Gene: DDX6

1656
HLR2|P54|RCK
DEAD-box helicase 6
protein-coding
11q23.3
Ensembl:ENSG00000110367 MIM:600326 Vega:OTTHUMG00000166411 UniprotKB:P26196
NC_000011.10
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.668e-1 (AD)  1.082e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25131247chr11:118660965DDX6Promoter1.975e-4Alcohol use disorders26763658
cg16744438chr11:118657127DDX67.260e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE4A0.935
SPIRE10.92
NFAT50.918
ZNF7700.918
PTPRJ0.911
RAB5B0.91
SLC12A60.91
TSTD20.91
MTPN0.903
LNPEP0.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.431
OR4F29-0.41
APOA1-0.323
NANOGNB-0.323
FAM229A-0.31
HMX1-0.287
ANP32C-0.285
S100A1-0.28
KLRC3-0.27
BCL7C-0.269

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01694D-tartaric acidSmall Molecule147-71-7ExperimentalTarget
ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of DDX6 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of DDX6 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of DDX6 mRNA17585979
D000082AcetaminophenAcetaminophen results in increased expression of DDX6 mRNA11264010
D000086AcetazolamideAcetazolamide results in increased expression of DDX6 mRNA19274763
D020106AcrylamideAcrylamide results in decreased expression of DDX6 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DDX6 mRNA19770486
C015001arsenitearsenite affects the methylation of DDX6 promoter23974009
D001280AtrazineAtrazine results in decreased expression of DDX6 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to DDX6 promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DDX6 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of DDX6 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of DDX6 mRNA21786754
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DDX6 mRNA28628672
C013418bromfenacoumbromfenacoum results in decreased expression of DDX6 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of DDX6 mRNA15003993
D002509CephaloridineCephaloridine results in decreased expression of DDX6 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DDX6 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of DDX6 mRNA23125180
D003042CocaineCocaine results in increased expression of DDX6 mRNA17898221
D019327Copper SulfateCopper Sulfate results in increased expression of DDX6 mRNA19549813
C093628cyproconazolecyproconazole results in decreased expression of DDX6 mRNA22334560|2397080
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DDX6 mRNA28628672
D004041Dietary FatsDietary Fats results in decreased expression of DDX6 mRNA25016146
D004317DoxorubicinDoxorubicin results in decreased expression of DDX6 mRNA19277126
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DDX6 protein23301498
C109476epoxiconazoleepoxiconazole results in decreased expression of DDX6 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DDX6 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DDX6 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DDX6 mRNA23550701
C001277geldanamycingeldanamycin results in increased expression of DDX6 mRNA26705709
D005839GentamicinsGentamicins results in increased expression of DDX6 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DDX6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DDX6 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of DDX6 mRNA27392435
C410337K 7174K 7174 results in decreased expression of DDX6 mRNA24086573
C045463leflunomideleflunomide results in decreased expression of DDX6 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DDX6 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of DDX6 mRNA27544571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DDX6 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in decreased expression of DDX6 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DDX6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DDX6 mRNA"25554681
C014707nitrosobenzylmethylamine[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DDX6 mRNA12517797
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of DDX6 mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of DDX6 mRNA23948077
D010634PhenobarbitalPhenobarbital results in decreased expression of DDX6 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DDX6 mRNA19710929
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of DDX6 mRNA21334430
D011374ProgesteroneProgesterone affects the expression of DDX6 mRNA17251523
C045950propiconazolepropiconazole results in decreased expression of DDX6 mRNA21278054|2233456
D012715Sesame OilSesame Oil results in increased expression of DDX6 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DDX6 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of DDX6 mRNA19073995
D012834SilverSilver results in decreased expression of DDX6 mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of DDX6 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of DDX6 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DDX6 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DDX6 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DDX6 promoter]19654925
D013849ThimerosalThimerosal results in decreased expression of DDX6 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of DDX6 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of DDX6 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DDX6 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of DDX6 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of DDX6 mRNA16788091
D014241TrichloroethyleneTrichloroethylene results in decreased expression of DDX6 mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX6 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of DDX6 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DDX6 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of DDX6 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of DDX6 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased expression of DDX6 mRNA21427059
C025643vinclozolinvinclozolin affects the expression of DDX6 mRNA19015723
C111237vorinostatvorinostat results in decreased expression of DDX6 mRNA27188386
D015032Zinc[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DDX6 mRNA12517797

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003724RNA helicase activity-TAS1579499  
GO:0004386helicase activity-TAS1394235  1579499  
GO:0005515protein binding-IPI16364915  16699599  16756390  17392519  19966221  20543818  
20584987  20616046  24862572  25036637  25416956  26184334  
26496610  27107012  
GO:0005524ATP binding-IEA-  
GO:0019904protein domain specific binding-IPI24768540  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0007283spermatogenesis-IEA-  
GO:0019074viral RNA genome packaging-IMP22022269  
GO:0019827stem cell population maintenance-IEA-  
GO:0033962cytoplasmic mRNA processing body assembly-IDA20826699  
GO:0043928exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay-TAS-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000792heterochromatin-IEA-  
GO:0000932P-body-IDA16699599  20616046  20826699  22915799  23125361  
GO:0000932P-body-IMP22022269  
GO:0001520outer dense fiber-IEA-  
GO:0005634nucleus-IDA26184334  
GO:0005737cytoplasm-IDA26184334  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0010494cytoplasmic stress granule-IDA17392519  26184334  
GO:0016020membrane-HDA19946888  
GO:0016442RISC complex-IDA20616046  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA-  
GO:0043186P granule-IEA-  
GO:0097227sperm annulus-IEA-  
KEGG ID KEGG Term
hsa03018RNA degradation
Reactome ID Reactome Term Evidence
R-HSA-429914Deadenylation-dependent mRNA decayTAS
R-HSA-430039mRNA decay by 5' to 3' exoribonucleaseTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21742680Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. (2011 Sep 1)Lachance DHAm J Epidemiol