Gene info: ID 167227

Gene: DCP2

GENE ID: 167227

Synonyms: NUDT20

Description: decapping mRNA 2

Gene type: protein-coding

Location: 5q22.2

dbXrefs: Ensembl:ENSG00000172795 MIM:609844 Vega:OTTHUMG00000162853 UniprotKB:Q8IU60

RefSeq: NG_029929.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.590e-2 (AD) 7.594e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RC3H2	0.933
NUP50	0.931
LIN7A	0.925
RNGTT	0.925
PMPCB	0.925
KLHL7	0.923
APAF1	0.922
DYM	0.921
GMPS	0.921
ETNK1	0.921

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.483
OR4F29	-0.451
PLA2G5	-0.387
AQP5	-0.361
S100A1	-0.351
ASB4	-0.345
HEY2	-0.322
BTBD17	-0.317
NKX6-1	-0.317
RBP1	-0.317

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of DCP2 protein	26194647
D000082	Acetaminophen	Acetaminophen affects the expression of DCP2 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of DCP2 gene	27153756
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of DCP2 mRNA	24449571
C006632	arsenic trioxide	DCP2 protein results in increased susceptibility to arsenic trioxide	20707922
D001280	Atrazine	Atrazine results in decreased expression of DCP2 mRNA	22378314
C044887	beta-methylcholine	beta-methylcholine affects the expression of DCP2 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of DCP2 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of DCP2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of DCP2 mRNA	25181051
D016572	Cyclosporine	Cyclosporine results in increased expression of DCP2 mRNA	25562108
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of DCP2 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in decreased expression of DCP2 mRNA	25016146
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of DCP2 mRNA	26924002
D006046	Gold	Gold results in decreased expression of DCP2 mRNA	25523186
C544151	jinfukang	jinfukang results in decreased expression of DCP2 mRNA	27392435
D008727	Methotrexate	DCP2 protein affects the susceptibility to Methotrexate	16217747
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of DCP2 mRNA	23649840
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of DCP2 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of DCP2 mRNA"	25554681
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of DCP2 mRNA	18593933
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of DCP2 mRNA	23892564
D010936	Plant Extracts	Plant Extracts results in increased expression of DCP2 mRNA	23557933
D012314	RNA Cap Analogs	RNA Cap Analogs affects the susceptibility to DCP2 protein	21447710
C017947	sodium arsenite	sodium arsenite affects the expression of DCP2 mRNA	29319823
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of DCP2 mRNA	27862939
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DCP2 mRNA	21632981
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DCP2 mRNA	22298810
C012589	trichostatin A	trichostatin A results in increased expression of DCP2 mRNA	24935251
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of DCP2 mRNA	12163651
C057693	troglitazone	troglitazone results in decreased expression of DCP2 mRNA	28973697
D014520	Urethane	Urethane results in increased expression of DCP2 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of DCP2 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in decreased methylation of DCP2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of DCP2 mRNA	29154799
C025643	vinclozolin	vinclozolin results in increased expression of DCP2 mRNA	23555832
D014801	Vitamin A	Vitamin A deficiency results in decreased expression of DCP2 mRNA	12163651
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of DCP2 mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004534	5'-3' exoribonuclease activity	-	IMP	26950371
GO:0005515	protein binding	-	IPI	12417715 15231747 15687258 16364915 16699599 18326031 19966221 20543818 20584987 20616046 21876179 23085078 25036637 26496610
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	-	TAS	-
GO:0030145	manganese ion binding	-	IEA	-
GO:0050072	m7G(5')pppN diphosphatase activity	-	IBA	21873635
GO:0050072	m7G(5')pppN diphosphatase activity	-	IDA	21070968
GO:0070034	telomerase RNA binding	-	IC	26950371

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	IEA	-
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	-	IBA	21873635
GO:0006402	mRNA catabolic process	-	IDA	21070968
GO:0032211	negative regulation of telomere maintenance via telomerase	-	IMP	26950371
GO:0043488	regulation of mRNA stability	-	TAS	-
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	-
GO:0071044	histone mRNA catabolic process	-	IMP	18172165
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	-
GO:1904872	regulation of telomerase RNA localization to Cajal body	-	IMP	26950371

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000932	P-body	-	IBA	21873635
GO:0000932	P-body	-	IDA	20616046
GO:0005654	nucleoplasm	-	IDA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0016442	RISC complex	-	IDA	20616046
GO:0030054	cell junction	-	IDA	-
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	-

KEGG ID	KEGG Term
hsa03018	RNA degradation

Reactome ID	Reactome Term	Evidence
R-HSA-380994	ATF4 activates genes	TAS
R-HSA-381042	PERK regulates gene expression	TAS
R-HSA-381119	Unfolded Protein Response (UPR)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-429914	Deadenylation-dependent mRNA decay	TAS
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	TAS
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	TAS
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	TAS
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	TAS
R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA	TAS
R-HSA-8953854	Metabolism of RNA	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23300696	Down-regulation of Decapping Protein 2 mediates chronic nicotine exposure-induced locomotor hyperactivity in Drosophila. (2012)	Ren J	PLoS One
27227246	Global Priorities for Addressing the Burden of Mental, Neurological, and Substance Use Disorders (2016 Mar 14)	Patel V	-