Gene: TMPRSS6

164656
IRIDA
transmembrane serine protease 6
protein-coding
22q12.3
Ensembl:ENSG00000187045 MIM:609862 Vega:OTTHUMG00000150541 UniprotKB:Q8IU80
NG_012856.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.386e-1 (AD)  2.406e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18617091chr22:37495019TMPRSS61.000e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SAG0.957
GPR1010.955
ENTHD10.953
DRD30.945
DGKK0.934
GPR10.92
AMBN0.918
CHAT0.912
SLC35D30.909
PRLR0.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYTL2-0.412
SLC17A7-0.398
NXPH3-0.342
ALDH1A1-0.333
GALNT9-0.31
MEIS3-0.308
SOHLH1-0.302
NANOS3-0.291
NEUROD2-0.287
TBR1-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TMPRSS6 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TMPRSS6 mRNA]"19467301
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of TMPRSS6 mRNA16788091
D000082AcetaminophenAcetaminophen results in decreased expression of TMPRSS6 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of TMPRSS6 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of TMPRSS6 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TMPRSS6 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TMPRSS6 mRNA23630614
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of TMPRSS6 mRNA17639512
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMPRSS6 mRNA21871943|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMPRSS6 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMPRSS6 mRNA22300585
C006780bisphenol Abisphenol A results in decreased expression of TMPRSS6 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TMPRSS6 mRNA27339419
D003471CuprizoneCuprizone results in decreased expression of TMPRSS6 mRNA26577399
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TMPRSS6 mRNA26924002
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TMPRSS6 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of TMPRSS6 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of TMPRSS6 mRNA19467301
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of TMPRSS6 mRNA28943392
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TMPRSS6 mRNA21658437
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TMPRSS6 mRNA"19480007
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TMPRSS6 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TMPRSS6 mRNA17942748
D005557FormaldehydeFormaldehyde results in increased expression of TMPRSS6 mRNA18045764
C039281furanfuran results in increased methylation of TMPRSS6 gene22079235
D007501IronTMPRSS6 gene SNP affects the abundance of Iron19820698|1982069
D010634PhenobarbitalPhenobarbital affects the expression of TMPRSS6 mRNA19159669
C014153pirimiphos methylpirimiphos methyl results in increased expression of TMPRSS6 mRNA27845199
C045950propiconazolepropiconazole results in decreased expression of TMPRSS6 mRNA21278054
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of TMPRSS6 mRNA17639512
C089730rosiglitazonerosiglitazone results in decreased expression of TMPRSS6 mRNA25572481
D012643SeleniumSelenium results in increased expression of TMPRSS6 mRNA19244175
D053260SootSoot results in increased expression of TMPRSS6 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMPRSS6 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TMPRSS6 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TMPRSS6 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMPRSS6 mRNA28213091
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of TMPRSS6 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of TMPRSS6 mRNA23411599
D014635Valproic AcidValproic Acid results in decreased expression of TMPRSS6 mRNA29154799
D014810Vitamin EVitamin E results in increased expression of TMPRSS6 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0004252serine-type endopeptidase activity-IDA12149247  
GO:0005515protein binding-IPI19357398  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001525angiogenesis-NAS12149247  
GO:0006508proteolysis-IDA12149247  
GO:0006879cellular iron ion homeostasis-ISS-  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0030198extracellular matrix organization-NAS12149247  
GO:0030514negative regulation of BMP signaling pathway-IEA-  
GO:0030574collagen catabolic process-TAS-  
GO:0033619membrane protein proteolysis-IMP25156943  
GO:0035556intracellular signal transduction-NAS12149247  
GO:0042730fibrinolysis-IBA21873635  
GO:0042730fibrinolysis-IDA12149247  
GO:0045892negative regulation of transcription, DNA-templated-IMP25156943  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0055072iron ion homeostasis-IBA21873635  
GO:0055072iron ion homeostasis-IMP18408718  
GO:0097264self proteolysis-IMP25156943  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA25156943  
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA19357398  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IDA12149247  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationIEA
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29133146Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population. (2018 Feb 5)Seiki TGene