Gene: DCT

1638
TRP-2|TYRP2
dopachrome tautomerase
protein-coding
13q32.1
Ensembl:ENSG00000080166 MIM:191275 Vega:OTTHUMG00000017206 UniprotKB:P40126
NC_000013.11
PubMed
0   ANCO-SNPs
ND|AD
1   
4.468e-1 (AD)  7.889e-1 (ND)   (Frontal_Cortex)
8.653e-1 (AD)  3.733e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IREB20.714
ZNF7360.711
RNPC30.703
COG50.702
L2HGDH0.7
TBC1D320.695
ACADSB0.692
DOPEY10.692
DOCK40.691
AKAP100.689

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRB1-0.327
MTRNR2L6-0.324
KLRK1-0.311
MTRNR2L10-0.298
GNG8-0.297
KRT72-0.296
GZMK-0.292
CD2-0.288
TBX21-0.287
FMO3-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of DCT mRNA"22698814|2890350
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DCT mRNA"25614096
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased expression of DCT mRNA]28601556
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of DCT protein]"21816215
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of DCT protein]"21816215
C0306925,6-dihydroxy-2-indolylcarboxylic acid"DCT gene mutant form results in decreased abundance of 5,6-dihydroxy-2-indolylcarboxylic acid"11277491
D000082AcetaminophenAcetaminophen results in increased expression of DCT mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of DCT mRNA17562736
D000117AcetylglucosamineAcetylglucosamine results in increased expression of DCT mRNA18047607
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DCT gene27153756
C011164amentoflavoneamentoflavone analog results in decreased expression of DCT mRNA17473463
C011164amentoflavoneamentoflavone analog results in decreased expression of DCT protein17473463
D016718Arachidonic AcidArachidonic Acid results in decreased expression of DCT mRNA16623957
C047721artemisic acidartemisic acid results in decreased expression of DCT mRNA23063590
C010038azelaic acidazelaic acid results in decreased expression of DCT protein20804622
C010038azelaic acid[Taurine co-treated with azelaic acid] results in decreased expression of DCT protein20804622
D001507BeclomethasoneBeclomethasone results in increased expression of DCT mRNA23656298
C012768benzanthronebenzanthrone results in increased expression of DCT protein28029781
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased methylation of DCT promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DCT mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DCT mRNA27195522
C006780bisphenol Abisphenol A results in decreased expression of DCT mRNA25181051
D002110CaffeineCaffeine results in decreased expression of DCT mRNA23774253
D002110CaffeineCaffeine results in increased expression of DCT mRNA18444173
D002185Cannabidiol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased expression of DCT mRNA]28601556
D002185CannabidiolCannabidiol results in increased expression of DCT mRNA28601556
D002185CannabidiolCannabidiol results in increased expression of DCT protein28601556
D002185CannabidiolSB 203580 inhibits the reaction [Cannabidiol results in increased expression of DCT mRNA]28601556
D002220CarbamazepineCarbamazepine results in decreased expression of DCT mRNA23774253
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DCT mRNA27339419
D002922CiguatoxinsCiguatoxins affects the expression of DCT mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of DCT mRNA17585979
D005576ColforsinColforsin results in increased expression of DCT mRNA28601556
D005576ColforsinColforsin results in increased expression of DCT protein17460731|2860155
C029892cupric chloridecupric chloride results in decreased expression of DCT mRNA21072851
D003471CuprizoneCuprizone results in increased expression of DCT mRNA27523638
C093628cyproconazolecyproconazole affects the expression of DCT mRNA21621602
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of DCT mRNA24317228
D016190CarboplatinDCT protein results in decreased susceptibility to Carboplatin15897911
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of DCT mRNA28962523
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of DCT mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of DCT mRNA22609946|2501614
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of DCT mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of DCT mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of DCT mRNA]17942915
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of DCT mRNA26924002
D004237DiuronDiuron results in decreased expression of DCT mRNA21551480
D004317DoxorubicinDoxorubicin affects the expression of DCT mRNA15205334
D004365Drugs, Chinese Herbal"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of DCT protein]"21816215
D004365Drugs, Chinese Herbal"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of DCT protein]"21816215
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of DCT protein"21816215
D004642EmodinEmodin results in decreased expression of DCT mRNA26972667
D004642EmodinEmodin results in decreased expression of DCT protein26972667
C034096ethoxyacetic acidethoxyacetic acid affects the expression of DCT mRNA21621602
D005047EtoposideDCT protein affects the susceptibility to Etoposide16217747
C041877eumelaninDCT gene mutant form results in decreased abundance of eumelanin16584806
D005472FluorouracilFluorouracil affects the expression of DCT mRNA15205334
C061365flusilazoleflusilazole affects the expression of DCT mRNA21621602
D019833GenisteinGenistein results in decreased expression of DCT mRNA16705744|1844417
C004312glycidolglycidol results in increased expression of DCT mRNA24915197
D007545IsoproterenolIsoproterenol results in increased expression of DCT mRNA20003209
C011890kojic acidkojic acid results in decreased expression of DCT protein27586645
