Gene: TTLL8

164714
-
tubulin tyrosine ligase like 8
protein-coding
22q13.33
Ensembl:ENSG00000138892 Vega:OTTHUMG00000150241 UniprotKB:A6PVC2
NC_000022.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs137878chr22:50018362 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRYBA40.402
SERPINA70.397
FSCN30.393
ITK0.388
IGFL30.388
TBX200.38
ARMS20.38
BNC10.369
CALCA0.362
WNT3A0.36

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LYPD8-0.222
LRRC38-0.216
KCNK17-0.196
LHFPL5-0.196
MYCNOS-0.195
TMEM233-0.188
GNRHR-0.187
METTL24-0.186
CRABP1-0.184
GP5-0.183

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TTLL8 mRNA"28903501
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TTLL8 mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of TTLL8 mRNA25181051
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TTLL8 mRNA"24972896
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TTLL8 mRNA"20188158
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TTLL8 mRNA28903501
D014635Valproic AcidValproic Acid results in increased methylation of TTLL8 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0070735protein-glycine ligase activity-ISS-  
GO:0070735protein-glycine ligase activity-TAS-  
GO:0070736protein-glycine ligase activity, initiating-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0018094protein polyglycylation-ISS-  
GO:0018094protein polyglycylation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IEA-  
GO:0005929cilium-ISS-  
GO:0005930axoneme-ISS-  
GO:0015630microtubule cytoskeleton-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal