Gene info: ID 166336

SNP ID	Position	Alleles	Trait	Variation Type
rs201013261	chr3:64125982-64125983 (GRCh38.p7)	insAC	nicotine dependence	Insertion
rs1024895	chr3:64125982 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs830010	chr3:64123061 (GRCh38.p7)	C>A	nicotine dependence	SNV(Single Nucleotide Variation)
rs1096170	chr3:64118712 (GRCh38.p7)	C>T	nicotine dependence	SNV(Single Nucleotide Variation)

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg18450254	chr3:64200005	PRICKLE2		2.300e-21	Smoking	27651444

Gene Symbol	Pearson Correlation Coefficient
CSRNP2	0.93
CCSAP	0.928
TBPL1	0.92
NEDD4L	0.914
DCAF10	0.912
FEM1B	0.912
ARHGEF7	0.911
KAT7	0.91
CCDC6	0.909
AFTPH	0.909

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.544
OR4F29	-0.496
ASB4	-0.439
TFPI2	-0.436
KLRB1	-0.419
FZD10	-0.405
KLRF1	-0.395
MYL3	-0.393
IL18RAP	-0.39
CSAG1	-0.389

DrugBank
CTD

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C012796	2-butenal	2-butenal results in decreased expression of PRICKLE2 mRNA	20471460
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRICKLE2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRICKLE2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of PRICKLE2 mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PRICKLE2 mRNA	27153756
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of PRICKLE2 gene	25435355
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PRICKLE2 mRNA	21839799
C006780	bisphenol A	bisphenol A affects the expression of PRICKLE2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of PRICKLE2 mRNA	29275510
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRICKLE2 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of PRICKLE2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of PRICKLE2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of PRICKLE2 gene	28505145
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRICKLE2 mRNA	28628672
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of PRICKLE2 mRNA	21356183
D003042	Cocaine	Cocaine results in increased expression of PRICKLE2 mRNA	17898221
D003471	Cuprizone	Cuprizone results in decreased expression of PRICKLE2 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of PRICKLE2 mRNA	20106945\|2798913
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRICKLE2 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRICKLE2 mRNA	28628672
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of PRICKLE2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of PRICKLE2 mRNA	27392435
D002117	Calcitriol	Calcitriol results in decreased expression of PRICKLE2 mRNA	16002434
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of PRICKLE2 mRNA	22079256
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PRICKLE2 mRNA	22079256
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of PRICKLE2 mRNA	23649840
D005557	Formaldehyde	Formaldehyde results in increased expression of PRICKLE2 mRNA	23649840
C039281	furan	furan results in increased methylation of PRICKLE2 gene	22079235
D017313	Fenretinide	Fenretinide results in increased expression of PRICKLE2 mRNA	28973697
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRICKLE2 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRICKLE2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRICKLE2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRICKLE2 mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of PRICKLE2 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of PRICKLE2 mRNA	27392435
D007854	Lead	Lead affects the expression of PRICKLE2 mRNA	28903495
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased methylation of PRICKLE2 gene	21212295
D008070	Lipopolysaccharides	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of PRICKLE2 gene	21212295
D008070	Lipopolysaccharides	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of PRICKLE2 gene	21212295
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of PRICKLE2 mRNA	20713471
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PRICKLE2 mRNA	23649840
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PRICKLE2 mRNA"	25554681
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of PRICKLE2 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of PRICKLE2 mRNA	25729387
D052638	Particulate Matter	Particulate Matter results in decreased expression of PRICKLE2 mRNA	22178795
D010634	Phenobarbital	Phenobarbital affects the methylation of PRICKLE2 gene	19233941
D010634	Phenobarbital	Phenobarbital affects the methylation of PRICKLE2 promoter	19482888
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRICKLE2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PRICKLE2 mRNA	26272509
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PRICKLE2 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of PRICKLE2 mRNA	22079256\|2271453
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of PRICKLE2 mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of PRICKLE2 mRNA	19162173
D011441	Propylthiouracil	Propylthiouracil results in increased expression of PRICKLE2 mRNA	24780913
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of PRICKLE2 mRNA	21427059
D012643	Selenium	Selenium results in decreased methylation of PRICKLE2 gene	21606628
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of PRICKLE2 mRNA	25895662
C009277	sodium arsenate	sodium arsenate results in increased expression of PRICKLE2 mRNA	21795629
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of PRICKLE2 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of PRICKLE2 gene	21212295
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of PRICKLE2 gene	21212295
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased methylation of PRICKLE2 gene	21212295
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased methylation of PRICKLE2 gene	21212295
C009495	titanium dioxide	titanium dioxide results in decreased expression of PRICKLE2 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of PRICKLE2 mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of PRICKLE2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of PRICKLE2 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of PRICKLE2 mRNA	20488242
C012589	trichostatin A	trichostatin A results in increased expression of PRICKLE2 mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PRICKLE2 mRNA"	26179874
D014635	Valproic Acid	Valproic Acid affects the expression of PRICKLE2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of PRICKLE2 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of PRICKLE2 mRNA	23179753\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of PRICKLE2 mRNA	21427059
D014638	Vanadates	Vanadates results in increased expression of PRICKLE2 mRNA	22714537

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	-
GO:0031965	nuclear membrane	-	IEA	-

Gene: PRICKLE2

ANCO-SNPs

DNA Methylation

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

There is no DrugBank record for this gene !

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)