Gene: BMPER

168667
CRIM3|CV-2|CV2
BMP binding endothelial regulator
protein-coding
7p14.3
Ensembl:ENSG00000164619 MIM:608699 Vega:OTTHUMG00000128675 UniprotKB:Q8N8U9
NG_031933.1
SNP Mapped
1   ANCO-SNPs
AD
0   
7.646e-1 (AD)  1.103e-1 (ND)   (Frontal_Cortex)
3.772e-1 (AD)  4.139e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1362456chr7:34064613 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNJ10.941
PLCL20.937
DCLK10.935
FRMPD40.935
NBEA0.934
GPR1580.934
BHLHB90.934
LMTK20.934
FAM102B0.933
MYCBP20.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.569
COPZ2-0.554
RAB13-0.553
ASB4-0.547
MYL3-0.541
YES1-0.534
MYOM1-0.529
RNF135-0.521
ROM1-0.52
STON2-0.511

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of BMPER mRNA19041380
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of BMPER mRNA"20406850
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of BMPER mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of BMPER mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of BMPER mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BMPER gene27153756
D001151ArsenicArsenic affects the expression of BMPER protein24675094
C487081belinostatbelinostat results in increased expression of BMPER mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BMPER mRNA19770486
D004958EstradiolEstradiol results in increased expression of BMPER mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of BMPER mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of BMPER mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of BMPER mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of BMPER gene28505145
D002737ChloropreneChloroprene results in decreased expression of BMPER mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BMPER mRNA20938992
D003300Copper[Copper co-treated with Dietary Sucrose] results in decreased expression of BMPER mRNA26033743
D003471CuprizoneCuprizone results in increased expression of BMPER mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of BMPER mRNA27989131
C014347decitabinedecitabine results in increased expression of BMPER mRNA27915011
D003907DexamethasoneDexamethasone results in increased expression of BMPER mRNA22733784
D003976DiazinonDiazinon results in increased expression of BMPER mRNA29108742
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of BMPER mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of BMPER mRNA27392435
D002945CisplatinCisplatin results in decreased expression of BMPER mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of BMPER mRNA18042831
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in decreased expression of BMPER mRNA26033743
C118739entinostatentinostat results in increased expression of BMPER mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BMPER mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BMPER mRNA20938992
D004397FonofosFonofos results in increased methylation of BMPER promoter22847954
C039281furanfuran results in increased expression of BMPER mRNA24183702
C039281furanfuran results in increased expression of BMPER mRNA27387713
D017313FenretinideFenretinide results in decreased expression of BMPER mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of BMPER mRNA26846883
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of BMPER mRNA27392435
C544151jinfukangjinfukang results in decreased expression of BMPER mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BMPER mRNA20938992
D008727MethotrexateMethotrexate affects the expression of BMPER mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of BMPER mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of BMPER mRNA26924002
C523799MRK 003BMPER results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of BMPER mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BMPER mRNA"25554681|2562005
C029938nickel sulfatenickel sulfate results in decreased expression of BMPER mRNA22714537
D053610Opiate AlkaloidsBMPER gene SNP affects the susceptibility to Opiate Alkaloids18438686
D000073878Palm OilPalm Oil results in increased expression of BMPER mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of BMPER mRNA26272509
D010278ParathionParathion results in increased methylation of BMPER promoter22847954
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of BMPER mRNA23602845
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BMPER mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of BMPER mRNA18301758|2081375
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BMPER mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of BMPER mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of BMPER mRNA22714537
D017035PravastatinPravastatin results in increased expression of BMPER mRNA27225895
D017035PravastatinPravastatin affects the expression of BMPER mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of BMPER mRNA28903501
C005556propionaldehydepropionaldehyde results in increased expression of BMPER mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of BMPER mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of BMPER mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of BMPER mRNA23221170
C017947sodium arsenitesodium arsenite results in decreased expression of BMPER mRNA22714537
D053260SootSoot results in increased expression of BMPER mRNA22461453
C075117squalestatin 1squalestatin 1 affects the expression of BMPER mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of BMPER mRNA27225895
C012568terbufosterbufos results in increased methylation of BMPER promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of BMPER mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BMPER mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BMPER mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BMPER mRNA19770486
C009495titanium dioxidetitanium dioxide results in increased expression of BMPER mRNA23557971
C066340tolcaponetolcapone binds to BMPER protein19783845
D014212TretinoinTretinoin results in decreased expression of BMPER mRNA18230668
D014212TretinoinTretinoin results in increased expression of BMPER mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of BMPER mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMPER mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of BMPER mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of BMPER gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001657ureteric bud development-IEA-  
GO:0002043blood vessel endothelial cell proliferation involved in sprouting angiogenesis-IDA18787191  
GO:0010594regulation of endothelial cell migration-IDA18787191  
GO:0030514negative regulation of BMP signaling pathway-TAS18787191  
GO:0042118endothelial cell activation-IDA18787191  
GO:0048839inner ear development-IEA-  
GO:0060393regulation of pathway-restricted SMAD protein phosphorylation-IDA18787191  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA18787191  
GO:1903672positive regulation of sprouting angiogenesis-IGI28124060  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA18787191  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal