Gene: COCH

1690
COCH-5B2|COCH5B2|DFNA9
cochlin
protein-coding
14q12
Ensembl:ENSG00000100473 MIM:603196 Vega:OTTHUMG00000029432 UniprotKB:O43405
NG_008211.2
PubMed
0   ANCO-SNPs
CD
7   
2.524e-1 (AD)  2.683e-1 (ND)   (Frontal_Cortex)
7.146e-1 (AD)  7.428e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANKRD34B0.867
SYNDIG1L0.852
DGKK0.829
PENK0.827
SLC35D30.825
HTR2C0.82
OTOF0.82
AMBN0.819
GPR1490.817
GPR10.812

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDKN2C-0.351
ZIC2-0.346
RGL3-0.305
ALDH1A1-0.3
ZIC5-0.296
CSAG1-0.291
MAGEA12-0.29
OTOS-0.289
FOXJ1-0.289
RNF182-0.287

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of COCH mRNA25596134
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COCH mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COCH mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COCH mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COCH mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of COCH mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COCH mRNA"25510870
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of COCH mRNA28522335
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of COCH mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COCH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COCH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COCH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COCH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COCH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COCH mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of COCH mRNA22230336
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of COCH mRNA25596134
C487081belinostatbelinostat results in decreased expression of COCH mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COCH mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COCH mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of COCH mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of COCH mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of COCH mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of COCH mRNA18958704
D019256Cadmium ChlorideCadmium Chloride results in increased expression of COCH mRNA25596134
D002110CaffeineCaffeine results in decreased expression of COCH mRNA20864626
D002220CarbamazepineCarbamazepine affects the expression of COCH mRNA25979313
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of COCH mRNA25596134
C059262cidofovircidofovir results in increased expression of COCH mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of COCH mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of COCH mRNA20971185
D003300CopperCopper deficiency results in increased expression of COCH mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of COCH mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of COCH mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of COCH mRNA22077320
D003520CyclophosphamideCOCH protein affects the susceptibility to Cyclophosphamide16217747
D016572CyclosporineCyclosporine results in decreased expression of COCH mRNA25562108|2798913
D003976DiazinonDiazinon results in increased expression of COCH mRNA29108742
D002945CisplatinCisplatin results in decreased expression of COCH mRNA27392435
D002945CisplatinCisplatin results in increased expression of COCH mRNA25596134|2759478
C000944dicrotophosdicrotophos results in decreased expression of COCH mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of COCH mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of COCH mRNA17394237
D005472FluorouracilCOCH protein affects the susceptibility to Fluorouracil16217747
C069837fullerene C60fullerene C60 results in increased expression of COCH mRNA19167457
D019833GenisteinGenistein results in decreased expression of COCH mRNA21810550
D007052IbuprofenIbuprofen results in decreased expression of COCH mRNA25596134
C492448ICG 001ICG 001 results in increased expression of COCH mRNA26191083
C544151jinfukangjinfukang results in increased expression of COCH mRNA27392435
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of COCH mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of COCH mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of COCH mRNA20864626
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of COCH mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of COCH mRNA21664453
D016685MitomycinCOCH protein affects the susceptibility to Mitomycin16217747
D008942MitoxantroneCOCH protein affects the susceptibility to Mitoxantrone16217747
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of COCH mRNA20864626
D009532NickelNickel results in decreased expression of COCH mRNA24768652
C029938nickel sulfatenickel sulfate results in decreased expression of COCH mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of COCH mRNA20971185
C025589ochratoxin Aochratoxin A results in increased acetylation of COCH promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of COCH promoter] which results in increased expression of COCH mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of COCH mRNA29098329
D010100OxygenOxygen deficiency results in decreased expression of COCH mRNA24236059|2559613
D017239PaclitaxelPaclitaxel results in increased expression of COCH mRNA18754875
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of COCH mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of COCH mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COCH mRNA"27188386
C019536potassium bromatepotassium bromate results in decreased expression of COCH mRNA23588252
C045362prochlorazprochloraz results in increased expression of COCH mRNA21470553
D011374ProgesteroneProgesterone results in increased expression of COCH mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of COCH mRNA24780913
D015474IsotretinoinIsotretinoin results in increased expression of COCH mRNA20436886
C089730rosiglitazonerosiglitazone results in decreased expression of COCH mRNA25596134
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of COCH mRNA12818353
C017947sodium arsenitesodium arsenite affects the methylation of COCH gene28589171
D016559TacrolimusTacrolimus results in increased expression of COCH mRNA25270620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to COCH promoter]19654925
D014241TrichloroethyleneTrichloroethylene results in increased methylation of COCH gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COCH mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of COCH mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of COCH mRNA"26179874
D017974Uranium CompoundsUranium Compounds results in decreased expression of COCH mRNA19654044
D014635Valproic AcidValproic Acid affects the expression of COCH mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of COCH mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of COCH gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COCH mRNA"27188386
D015032ZincZinc deficiency results in decreased expression of COCH mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21886777  
GO:0005518collagen binding-IDA22610276  
GO ID GO Term Qualifier Evidence PubMed
GO:0003429growth plate cartilage chondrocyte morphogenesis-IBA21873635  
GO:0007605sensory perception of sound-IEA-  
GO:0008360regulation of cell shape-IMP21886777  
GO:0042742defense response to bacterium-IEA-  
GO:0045089positive regulation of innate immune response-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0031012extracellular matrix-IDA22610276  
GO:0062023collagen-containing extracellular matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23840704Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity. (2013)Geng LPLoS One
26712009Long-acting cocaine hydrolase for addiction therapy. (2016 Jan 12)Chen XProc Natl Acad Sci U S A
25814464Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase. (2015 Aug)Murthy VCell Mol Neurobiol
18514640An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties. (2008 Sep 25)Gao YChem Biol Interact
22264200Modification of pharmacokinetic and abuse-related effects of cocaine by human-derived cocaine hydrolase in monkeys. (2013 Jan)Schindler CWAddict Biol
26968195Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector-Delivered Cocaine Hydrolase. (2016 May)Smethells JRJ Pharmacol Exp Ther
24407266Long-term reduction of cocaine self-administration in rats treated with adenoviral vector-delivered cocaine hydrolase: evidence for enzymatic activity. (2014 May)Zlebnik NENeuropsychopharmacology