Gene: DCX

1641
DBCN|DC|LISX|SCLH|XLIS
doublecortin
protein-coding
Xq23
Ensembl:ENSG00000077279 MIM:300121 Vega:OTTHUMG00000022204 UniprotKB:O43602
NG_011750.1
PubMed
0   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGI10.926
ADD20.91
TMEM178B0.909
GRIK20.909
UNC800.908
CACNA1D0.906
SLIT20.904
TMEM132D0.9
GPRASP10.899
NBEA0.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.56
ROM1-0.55
HEY2-0.54
MYL3-0.53
HEBP2-0.529
TGIF1-0.522
SNHG18-0.517
EMP3-0.509
TSPO-0.505
AGTRAP-0.495

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DCX mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DCX mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DCX mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DCX mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DCX mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DCX mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCX mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCX mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCX mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCX mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in decreased expression of DCX protein]"28982980
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCX mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCX mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCX mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCX mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DCX gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DCX mRNA16483693
D001151ArsenicArsenic results in decreased expression of DCX mRNA24019935
C006632arsenic trioxidearsenic trioxide results in increased expression of DCX mRNA20458559
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of DCX protein15255259
C038328BEP protocolBEP protocol results in increased expression of DCX mRNA18987330
C006780bisphenol Abisphenol A affects the expression of DCX mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of DCX mRNA25381574|2596372
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA]25963729
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [Ethanol results in decreased expression of DCX protein]17067360
D002235Carbofuran"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in decreased expression of DCX protein]"28982980
D002235CarbofuranCarbofuran results in decreased expression of DCX mRNA28982980
D002235CarbofuranCarbofuran results in decreased expression of DCX protein22240977|2898298
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCX mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of DCX mRNA26272509
D004390ChlorpyrifosChlorpyrifos results in decreased expression of DCX mRNA23428981
D002998ClonazepamClonazepam results in decreased expression of DCX protein19437554
D003471CuprizoneCuprizone affects the expression of DCX mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA]25963729
D003474CurcuminCurcumin results in increased expression of DCX mRNA25963729
C024629dimethyl phthalatedimethyl phthalate affects the expression of DCX mRNA26924002
D000431EthanolEthanol results in decreased expression of DCX mRNA29018328
D000431EthanolButylated Hydroxytoluene inhibits the reaction [Ethanol results in decreased expression of DCX protein]17067360
D000431EthanolEthanol results in decreased expression of DCX protein17067360
D005013EthosuximideEthosuximide inhibits the reaction [APP protein modified form results in decreased expression of DCX mRNA]26420483
D005013EthosuximideEthosuximide results in increased expression of DCX mRNA26420483
D005472FluorouracilFluorouracil results in decreased expression of DCX protein18702703
D005947GlucoseGlucose results in increased expression of DCX protein23776576
C042720mercuric bromidemercuric bromide results in decreased expression of DCX mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCX mRNA"27188386
D008727MethotrexateMethotrexate results in increased expression of DCX mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DCX mRNA28001369
C025589ochratoxin Aochratoxin A results in decreased expression of DCX mRNA21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of DCX mRNA]21703336
D010126OzoneOzone results in decreased expression of DCX protein19833740
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DCX mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of DCX mRNA26705709
D010634PhenobarbitalPhenobarbital results in decreased expression of DCX protein19437554
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCX mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of DCX mRNA26272509
D011441PropylthiouracilPropylthiouracil results in increased expression of DCX mRNA24780913
C059514resveratrolresveratrol results in increased expression of DCX protein18089832
D019821SimvastatinSimvastatin results in increased expression of DCX18544044
C009277sodium arsenatesodium arsenate affects the expression of DCX protein27751817
D013605T-2 ToxinT-2 Toxin results in increased expression of DCX mRNA26314264
D013792ThalidomideThalidomide results in increased expression of DCX mRNA28892372
D013849ThimerosalThimerosal results in increased expression of DCX mRNA24675092
D014212TretinoinTretinoin results in increased expression of DCX mRNA16012519
C012589trichostatin Atrichostatin A results in increased expression of DCX mRNA24935251
D014415TunicamycinTunicamycin results in decreased expression of DCX mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCX mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of DCX mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of DCX gene29154799
D014635Valproic AcidValproic Acid results in increased expression of DCX mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of DCX mRNA17292431
D015034Zinc OxideZinc Oxide analog results in decreased expression of DCX mRNA27215404
D015034Zinc OxideZinc Oxide analog results in decreased expression of DCX protein27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of DCX protein27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21044950  21516116  24607389  25416956  
GO:0008017microtubule binding-IDA14741102  
GO:0008017microtubule binding-IMP27292316  
GO:0019901protein kinase binding-IPI14741102  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IDA14741102  
GO:0007399nervous system development-TAS9489699  
GO:0007417central nervous system development-TAS9489699  
GO:0035082axoneme assembly-IBA21873635  
GO:0035556intracellular signal transduction-IEA-  
GO:0042461photoreceptor cell development-IBA21873635  
GO:0060041retina development in camera-type eye-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-TAS11001923  
GO:0005874microtubule-IEA-  
GO:0005875microtubule associated complex-TAS11001923  
GO:0005930axoneme-IBA21873635  
GO:0043005neuron projection-IDA14741102  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-447043Neurofascin interactionsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18563059Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice. (2009 Apr)Stevenson JRNeuropsychopharmacology
8961796Effects of cigarette smoking on EEG spectral-band power, dimensional complexity, and nonlinearity during reaction-time task performance. (1996 Nov)Houlihan MEPsychophysiology
20334723Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats. (2010 Jun)Hansson ACInt J Neuropsychopharmacol
24076087Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis. (2013 Dec 19)Briones TLNeuroscience
15926919Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neurons. (2005 May)He JEur J Neurosci