Gene: PARP15

165631
ARTD7|BAL3|pART7
poly(ADP-ribose) polymerase family member 15
protein-coding
3q21.1
Ensembl:ENSG00000173200 MIM:612066 Vega:OTTHUMG00000159523 UniprotKB:Q460N3
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.330e-1 (AD)  6.930e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LILRB20.879
SLAMF60.864
TRIM60.857
SLAMF70.833
SPTLC30.827
TNFAIP80.819
KLHDC7B0.819
CASP80.816
RIPK30.814
DAPP10.812

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.522
MAGIX-0.482
CYP46A1-0.481
CHRNA4-0.471
ZNF835-0.467
DBP-0.467
MYADML2-0.465
C1orf53-0.462
HRH3-0.461
C15orf59-0.453

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08348N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PARP15 mRNA24449571
D016650Fluorescein-5-isothiocyanateFluorescein-5-isothiocyanate binds to PARP15 protein27129696
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PARP15 mRNA23086925
D009532NickelNickel results in increased expression of PARP15 mRNA24768652

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001191transcriptional repressor activity, RNA polymerase II transcription factor binding-IMP16061477  
GO:0003950NAD+ ADP-ribosyltransferase activity-IMP16061477  25635049  
GO:0005515protein binding-IPI23473667  
GO:0070403NAD+ binding-IMP16061477  25635049  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP16061477  
GO:0006351transcription, DNA-templated-IEA-  
GO:0070212protein poly-ADP-ribosylation-IMP16061477  25635049  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC16061477  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28814981CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)Morandi LClin Epigenetics