Gene: DEFB1

1672
BD1|DEFB-1|DEFB101|HBD1
defensin beta 1
protein-coding
8p23.1
Ensembl:ENSG00000164825 MIM:602056 Vega:OTTHUMG00000090367 UniprotKB:P60022
NC_000008.11
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.473e-1 (AD)  4.133e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR9Q20.523
TAS2R410.484
CD1B0.473
OR2A140.466
DMRTC20.464
MTRNR2L50.463
MEOX10.463
LMX1B0.462
OR56A30.461
PRDM140.461

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNGA4-0.246
FAM19A4-0.239
TMEM253-0.221
GAS2-0.214
MND1-0.211
LDHAL6A-0.204
GOLGA8K-0.203
ACRV1-0.202
MBOAT4-0.201
HEPACAM2-0.199

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of DEFB1 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DEFB1 mRNA"27291303
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DEFB1 mRNA"20959002
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DEFB1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DEFB1 mRNA23630614
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of DEFB1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DEFB1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DEFB1 mRNA24449571
D001151ArsenicArsenic results in decreased expression of DEFB1 mRNA18511430
D001151ArsenicArsenic results in decreased expression of DEFB1 protein18511430
C406592azaspiracidazaspiracid results in decreased expression of DEFB1 mRNA28939011
C447119bazedoxifene[Progesterone co-treated with bazedoxifene] results in increased expression of DEFB1 mRNA18367319
C487081belinostatbelinostat results in decreased expression of DEFB1 mRNA27188386
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of DEFB1 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DEFB1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DEFB1 mRNA19770486|2196490
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of DEFB1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of DEFB1 mRNA19484750
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of DEFB1 mRNA18367319
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of DEFB1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of DEFB1 mRNA24586524
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of DEFB1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of DEFB1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of DEFB1 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DEFB1 mRNA23650126
D002922CiguatoxinsCiguatoxins affects the expression of DEFB1 mRNA18353800
D019327Copper SulfateCopper Sulfate results in increased expression of DEFB1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of DEFB1 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of DEFB1 mRNA21865292
C007262deoxynivalenoldeoxynivalenol results in decreased expression of DEFB1 mRNA25701311
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of DEFB1 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of DEFB1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of DEFB1 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of DEFB1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of DEFB1 mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of DEFB1 mRNA26485663
D004391DustDust results in decreased expression of DEFB1 mRNA17805423
C118739entinostatentinostat results in decreased expression of DEFB1 mRNA27188386
D004917ErythromycinErythromycin results in decreased expression of DEFB1 mRNA27503388
D004917Erythromycin[Penicillin G co-treated with Erythromycin] results in decreased expression of DEFB1 mRNA27503388
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of DEFB1 mRNA28329830
D005480FlurbiprofenFlurbiprofen results in decreased expression of DEFB1 mRNA16949054
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of DEFB1 mRNA28433809
C000625835HFPO2 compoundHFPO2 compound results in increased expression of DEFB1 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of DEFB1 mRNA27553808
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DEFB1 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DEFB1 mRNA25613284
D007545IsoproterenolIsoproterenol results in decreased expression of DEFB1 mRNA24286936
D007545IsoproterenolIsoproterenol results in increased expression of DEFB1 mRNA24286936
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of DEFB1 mRNA27392435
D007649KetamineKetamine results in decreased expression of DEFB1 mRNA20080153
C111332Lasofoxifene[Progesterone co-treated with Lasofoxifene] results in increased expression of DEFB1 mRNA18367319
C052901lemongrass oillemongrass oil results in increased expression of DEFB1 mRNA25660481
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of DEFB1 mRNA"24972896
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of DEFB1 mRNA"21865417
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of DEFB1 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of DEFB1 mRNA21199063
C500085muraglitazarmuraglitazar results in increased expression of DEFB1 mRNA21515302
D009151Mustard GasMustard Gas results in increased expression of DEFB1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DEFB1 mRNA"25620056
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of DEFB1 mRNA23212921
D052638Particulate MatterParticulate Matter results in decreased expression of DEFB1 mRNA22178795
D010400Penicillin G[Penicillin G co-treated with Erythromycin] results in decreased expression of DEFB1 mRNA27503388
D010400Penicillin GPenicillin G results in decreased expression of DEFB1 mRNA27503388
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of DEFB1 mRNA17616710
D010634PhenobarbitalPhenobarbital affects the expression of DEFB1 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of DEFB1 mRNA23091169
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of DEFB1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of DEFB1 mRNA18301758|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of DEFB1 mRNA]20059764
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of DEFB1 mRNA28433809
D059808PolyphenolsPolyphenols results in decreased expression of DEFB1 mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in decreased expression of DEFB1 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of DEFB1 mRNA20660070
D011374Progesterone[Progesterone co-treated with bazedoxifene] results in increased expression of DEFB1 mRNA18367319
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of DEFB1 mRNA18367319
D011374Progesterone[Progesterone co-treated with Lasofoxifene] results in increased expression of DEFB1 mRNA18367319
D011374Progesterone[Progesterone co-treated with Raloxifene Hydrochloride] results in increased expression of DEFB1 mRNA18367319
D011374ProgesteroneProgesterone results in increased expression of DEFB1 mRNA19690047
D020849Raloxifene Hydrochloride[Progesterone co-treated with Raloxifene Hydrochloride] results in increased expression of DEFB1 mRNA18367319
C089730rosiglitazonerosiglitazone results in increased expression of DEFB1 mRNA21515302
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DEFB1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of DEFB1 mRNA23221170
C017947sodium arsenitesodium arsenite results in decreased expression of DEFB1 mRNA25879800
C017947sodium arsenitesodium arsenite results in decreased expression of DEFB1 mRNA17350061
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DEFB1 mRNA19692669|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DEFB1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DEFB1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DEFB1 mRNA20959002|2121527
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of DEFB1 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DEFB1 mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of DEFB1 mRNA28943392
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DEFB1 mRNA27404394
D014241TrichloroethyleneTrichloroethylene results in increased expression of DEFB1 mRNA25549359
C057693troglitazonetroglitazone results in decreased expression of DEFB1 mRNA25572481
C057693troglitazonetroglitazone results in increased expression of DEFB1 mRNA19140230
C057693troglitazonetroglitazone results in increased expression of DEFB1 mRNA21515302
D014635Valproic AcidValproic Acid affects the expression of DEFB1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DEFB1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of DEFB1 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of DEFB1 mRNA20044591
C088658zoledronic acidzoledronic acid results in increased expression of DEFB1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25122636  
GO:0031731CCR6 chemokine receptor binding-IDA25122636  
GO:0042802identical protein binding-IDA23938203  
GO ID GO Term Qualifier Evidence PubMed
GO:0002227innate immune response in mucosa-IDA12860195  
GO:0006935chemotaxis-TAS10521347  
GO:0006955immune response-TAS10521347  
GO:0007186G-protein coupled receptor signaling pathway-TAS10521347  
GO:0009617response to bacterium-IDA12054642  
GO:0009617response to bacterium-ISS-  
GO:0019730antimicrobial humoral response-TAS-  
GO:0019731antibacterial humoral response-IDA12860195  
GO:0019933cAMP-mediated signaling-IDA25122636  
GO:0035584calcium-mediated signaling using intracellular calcium source-IDA25122636  
GO:0042742defense response to bacterium-IMP21115716  
GO:0045087innate immune response-ISS-  
GO:0045087innate immune response-NAS12517831  
GO:0050829defense response to Gram-negative bacterium-IMP25122636  
GO:0050830defense response to Gram-positive bacterium-IDA12860195  
GO:0050830defense response to Gram-positive bacterium-IMP25122636  
GO:0060474positive regulation of flagellated sperm motility involved in capacitation-IMP25122636  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IDA12860195  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IMP25122636  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA12860195  21115716  
GO:0005796Golgi lumen-TAS-  
GO:0019898extrinsic component of membrane-IDA23938203  
GO:0070062extracellular exosome-HDA23533145  
GO:0097225sperm midpiece-IDA25122636  
GO:1990742microvesicle-IDA23938203  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1461957Beta defensinsTAS
R-HSA-1461973DefensinsTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28485077LTF and DEFB1 polymorphisms are associated with susceptibility toward chronic periodontitis development. (2017 Oct)Zupin LOral Dis
16512757No association between selected candidate gene polymorphisms and severe chronic periodontitis. (2006 Mar)Wohlfahrt JCJ Periodontol
23046822Clinical application of human beta-defensin and CD14 gene polymorphism in evaluating the status of chronic inflammation. (2012 Sep 19)Loo WTJ Transl Med