| C025205 | 1,10-phenanthroline | "1,10-phenanthroline results in decreased activity of AKR1C1 protein" | 12604236|8573067 |
| C026486 | 1,2,5,6-dibenzanthracene | "1,2,5,6-dibenzanthracene results in increased expression of AKR1C1 mRNA" | 17253728 |
| C053486 | 1,7-phenanthroline | "1,7-phenanthroline results in decreased activity of AKR1C1 protein" | 8573067 |
| C063002 | 2,3-dimethoxy-1,4-naphthoquinone | "2,3-dimethoxy-1,4-naphthoquinone results in increased expression of AKR1C1 mRNA" | 9973208 |
| C012796 | 2-butenal | 2-butenal results in increased expression of AKR1C1 mRNA | 20471460 |
| C018855 | 2-tert-butylhydroquinone | 2-tert-butylhydroquinone results in increased expression of AKR1C1 mRNA | 9973208 |
| C018156 | 3',3'',5',5''-tetrabromophenolphthalein | "3',3'',5',5''-tetrabromophenolphthalein results in decreased activity of AKR1C1 protein" | 12604236 |
| C014464 | 3,4-dichloroaniline | "3,4-dichloroaniline results in increased expression of AKR1C1 mRNA" | 24172598 |
| C422925 | 3,7-dihydroxyflavone | "3,7-dihydroxyflavone binds to and results in decreased activity of AKR1C1 protein" | 16962702 |
| C009505 | 4,4'-diaminodiphenylmethane | "4,4'-diaminodiphenylmethane results in decreased expression of AKR1C1 mRNA" | 25380136 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C032642 | 4-aminophenylarsenoxide | 4-aminophenylarsenoxide binds to AKR1C1 protein | 26598702 |
| C032642 | 4-aminophenylarsenoxide | arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C1 protein] | 26598702 |
| C058818 | 4-benzoylbenzoic acid | 4-benzoylbenzoic acid analog results in decreased activity of AKR1C1 protein | 19010312 |
| C027576 | 4-hydroxy-2-nonenal | AKR1C1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal | 23165153 |
| C027576 | 4-hydroxy-2-nonenal | AKR1C1 protein results in increased metabolism of 4-hydroxy-2-nonenal | 23165153 |
| C038193 | 4-hydroxybenzoic acid | 4-hydroxybenzoic acid analog results in decreased activity of AKR1C1 protein | 27163852 |
| C117714 | 4-hydroxyequilenin-o-quinone | [AKR1C1 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone | 21910479 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | AKR1C1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 11306090 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | AKR1C1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 28257955 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | drospirenone inhibits the reaction [AKR1C1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] | 28257955 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | Ethinyl Estradiol inhibits the reaction [AKR1C1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] | 28257955 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | Progesterone inhibits the reaction [AKR1C1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] | 28257955 |
| C403894 | 4-oxo-2-nonenal | AKR1C1 protein results in decreased susceptibility to 4-oxo-2-nonenal | 23165153 |
| C403894 | 4-oxo-2-nonenal | AKR1C1 protein results in increased reduction of 4-oxo-2-nonenal | 23165153 |
| C075773 | 4-phenylbutyric acid | 4-phenylbutyric acid results in increased expression of AKR1C1 mRNA | 14583596 |
| C468646 | 5,12-naphthacenequinone | "5,12-naphthacenequinone results in increased expression of AKR1C1 mRNA" | 17253728 |
| C454687 | 5-dihydrodeoxycorticosterone | AKR1C1 protein affects the reduction of 5-dihydrodeoxycorticosterone | 12604236 |
| C454687 | 5-dihydrodeoxycorticosterone | AKR1C1 protein results in increased metabolism of 5-dihydrodeoxycorticosterone | 11995921 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C077646 | 7,12-benz(a)anthraquinone | "7,12-benz(a)anthraquinone results in increased expression of AKR1C1 mRNA" | 17253728 |
| C429845 | 7-hydroxyflavone | 7-hydroxyflavone binds to and results in decreased activity of AKR1C1 protein | 16962702 |
| C020738 | 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene | "9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of AKR1C1 mRNA" | 26238291 |
| C005399 | 9,10-phenanthrenequinone | "AKR1C1 protein results in increased metabolism of 9,10-phenanthrenequinone" | 17950253 |
| C005399 | 9,10-phenanthrenequinone | "AKR1C1 protein results in increased reduction of 9,10-phenanthrenequinone" | 21851338|2326171 |
| C005399 | 9,10-phenanthrenequinone | "AKR1C1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone" | 21910479 |
| C031390 | 9-cis-retinal | AKR1C1 protein results in increased reduction of 9-cis-retinal | 21851338 |
| C023723 | acenaphthene-1-ol | [AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol | 25446855 |
| C023723 | acenaphthene-1-ol | AKR1C1 protein results in increased metabolism of acenaphthene-1-ol | 19007763 |
| C023723 | acenaphthene-1-ol | AKR1C1 protein results in increased oxidation of acenaphthene-1-ol | 23261716 |
| C023723 | acenaphthene-1-ol | dichloro(4-cymene)ruthenium(II) analog inhibits the reaction [[AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol] | 25446855 |
| C023723 | acenaphthene-1-ol | dichloro(4-cymene)ruthenium(II) inhibits the reaction [[AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol] | 25446855 |
| C023723 | acenaphthene-1-ol | Ruthenium Compounds analog inhibits the reaction [[AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol] | 25446855 |
| D000082 | Acetaminophen | Acetaminophen results in decreased expression of AKR1C1 mRNA | 26690555 |
| D000082 | Acetaminophen | Acetaminophen results in increased expression of AKR1C1 mRNA | 21420995 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of AKR1C1 gene | 27153756 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of AKR1C1 mRNA | 22484513 |
| D043582 | 5-alpha-Dihydroprogesterone | AKR1C1 protein affects the reduction of 5-alpha-Dihydroprogesterone | 12604236 |
| D043582 | 5-alpha-Dihydroprogesterone | AKR1C1 protein results in increased reduction of 5-alpha-Dihydroprogesterone | 11995921 |
| D004092 | 20-alpha-Dihydroprogesterone | AKR1C1 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone | 16962702 |
| D013196 | Dihydrotestosterone | AKR1C1 protein results in increased metabolism of Dihydrotestosterone | 14672942 |
| D013196 | Dihydrotestosterone | Flufenamic Acid inhibits the reaction [AKR1C1 protein results in increased metabolism of Dihydrotestosterone] | 14672942 |
| C510582 | alpha-methylcinnamic acid | alpha-methylcinnamic acid inhibits the reaction [AKR1C1 protein affects the susceptibility to oxaliplatin] | 23933386 |
| D000638 | Amiodarone | Amiodarone results in increased expression of AKR1C1 mRNA | 21163907 |
| C031385 | anthranilic acid | anthranilic acid analog results in decreased activity of AKR1C1 protein | 19007763 |
| C006632 | arsenic trioxide | AKR1C1 protein results in decreased susceptibility to arsenic trioxide | 20707922 |
| C006632 | arsenic trioxide | [arsenic trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA | 25913414 |
| C006632 | arsenic trioxide | arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C1 protein] | 26598702 |
| D001241 | Aspirin | Aspirin results in decreased activity of AKR1C1 protein | 19010312 |
| D001379 | Azathioprine | Azathioprine results in increased expression of AKR1C1 mRNA | 22623647 |
| C051597 | Bandrowski's base | Bandrowski's base results in increased expression of AKR1C1 mRNA | 20566472 |
| C030935 | benz(a)anthracene | benz(a)anthracene results in increased expression of AKR1C1 mRNA | 17253728|2223671 |
| D001553 | Benzbromarone | Benzbromarone results in decreased activity of AKR1C1 protein | 12604236 |
| C041511 | benzo(a)fluorene | benzo(a)fluorene results in increased expression of AKR1C1 mRNA | 17253728 |
| C030233 | benzo(a)pyrene-1,6-quinone | "AKR1C1 protein results in increased reduction of and affects the activity of benzo(a)pyrene-1,6-quinone" | 21910479 |
| C018003 | benzo(a)pyrene-3,6-quinone | "AKR1C1 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3,6-quinone" | 21910479 |
| C017228 | benzo(a)pyrene 7,8-dihydrodiol | "[AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol" | 21910479 |
| C076588 | benzo(a)pyrene-7,8-dione | "[AKR1C1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione" | 21910479 |
| C076588 | benzo(a)pyrene-7,8-dione | "benzo(a)pyrene-7,8-dione results in increased expression of AKR1C1 mRNA" | 9973208 |
| C076588 | benzo(a)pyrene-7,8-dione | "AKR1C1 protein results in increased chemical synthesis of benzo(a)pyrene-7,8-dione" | 22394341 |
| C006703 | benzo(b)fluoranthene | benzo(b)fluoranthene results in increased expression of AKR1C1 mRNA | 17253728 |
| C041512 | benzo(b)fluorene | benzo(b)fluorene results in increased expression of AKR1C1 mRNA | 17253728 |
| D019324 | beta-Naphthoflavone | beta-Naphthoflavone results in increased expression of AKR1C1 mRNA | 17253728 |
| C039389 | benzo(h)quinoline-5,6-dione | "benzo(h)quinoline-5,6-dione results in increased expression of AKR1C1 mRNA" | 9973208 |
| D019817 | Benzoic Acid | Benzoic Acid results in increased expression of AKR1C1 mRNA | 20566472 |
| C022921 | benzo(k)fluoranthene | benzo(k)fluoranthene results in increased expression of AKR1C1 mRNA | 17253728 |
| D001564 | Benzo(a)pyrene | AKR1C1 protein affects the susceptibility to Benzo(a)pyrene | 19800895 |
| D001564 | Benzo(a)pyrene | AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon] | 19800895 |
| D001564 | Benzo(a)pyrene | AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion] | 19800895 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C1 protein] | 19800895 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of AKR1C1 mRNA | 16545412 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of AKR1C1 mRNA | 15735009|1725372 |
| D001564 | Benzo(a)pyrene | Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C1 mRNA] | 19800895 |
| D001564 | Benzo(a)pyrene | [Particulate Matter co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA | 17612574 |
| D001564 | Benzo(a)pyrene | [Vehicle Emissions co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA | 17612574 |
| D001564 | Benzo(a)pyrene | AKR1C1 protein results in increased metabolism of Benzo(a)pyrene | 22394341 |
| C006710 | benzotriphenylene | benzotriphenylene results in increased expression of AKR1C1 mRNA | 17253728 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] | 23165153 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1C1 mRNA | 21215737|2316515 |
| D004958 | Estradiol | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C1 mRNA | 19619570 |
| D004958 | Estradiol | Estradiol results in increased expression of AKR1C1 mRNA | 19619570 |
| C095105 | bexarotene | bexarotene results in increased expression of AKR1C1 mRNA | 17178900 |
| C543008 | bis(4-hydroxyphenyl)sulfone | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1C1 mRNA | 28628672 |
| D000069286 | Bortezomib | [arsenic trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA | 25913414 |
| D000069286 | Bortezomib | Bortezomib results in increased expression of AKR1C1 mRNA | 21215737 |
| D019819 | Budesonide | AKR1C1 protein results in increased reduction of Budesonide | 21276783 |
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in increased expression of AKR1C1 mRNA | 15336504 |
| D002104 | Cadmium | Cadmium results in increased expression of AKR1C1 mRNA | 21172416 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in decreased expression of AKR1C1 mRNA | 25993096 |
| C037123 | cadmium sulfate | [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA | 18654764 |
| C055494 | caffeic acid phenethyl ester | caffeic acid phenethyl ester results in decreased activity of AKR1C1 protein | 27163852 |
| D002330 | Carmustine | AKR1C1 mRNA affects the susceptibility to Carmustine | 16365179 |
| D002635 | Chenodeoxycholic Acid | Chenodeoxycholic Acid results in decreased expression of AKR1C1 mRNA | 27174168 |
| D020245 | p-Chloromercuribenzoic Acid | "[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| D020245 | p-Chloromercuribenzoic Acid | p-Chloromercuribenzoic Acid results in increased expression of AKR1C1 mRNA | 26272509 |
| C031180 | chrysene | chrysene results in increased expression of AKR1C1 mRNA | 17253728 |
| D002911 | Chrysenes | AKR1C1 protein results in increased reduction of and affects the activity of Chrysenes | 21910479 |
| C039671 | ciglitazone | [ciglitazone binds to PPARG protein alternative form] which results in increased expression of AKR1C1 mRNA | 16197558 |
| C039671 | ciglitazone | [ciglitazone binds to PPARG protein] which results in increased expression of AKR1C1 mRNA | 16197558 |
| C012843 | cinnamic aldehyde | cinnamic aldehyde results in increased expression of AKR1C1 mRNA | 19524605 |
| C020722 | cinnamyl alcohol | cinnamyl alcohol results in increased expression of AKR1C1 mRNA | 20566472 |
| C005522 | cloxazolam | cloxazolam results in decreased activity of AKR1C1 protein | 12604236 |
| D003035 | Cobalt | [tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA | 20105288 |
| C018021 | cobaltous chloride | [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA | 18654764 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased expression of AKR1C1 mRNA | 20105288 |
| D009243 | NAD | [AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol | 25446855 |
| D009243 | NAD | dichloro(4-cymene)ruthenium(II) analog inhibits the reaction [[AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol] | 25446855 |
| D009243 | NAD | dichloro(4-cymene)ruthenium(II) inhibits the reaction [[AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol] | 25446855 |
| D009243 | NAD | Ruthenium Compounds analog inhibits the reaction [[AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol] | 25446855 |
| D009249 | NADP | "[AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol" | 21910479 |
| D009249 | NADP | [AKR1C1 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone | 21910479 |
| D009249 | NADP | "[AKR1C1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione" | 21910479 |
| D009249 | NADP | NADP promotes the reaction [AKR1C1 protein results in increased reduction of cyclopentanone] | 23261716 |
| C075384 | coniferaldehyde | coniferaldehyde results in increased expression of AKR1C1 mRNA | 26275128 |
| C075384 | coniferaldehyde | coniferaldehyde results in increased expression of AKR1C1 protein | 26275128 |
| C075384 | coniferaldehyde | NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein] | 26275128 |
| D003300 | Copper | [NSC 689534 binds to Copper] which results in increased expression of AKR1C1 mRNA | 20971185 |
