Gene: CITED4

163732
-
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
protein-coding
1p34.2|1p35-p34
Ensembl:ENSG00000179862 MIM:606815 Vega:OTTHUMG00000007728 UniprotKB:Q96RK1
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.630e-1 (AD)  4.089e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MESP10.838
CALY0.812
TRAPPC50.812
H1FX0.81
RPRML0.804
ZNF4140.795
TMEM1600.79
UBALD10.781
TGFBR3L0.779
COMTD10.779

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.438
KIAA0754-0.411
RAI14-0.405
OR4F29-0.393
FHL5-0.353
DISC1-0.347
REST-0.345
NEK7-0.342
PABPC4L-0.341
CTNNA3-0.336

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CITED4 protein20106945
D000447AldehydesAldehydes results in increased expression of CITED4 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CITED4 mRNA16483693
D001280AtrazineAtrazine results in increased expression of CITED4 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CITED4 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CITED4 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CITED4 mRNA21839799
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CITED4 mRNA25566086
D004958EstradiolEstradiol affects the expression of CITED4 mRNA22574217
C006780bisphenol Abisphenol A results in increased methylation of CITED4 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of CITED4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CITED4 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of CITED4 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of CITED4 mRNA26191083
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CITED4 mRNA20938992
D003042CocaineCocaine results in decreased expression of CITED4 mRNA27899881
D019327Copper SulfateCopper Sulfate results in decreased expression of CITED4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CITED4 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CITED4 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of CITED4 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CITED4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CITED4 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of CITED4 mRNA21852083
C014476diethyl maleatediethyl maleate results in decreased expression of CITED4 mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CITED4 mRNA21527772
D002117CalcitriolCalcitriol results in increased expression of CITED4 mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CITED4 mRNA"22485181
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CITED4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CITED4 mRNA15834898|1735126
C082360fipronilfipronil results in decreased expression of CITED4 mRNA23962444
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CITED4 mRNA20938992
D004397FonofosFonofos results in increased methylation of CITED4 promoter22847954
C004312glycidolglycidol results in decreased expression of CITED4 mRNA24915197
D017313FenretinideFenretinide results in increased expression of CITED4 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CITED4 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CITED4 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CITED4 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of CITED4 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CITED4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CITED4 mRNA23086925
D008558MelphalanMelphalan results in increased expression of CITED4 mRNA22363485
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of CITED4 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of CITED4 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CITED4 mRNA20938992
C568376MT19c compoundMT19c compound results in decreased expression of CITED4 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CITED4 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of CITED4 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CITED4 mRNA25729387
D010278ParathionParathion results in increased methylation of CITED4 promoter22847954
C046012pentanalpentanal results in increased expression of CITED4 mRNA26079696
D011374ProgesteroneProgesterone results in increased expression of CITED4 mRNA22238285
C005556propionaldehydepropionaldehyde results in increased expression of CITED4 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of CITED4 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CITED4 mRNA21427059
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of CITED4 mRNA19564919
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CITED4 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of CITED4 mRNA21795629
D018038Sodium SeleniteSodium Selenite results in increased expression of CITED4 mRNA18175754
C012568terbufosterbufos results in increased methylation of CITED4 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CITED4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CITED4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CITED4 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CITED4 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CITED4 mRNA22363418
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of CITED4 mRNA25729387
D019772TopotecanTopotecan affects the expression of CITED4 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CITED4 gene27618143
C057693troglitazonetroglitazone results in decreased expression of CITED4 mRNA19140230
D014520UrethaneUrethane results in decreased expression of CITED4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CITED4 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of CITED4 mRNA20546886|2142705

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0032502developmental process-IBA21873635  
GO:0043627response to estrogen-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8866907Activation of the TFAP2 (AP-2) family of transcription factorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29540343Genome-Wide DNA Methylation in Prediagnostic Blood and Bladder Cancer Risk in the Women's Health Initiative. (2018 Jun)Jordahl KMCancer Epidemiol Biomarkers Prev