Gene info: ID 1642

Gene: DDB1

GENE ID: 1642

Description: damage specific DNA binding protein 1

Gene type: protein-coding

Location: 11q12.2

dbXrefs: Ensembl:ENSG00000167986 MIM:600045 Vega:OTTHUMG00000168209 UniprotKB:Q16531

RefSeq: NG_032697.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.540e-1 (AD) 8.648e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PIGS	0.945
PFKM	0.945
AP2B1	0.944
VPS39	0.943
KIAA0319L	0.938
PSMD1	0.935
APLP2	0.935
VCP	0.933
TRAP1	0.933
C6orf89	0.933

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.677
OR4F29	-0.623
MTRNR2L6	-0.388
MTRNR2L9	-0.369
KLRK1	-0.341
PPBP	-0.333
MTRNR2L10	-0.328
RAI14	-0.322
FMO3	-0.32
CTNNA3	-0.319

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of DDB1 mRNA"	21346803
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of DDB1 mRNA	21983209
D000082	Acetaminophen	Acetaminophen results in decreased expression of DDB1 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of DDB1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of DDB1 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DDB1 mRNA	16483693
C054672	antimony trichloride	antimony trichloride results in decreased expression of DDB1 mRNA	20509621
C054672	antimony trichloride	antimony trichloride results in decreased expression of DDB1 protein	20509621
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of DDB1 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in increased expression of DDB1 protein	25419056
D017636	Asbestos, Amphibole	"Asbestos, Amphibole affects the expression of DDB1 protein"	20855422
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased methylation of DDB1 promoter	28329817
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DDB1 mRNA"	20382639
D004958	Estradiol	Estradiol results in decreased expression of DDB1 mRNA	24349563
C006780	bisphenol A	bisphenol A results in decreased expression of DDB1 mRNA	26982218
C006780	bisphenol A	bisphenol A results in increased expression of DDB1 mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of DDB1 mRNA	26472689
D002220	Carbamazepine	Carbamazepine affects the expression of DDB1 mRNA	25979313
D002259	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of DDB1 mRNA	16039398
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDB1 gene	20938992
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DDB1 mRNA	17602206
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of DDB1 mRNA	21878529
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of DDB1 mRNA	11056294
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of DDB1 mRNA	23914054
D013759	Dronabinol	Dronabinol results in decreased expression of DDB1 mRNA	16039398
D013759	Dronabinol	Dronabinol results in increased expression of DDB1 mRNA	18454173
D003907	Dexamethasone	Dexamethasone results in increased expression of DDB1 mRNA	22733784
D003976	Diazinon	Diazinon results in increased methylation of DDB1 gene	22964155
D004000	Dichloroethylenes	Dichloroethylenes results in increased expression of DDB1 mRNA	14565619
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DDB1 mRNA	17602206
D004237	Diuron	Diuron results in decreased expression of DDB1 mRNA	21551480
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDB1 gene	20938992
C056933	fumonisin B1	fumonisin B1 results in increased expression of DDB1 mRNA	16221962
D005839	Gentamicins	Gentamicins results in decreased expression of DDB1 mRNA	22061828
C561695	(+)-JQ1 compound	(+)-JQ1 compound analog binds to DDB1 protein	24972113
D001556	Lindane	Lindane results in increased expression of DDB1 mRNA	24349563
D008070	Lipopolysaccharides	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of DDB1 mRNA	22777745
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDB1 gene	20938992
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of DDB1 protein	26558463
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of DDB1 protein	26558463
C028577	monobutyl phthalate	monobutyl phthalate affects the expression of DDB1 mRNA	20864626
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of DDB1 mRNA	19382146
D009538	Nicotine	Nicotine results in decreased expression of DDB1 mRNA	16949557
C482205	nutlin 3	nutlin 3 results in increased expression of DDB1 mRNA	16439677
C030110	oxaliplatin	oxaliplatin results in increased expression of DDB1 mRNA	17762391
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of DDB1 mRNA	25729387
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of DDB1 protein	26879310
C010423	pyrithione zinc	pyrithione zinc results in increased expression of DDB1 mRNA	21424779
D012524	Sarin	Sarin results in increased expression of DDB1 protein	25842371
C009277	sodium arsenate	sodium arsenate results in decreased expression of DDB1 mRNA	24349563
C017947	sodium arsenite	sodium arsenite results in decreased expression of DDB1 mRNA	19382146
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DDB1 mRNA	21570461
D019284	Thapsigargin	Thapsigargin results in increased expression of DDB1 protein	24648495
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of DDB1 mRNA	25729387
C022884	undecane	undecane results in decreased expression of DDB1 protein	17337753
C073339	usnic acid	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of DDB1 mRNA	22777745
C025643	vinclozolin	vinclozolin affects the expression of DDB1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of DDB1 mRNA	23034163

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	TAS	8798680
GO:0003684	damaged DNA binding	-	IBA	21873635
GO:0003684	damaged DNA binding	contributes_to	IDA	22334663
GO:0005515	protein binding	-	IPI	9418871 12732143 14739464 16227264 16473935 16949367 16964240 17041588 17314515 17360488 17932509 19109893 19264781 19651607 19966799 20223979 20855601 21113133 21988832 22039351 22157821 22810585 22822215 23238014 23314863 24292623 24412650 26131937 26496610 26909574 28437394
GO:0030674	protein binding, bridging	-	IPI	14739464
GO:0044877	protein-containing complex binding	-	IPI	11564863
GO:0071987	WD40-repeat domain binding	-	IPI	16949367
GO:0097602	cullin family protein binding	-	IPI	14739464

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000715	nucleotide-excision repair, DNA damage recognition	-	TAS	-
GO:0006281	DNA repair	-	TAS	8798680
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	-
GO:0006289	nucleotide-excision repair	-	IBA	21873635
GO:0006289	nucleotide-excision repair	-	TAS	8407967
GO:0006293	nucleotide-excision repair, preincision complex stabilization	-	TAS	-
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	-
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	-
GO:0006511	ubiquitin-dependent protein catabolic process	-	IDA	11673459
GO:0006974	cellular response to DNA damage stimulus	-	IMP	16949367
GO:0010498	proteasomal protein catabolic process	-	IMP	25970626
GO:0016032	viral process	-	IEA	-
GO:0016055	Wnt signaling pathway	-	IEA	-
GO:0016567	protein ubiquitination	-	IMP	28437394
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	-
GO:0035518	histone H2A monoubiquitination	-	IDA	22334663
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	IBA	21873635
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	IMP	14739464 20223979
GO:0043687	post-translational protein modification	-	TAS	-
GO:0045070	positive regulation of viral genome replication	-	IMP	23137809
GO:0045732	positive regulation of protein catabolic process	-	IMP	16949367
GO:0046726	positive regulation by virus of viral protein levels in host cell	-	IMP	23137809
GO:0051702	interaction with symbiont	-	IDA	23137809
GO:0070911	global genome nucleotide-excision repair	-	TAS	-
GO:0070914	UV-damage excision repair	-	IDA	22334663
GO:1901990	regulation of mitotic cell cycle phase transition	-	IMP	17088560
GO:1902188	positive regulation of viral release from host cell	-	IMP	23137809

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000784	nuclear chromosome, telomeric region	-	HDA	19135898
GO:0005615	extracellular space	-	HDA	22664934
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	18593899 20223979
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	18593899 20223979 23137809
GO:0031461	cullin-RING ubiquitin ligase complex	-	IBA	21873635
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	-	IDA	12732143 14739464 18794347 20129063 20223979
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	-	IDA	18794347 21628527 22334663
GO:0032991	protein-containing complex	-	IMP	28437394
GO:0070062	extracellular exosome	-	HDA	19056867
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	-	IDA	18381890
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	-	IMP	16949367

KEGG ID	KEGG Term
hsa03420	Nucleotide excision repair
hsa04120	Ubiquitin mediated proteolysis

Reactome ID	Reactome Term	Evidence
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5696394	DNA Damage Recognition in GG-NER	TAS
R-HSA-5696395	Formation of Incision Complex in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-5696400	Dual Incision in GG-NER	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-73893	DNA Damage Bypass	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-8951664	Neddylation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28379545	Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck. (2017 May 1)	Han P	Carcinogenesis