| D019327 | Copper Sulfate | Copper Sulfate results in increased expression of AKR1C1 mRNA | 19549813 |
| C010092 | cresolphthalein | cresolphthalein results in decreased activity of AKR1C1 protein | 12604236 |
| C016327 | cyclopentanol | AKR1C1 protein results in increased oxidation of cyclopentanol | 23261716 |
| C007201 | cyclopentanone | AKR1C1 protein results in increased reduction of cyclopentanone | 23261716 |
| C007201 | cyclopentanone | NADP promotes the reaction [AKR1C1 protein results in increased reduction of cyclopentanone] | 23261716 |
| D016572 | Cyclosporine | Cyclosporine results in increased expression of AKR1C1 mRNA | 25562108 |
| D003907 | Dexamethasone | Dexamethasone results in increased expression of AKR1C1 mRNA | 25047013 |
| D003907 | Dexamethasone | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1C1 mRNA | 28628672 |
| D003907 | Dexamethasone | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA | 28628672 |
| D003975 | Diazepam | Diazepam results in decreased activity of AKR1C1 protein | 11995921|1260423 |
| C041517 | dibenzo(a,l)pyrene | "[Particulate Matter co-treated with dibenzo(a,l)pyrene] results in increased expression of AKR1C1 mRNA" | 17612574 |
| C041517 | dibenzo(a,l)pyrene | "[Vehicle Emissions co-treated with dibenzo(a,l)pyrene] results in increased expression of AKR1C1 mRNA" | 17612574 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in increased expression of AKR1C1 mRNA | 18214805 |
| C530610 | dichloro(4-cymene)ruthenium(II) | dichloro(4-cymene)ruthenium(II) analog inhibits the reaction [[AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol] | 25446855 |
| C530610 | dichloro(4-cymene)ruthenium(II) | dichloro(4-cymene)ruthenium(II) inhibits the reaction [[AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol] | 25446855 |
| D002945 | Cisplatin | AKR1C1 protein results in decreased susceptibility to Cisplatin | 20953859|2316515 |
| D002945 | Cisplatin | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] | 23165153 |
| D002945 | Cisplatin | [Cisplatin co-treated with jinfukang] results in increased expression of AKR1C1 mRNA | 27392435 |
| D002945 | Cisplatin | Cisplatin results in increased expression of AKR1C1 mRNA | 23165153|2739243 |
| D002945 | Cisplatin | [Cisplatin results in increased expression of AKR1C1] which results in decreased susceptibility to Cisplatin | 23165153 |
| D002945 | Cisplatin | Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin] | 23165153 |
| C036042 | dicyclohexyl phthalate | dicyclohexyl phthalate affects the expression of AKR1C1 mRNA | 26924002 |
| C023635 | dienogest | dienogest results in decreased expression of AKR1C1 mRNA | 23183084 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in increased expression of AKR1C1 mRNA | 28412506 |
| D002117 | Calcitriol | Calcitriol results in increased expression of AKR1C1 mRNA | 12040012|2159239 |
| D002117 | Calcitriol | [Testosterone co-treated with Calcitriol] results in increased expression of AKR1C1 mRNA | 21592394 |
| D004101 | Dihydroxydihydrobenzopyrenes | AKR1C1 protein results in increased reduction of and affects the activity of Dihydroxydihydrobenzopyrenes | 21910479 |
| D004128 | Dimethylnitrosamine | Dimethylnitrosamine results in decreased expression of AKR1C1 mRNA | 25380136 |
| C024629 | dimethyl phthalate | dimethyl phthalate affects the expression of AKR1C1 mRNA | 26924002 |
| D004137 | Dinitrochlorobenzene | Dinitrochlorobenzene results in increased expression of AKR1C1 mRNA | 20566472 |
| D004178 | Diquat | Diquat results in increased expression of AKR1C1 mRNA | 21172416 |
| D004221 | Disulfiram | Disulfiram results in increased expression of AKR1C1 mRNA | 20566472 |
| D004237 | Diuron | Diuron metabolite results in increased expression of AKR1C1 mRNA | 24172598 |
| C035144 | drospirenone | drospirenone inhibits the reaction [AKR1C1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] | 28257955 |
| D000068538 | Dutasteride | Dutasteride results in increased expression of AKR1C1 mRNA | 16806904 |
| D004394 | Dydrogesterone | AKR1C1 protein results in increased metabolism of Dydrogesterone | 21182831 |
| D004394 | Dydrogesterone | Dydrogesterone results in decreased activity of AKR1C1 protein | 21182831 |
| D004394 | Dydrogesterone | Dydrogesterone results in decreased expression of AKR1C1 mRNA | 23183084 |
| D004394 | Dydrogesterone | Dydrogesterone results in increased expression of AKR1C1 mRNA | 23183084 |
| C118739 | entinostat | entinostat results in decreased expression of AKR1C1 mRNA | 27188386 |
| D004785 | Environmental Pollutants | Environmental Pollutants results in increased expression of AKR1C1 mRNA | 20064776 |
| D004949 | Estazolam | Estazolam results in decreased activity of AKR1C1 protein | 11995921 |