D007840LatexLatex analog results in decreased expression of DCT mRNA24768652
C013598methoxyacetic acidmethoxyacetic acid affects the expression of DCT mRNA21621602
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DCT mRNA26011545
D016685MitomycinDCT protein affects the susceptibility to Mitomycin16217747
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DCT mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DCT mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DCT mRNA"25620056
D009532NickelNickel results in decreased expression of DCT mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of DCT mRNA16780908
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of DCT mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of DCT mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of DCT mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of DCT mRNA19482888
C415326phenoxyacetic acidphenoxyacetic acid affects the expression of DCT mRNA21621602
C018362pheomelaninDCT gene mutant form results in decreased abundance of pheomelanin16584806
C018362pheomelaninDCT gene mutant form results in increased abundance of pheomelanin16584806
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of DCT mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of DCT mRNA20813756|2381119
D010936Plant ExtractsPlant Extracts results in decreased expression of DCT mRNA17473463
D010936Plant ExtractsPlant Extracts results in decreased expression of DCT protein17473463
C045950propiconazolepropiconazole results in decreased expression of DCT mRNA21278054
D011794QuercetinQuercetin affects the expression of DCT protein21290442
D011794QuercetinQuercetin analog inhibits the reaction [POMC protein modified form results in increased expression of DCT protein]26586997
D011794QuercetinQuercetin results in increased expression of DCT protein24318284
C059514resveratrolresveratrol results in decreased expression of DCT protein17460731
C093642SB 203580SB 203580 inhibits the reaction [Cannabidiol results in increased expression of DCT mRNA]28601556
C018145scoparonescoparone results in increased expression of DCT mRNA17049123
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DCT mRNA25895662
C049412swerosidesweroside results in decreased expression of DCT protein26051519
D013629TamoxifenTamoxifen affects the expression of DCT mRNA20937368
D013654Taurine[Taurine co-treated with azelaic acid] results in decreased expression of DCT protein20804622
D013654TaurineTaurine results in decreased expression of DCT protein20804622
C047246temozolomideDCT protein results in decreased susceptibility to temozolomide15897911
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of DCT mRNA]20973933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DCT mRNA20973933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DCT mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DCT mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DCT protein28029781
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of DCT mRNA15892717
D013755Tetradecanoylphorbol Acetatetrichostatin A inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of DCT mRNA]15892717
D013755Tetradecanoylphorbol Acetatetrichostatin A inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of DCT protein]15892717
C009495titanium dioxidetitanium dioxide results in decreased expression of DCT mRNA23557971
D014212TretinoinTretinoin results in decreased expression of DCT mRNA23774253
D014212TretinoinTretinoin results in decreased expression of DCT mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in decreased expression of DCT mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of DCT mRNA15901671
C012589trichostatin Atrichostatin A inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of DCT mRNA]15892717
C012589trichostatin Atrichostatin A inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of DCT protein]15892717
C057693troglitazonetroglitazone results in increased expression of DCT mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of DCT mRNA15901671|2377425
D001335Vehicle EmissionsVehicle Emissions affects the expression of DCT mRNA23940539
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DCT gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004167dopachrome isomerase activity-IBA21873635  
GO:0004167dopachrome isomerase activity-ISS-  
GO:0005507copper ion binding-TAS8206391  
GO:0016491oxidoreductase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002052positive regulation of neuroblast proliferation-IBA21873635  
GO:0002052positive regulation of neuroblast proliferation-IEA-  
GO:0006583melanin biosynthetic process from tyrosine-IBA21873635  
GO:0006583melanin biosynthetic process from tyrosine-ISS-  
GO:0008544epidermis development-TAS8206391  
GO:0021847ventricular zone neuroblast division-IBA21873635  
GO:0021847ventricular zone neuroblast division-IEA-  
GO:0042438melanin biosynthetic process-TAS-  
GO:0048066developmental pigmentation-IBA21873635  
GO:0048066developmental pigmentation-IEA-  
GO:0048468cell development-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-ISS-  
GO:0016021integral component of membrane-IEA-  
GO:0033162melanosome membrane-TAS-  
GO:0042470melanosome-IBA21873635  
GO:0042470melanosome-ISS-  
KEGG ID KEGG Term
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa04916Melanogenesis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-5662702Melanin biosynthesisTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24824616A comprehensive approach to identify reliable reference gene candidates to investigate the link between alcoholism and endocrinology in Sprague-Dawley rats. (2014)Taki FAPLoS One