Gene: DDB2

1643
DDBB|UV-DDB2|XPE
damage specific DNA binding protein 2
protein-coding
11p11.2
Ensembl:ENSG00000134574 MIM:600811 Vega:OTTHUMG00000187453 UniprotKB:Q92466
NG_009365.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.806e-1 (AD)  5.264e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRADD0.757
THEMIS20.748
GRN0.745
RPS6KA10.745
SYNGR20.744
PLXDC20.741
MAN2B10.74
ANKRD13A0.74
TRAFD10.738
MYO9B0.737

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.439
OR4F29-0.423
HES5-0.285
DIO2-0.282
WIF1-0.254
WNT7B-0.249
PTGDR2-0.246
CRH-0.245
NPBWR1-0.238
POU3F4-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DDB2 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDB2 mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of DDB2 mRNA"28073004
D000082AcetaminophenAcetaminophen results in increased expression of DDB2 mRNA22230336
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of DDB2 mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 affects the expression of DDB2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DDB2 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DDB2 mRNA19770486
D001151ArsenicArsenic affects the methylation of DDB2 gene25304211
D001151ArsenicArsenic results in decreased expression of DDB2 mRNA19945496
C006632arsenic trioxidearsenic trioxide affects the expression of DDB2 mRNA25873331
D001280AtrazineAtrazine results in increased expression of DDB2 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of DDB2 mRNA26377693
C072019benzo(a)pyrene diolepoxide Ibenzo(a)pyrene diolepoxide I results in increased expression of DDB2 mRNA27694624
C072019benzo(a)pyrene diolepoxide Ibenzo(a)pyrene diolepoxide I results in increased expression of DDB2 protein27694624
C072019benzo(a)pyrene diolepoxide Ipifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of DDB2 mRNA]27694624
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DDB2 mRNA22209252
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of DDB2 mRNA20624995|2187364
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DDB2 mRNA15735009|2006483
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DDB2 protein23894430
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DDB2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DDB2 mRNA22641617
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DDB2 mRNA"28593498
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DDB2 protein"18085531
D004958EstradiolEstradiol results in increased expression of DDB2 mRNA19167446
C006780bisphenol Abisphenol A affects the expression of DDB2 mRNA21786754
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of DDB2 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of DDB2 mRNA26079696
D002101Cacodylic Acid[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of DDB2 mRNA23192986
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DDB2 mRNA26472689|2652539
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DDB2 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DDB2 mRNA24794047
C059262cidofovircidofovir results in increased expression of DDB2 mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of DDB2 mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of DDB2 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of DDB2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DDB2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of DDB2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of DDB2 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of DDB2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of DDB2 mRNA21632981|2556210
D016572CyclosporineCyclosporine results in increased expression of DDB2 mRNA20106945
D0150842,4-Dichlorophenoxyacetic Acid"2,4-Dichlorophenoxyacetic Acid results in increased expression of DDB2 mRNA"15878651
C014347decitabinedecitabine affects the expression of DDB2 mRNA23300844
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of DDB2 mRNA"15735009|2240954
D002945CisplatinCisplatin affects the expression of DDB2 mRNA23300844
D002945CisplatinCisplatin results in increased expression of DDB2 mRNA21532991|2559613
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of DDB2 mRNA21858171
D002117CalcitriolCalcitriol results in decreased expression of DDB2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of DDB2 mRNA21592394
C062856dimethylarsine[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of DDB2 mRNA25873331
C024629dimethyl phthalatedimethyl phthalate affects the expression of DDB2 mRNA26924002
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of DDB2 mRNA23649840
D005472FluorouracilDDB2 protein affects the susceptibility to Fluorouracil15331170
D005472FluorouracilFluorouracil results in increased expression of DDB2 mRNA15331170|1658454
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of DDB2 mRNA]17982676
C065180fluvastatinfluvastatin results in decreased expression of DDB2 mRNA24964743
C065180fluvastatinfluvastatin results in decreased expression of DDB2 protein24964743
C065180fluvastatin[fluvastatin results in decreased expression of DDB2] which results in increased expression of SOD2 mRNA24964743
C065180fluvastatinMevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 mRNA]24964743
C065180fluvastatinMevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 protein]24964743
D005557FormaldehydeFormaldehyde results in increased expression of DDB2 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of DDB2 mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DDB2 mRNA20044591
D006918HydroxyureaHydroxyurea results in increased expression of DDB2 mRNA18647660
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DDB2 mRNA25613284
C051890irinotecanirinotecan metabolite results in increased expression of DDB2 mRNA15956246
C051890irinotecanirinotecan results in increased expression of DDB2 mRNA15956246
C410337K 7174K 7174 results in decreased expression of DDB2 mRNA24086573
C045463leflunomideleflunomide results in decreased expression of DDB2 mRNA28988120
C015329lycopenelycopene results in increased expression of DDB2 mRNA16886892
C543395methylarsine[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of DDB2 mRNA25873331
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DDB2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DDB2 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of DDB2 mRNA29191790
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 mRNA]24964743
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 protein]24964743
D016685MitomycinMitomycin promotes the reaction [TP53 protein results in increased expression of DDB2 mRNA]18647660
D016685MitomycinMitomycin results in increased expression of DDB2 mRNA18647660
C020300monomethylarsonic acid[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of DDB2 mRNA23192986
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of DDB2 mRNA19945496|2210804
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DDB2 mRNA26924002
D009020MorphineMorphine results in increased expression of DDB2 mRNA19397953
D009020MorphineNaloxone inhibits the reaction [Morphine results in increased expression of DDB2]19397953
D009270NaloxoneNaloxone inhibits the reaction [Morphine results in increased expression of DDB2]19397953
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DDB2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DDB2 mRNA"25554681
D015376NimustineTP53 affects the reaction [Nimustine results in increased expression of DDB2 mRNA]18089819
C010615Nonidet P-40Nonidet P-40 results in decreased expression of DDB2 mRNA26552463
D010100OxygenOxygen deficiency results in increased expression of DDB2 mRNA25596134
D010126OzoneOzone results in increased expression of DDB2 mRNA27206323
D010269ParaquatParaquat results in increased expression of DDB2 mRNA23613995
D010278ParathionDDB2 gene SNP affects the susceptibility to Parathion22102698
D052638Particulate MatterParticulate Matter results in decreased expression of DDB2 mRNA24769257
D010416PentachlorophenolPentachlorophenol results in increased expression of DDB2 mRNA24642059
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of DDB2 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of DDB2 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of DDB2 mRNA23091169
C121565pifithrinpifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of DDB2 mRNA]27694624
C121565pifithrinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDB2 mRNA]20064835
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DDB2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of DDB2 mRNA18301758|2081375
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of DDB2 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of DDB2 mRNA23557933
D011740Pyrimidine DimersDDB2 protein binds to Pyrimidine Dimers24753253
D011794QuercetinQuercetin results in increased expression of DDB2 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of DDB2 mRNA19167446
C059514resveratrolresveratrol results in increased expression of DDB2 mRNA25888808
C547185riccardin Driccardin D results in decreased expression of DDB2 mRNA24069304
C017947sodium arsenite[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of DDB2 mRNA25873331
C017947sodium arsenite[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of DDB2 mRNA23192986
C017947sodium arsenitesodium arsenite results in decreased expression of DDB2 mRNA12377979|2587980
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of DDB2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of DDB2 mRNA21592394
D013749Tetrachlorodibenzodioxinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDB2 mRNA]20064835
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DDB2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DDB2 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DDB2 mRNA25613284
C523062thio-dimethylarsinatethio-dimethylarsinate results in increased expression of DDB2 mRNA27320638
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DDB2 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DDB2 mRNA27694624
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDB2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of DDB2 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DDB2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of DDB2 mRNA29024780
D014520UrethaneUrethane results in decreased expression of DDB2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DDB2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DDB2 mRNA23179753|2800136
D014800VitalliumVitallium analog results in decreased expression of DDB2 mRNA23825117
D015032ZincZinc deficiency results in increased expression of DDB2 mRNA12888634

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS8798680  
GO:0003684damaged DNA bindingCONTRIBUTES_TOIBA21873635  
GO:0003684damaged DNA bindingcontributes_toIDA22334663  
GO:0004842ubiquitin-protein transferase activityCONTRIBUTES_TOIBA21873635  
GO:0004842ubiquitin-protein transferase activitycontributes_toIDA12732143  
GO:0005515protein binding-IPI9418871  12732143  16473935  16949367  17041588  17360488  
19109893  19966799  22039351  22822215  26496610  
GO:0044877protein-containing complex binding-IPI11564863  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IBA21873635  
GO:0000209protein polyubiquitination-IDA12732143  
GO:0000715nucleotide-excision repair, DNA damage recognition-TAS-  
GO:0006281DNA repair-TAS8798680  
GO:0006289nucleotide-excision repair-TAS8407967  
GO:0006290pyrimidine dimer repair-IBA21873635  
GO:0006290pyrimidine dimer repair-IEA-  
GO:0006293nucleotide-excision repair, preincision complex stabilization-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0009411response to UV-IBA21873635  
GO:0009411response to UV-IDA12732143  
GO:0010224response to UV-B-IBA21873635  
GO:0016579protein deubiquitination-TAS-  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0035518histone H2A monoubiquitination-IBA21873635  
GO:0035518histone H2A monoubiquitination-IDA22334663  
GO:0043687post-translational protein modification-TAS-  
GO:0051865protein autoubiquitination-IBA21873635  
GO:0051865protein autoubiquitination-IDA12732143  
GO:0070911global genome nucleotide-excision repair-TAS-  
GO:0070914UV-damage excision repair-IBA21873635  
GO:0070914UV-damage excision repair-IDA22334663  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0030054cell junction-IDA-  
GO:0031465Cul4B-RING E3 ubiquitin ligase complex-IBA21873635  
GO:0031465Cul4B-RING E3 ubiquitin ligase complex-IDA22334663  
GO:0032991protein-containing complex-IDA12732143  
GO:0080008Cul4-RING E3 ubiquitin ligase complex-IMP16949367  
KEGG ID KEGG Term
hsa03420Nucleotide excision repair
hsa04115p53 signaling pathway
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-5696394DNA Damage Recognition in GG-NERTAS
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26760766Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks. (2016 Feb 9)Liu JOncotarget
23144912DNA repair and cell cycle biomarkers of radiation exposure and inflammation stress in human blood. (2012)Budworth HPLoS One
29459183Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures. (2018 Apr)Nikodemova MEnviron Int
27694624Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations. (2016 Dec 15)Christmann MNucleic Acids Res