Gene: DMXL1

1657
-
Dmx like 1
protein-coding
5q23.1
Ensembl:ENSG00000172869 MIM:605671 Vega:OTTHUMG00000128898 UniprotKB:Q9Y485
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.987e-1 (AD)  2.591e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7717384chr5:119145510 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LTN10.943
SNX130.926
PANK30.92
RALGAPA10.919
CEP1700.917
ZBTB410.912
TRAPPC80.911
TTC370.909
ATRX0.909
TAOK10.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.501
OR4F29-0.474
CSAG1-0.395
MTRNR2L6-0.336
MTRNR2L10-0.326
MTRNR2L8-0.322
MTRNR2L9-0.321
MTRNR2L2-0.315
SERPINH1-0.311
HSPA6-0.3

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of DMXL1 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DMXL1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DMXL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DMXL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of DMXL1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of DMXL1 mRNA17562736
C109238acylineacyline results in increased expression of DMXL1 mRNA17510436
D001104ArbutinArbutin results in decreased expression of DMXL1 mRNA17103032
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DMXL1 mRNA20106945|2163298
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of DMXL1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of DMXL1 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of DMXL1 mRNA26496021
D003010ClorgylineClorgyline results in increased expression of DMXL1 mRNA19691856
C018021cobaltous chloridecobaltous chloride results in increased expression of DMXL1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of DMXL1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of DMXL1 mRNA"19167446
D016572CyclosporineCyclosporine results in increased expression of DMXL1 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of DMXL1 mRNA19770486
D002945CisplatinCisplatin results in decreased expression of DMXL1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of DMXL1 mRNA28302478
C118739entinostatentinostat results in increased expression of DMXL1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DMXL1 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DMXL1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DMXL1 mRNA29097150
C039281furanfuran results in increased methylation of DMXL1 gene22079235
D017313FenretinideFenretinide results in decreased expression of DMXL1 mRNA28973697
C544151jinfukangjinfukang results in decreased expression of DMXL1 mRNA27392435
C011890kojic acidkojic acid results in decreased expression of DMXL1 mRNA16595896
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DMXL1 mRNA25729387
D010634PhenobarbitalPhenobarbital affects the expression of DMXL1 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of DMXL1 mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of DMXL1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DMXL1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DMXL1 mRNA22079256
D011794QuercetinQuercetin affects the expression of DMXL1 protein19207037
D011794QuercetinQuercetin results in decreased expression of DMXL1 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of DMXL1 mRNA21632981
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DMXL1 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of DMXL1 mRNA28542535
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DMXL1 gene25560391
C025643vinclozolinvinclozolin affects the expression of DMXL1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007035vacuolar acidification-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0043291RAVE complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal