Gene: NIM1K

167359
NIM1
NIM1 serine/threonine protein kinase
protein-coding
5p12
Ensembl:ENSG00000177453 Vega:OTTHUMG00000131147 UniprotKB:Q8IY84
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.653e-1 (AD)  3.840e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12523436chr5:43276367 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of NIM1K mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NIM1K mRNA"19114083
D000447AldehydesAldehydes results in increased expression of NIM1K mRNA25014914
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NIM1K mRNA22316170
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in increased expression of NIM1K mRNA17630414
C006780bisphenol Abisphenol A results in decreased expression of NIM1K mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of NIM1K mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NIM1K mRNA25993096
D002220CarbamazepineCarbamazepine affects the expression of NIM1K mRNA25979313
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of NIM1K mRNA28962523
D019422Dietary SucroseDietary Sucrose results in decreased expression of NIM1K mRNA26033743
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of NIM1K mRNA"27840820
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of NIM1K mRNA20064776
D018120FinasterideFinasteride results in increased expression of NIM1K mRNA24136188
C039281furanfuran results in decreased expression of NIM1K mRNA26194646
D005897GlafenineGlafenine results in decreased expression of NIM1K mRNA24136188
D010100OxygenOxygen deficiency results in increased expression of NIM1K mRNA24236059
C046012pentanalpentanal results in increased expression of NIM1K mRNA26079696
C059514resveratrol[resveratrol co-treated with Streptozocin] results in decreased expression of NIM1K mRNA25905778
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NIM1K mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of NIM1K mRNA25993096
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in decreased expression of NIM1K mRNA25905778
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in increased expression of NIM1K mRNA17630414
D014635Valproic AcidValproic Acid results in increased expression of NIM1K mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA15733851  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA15733851  
GO:0005524ATP binding-IDA15733851  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IDA15733851  
GO:0032007negative regulation of TOR signaling-IBA21873635  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0042149cellular response to glucose starvation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0031588nucleotide-activated protein kinase complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal