Gene: GALNTL5

168391
GALNACT19|GALNT15|GalNAc-T5L
polypeptide N-acetylgalactosaminyltransferase like 5
protein-coding
7q36.1
Ensembl:ENSG00000106648 MIM:615133 Vega:OTTHUMG00000157306 UniprotKB:Q7Z4T8
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
2.329e-1 (AD)  7.404e-2 (ND)   (Frontal_Cortex)
5.095e-1 (AD)  5.494e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10952334chr7:151956550 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KHDRBS30.706
CRTAC10.702
SERPINF10.691
CCDC1360.684
TMEM1550.682
FHL20.682
CCK0.68
NUAK10.679
NELL10.669
NCALD0.669

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.482
PARD3B-0.476
NEDD1-0.469
SNTB1-0.468
EYA1-0.466
SLC7A11-0.462
NKAIN3-0.46
CDC14A-0.456
YAP1-0.451
PDLIM5-0.45

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GALNTL5 mRNA22129741
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to GALNTL5 promoter]19654925
C006780bisphenol Abisphenol A results in decreased expression of GALNTL5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GALNTL5 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GALNTL5 mRNA24982889
D004041Dietary FatsDietary Fats results in decreased expression of GALNTL5 mRNA28031460
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GALNTL5 mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GALNTL5 mRNA22129741
C012589trichostatin Atrichostatin A results in increased expression of GALNTL5 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of GALNTL5 mRNA24935251|2800136

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005112Notch binding-IBA21873635  
GO:0016757transferase activity, transferring glycosyl groupsNOTIDA24398516  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006486protein glycosylationNOTIDA24398516  
GO:0007286spermatid development-IBA21873635  
GO:0007286spermatid development-IMP24398516  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0031902late endosome membrane-IEA-  
KEGG ID KEGG Term
hsa00512Mucin type O-Glycan biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-913709O-linked glycosylation of mucinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal