decreased activity of ACE protein21782455
C0100244-aminophenylmercuriacetate4-aminophenylmercuriacetate results in increased secretion of ACE protein15182369
C006358acetohydroxamic acidacetohydroxamic acid binds to ACE protein2831219
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of ACE mRNA19920212
C412373AG 1879AG 1879 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]15932931
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased methylation of ACE gene"26018793
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of ACE mRNA"26018793
D000450AldosteroneAG 1879 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]15932931
D000450AldosteroneAldosterone results in increased activity of ACE protein15932931
D000450AldosteroneAldosterone results in increased expression of ACE mRNA15932931
D000450Aldosterone"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]"15932931
D000450AldosteroneDactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein]15932931
D000450AldosteroneDactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]15932931
D000450AldosteroneGenistein inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]15932931
D000450AldosteroneSpironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]15932931
D000450AldosteroneSpironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]15932931
D000450Aldosteronetyrphostin AG 1478 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]15932931
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ACE mRNA28522335
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]"15932931
D000535AluminumAluminum results in decreased activity of ACE protein12008977
D000640Amitrole"Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of ACE protein]"25891026
D017311AmlodipineAmlodipine results in decreased expression of ACE mRNA16392774
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ACE mRNA16483693
D000806Angiotensin-Converting Enzyme InhibitorsAngiotensin-Converting Enzyme Inhibitors results in decreased activity of ACE protein15667801
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ACE mRNA24449571
D047310ApigeninApigenin results in decreased activity of ACE protein21782455
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of ACE mRNA18585445
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [epigallocatechin gallate results in decreased activity of ACE protein]28544013
D001241AspirinACE polymorphism affects the susceptibility to Aspirin18727619
D001280AtrazineAtrazine results in increased expression of ACE mRNA25929836|2689195
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of ACE mRNA18585445
C044946benazeprilACE gene polymorphism affects the susceptibility to benazepril11007831|1265232
C044946benazeprilbenazepril results in decreased activity of ACE protein8359184
C044946benazeprilbenazepril results in decreased activity of ACE protein15315341|1636483
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACE mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACE mRNA22610609|2719552
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACE mRNA21839799
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[Butyrates co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the localization of ACE protein mutant form20454656
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[Butyrates co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased activity of ACE protein mutant form20454656
D004958Estradiol[Estradiol co-treated with Testosterone] results in increased expression of ACE mRNA11375906
D001623BetamethasoneBetamethasone results in increased expression of ACE protein19047579
D001629BezafibrateBezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]16979161
D001629BezafibrateBezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE protein]16979161
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [VEGFA protein results in increased expression of ACE protein]11158990
C006780bisphenol Abisphenol A results in increased expression of ACE mRNA27622962
C006780bisphenol Abisphenol A results in decreased methylation of ACE promoter27312807
C006780bisphenol Abisphenol A results in increased expression of ACE mRNA24534842
C006780bisphenol A[bisphenol A co-treated with Fructose] results in increased expression of ACE mRNA27622962
C006780bisphenol Abisphenol A results in decreased expression of ACE mRNA25181051
C032688boric acidboric acid inhibits the reaction [epigallocatechin gallate results in decreased activity of ACE protein]28544013
D000069286Bortezomib[Butyrates co-treated with Bortezomib] results in increased activity of ACE protein mutant form20454656
C040918buteinbutein results in decreased activity of ACE protein21782455
D002087Butyrates[Butyrates co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the localization of ACE protein mutant form20454656
D002087Butyrates[Butyrates co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased activity of ACE protein mutant form20454656
D002087Butyrates[Butyrates co-treated with Bortezomib] results in increased activity of ACE protein mutant form20454656
D002104CadmiumCadmium results in increased expression of ACE mRNA23256528
D019256Cadmium Chloride[nickel chloride co-treated with Cadmium Chloride] results in increased expression of ACE mRNA19187980
C081643candesartancandesartan affects the expression of ACE mRNA18796534
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ACE protein12629582
C043211carvedilolcarvedilol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ACE mRNA]15071347
C043211carvedilolcarvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]18992766
C070295catalase-polyethylene glycol"catalase-polyethylene glycol inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE protein]"25891026
C054518ceronaprilceronapril results in decreased activity of ACE protein1812274
C511403CGS 35601CGS 35601 results in decreased activity of ACE protein16364833
D047188ChalconesChalcones analog results in decreased activity of ACE protein21782455
D002614Chelating AgentsChelating Agents analog results in decreased activity of ACE protein22200082
D002857ChromiumChromium results in decreased activity of ACE protein18374418
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ACE mRNA28472532
D017315CilazaprilACE gene polymorphism affects the susceptibility to Cilazapril15498266
C018021cobaltous chloridecobaltous chloride results in increased expression of ACE mRNA25511041
C018021cobaltous chloridecobaltous chloride results in increased expression of ACE protein25511041
D003042CocaineACE inhibits the reaction [Cocaine affects the abundance of Dinoprostone]14738173
D003042CocaineACE inhibits the reaction [Cocaine affects the abundance of Epoprostenol]14738173
D003078Colchicinecarvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]18992766
D003078ColchicineColchicine results in decreased activity of ACE protein17135773|1898020
D003078ColchicineColchicine results in decreased expression of ACE protein17652827
D003078ColchicineQuercetin inhibits the reaction [Colchicine results in decreased activity of ACE protein]18980205
D003078Colchicineresveratrol inhibits the reaction [Colchicine results in decreased activity of ACE protein]17135773
D003078ColchicineRivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein]17652827
D003345CorticosteroneCorticosterone results in increased expression of ACE mRNA15755911
D016578Crack CocaineCrack Cocaine results in increased activity of ACE protein10372843
D003471CuprizoneCuprizone results in increased expression of ACE mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Paraquat affects the expression of ACE protein]10666014
D003520CyclophosphamideCyclophosphamide results in decreased expression of ACE mRNA27281708
D003609DactinomycinDactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein]15932931
D003609DactinomycinDactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]15932931
D003907DexamethasoneDexamethasone results in increased expression of ACE mRNA22733784
D003907DexamethasoneDexamethasone results in decreased activity of ACE protein1659346|9498404
D003907DexamethasoneDexamethasone results in increased expression of ACE mRNA15932931
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of ACE mRNA]15932931
C503840dieckoldieckol results in decreased activity of ACE protein21556221
D004041Dietary FatsDietary Fats affects the activity of ACE protein27260466
D004041Dietary FatsDietary Fats affects the expression of ACE mRNA27260466
D004041Dietary FatsDietary Fats results in increased expression of ACE mRNA18503570|2501614
D004041Dietary FatsQuercetin affects the reaction [Dietary Fats affects the activity of ACE protein]27260466
D004041Dietary FatsQuercetin affects the reaction [Dietary Fats affects the expression of ACE mRNA]27260466
D004041Dietary Fatsresveratrol affects the reaction [Dietary Fats affects the activity of ACE protein]27260466
D004041Dietary Fatsresveratrol affects the reaction [Dietary Fats affects the expression of ACE mRNA]27260466
D004041Dietary FatsThioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]27260466
D004041Dietary FatsThioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA]27260466
D004041Dietary FatsDietary Fats results in increased expression of ACE mRNA18796534
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACE mRNA18164116
D004317DoxorubicinDoxorubicin affects the activity of ACE protein8303709
D004492Edetic AcidEdetic Acid results in decreased activity of ACE protein28544013
D004492Edetic AcidZinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein]28544013
D004656EnalaprilACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]20829712
D004656EnalaprilACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]20829712
D004656EnalaprilEnalapril results in decreased activity of ACE protein20679179|2897348
D004656EnalaprilEnalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]23733546
D004656EnalaprilEnalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]23733546
D004656EnalaprilEnalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]15728788
D004656EnalaprilEnalapril results in decreased activity of ACE protein15728788|1581641
D004656EnalaprilEnalapril results in increased expression of ACE mRNA15728788
D004656EnalaprilEnalapril inhibits the reaction [ACE protein results in increased degradation of KNG1 protein modified form]2008223
D004656EnalaprilEnalapril inhibits the reaction [ACE protein results in increased degradation of TAC1 protein modified form]2008223
D004656EnalaprilEnalapril results in decreased activity of ACE protein16327016|9175058
D015773EnalaprilatEnalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein]16452552
C045651epigallocatechin gallateAscorbic Acid inhibits the reaction [epigallocatechin gallate results in decreased activity of ACE protein]28544013
C045651epigallocatechin gallateboric acid inhibits the reaction [epigallocatechin gallate results in decreased activity of ACE protein]28544013
C045651epigallocatechin gallateepigallocatechin gallate binds to and results in decreased activity of ACE protein28544013
D004966Estrogens, Conjugated (USP)"Estrogens, Conjugated (USP) results in decreased activity of ACE protein"11345361
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ACE mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACE mRNA17942748
C004912ethylbenzene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ACE gene26018793
C004912ethylbenzene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ACE mRNA26018793
D017316FadrozoleFadrozole results in decreased expression of ACE protein18586661
C017690fenvaleratefenvalerate affects the methylation of ACE gene23548413
D005419FlavonoidsFlavonoids results in decreased expression of ACE mRNA18035473
C007738fluoranthenefluoranthene results in increased expression of ACE mRNA20117838
D005492Folic AcidEnalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]15728788
D005492Folic AcidFolic Acid results in increased expression of ACE mRNA15728788
D017328FosinoprilFosinopril results in decreased activity of ACE protein17337423
D005632Fructose[bisphenol A co-treated with Fructose] results in increased expression of ACE mRNA27622962
D005632FructoseFructose results in increased expression of ACE mRNA17587757
C039281furanfuran results in increased expression of ACE mRNA27387713
C057580gallocatecholgallocatechol results in decreased activity of ACE protein16390204
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of ACE mRNA21782745
D019833GenisteinGenistein inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]15932931
D019833GenisteinGenistein results in increased expression of ACE mRNA21782745
D005947GlucoseEnalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein]16452552
D005947GlucoseGlucose results in increased expression of ACE protein16452552
C058504goralatide[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide20096676
C058504goralatidegoralatide results in decreased expression of ACE mRNA20096676
C058504goralatidegoralatide results in increased expression of ACE mRNA20096676
C412815GW 4064GW 4064 results in increased expression of ACE mRNA26655953
C020754herbimycinherbimycin inhibits the reaction [VEGFA protein results in increased expression of ACE protein]11158990
C010980hippuryl-histidyl-leucineACE protein affects the metabolism of hippuryl-histidyl-leucine15932931
D017313FenretinideFenretinide results in decreased expression of ACE mRNA28973697
D006830HydralazineHydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]16326922
D006834HydrazinesHydrazines results in decreased expression of ACE mRNA21647536
D006852HydrochlorothiazideHydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]16326922
D006852HydrochlorothiazideHydrochlorothiazide results in increased expression of ACE mRNA18796534
D006861Hydrogen Peroxide[GPX1 gene polymorphism co-treated with ACE gene polymorphism] affects the susceptibility to Hydrogen Peroxide20444272
C492448ICG 001ICG 001 inhibits the reaction [AGT protein results in increased expression of ACE protein]28578904
C492448ICG 001ICG 001 inhibits the reaction [AGT protein results in increased expression of ACE protein]28578904
C076966idraprilidrapril results in decreased activity of ACE protein1383623
C076966idraprilidrapril results in decreased activity of ACE protein1383623
C076966idraprilidrapril results in decreased activity of ACE protein1383623
C078006imidaprilatimidaprilat results in decreased activity of ACE protein16406270
D007200IndicanIndican results in increased expression of ACE mRNA25056788
D007213IndomethacinIndomethacin promotes the reaction [VEGFA protein results in increased expression of ACE protein]11158990
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ACE mRNA25613284
D007649KetamineKetamine results in increased expression of ACE mRNA20080153
D007854LeadLead results in increased activity of ACE protein21364929
C008261lead acetatelead acetate affects the expression of ACE mRNA21864555|2264161
D017706LisinoprilLisinopril analog results in decreased activity of ACE protein22200082
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of ACE protein]28578904
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of ACE protein]28578904
D019808LosartanLosartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein]25511041
D047311LuteolinLuteolin results in decreased activity of ACE protein21782455
C054218manidipinemanidipine results in decreased expression of ACE mRNA16392774
C545385MequindoxMequindox affects the expression of ACE mRNA20553828
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of ACE mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of ACE mRNA21782745
D008777MethyltestosteroneMethyltestosterone results in decreased expression of ACE mRNA29191790
D008790MetoprololACE gene polymorphism affects the susceptibility to Metoprolol20819590
C063855microcystin RRmicrocystin RR results in increased expression of ACE mRNA28330766
C063855microcystin RRmicrocystin RR results in increased expression of ACE protein28330766
C059539midostaurinmidostaurin results in decreased expression of ACE mRNA20980353
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of ACE mRNA]15932931
D009151Mustard GasACE gene affects the susceptibility to Mustard Gas18702808
D009151Mustard GasMustard Gas affects the expression of ACE mRNA15651846
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [VEGFA protein results in increased expression of ACE protein]11158990
C003297nandrolone decanoatenandrolone decanoate results in increased expression of ACE mRNA17906098
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ACE protein"21135415
D009525NiacinNiacin results in decreased activity of ACE protein18374418
C022838nickel chloride[nickel chloride co-treated with Cadmium Chloride] results in increased expression of ACE mRNA19187980
C028007nickel monoxidenickel monoxide results in decreased expression of ACE mRNA19167457
D009538NicotineNicotine results in increased expression of ACE mRNA11166759
D009569Nitric OxideHydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]16326922
D009569Nitric OxideHydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]16326922
D009569Nitric OxideNitric Oxide deficiency results in increased expression of ACE mRNA10948087|1632692
D009569Nitric OxideACE protein inhibits the reaction [KNG1 protein results in increased abundance of Nitric Oxide]12672649
C007350nitrofennitrofen results in decreased activity of ACE protein9498404
C106266omapatrilatomapatrilat results in decreased activity of ACE protein11762555
D010100OxygenLosartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein]25511041
D010100OxygenOxygen deficiency results in increased expression of ACE mRNA25511041
D010100OxygenOxygen deficiency results in increased expression of ACE protein25511041
D010269ParaquatParaquat results in decreased activity of ACE protein15297733
D010269ParaquatParaquat results in decreased activity of ACE protein12161173
D010269Paraquatpimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein]12161173
D010269ParaquatCurcumin inhibits the reaction [Paraquat affects the expression of ACE protein]10666014
D010269ParaquatParaquat affects the expression of ACE protein10666014
D010269ParaquatParaquat results in decreased activity of ACE protein16182431
D010269ParaquatParaquat results in decreased expression of ACE mRNA20465954
D010269ParaquatUnithiol inhibits the reaction [Paraquat results in decreased expression of ACE mRNA]20465954
D052638Particulate MatterParticulate Matter results in decreased activity of ACE protein12396869
D052638Particulate MatterParticulate Matter results in decreased expression of ACE mRNA12396869
D020913PerindoprilACE gene polymorphism affects the susceptibility to Perindopril11007831
D015232DinoprostoneACE inhibits the reaction [Cocaine affects the abundance of Dinoprostone]14738173
D010656PhenylephrineACE protein affects the susceptibility to Phenylephrine18431347
C004479pimagedinepimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein]12161173
C060836pioglitazonepioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]16979161
C060836pioglitazonepioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE protein]16979161
C006253pirinixic acidpirinixic acid results in decreased expression of ACE mRNA17426115
D010936Plant ExtractsPlant Extracts results in decreased activity of ACE protein26961486
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ACE mRNA23608068
D044945ProanthocyanidinsProanthocyanidins results in decreased activity of ACE protein16390204
D044945ProanthocyanidinsProanthocyanidins results in decreased activity of ACE protein16390204
D011441PropylthiouracilPropylthiouracil results in decreased expression of ACE mRNA24780913
D015237DinoprostDinoprost results in increased expression of ACE mRNA20484870
D011464EpoprostenolACE inhibits the reaction [Cocaine affects the abundance of Epoprostenol]14738173
D011692Puromycin AminonucleosidePuromycin Aminonucleoside affects the activity of ACE protein1318808
D011720PyrazolesPyrazoles analog results in decreased activity of ACE protein21782455
D011794QuercetinQuercetin affects the reaction [Dietary Fats affects the activity of ACE protein]27260466
D011794QuercetinQuercetin affects the reaction [Dietary Fats affects the expression of ACE mRNA]27260466
D011794QuercetinQuercetin inhibits the reaction [Colchicine results in decreased activity of ACE protein]18980205
D011794QuercetinQuercetin results in increased expression of ACE mRNA18095365
C041125quinaprilquinapril results in decreased activity of ACE protein8227822
C041125quinaprilquinapril results in decreased activity of ACE protein15728788
C502851quinocetonequinocetone results in increased expression of ACE mRNA26296292
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of ACE mRNA15849065
D017257RamiprilRamipril results in decreased activity of ACE protein10543928|3034026
C059514resveratrolresveratrol affects the reaction [Dietary Fats affects the activity of ACE protein]27260466
C059514resveratrolresveratrol affects the reaction [Dietary Fats affects the expression of ACE mRNA]27260466
C059514resveratrolresveratrol inhibits the reaction [Colchicine results in decreased activity of ACE protein]17135773
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]22191573
C059514resveratrolresveratrol results in decreased expression of ACE protein21962734
D000068836RivastigmineRivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein]17652827
D012834SilverSilver results in increased expression of ACE mRNA26277626
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased expression of ACE mRNA]28973481
C017947sodium arseniteHIF1A affects the reaction [sodium arsenite results in increased expression of ACE mRNA]28973481
C017947sodium arsenitesodium arsenite promotes the reaction [[XBP1 protein binds to HIF1A protein] which binds to ACE enhancer]28973481
C017947sodium arsenitesodium arsenite results in increased expression of ACE mRNA28973481
C017947sodium arsenitesodium arsenite results in increased expression of ACE protein28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased expression of ACE mRNA]28973481
C016104sodium bichromatesodium bichromate results in decreased expression of ACE mRNA22561333
D012965Sodium ChlorideACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]20829712
D012965Sodium ChlorideACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]20829712
D017673Sodium Chloride, Dietary"Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of ACE protein]"25891026
D017673Sodium Chloride, Dietary"catalase-polyethylene glycol inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE protein]"25891026
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased expression of ACE"26518973
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased expression of ACE mRNA"18796534
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased expression of ACE protein"25891026
D017673Sodium Chloride, Dietary"Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE]"26518973
D012969Sodium FluorideSodium Fluoride results in decreased expression of ACE protein28918527
D013148SpironolactoneSpironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]15932931
D013148SpironolactoneSpironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]15932931
D013148SpironolactoneSpironolactone results in decreased expression of ACE protein18586661
D013311StreptozocinBezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]16979161
D013311StreptozocinBezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE protein]16979161
D013311StreptozocinEnalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]23733546
D013311StreptozocinEnalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]23733546
D013311Streptozocinpioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]16979161
D013311Streptozocinpioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE protein]16979161
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]22191573
D013311StreptozocinStreptozocin results in increased expression of ACE mRNA15793251|1697916
D013311StreptozocinStreptozocin results in increased expression of ACE protein16979161|2373354
D013311StreptozocinValsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]23733546
D013311StreptozocinValsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein]23733546
D010042OuabainOuabain affects the expression of ACE mRNA16565308
D010042OuabainOuabain affects the expression of ACE protein16565308
D014284TriiodothyronineTriiodothyronine results in increased expression of and results in increased activity of ACE protein1659346
C084178telmisartantelmisartan results in decreased expression of ACE mRNA19171132
C055603temocapril hydrochloridetemocapril hydrochloride results in decreased activity of ACE protein10975594
D013739Testosterone[Estradiol co-treated with Testosterone] results in increased expression of ACE mRNA11375906
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACE mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ACE mRNA19490992
D013755Tetradecanoylphorbol Acetatecarvedilol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ACE mRNA]15071347
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [VEGFA protein results in increased expression of ACE protein]11158990
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of ACE mRNA15071347
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ACE mRNA25613284
D008063Thioctic AcidThioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]27260466
D008063Thioctic AcidThioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA]27260466
D008063Thioctic Acid"Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE]"26518973
D013974ThyroxineThyroxine results in increased expression of ACE mRNA18093424
C009495titanium dioxidetitanium dioxide results in decreased expression of ACE mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of ACE mRNA26277626
D014050Toluene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ACE gene26018793
D014050Toluene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ACE mRNA26018793
D014118Toxins, Biological"Toxins, Biological affects the expression of ACE mRNA"19682533
D014118Toxins, Biological"Toxins, Biological analog results in decreased activity of ACE protein"25010655
C052035trandolapriltrandolapril results in decreased activity of ACE protein27428043
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ACE mRNA"26743178
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]15932931
D014494UnithiolUnithiol inhibits the reaction [Paraquat results in decreased expression of ACE mRNA]20465954
D014635Valproic AcidValproic Acid results in increased methylation of ACE gene29154799
D000068756ValsartanValsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]23733546
D000068756ValsartanValsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein]23733546
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ACE gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of ACE mRNA25423262
C025643vinclozolinvinclozolin affects the expression of ACE mRNA19015723
D014992Xylenes[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ACE gene26018793
D014992Xylenes[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ACE mRNA26018793
C011145zaprinastzaprinast promotes the reaction [VEGFA protein results in increased expression of ACE protein]11158990
D015032ZincZinc results in decreased activity of ACE protein17114810
D019287Zinc SulfateZinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein]28544013

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-IDA15283675  18495113  
GO:0004180carboxypeptidase activity-IEA-  
GO:0008144drug binding-IDA1320019  
GO:0008237metallopeptidase activity-IBA21873635  
GO:0008237metallopeptidase activity-IDA1320019  1668266  2849100  17077303  
GO:0008237metallopeptidase activity-ISS-  
GO:0008237metallopeptidase activity-TAS2554286  
GO:0008238exopeptidase activity-IBA21873635  
GO:0008238exopeptidase activity-IDA2983326  
GO:0008239dipeptidyl-peptidase activity-IBA21873635  
GO:0008240tripeptidyl-peptidase activity-IDA2983326  
GO:0008241peptidyl-dipeptidase activity-IBA21873635  
GO:0008241peptidyl-dipeptidase activity-IDA1320019  1668266  1851160  2849100  6208535  7683654  
7876104  15283675  17077303  19773553  
GO:0008241peptidyl-dipeptidase activity-ISS11303049  
GO:0008241peptidyl-dipeptidase activity-TAS2554286  
GO:0008270zinc ion binding-IDA12540854  
GO:0031404chloride ion binding-IDA12540854  
GO:0031434mitogen-activated protein kinase kinase binding-IPI14615289  
GO:0031711bradykinin receptor binding-IPI17077303  
GO:0051019mitogen-activated protein kinase binding-IPI14615289  
GO:0070573metallodipeptidase activity-EXP1848554  1851160  2846041  20011602  
GO ID GO Term Qualifier Evidence PubMed
GO:0001822kidney development-IMP16116425  
GO:0001974blood vessel remodeling-IC1668266  
GO:0002003angiotensin maturation-IC1668266  
GO:0002003angiotensin maturation-TAS-  
GO:0002019regulation of renal output by angiotensin-IC1668266  
GO:0002446neutrophil mediated immunity-ISS-  
GO:0002474antigen processing and presentation of peptide antigen via MHC class I-TAS23257181  
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin-IBA21873635  
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin-IC1668266  
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin-IMP174834  
GO:0003084positive regulation of systemic arterial blood pressure-IBA21873635  
GO:0006508proteolysis-TAS2554286  
GO:0007283spermatogenesis-ISS-  
GO:0008217regulation of blood pressure-ISS11303049  
GO:0014910regulation of smooth muscle cell migration-ISS-  
GO:0019229regulation of vasoconstriction-IC1668266  
GO:0032943mononuclear cell proliferation-IC7876104  
GO:0042447hormone catabolic process-IDA7876104  
GO:0042447hormone catabolic process-ISS11303049  
GO:0043171peptide catabolic process-IDA4322742  15283675  
GO:0045777positive regulation of blood pressure-IBA21873635  
GO:0050435amyloid-beta metabolic process-IDA18495113  19773553  
GO:0050482arachidonic acid secretion-IDA17077303  
GO:0060047heart contraction-ISS-  
GO:0060177regulation of angiotensin metabolic process-IDA1851160  
GO:0060218hematopoietic stem cell differentiation-IC7876104  
GO:0061098positive regulation of protein tyrosine kinase activity-ISS-  
GO:0071838cell proliferation in bone marrow-ISS-  
GO:0097746regulation of blood vessel diameter-IC4322742  
GO:1900086positive regulation of peptidyl-tyrosine autophosphorylation-ISS-  
GO:1902033regulation of hematopoietic stem cell proliferation-IC7876104  
GO:1902033regulation of hematopoietic stem cell proliferation-ISS-  
GO:1903597negative regulation of gap junction assembly-ISS-  
GO:2000170positive regulation of peptidyl-cysteine S-nitrosylation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA1668266  4322742  15283675  
GO:0005764lysosome-IDA11076943  
GO:0005768endosome-IDA17077303  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA17077303  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IDA9449382  
GO:0016021integral component of membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0070062extracellular exosome-IDA15326289  21082674  
KEGG ID KEGG Term
hsa04614Renin-angiotensin system
hsa05142Chagas disease (American trypanosomiasis)
hsa05410Hypertrophic cardiomyopathy (HCM)
Reactome ID Reactome Term Evidence
R-HSA-2022377Metabolism of Angiotensinogen to AngiotensinsTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27188349[Influences of genetic and environmental factors on smoking related behaviors among male twin adults in China]. (2016 May)Bao ZQZhonghua Liu Xing Bing Xue Za Zhi
15799209Treatment of microalbuminuria in patients with type 2 diabetes mellitus. (2002)Jerums GTreat Endocrinol
14632699Peripheral vascular disease in Type 2 diabetic Chinese patients: associations with metabolic indices, concomitant vascular disease and genetic factors. (2003 Dec)Thomas GNDiabet Med
12436155Cost-effectiveness of hypertension treatment: a population-based study. (2002 Jul 4)Dias da Costa JSSao Paulo Med J
14504631Association of the angiotensin-converting enzyme (ACE) gene G2350A dimorphism with essential hypertension. (2003 Oct)Saeed Mahmood MJ Hum Hypertens
14504630Relation between the angiotensin-converting enzyme insertion/deletion polymorphism and blood pressure in Japanese male subjects. (2003 Oct)Todoroki MJ Hum Hypertens
28086795Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study. (2017 Jan 13)Fawzy MSBMC Cardiovasc Disord
12669270No association between the angiotensin-converting-enzyme gene insertion/deletion polymorphism and the occurrence of macroangiopathy in patients with diabetes mellitus type 2. (2003 Jan)Klemm THorm Metab Res
16720024How well does the metabolic syndrome defined by five definitions predict incident diabetes and incident coronary heart disease in a Chinese population? (2007 May)Wang JJAtherosclerosis
18177592Intensified inhibition of renin-angiotensin system: a way to improve renal protection? (2007 Nov)Cravedi PCurr Hypertens Rep
28028641The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients. (2017 Apr)Nadalin SJ Neural Transm (Vienna)
16136003Association of ACE polymorphisms with left ventricular hypertrophy. (2005 Aug)Saeed MNeuro Endocrinol Lett
6287548Angiotensin-converting enzyme in serum and in bronchoalveolar lavage in sarcoidosis. (1982)Gupta RGRespiration
15580058The paradoxical association of common polymorphisms of the renin-angiotensin system genes with risk of myocardial infarction. (2004 Dec)Andrikopoulos GKEur J Cardiovasc Prev Rehabil
8573991ACE inhibitors. Differential use in elderly patients with hypertension. (1995 Nov)Israili ZHDrugs Aging
17488145Approaches to prevention of cardiovascular complications and events in diabetes mellitus. (2007)Coccheri SDrugs
25900675Psychosocial complexity in multimorbidity: the legacy of adverse childhood experiences. (2015 Jun)Sinnott CFam Pract
20673306Cellulite, smoking and angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism. (2011 Sep)Stavroulaki AJ Eur Acad Dermatol Venereol
23661462The insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary disease. (2013 Apr 25)Simsek SGenet Mol Res
8729589Risk factor management: the cardiologist's perspective. (1996 Jan)Jackson GBr J Clin Pract Suppl
29080551The dexamethasone corticotropin releasing hormone test in healthy and depressed women with and without childhood adversity. (2018 Jan)Spitzer CPsychoneuroendocrinology
19160880How to prevent progression to end stage renal disease. (2007 Jul-Sep)Riegersperger MJ Ren Care
17060115Factors influencing the decision to start drug treatment in hypertension. A questionnaire study comparing general practitioners and hypertension specialists in Denmark. (2006)Lynggaard MDBlood Press
9918518Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke. (1999 Jan 26)Zee RYCirculation
26597211Statins are independently associated with increased HbA1c in type 1 diabetes--The Thousand & 1 Study. (2016 Jan)Jensen MTDiabetes Res Clin Pract
17584560Sexual function, satisfaction, and association of erectile dysfunction with cardiovascular disease and risk factors in cardiovascular high-risk patients: substudy of the ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNT Study in ACE-INtolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND). (2007 Jul)Bohm MAm Heart J
12235735[Treatment of hypertension in type 2 diabetes mellitus--2002 update]. (2002 Aug)Teuscher AUTher Umsch
18385968Brain renin angiotensin in disease. (2008 Jun)Phillips MIJ Mol Med (Berl)
11712826Conditional risk factors in men with previous myocardial infarction: relevance of C3 and homocysteine. (2001 Oct)Muscari AActa Cardiol
12197410[The role of infection and inflammation in the pathogenesis of atherosclerosis]. (2002 Jul)Jaber JVnitr Lek
15957667Assessing alcohol misuse during pregnancy: evaluating psychometric properties of the CAGE, T-ACE and TWEAK in a Brazilian setting. (2005 Mar)Moraes CLJ Stud Alcohol
25587456The drop that spilled the cup: acute myocardial infarction in a young woman with underlying thrombophilic polymorphisms and oral contraceptive use. (2014)Russo NCase Rep Cardiol
26023569Association of Angiotensin converting enzyme gene insertion / deletion polymorphism with risk of ischemic heart disease in a population of smokers in southern India. (2015 Apr)Metta SJ Clin Diagn Res
14693977Physician, organizational, and patient factors associated with suboptimal blood pressure management in type 2 diabetic patients in primary care. (2004 Jan)Schaars CFDiabetes Care
17537156Angiotensin-converting enzyme gene polymorphism and stroke in type 2 diabetic patients in Taiwan. (2007 Jun)Tseng CHEur J Clin Invest
24886026National household survey of adverse childhood experiences and their relationship with resilience to health-harming behaviors in England. (2014 May 2)Bellis MABMC Med
12015366ACE gene and physical activity, blood pressure, and hypertension: a population study in Finland. (2002 Jun)Fuentes RMJ Appl Physiol (1985)
21731804Effect of gender difference in management of heart failure patients in aseer, saudi arabia. (2011 Jan)Assiri ASHeart Views
10090349Blood pressure and the risk of complex arrhythmia in renal insufficiency, hemodialysis, and renal transplant patients. (1999 Feb)de Lima JJAm J Hypertens
28119386Survival prospects after acute myocardial infarction in the UK: a matched cohort study 1987-2011. (2017 Jan 24)Gitsels LABMJ Open
10676718ACE gene polymorphism and survival in atherosclerotic renovascular disease. (2000 Feb)Losito AAm J Kidney Dis
17851834Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with increased risk for oral cancer. (2007)Vairaktaris EActa Oncol
10446079Angiotensin-converting enzyme gene polymorphism and carotid wall thickening in a community population. (1999 Aug)Hung JArterioscler Thromb Vasc Biol
14521778[A cross-sectional study on angiotensin-converting enzyme and angiotensin II type I receptor gene polymorphism and cerebral infarction]. (2003 Sep)Yuan XDZhonghua Liu Xing Bing Xue Za Zhi
16036530Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study. (2005 Jun)Rothenbacher DScand J Gastroenterol
16131852Consistency of reported alcohol use by pregnant women: anonymous versus confidential questionnaires with item nonresponse differences. (2005 Aug)Alvik AAlcohol Clin Exp Res
28975444Economic Hardship in Childhood: A Neglected Issue in ACE Studies? (2018 Mar)Braveman PMatern Child Health J
9385011Primary care: detection of women with alcohol use disorders. (1997 Mar-Apr)Chang GHarv Rev Psychiatry
27965002Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study. (2017 Jan)Lennox BRLancet Psychiatry
8986941Benefit versus risk of calcium antagonists in hypertensive patients with concomitant risk factors. (1996 Nov)Mancia GJ Hypertens Suppl
16545650Cardioprotective medication is associated with improved survival in patients with peripheral arterial disease. (2006 Mar 21)Feringa HHJ Am Coll Cardiol
15151261The Diamant Alpin Dialysis cohort study: clinico-biological characteristics and cardiovascular genetic risk profile of incident patients. (2004 Jan-Feb)Pernod GJ Nephrol
20464670Secondary medical prevention in patients with peripheral arterial disease - prescriptions of vascular surgeons and medical doctors (angiologists) in a multidisciplinary vascular centre. (2010 May)Klein-Weigel PFVasa
6282229Elevation of serum angiotensin-converting enzyme level. Occurrence in alcoholic liver disease. (1982 May)Borowsky SAArch Intern Med
20356378Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters. (2010 Mar 31)Wang TRespir Res
23669275Residential proximity to major roadways and renal function. (2013 Aug)Lue SHJ Epidemiol Community Health
8583482ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group. (1995 Nov)Ramsay LEJ Hum Hypertens
6099452[Cigarette smoking and lung metabolism--effect of cigarette smoke exposure on blood levels of histamine, serotonin and ACE activity in guinea pigs]. (1984 Nov)Kitamura SNihon Kyobu Shikkan Gakkai Zasshi
16497685Treatment benefit by perindopril in patients with stable coronary artery disease at different levels of risk. (2006 Apr)Deckers JWEur Heart J
264612299mTc-DTPA clearance measured by a dual head gamma camera in healthy subjects and patients with sarcoidosis. Studies of reproducibility and relation to bronchoalveolar lavage findings. (1989)Thunberg SEur J Nucl Med
17496526Reducing the risks of cardiovascular disease in liver allograft recipients. (2007 May 15)Mells GTransplantation
23801948Acetaldehyde and parkinsonism: role of CYP450 2E1. (2013)Vaglini FFront Behav Neurosci
21984781The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy. (2012 Mar)Kolakovic AJ Renin Angiotensin Aldosterone Syst
11712769The vascular biology of hypertension and atherosclerosis and intervention with calcium antagonists and angiotensin-converting enzyme inhibitors. (2001 Nov)Pepine CJClin Cardiol
19681467[Primary prevention of cardiovascular disease]. (2009 Feb)Katic TActa Med Croatica
15076189Smoking-dependent effects of the angiotensin-converting enzyme gene insertion/deletion polymorphism on blood pressure. (2004 Feb)Schut AFJ Hypertens
17921816The M235T polymorphism in the angiotensinogen gene is associated with the risk of malignant hypertension in white patients. (2007 Nov)van den Born BJJ Hypertens
12532688[Pulse wave velocity and urinary albumin excretion in hypertensive patients treated with perindopril]. (2002)Toblli JEMedicina (B Aires)
12023681Angiotensin-converting enzyme I/D polymorphism and hypertension: the Ohasama study. (2002 Jun)Matsubara MJ Hypertens
16878429Effects of pentoxifylline on the urinary protein excretion profile of type 2 diabetic patients with microproteinuria: a double-blind, placebo-controlled randomized trial. (2006 Jul)Rodriguez-Moran MClin Nephrol
16704688Angiotensin-converting enzyme insertion/deletion polymorphism and retinal artery occlusion. (2006 Jun)Schafer EActa Ophthalmol Scand
28058974Smoking has no impact on survival and it is not associated with ACE gene I/D polymorphism in hemodialysis patients. (2017 Jan)Kiss IJ Renin Angiotensin Aldosterone Syst
10347327Quality of care for patients hospitalized with heart failure at academic medical centers. (1999 Jun)Nohria AAm Heart J
27449778The Relationship of Adverse Childhood Events to Smoking, Overweight, Obesity and Binge Drinking Among Women in Hawaii. (2017 Feb)Remigio-Baker RAMatern Child Health J
