Gene info: ID 1652

Gene: DDT

GENE ID: 1652

Synonyms: D-DT|DDCT|MIF-2|MIF2

Description: D-dopachrome tautomerase

Gene type: protein-coding

Location: 22q11.23

dbXrefs: Ensembl:ENSG00000099977 MIM:602750 Vega:OTTHUMG00000150798 UniprotKB:P30046

RefSeq: NC_000022.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 18

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.040e-1 (AD) 3.154e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SCAND1	0.876
AURKAIP1	0.871
THAP7	0.87
NUBP2	0.868
NDUFA11	0.866
DGCR6L	0.865
NDUFS8	0.861
C19orf70	0.861
MRPL54	0.856
TIMM13	0.854

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.637
OR4F29	-0.617
MTRNR2L9	-0.393
CCDC36	-0.379
MTRNR2L6	-0.37
MTRNR2L10	-0.363
DNAH11	-0.345
TTLL10-AS1	-0.329
MTRNR2L3	-0.326
SFTPA1	-0.326

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of DDT mRNA"	19162173
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of DDT mRNA"	28903501
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DDT mRNA"	25510870
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of DDT mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of DDT mRNA]"	19414516
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DDT mRNA"	19114083
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DDT mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DDT mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DDT mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DDT mRNA"	25510870
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to DDT protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to DDT protein]	26598702
D000082	Acetaminophen	Acetaminophen results in decreased expression of DDT mRNA	29067470
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of DDT mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DDT mRNA]	17585979
D000242	Cyclic AMP	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of DDT mRNA]"	19414516
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of DDT protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of DDT mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of DDT gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of DDT mRNA	19770486
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of DDT mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DDT mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to DDT protein]	26598702
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DDT mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DDT mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DDT mRNA	22228805
D004958	Estradiol	Estradiol results in decreased expression of DDT mRNA	23019147
C006780	bisphenol A	bisphenol A affects the expression of DDT mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of DDT mRNA	25181051
C006780	bisphenol A	[Fructose co-treated with bisphenol A] results in increased expression of DDT protein	26930160
C032036	bromobenzene	bromobenzene metabolite binds to DDT protein	17305373
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of DDT protein	22081424
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of DDT promoter	22457795
D002220	Carbamazepine	Carbamazepine affects the expression of DDT mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DDT protein	18930782
C100187	chloropicrin	chloropicrin results in increased expression of DDT mRNA	26352163
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of DDT mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DDT mRNA]	17585979
D003300	Copper	DDT protein binds to Copper	14534351
D003345	Corticosterone	Corticosterone results in increased expression of DDT mRNA	15755911
D016572	Cyclosporine	Cyclosporine results in decreased expression of DDT mRNA	20106945
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DDT mRNA]	27941970
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of DDT protein	16344271
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DDT mRNA	17379624\|2126653
D002945	Cisplatin	Cisplatin results in increased expression of DDT mRNA	27392435
D004008	Diclofenac	Diclofenac results in decreased expression of DDT mRNA	26934552
D004147	Dioxins	Dioxins affects the expression of DDT mRNA	20463971
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DDT protein	23301498
D005419	Flavonoids	Flavonoids results in decreased expression of DDT mRNA	18035473
D005485	Flutamide	Flutamide results in increased expression of DDT mRNA	24136188
D005632	Fructose	[Fructose co-treated with bisphenol A] results in increased expression of DDT protein	26930160
D005632	Fructose	Fructose results in decreased expression of DDT protein	26930160
C056933	fumonisin B1	fumonisin B1 results in decreased expression of DDT mRNA	16221962
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of DDT mRNA	17183730
C029424	hydrazine	hydrazine results in decreased expression of DDT protein	15370871
C492448	ICG 001	ICG 001 results in increased expression of DDT mRNA	26191083
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of DDT mRNA	21461237
D008148	Lovastatin	Lovastatin results in decreased expression of DDT mRNA	20493250
D008694	Methamphetamine	Methamphetamine affects the expression of DDT protein	17904249
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of DDT mRNA	23649840
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of DDT protein	19716841
C025589	ochratoxin A	ochratoxin A results in decreased expression of DDT mRNA	12700408
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DDT mRNA"	25510870
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of DDT protein	19854247
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of DDT mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of DDT mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of DDT mRNA	19162173
C006253	pirinixic acid	pirinixic acid results in increased expression of DDT mRNA	16221962\|1830175
D011374	Progesterone	Progesterone results in decreased expression of DDT mRNA	23018184
D011374	Progesterone	Progesterone results in increased expression of DDT mRNA	20726854
D015474	Isotretinoin	Isotretinoin results in decreased expression of DDT mRNA	20436886
C089730	rosiglitazone	rosiglitazone results in decreased expression of DDT mRNA	25572481
C016104	sodium bichromate	sodium bichromate results in decreased expression of DDT mRNA	24612858
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of DDT protein	28918527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DDT mRNA	21570461
D014212	Tretinoin	Tretinoin results in decreased expression of DDT mRNA	21934132
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of DDT gene	27618143
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of DDT mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of DDT mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of DDT mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased methylation of DDT gene	29154799
D014640	Vancomycin	Vancomycin results in increased expression of DDT mRNA	18930951
C025643	vinclozolin	vinclozolin results in increased expression of DDT mRNA	20566332\|2257069
D014859	Warfarin	Warfarin results in decreased expression of DDT mRNA	20493250

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004167	dopachrome isomerase activity	-	TAS	9480844
GO:0005126	cytokine receptor binding	-	IDA	21817065
GO:0033981	D-dopachrome decarboxylase activity	-	IEA	-
GO:0050178	phenylpyruvate tautomerase activity	-	IDA	21817065

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0010760	negative regulation of macrophage chemotaxis	-	IDA	21817065
GO:0032760	positive regulation of tumor necrosis factor production	-	IDA	21817065
GO:0042438	melanin biosynthetic process	-	IEA	-
GO:0050729	positive regulation of inflammatory response	-	IC	21817065
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IGI	21817065

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IDA	21817065
GO:0005737	cytoplasm	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
12199964	The effect of dithiothreitol on VLA-4 detection in peripheral blood and induced sputum cells. (2002 Jul-Aug)	Dominguez-Ortega J	Allergol Immunopathol (Madr)
1536596	Organochlorine pesticide residues in human milk in the Ribeirao Preto region, state of Sao Paulo, Brazil. (1992 Feb)	Matuo YK	Arch Environ Contam Toxicol
19966832	Male reproductive organs are at risk from environmental hazards. (2010 Mar)	Bonde JP	Asian J Androl
15238281	Associations between plasma DDE levels and immunologic measures in African-American farmers in North Carolina. (2004 Jul)	Cooper GS	Environ Health Perspect
9322121	Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma. (1997 Jun)	Dergham ST	Int J Pancreatol
22445419	Dimensions of impulsivity among heavy drinkers, smokers, and heavy drinking smokers: singular and combined effects. (2012 Jul)	Moallem NR	Addict Behav
19457543	Levels of chlorinated pesticides and polychlorinated biphenyls in Norwegian breast milk (2002-2006), and factors that may predict the level of contamination. (2009 Aug 1)	Polder A	Sci Total Environ
20701904	Early life environment, neurodevelopment and the interrelation with atopy. (2010 Oct)	Sunyer J	Environ Res
80916	Contaminants in human milk. (1978 Sep)	Olszyna-Marzys AE	Acta Paediatr Scand
15262173	Organochlorine compounds in breast-fed vs. bottle-fed infants: preliminary results at six weeks of age. (2004 Aug 15)	Lackmann GM	Sci Total Environ
11100299	Environmental factors in infertility. (2000 Dec)	Hruska KS	Clin Obstet Gynecol
8476311	Environmental exposure and lifestyle predictors of lead, cadmium, PCB, and DDT levels in Great Lakes fish eaters. (1993 Mar-Apr)	Hovinga ME	Arch Environ Health
3418740	Relation between the content of organochlorine compounds in Finnish human milk and characteristics of the mothers. (1988)	Mussalo-Rauhamaa H	J Toxicol Environ Health
26829394	Androgen Receptor Genotype in Humans and Susceptibility to Endocrine Disruptors. (2016)	Lundberg Giwercman Y	Horm Res Paediatr
12948891	The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p'-DDE. (2003 Sep)	Hauser R	Environ Health Perspect
9679221	The effect of cooking practices on the concentration of DDT and PCB compounds in the edible tissue of fish. (1998 Jul-Sep)	Wilson ND	J Expo Anal Environ Epidemiol
7528509	[Burden of DDT, HCH, HCB and PCB in human milk in the former German Democratic Republic. Research and toxicologic evaluation]. (1994 Aug)	Horn M	Zentralbl Hyg Umweltmed
19539994	Organochlorine and heavy metals in newborns: results from the Flemish Environment and Health Survey (FLEHS 2002-2006). (2009 Oct)	Koppen G	Environ Int