Gene: UBXN2A

165324
UBXD4
UBX domain protein 2A
protein-coding
2p23.3
Ensembl:ENSG00000173960 Vega:OTTHUMG00000125497 UniprotKB:P68543
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.473e-1 (AD)  9.606e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCNG10.868
GNAI30.847
LMAN10.839
SMC30.834
G3BP10.834
GABPA0.831
ZDHHC20.828
TAB20.823
SMAD50.82
TWF10.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.551
OR4F29-0.508
CHST13-0.302
KCNG2-0.296
GSG1-0.281
ADRA1D-0.274
NKD2-0.263
LRRC26-0.259
TPBGL-0.258
ABCC12-0.253

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of UBXN2A mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UBXN2A mRNA22316170
C006780bisphenol Abisphenol A results in increased expression of UBXN2A mRNA25181051
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of UBXN2A mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of UBXN2A mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of UBXN2A mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of UBXN2A mRNA25562108
D004317DoxorubicinDoxorubicin results in decreased expression of UBXN2A mRNA17888722|1927712
D005557FormaldehydeFormaldehyde results in increased expression of UBXN2A mRNA23649840
C544151jinfukangjinfukang results in decreased expression of UBXN2A mRNA27392435
C410337K 7174K 7174 results in increased expression of UBXN2A mRNA24086573
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of UBXN2A mRNA22839698
C045463leflunomideleflunomide results in increased expression of UBXN2A mRNA24136188
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UBXN2A mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UBXN2A mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of UBXN2A mRNA19812364
D010634PhenobarbitalPhenobarbital affects the expression of UBXN2A mRNA23091169
C049032pinosylvinpinosylvin results in decreased expression of UBXN2A mRNA23333577
C006253pirinixic acidpirinixic acid results in increased expression of UBXN2A mRNA18301758|1844570
D012834SilverSilver affects the expression of UBXN2A mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of UBXN2A mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UBXN2A mRNA21570461
C406224valdecoxibvaldecoxib results in increased expression of UBXN2A mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of UBXN2A mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of UBXN2A gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of UBXN2A mRNA26682919
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of UBXN2A mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21900206  
GO:0033130acetylcholine receptor binding-IEA-  
GO:0043130ubiquitin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0007030Golgi organization-IBA21873635  
GO:0010468regulation of gene expression-IEA-  
GO:0031396regulation of protein ubiquitination-IEA-  
GO:0031468nuclear envelope reassembly-IBA21873635  
GO:0042176regulation of protein catabolic process-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0043666regulation of phosphoprotein phosphatase activity-IEA-  
GO:0061025membrane fusion-IBA21873635  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005801cis-Golgi network-IEA-  
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26265139UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. (2015 Oct 15)Teng YBiochem Pharmacol