Gene: AES

166
AES-1|AES-2|ESP1|GRG|GRG5|Grg-5|TLE5
amino-terminal enhancer of split
protein-coding
19p13.3
Ensembl:ENSG00000104964 MIM:600188 Vega:OTTHUMG00000180567 UniprotKB:Q08117
NG_029870.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.334e-1 (AD)  7.174e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CA110.96
SLC25A60.95
FKBP80.945
UBXN60.943
RUNDC3A0.94
PPP1R12C0.937
UBE2M0.935
PDZD40.933
SH3GLB20.933
BAP10.933

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.867
OR4F29-0.854
KCNJ15-0.282
C1orf87-0.275
CR1-0.266
TFPI2-0.259
TREM1-0.257
CP-0.254
CXCR2-0.254
FOLR3-0.25

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of AES mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AES mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to AES protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AES protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AES mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of AES mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AES mRNA19770486
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of AES mRNA17023530
D001151ArsenicArsenic affects the expression of AES mRNA18414638
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AES protein]26598702
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AES mRNA26238291
C006780bisphenol Abisphenol A affects the expression of AES mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of AES mRNA25181051
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of AES mRNA15878706
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of AES mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AES mRNA15003993
C018475butyraldehydebutyraldehyde results in decreased expression of AES mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of AES mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of AES mRNA17484886
C018021cobaltous chloridecobaltous chloride results in decreased expression of AES mRNA19320972|1937684
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AES mRNA17361019|2126653
D004147DioxinsDioxins affects the expression of AES mRNA20463971
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of AES mRNA17347304
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of AES mRNA17347304
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of AES mRNA28329830
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of AES mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of AES mRNA21179406
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of AES mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AES mRNA23086925
C410337K 7174K 7174 results in decreased expression of AES mRNA24086573
C030667methylazoxymethanolmethylazoxymethanol results in increased expression of AES mRNA17107856
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AES mRNA23103053
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of AES mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AES mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AES mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AES mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of AES mRNA24136188
C012655nimesulidenimesulide results in decreased expression of AES mRNA24136188
D009569Nitric OxideNitric Oxide deficiency results in increased expression of AES mRNA15878706
D010269ParaquatParaquat results in decreased expression of AES mRNA16797015
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of AES mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AES mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of AES mRNA19159669
C006253pirinixic acidpirinixic acid results in decreased expression of AES mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of AES mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of AES protein23718831
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of AES mRNA19162173
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AES mRNA25895662
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of AES mRNA16214533
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AES mRNA21570461
D014212TretinoinTretinoin results in increased expression of AES mRNA16054129
D014241TrichloroethyleneTrichloroethylene results in decreased expression of AES mRNA19448997
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of AES mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AES mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of AES mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AES mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of AES mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AES gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-IDA19460168  
GO:0003714transcription corepressor activity-IPI10660609  
GO:0005515protein binding-IPI10660609  11390640  12441302  15006356  22952044  23732115  
25416956  
GO:0070491repressing transcription factor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP10660609  
GO:0001501skeletal system development-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007275multicellular organism development-TAS8365415  
GO:0009887animal organ morphogenesis-TAS9809752  
GO:0010629negative regulation of gene expression-IMP15006356  
GO:0016055Wnt signaling pathway-IEA-  
GO:0031668cellular response to extracellular stimulus-IEA-  
GO:0032091negative regulation of protein binding-IDA15489227  
GO:0040008regulation of growth-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA19460168  
GO:0060761negative regulation of response to cytokine stimulus-IMP15489227  
GO:0070555response to interleukin-1-IDA15489227  
GO:0090090negative regulation of canonical Wnt signaling pathway-IBA21873635  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA19460168  
GO:2000210positive regulation of anoikis-IMP15006356  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA22952044  
GO:0005667transcription factor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-195253Degradation of beta-catenin by the destruction complexIEA
R-HSA-195721Signaling by WNTIEA
R-HSA-4641265Repression of WNT target genesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2753006Cadmium and chromium as markers of smoking in human lung tissue. (1989 Aug)Paakko PEnviron Res
24965407Gefitinib as first-line treatment for patients with epidermal growth factor receptor-mutated advanced lung adenocarcinoma: a single institution experience in Taiwan. (2014 Apr-Jun)Lai SWJ BUON
22978775Maintenance therapy of gefitinib for non-small-cell lung cancer after first-line chemotherapy regardless of epidermal growth factor receptor mutation: a review in Chinese patients. (2012 Oct)Biaoxue RCurr Med Res Opin
27099485The Belgian trial with azithromycin for acute COPD exacerbations requiring hospitalization: an investigator-initiated study protocol for a multicenter, randomized, double-blind, placebo-controlled trial. (2016)Vermeersch KInt J Chron Obstruct Pulmon Dis
28044255Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study. (2017 Feb)Rutrick DAdv Ther
26620151Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor. (2016 May)Lazaar ALBr J Clin Pharmacol
20690782Population pharmacokinetic modelling of roflumilast and roflumilast N-oxide by total phosphodiesterase-4 inhibitory activity and development of a population pharmacodynamic-adverse event model. (2010 Sep)Lahu GClin Pharmacokinet
24877251Cost effectiveness of duloxetine for osteoarthritis: a Quebec societal perspective. (2014 May)Wielage RCArthritis Care Res (Hoboken)
17692720Efficacy and tolerability of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, in a 12-week, randomized, placebo-controlled, dose-response study with 40-week follow-up for smoking cessation in Japanese smokers. (2007 Jun)Nakamura MClin Ther
22007690Safety and tolerability of varenicline tartrate (Champix((R))/Chantix((R))) for smoking cessation in HIV-infected subjects: a pilot open-label study. (2012 Jan)Cui QAIDS Patient Care STDS
1826194Asbestos exposure and asbestos-related pleural and parenchymal disease. Associations with immune imbalance. (1991 Apr)Sprince NLAm Rev Respir Dis
28429843Pooled analysis of three randomized, double-blind, placebo controlled trials with rimonabant for smoking cessation. (2018 Jan)Robinson JDAddict Biol
25867537Prospective cohort study of clinical characteristics and management patterns for patients with non-small-cell lung cancer in the Russian Federation: EPICLIN-Lung. (2015 Jun)Tjulandin SCurr Med Res Opin
28176907A randomized trial of once-daily fluticasone furoate/vilanterol or vilanterol versus placebo to determine effects on arterial stiffness in COPD. (2017)Bhatt SPInt J Chron Obstruct Pulmon Dis