| D004976 | Ethacrynic Acid | Ethacrynic Acid results in increased expression of AKR1C1 mRNA | 9973208 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol inhibits the reaction [AKR1C1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] | 28257955 |
| D005020 | Ethyl Methanesulfonate | Ethyl Methanesulfonate results in increased expression of AKR1C1 mRNA | 23649840 |
| D005054 | Eugenol | Eugenol results in increased expression of AKR1C1 mRNA | 20566472 |
| C001209 | fenamic acid | fenamic acid analog results in decreased activity of AKR1C1 protein | 19010312 |
| C006012 | fenofibric acid | AKR1C1 protein results in increased reduction of fenofibric acid | 27599626 |
| D005411 | Flame Retardants | Flame Retardants results in decreased expression of AKR1C1 mRNA | 18534652 |
| D005411 | Flame Retardants | Flame Retardants results in increased expression of AKR1C1 mRNA | 18534652 |
| D005439 | Flufenamic Acid | Flufenamic Acid inhibits the reaction [AKR1C1 protein affects the susceptibility to oxaliplatin] | 23933386 |
| D005439 | Flufenamic Acid | Flufenamic Acid inhibits the reaction [AKR1C1 protein results in increased metabolism of Dihydrotestosterone] | 14672942 |
| D005439 | Flufenamic Acid | Flufenamic Acid results in decreased activity of AKR1C1 protein | 12604236|8573067 |
| C007734 | flunisolide | AKR1C1 protein results in increased reduction of flunisolide | 21276783 |
| D005445 | Flunitrazepam | Flunitrazepam results in decreased activity of AKR1C1 protein | 11995921 |
| D005472 | Fluorouracil | AKR1C1 protein affects the susceptibility to Fluorouracil | 16217747 |
| D005472 | Fluorouracil | Fluorouracil affects the expression of AKR1C1 mRNA | 16584549 |
| D005480 | Flurbiprofen | Flurbiprofen results in decreased activity of AKR1C1 protein | 19010312 |
| D005485 | Flutamide | Flutamide results in decreased expression of AKR1C1 mRNA | 24136188 |
| C039281 | furan | furan results in decreased expression of AKR1C1 mRNA | 25539665 |
| D017965 | gamma-Linolenic Acid | gamma-Linolenic Acid results in increased expression of AKR1C1 mRNA | 20664735 |
| C106014 | gedunin | gedunin results in increased expression of AKR1C1 mRNA | 17010675 |
| D005897 | Glafenine | Glafenine results in decreased expression of AKR1C1 mRNA | 24136188 |
| C057619 | glimepiride | glimepiride results in decreased activity of AKR1C1 protein | 26362498 |
| D005913 | Glipizide | Glipizide results in decreased activity of AKR1C1 protein | 26362498 |
| C010969 | gliquidone | gliquidone results in decreased activity of AKR1C1 protein | 26362498 |
| D005905 | Glyburide | Glyburide results in decreased activity of AKR1C1 protein | 26362498 |
| C071834 | glycidamide | glycidamide results in increased expression of AKR1C1 mRNA | 17822822 |
| D006034 | Glycyrrhetinic Acid | Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein | 12604236 |
| C089796 | hexabromocyclododecane | hexabromocyclododecane results in decreased expression of AKR1C1 mRNA | 18534652 |
| C089796 | hexabromocyclododecane | hexabromocyclododecane results in increased expression of AKR1C1 mRNA | 18534652 |
| D006589 | Hexestrol | Hexestrol results in decreased activity of AKR1C1 protein | 12604236|8573067 |
| C080043 | hexyl cinnamic aldehyde | hexyl cinnamic aldehyde results in increased expression of AKR1C1 mRNA | 20566472 |
| D017313 | Fenretinide | Fenretinide results in increased expression of AKR1C1 mRNA | 16671099 |
| D006854 | Hydrocortisone | AKR1C1 protein results in increased reduction of Hydrocortisone | 21276783 |
| D006861 | Hydrogen Peroxide | [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 mRNA | 19320734 |
| D006861 | Hydrogen Peroxide | [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 protein | 19320734 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased expression of AKR1C1 mRNA | 9973208 |
| D006914 | Hydroxysteroids | AKR1C1 protein results in increased abundance of Hydroxysteroids | 14672942 |
| D007052 | Ibuprofen | Ibuprofen results in decreased activity of AKR1C1 protein | 19010312 |
| C041508 | indeno(1,2,3-cd)pyrene | "indeno(1,2,3-cd)pyrene results in increased expression of AKR1C1 mRNA" | 17253728 |
| D007213 | Indomethacin | Indomethacin results in decreased activity of AKR1C1 protein | 12604236|1901031 |
| D007213 | Indomethacin | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1C1 mRNA | 28628672 |
| D007213 | Indomethacin | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA | 28628672 |
| D015056 | 1-Methyl-3-isobutylxanthine | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1C1 mRNA | 28628672 |
| D015056 | 1-Methyl-3-isobutylxanthine | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA | 28628672 |
| C036643 | isoeugenol | isoeugenol results in increased expression of AKR1C1 mRNA | 20566472 |
| C544151 | jinfukang | [Cisplatin co-treated with jinfukang] results in increased expression of AKR1C1 mRNA | 27392435 |
| C544151 | jinfukang | jinfukang results in increased expression of AKR1C1 mRNA | 27392435 |
| D019344 | Lactic Acid | Lactic Acid results in increased expression of AKR1C1 mRNA | 20566472 |
| D007854 | Lead | Lead affects the splicing of AKR1C1 mRNA | 28903495 |
| C008261 | lead acetate | lead acetate results in increased expression of AKR1C1 mRNA | 22839698 |
| C029891 | lead chloride | [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA | 18654764 |
| C029891 | lead chloride | lead chloride results in increased expression of AKR1C1 mRNA | 18654764 |
| C045463 | leflunomide | leflunomide results in decreased expression of AKR1C1 mRNA | 28988120 |
| C045463 | leflunomide | leflunomide results in decreased expression of AKR1C1 mRNA | 24136188 |
| D008095 | Lithocholic Acid | AKR1C1 protein binds to Lithocholic Acid | 8573067 |
| D008095 | Lithocholic Acid | Lithocholic Acid results in decreased activity of AKR1C1 protein | 12604236|8573067 |
| D008294 | Malathion | Malathion results in increased expression of AKR1C1 mRNA | 16079077|1821480 |
| D008469 | Meclofenamic Acid | Meclofenamic Acid results in decreased activity of AKR1C1 protein | 19010312|2636249 |
| D008472 | Medazepam | Medazepam results in decreased activity of AKR1C1 protein | 11995921|1260423 |
| D017258 | Medroxyprogesterone Acetate | Medroxyprogesterone Acetate results in decreased activity of AKR1C1 protein | 12604236|2118283 |
| D017258 | Medroxyprogesterone Acetate | Medroxyprogesterone Acetate results in decreased expression of AKR1C1 mRNA | 23183084 |
| D017258 | Medroxyprogesterone Acetate | Medroxyprogesterone Acetate results in increased expression of AKR1C1 mRNA | 18497975|2318308 |
| D008528 | Mefenamic Acid | Mefenamic Acid analog results in decreased activity of AKR1C1 protein | 19010312 |
| C042720 | mercuric bromide | mercuric bromide results in increased expression of AKR1C1 mRNA | 26272509 |
| C042720 | mercuric bromide | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in increased expression of AKR1C1 mRNA | 9973208 |
| C004925 | methylmercuric chloride | methylmercuric chloride results in increased expression of AKR1C1 mRNA | 28001369 |
| D008741 | Methyl Methanesulfonate | Methyl Methanesulfonate results in increased expression of AKR1C1 mRNA | 23649840 |
| C008480 | methylparaoxon | AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon] | 19800895 |
| C008480 | methylparaoxon | methylparaoxon results in increased expression of AKR1C1 mRNA | 19800895 |
| D008743 | Methyl Parathion | AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion] | 19800895 |
| D008743 | Methyl Parathion | Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C1 protein] | 19800895 |
| D008743 | Methyl Parathion | Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C1 mRNA] | 19800895 |
| D008743 | Methyl Parathion | Methyl Parathion results in increased activity of AKR1C1 protein | 19800895 |
| D008743 | Methyl Parathion | Methyl Parathion results in increased expression of AKR1C1 mRNA | 19800895 |
| C033069 | methyl salicylate | methyl salicylate results in increased expression of AKR1C1 mRNA | 20566472 |
| C406082 | monomethylarsonous acid | monomethylarsonous acid results in increased expression of AKR1C1 protein | 24625837 |
| C517284 | monomethyl phthalate | monomethyl phthalate affects the expression of AKR1C1 mRNA | 26924002 |
| C523799 | MRK 003 | MRK 003 results in decreased expression of AKR1C1 mRNA | 21169257 |
| D015058 | 1-Naphthylisothiocyanate | 1-Naphthylisothiocyanate results in decreased expression of AKR1C1 mRNA | 25380136 |
| D009288 | Naproxen | Naproxen results in decreased activity of AKR1C1 protein | 19010312 |
| C005273 | naringenin | naringenin binds to and results in decreased activity of AKR1C1 protein | 16962702 |
| C051752 | nefazodone | nefazodone results in decreased expression of AKR1C1 mRNA | 24136188 |
| C026385 | n-hexane | n-hexane results in increased expression of AKR1C1 mRNA | 20566472 |
| C029938 | nickel sulfate | nickel sulfate results in increased expression of AKR1C1 mRNA | 20566472 |
| D009567 | Nitrazepam | Nitrazepam results in decreased activity of AKR1C1 protein | 11995921 |
| D009640 | Norethindrone | Norethindrone results in decreased activity of AKR1C1 protein | 21182831 |
| C558013 | NSC 689534 | [NSC 689534 binds to Copper] which results in increased expression of AKR1C1 mRNA | 20971185 |
| C025589 | ochratoxin A | ochratoxin A results in decreased expression of AKR1C1 mRNA | 19287073 |
| C016627 | octyl gallate | octyl gallate results in decreased activity of AKR1C1 protein | 27163852 |
| C030110 | oxaliplatin | AKR1C1 protein affects the susceptibility to oxaliplatin | 23933386 |
| C030110 | oxaliplatin | alpha-methylcinnamic acid inhibits the reaction [AKR1C1 protein affects the susceptibility to oxaliplatin] | 23933386 |
| C030110 | oxaliplatin | Flufenamic Acid inhibits the reaction [AKR1C1 protein affects the susceptibility to oxaliplatin] | 23933386 |
| C030110 | oxaliplatin | Phenolphthalein inhibits the reaction [AKR1C1 protein affects the susceptibility to oxaliplatin] | 23933386 |
| C036006 | oxcarbazepine | AKR1C1 protein results in increased reduction of oxcarbazepine | 25063510 |
| D052638 | Particulate Matter | [Particulate Matter co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA | 17612574 |
| D052638 | Particulate Matter | "[Particulate Matter co-treated with dibenzo(a,l)pyrene] results in increased expression of AKR1C1 mRNA" | 17612574 |
| D052638 | Particulate Matter | Particulate Matter results in increased expression of AKR1C1 mRNA | 19410595|2476925 |
| C568608 | PCI 5002 | [PCI 5002 co-treated with Zinc] results in decreased expression of AKR1C1 mRNA | 18593933 |
| C023036 | perfluorooctanoic acid | perfluorooctanoic acid results in decreased expression of AKR1C1 mRNA | 23978341 |
| D020113 | Phenolphthalein | Phenolphthalein inhibits the reaction [AKR1C1 protein affects the susceptibility to oxaliplatin] | 23933386 |
| D020113 | Phenolphthalein | Phenolphthalein results in decreased activity of AKR1C1 protein | 12604236 |
| D010662 | Phenylmercuric Acetate | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| D010662 | Phenylmercuric Acetate | Phenylmercuric Acetate results in increased expression of AKR1C1 mRNA | 26272509 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AKR1C1 mRNA | 19710929 |
| C006253 | pirinixic acid | pirinixic acid results in decreased expression of AKR1C1 mRNA | 22484513 |
| D010938 | Plant Oils | Plant Oils results in increased expression of AKR1C1 mRNA | 23370395 |
| D011084 | Polycyclic Aromatic Hydrocarbons | Polycyclic Aromatic Hydrocarbons affects the expression of AKR1C1 mRNA | 22579512 |
| D011278 | Pregnanes | AKR1C1 protein affects the metabolism of Pregnanes metabolite | 12604236 |
| D011280 | Pregnanolone | AKR1C1 protein affects the metabolism of Pregnanolone | 12604236 |
| D011280 | Pregnanolone | AKR1C1 protein results in increased reduction of Pregnanolone | 11995921 |
| D011374 | Progesterone | AKR1C1 protein affects the metabolism of and results in decreased activity of Progesterone | 16962702 |
| D011374 | Progesterone | AKR1C1 protein affects the reduction of Progesterone | 12604236|1633806 |
| D011374 | Progesterone | AKR1C1 protein results in increased reduction of Progesterone | 11995921|2224560 |
| D011374 | Progesterone | Progesterone results in decreased expression of AKR1C1 mRNA | 23183084 |
| D011374 | Progesterone | Progesterone results in increased expression of AKR1C1 mRNA | 19690047 |
| D011374 | Progesterone | AKR1C1 protein results in decreased activity of Progesterone | 19320734 |
| D011374 | Progesterone | Progesterone inhibits the reaction [AKR1C1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] | 28257955 |
| D019840 | 2-Propanol | 2-Propanol results in increased expression of AKR1C1 mRNA | 20566472 |
| C038291 | prostaglandin G2 | AKR1C1 protein results in increased metabolism of prostaglandin G2 | 8573067 |
| C030986 | pyrimidine | pyrimidine analog results in decreased activity of AKR1C1 protein | 19007763 |
| C502851 | quinocetone | quinocetone results in decreased expression of AKR1C1 mRNA | 27046791 |
| D015125 | Oxyquinoline | Oxyquinoline results in increased expression of AKR1C1 mRNA | 21632981 |
| C005266 | quinomethionate | quinomethionate affects the expression of AKR1C1 mRNA | 15387888 |
| C005266 | quinomethionate | quinomethionate results in increased expression of AKR1C1 mRNA | 18214805 |
| D017382 | Reactive Oxygen Species | [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 mRNA | 19320734 |
| D017382 | Reactive Oxygen Species | [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 protein | 19320734 |
| D017382 | Reactive Oxygen Species | Reactive Oxygen Species results in increased expression of AKR1C1 mRNA | 9973208 |
| D017975 | Ruthenium Compounds | Ruthenium Compounds analog inhibits the reaction [[AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol] | 25446855 |
| D020156 | Salicylic Acid | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] | 23165153 |
| D020156 | Salicylic Acid | Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin] | 23165153 |
| D020156 | Salicylic Acid | Salicylic Acid results in decreased activity of AKR1C1 protein | 19010312|2316515 |
| C078903 | seocalcitol | seocalcitol results in increased expression of AKR1C1 mRNA | 12040012 |
| D012822 | Silicon Dioxide | Silicon Dioxide analog results in decreased expression of AKR1C1 mRNA | 25895662 |
| D012834 | Silver | NFE2L2 protein promotes the reaction [Silver results in increased expression of AKR1C1 mRNA] | 22036727 |
| D012834 | Silver | Silver results in increased expression of AKR1C1 mRNA | 22036727 |
| D019821 | Simvastatin | Simvastatin results in increased expression of AKR1C1 mRNA | 17428261 |
| C009277 | sodium arsenate | sodium arsenate results in increased expression of AKR1C1 mRNA | 12727804 |
| C017947 | sodium arsenite | sodium arsenite affects the expression of AKR1C1 mRNA | 29319823 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of AKR1C1 mRNA | 19696165|2088654 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of AKR1C1 protein | 19696165 |
| C016104 | sodium bichromate | sodium bichromate results in decreased expression of AKR1C1 mRNA | 25993096 |
| D012967 | Sodium Dodecyl Sulfate | Sodium Dodecyl Sulfate results in increased expression of AKR1C1 mRNA | 20566472 |
| C016766 | sulforafan | sulforafan results in increased expression of AKR1C1 mRNA | 24383545|2584133 |
| D013467 | Sulindac | Sulindac results in decreased activity of AKR1C1 protein | 19010312 |
| C025462 | sulindac sulfide | sulindac sulfide results in increased expression of AKR1C1 mRNA | 16184548 |
| D014284 | Triiodothyronine | Triiodothyronine results in increased expression of AKR1C1 mRNA | 15507505 |
| C047246 | temozolomide | AKR1C1 mRNA affects the susceptibility to temozolomide | 16365179 |
| D013739 | Testosterone | [Testosterone co-treated with Calcitriol] results in increased expression of AKR1C1 mRNA | 21592394 |
| D013739 | Testosterone | Testosterone results in increased expression of AKR1C1 mRNA | 21592394 |
| C004648 | testosterone enanthate | testosterone enanthate affects the expression of AKR1C1 mRNA | 17440010 |
| D013749 | Tetrachlorodibenzodioxin | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C1 mRNA | 19619570 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of AKR1C1 mRNA | 19619570 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of AKR1C1 mRNA | 22298810 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of AKR1C1 mRNA | 21215274 |
| C009413 | tetrahydrodeoxycorticosterone | AKR1C1 protein affects the oxidation of tetrahydrodeoxycorticosterone | 12604236 |
| C019106 | tetralol | AKR1C1 protein affects the oxidation of tetralol | 12604236 |
| C019106 | tetralol | AKR1C1 protein results in increased metabolism of tetralol | 23165153 |
| D013853 | Thioacetamide | Thioacetamide results in decreased expression of AKR1C1 mRNA | 23411599|2622270 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in increased expression of AKR1C1 mRNA | 27404394|2786577 |
| C479163 | tofacitinib | AKR1C1 protein results in increased metabolism of tofacitinib metabolite | 27117606 |
| C066340 | tolcapone | tolcapone binds to AKR1C1 protein | 19783845 |
| D014241 | Trichloroethylene | Trichloroethylene results in increased methylation of AKR1C1 gene | 27618143 |
| C012589 | trichostatin A | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C012589 | trichostatin A | trichostatin A results in increased expression of AKR1C1 mRNA | 24935251|2627250 |
| C050414 | tripterine | tripterine results in increased expression of AKR1C1 mRNA | 17010675 |
| C016805 | tris(1,3-dichloro-2-propyl)phosphate | "tris(1,3-dichloro-2-propyl)phosphate results in increased expression of AKR1C1 mRNA" | 26179874 |
| C013320 | tris(2-butoxyethyl) phosphate | tris(2-butoxyethyl) phosphate results in decreased expression of AKR1C1 mRNA | 29024780 |
| C002802 | tungsten carbide | [tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA | 20105288 |
| C002802 | tungsten carbide | tungsten carbide results in decreased expression of AKR1C1 mRNA | 20105288 |
| D014520 | Urethane | Urethane results in decreased expression of AKR1C1 mRNA | 28818685 |
| D014580 | Ursodeoxycholic Acid | Ursodeoxycholic Acid results in decreased activity of AKR1C1 protein | 12604236 |
| C406224 | valdecoxib | valdecoxib results in decreased expression of AKR1C1 mRNA | 24136188 |
| D014635 | Valproic Acid | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| D014635 | Valproic Acid | Valproic Acid results in increased expression of AKR1C1 mRNA | 23179753|2438349 |
| D001335 | Vehicle Emissions | [Vehicle Emissions co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA | 17612574 |
| D001335 | Vehicle Emissions | "[Vehicle Emissions co-treated with dibenzo(a,l)pyrene] results in increased expression of AKR1C1 mRNA" | 17612574 |
| D024483 | Vitamin K 3 | Vitamin K 3 affects the expression of AKR1C1 mRNA | 20044591 |
| C111237 | vorinostat | "[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA" | 27188386 |
| C111237 | vorinostat | vorinostat results in increased expression of AKR1C1 mRNA | 26272509 |
| D015032 | Zinc | [PCI 5002 co-treated with Zinc] results in decreased expression of AKR1C1 mRNA | 18593933 |
| C020549 | zomepirac | zomepirac results in decreased activity of AKR1C1 protein | 19010312 |