23757433Copeptin, a surrogate marker for arginine vasopressin, is associated with cardiovascular and all-cause mortality in patients with type 2 diabetes (ZODIAC-31). (2013 Oct)Riphagen IJDiabetes Care
16032613Changes in cardiac troponin T measurements are associated with adverse cardiac events in patients with chronic kidney disease. (2005 Jul)Han JHAm J Emerg Med
19590915[Can we influence the progression of chronic kidney disease?]. (2009 Jul)Kuhlmann UUrologe A
9922719Intima-media thickness of carotid arteries in borderline hypertensives. (1999 Jan)Pit'ha JJ Neuroimaging
18609530The effect of hemoglobin level on arteriovenous fistula survival in Iranian hemodialysis patients. (2008 Apr-Jun)Khavanin Zadeh MJ Vasc Access
27386953Prioritization of treatments for lower extremity peripheral artery disease in low- and middle-income countries. (2017 Jun)Fowkes FGInt Angiol
10404692Retinopathy is independently related to microalbuminuria in type 2 diabetes mellitus. (1999 Jun)Wirta OClin Nephrol
22371744Risk factor control and adherence to treatment in patients with coronary heart disease in the Republic of Srpska, Bosnia and Herzegovina in 2005-2006. (2010 Apr 30)Vulic DArch Med Sci
12356632Angiotensin-converting enzyme genotype modulates pulmonary function and exercise capacity in treated patients with congestive stable heart failure. (2002 Oct 1)Abraham MRCirculation
16138565Association of angiotensin converting enzyme gene polymorphisms with left ventricular hypertrophy. (2005 Apr)Saeed MHypertens Res
15875760The link between angiotensin-converting enzyme genotype and pulmonary artery pressure in patients with COPD. (2005 Mar)Tkacova RWien Klin Wochenschr
11416476Diagnosis and Treatment of Systolic Heart Failure in the Elderly. (1998 Nov)Frishman WHAm J Geriatr Cardiol
22144991Angiotensin-converting enzyme genotype and peripheral arterial disease in diabetic patients. (2012)Tseng CHExp Diabetes Res
10215283Cardiovascular risk factors, angiotensin-converting enzyme gene I/D polymorphism, and left ventricular mass in systemic hypertension. (1999 Apr 15)Celentano AAm J Cardiol
15719338Deprivation and dialysis: pathways to kidney failure in Australian Aborigines. (2005 Jan)Thomas MAdv Chronic Kidney Dis
15456327Slowing the progression of adult chronic kidney disease: therapeutic advances. (2004)Taal MWDrugs
11256540Additional beneficial effects of canrenoate in patients with anterior myocardial infarction on ACE-inhibitor treatment. A pilot study. (2001 Feb)Di Pasquale PItal Heart J
9112017Predictors of the progression of diabetic nephropathy and the beneficial effect of angiotensin-converting enzyme inhibitors in NIDDM patients. (1997 Apr)Yokoyama HDiabetologia
10423115Is cancer related to hypertension or to its treatment? (1999 Jul-Aug)Lever AFClin Exp Hypertens
15213845Impaired fibrinolysis in retinal vein occlusion: a role for genetic determinants of PAI-1 levels. (2004 Jul)Gori AMThromb Haemost
22456784The Alu polymorphism of angiotensin I converting enzyme (ACE) and atherosclerosis, incident chronic diseases and mortality in an elderly Chinese population. (2012 Mar)Woo JJ Nutr Health Aging
6092123Serum angiotensin converting enzyme (ACE) in silicosis. (1984 Oct)Bucca CEur J Respir Dis
11802972[Insertion/deletion polymorphsim of the angiotensin I converting enzyme gene and pulmonary thromboembolism in Chinese population]. (2001 May)Lu YZhonghua Jie He He Hu Xi Za Zhi
15470338Angiotensin-converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass. (2004 Oct)Pretorius MClin Pharmacol Ther
24008986Rapid lung function decline in smokers is a risk factor for COPD and is attenuated by angiotensin-converting enzyme inhibitor use. (2014 Apr)Petersen HChest
12891272[Polymorphic markers I/D and G7831A of angiotensin-I-converting enzyme gene and left ventricular hypertrophy in patients with essential hypertension]. (2003)Brazhnik VAKardiologiia
7970076[Alcoholism and pregnancy]. (1994 Jul-Aug)Bellati UMinerva Ginecol
22193380Peripheral arterial disease and abdominal aortic aneurysm in elderly people. (2011 Dec)Aronow WSMinerva Med
16398206[Management of acute transmural myocardial infarction: a study on 200 patients admitted to a tertiary care medical center]. (2005 Jan-Mar)Kassab RJ Med Liban
11587159Differential effects of ACE-inhibition and angiotensin II antagonism on fibrinolysis and insulin sensitivity in hypertensive postmenopausal women. (2001 Sep)Fogari RAm J Hypertens
25223563An FDA overview of rodent carcinogenicity studies of angiotensin II AT-1 receptor blockers: pulmonary adenomas and carcinomas. (2014 Nov)Link WTRegul Toxicol Pharmacol
26687160Insertion/Insertion Genotype of Angiotensin I-Converting-Enzyme Gene Predicts Risk of Myocardial Infarction in North East India. (2016 Apr)Baruah SBiochem Genet
22776130Polymorphism of angiotensin I-converting enzyme gene is related to oral cancer and lymph node metastasis in male betel quid chewers. (2012 Dec)Liu YTOral Oncol
16679861Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association: the Hisayama Study. (2006 Jun)Arima HEur J Cancer Prev
15601400Antecedents of renal disease in Aborigines. (2004 Dec)Thomas MNephrology (Carlton)
11410114Lisinopril improves endothelial function in chronic cigarette smokers. (2001 Jul)Butler RClin Sci (Lond)
11210166Statistical analysis of geographical features of lung cancer mortality in Japan. (2000 Dec)Kawasaki HJpn J Clin Oncol
9669791Alcohol screening questionnaires in women: a critical review. (1998 Jul 8)Bradley KAJAMA
12511525Angiotensinogen 235T allele "dosage" is associated with blood pressure phenotypes. (2003 Jan)Pereira ACHypertension
27865662Sex differences in acute myocardial infarction: Is it only the age? (2017 Mar 15)Valero-Masa MJInt J Cardiol
12204015Angiotensin-converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardiomyopathy. (2002 Sep 3)Fernandez-Sola JAnn Intern Med
22254198Pathogenesis of aortic stenosis: not just a matter of wear and tear. (2011)Sverdlov ALAm J Cardiovasc Dis
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