Gene: SLC30A8

169026
ZNT8|ZnT-8
solute carrier family 30 member 8
protein-coding
8q24.11
Ensembl:ENSG00000164756 MIM:611145 Vega:OTTHUMG00000164962 UniprotKB:Q8IWU4
NG_016991.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.050e-1 (AD)  8.362e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRNA30.66
MYB0.647
C6orf1410.642
CHAT0.622
DRD30.607
USH1G0.603
GPR10.601
KRTAP4-10.6
ENTHD10.596
OTOF0.59

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF182-0.274
ALDH1A1-0.254
CDKN2C-0.245
NANOS3-0.242
RAB41-0.239
MYL3-0.232
ZIC2-0.23
ASCL1-0.22
ENO3-0.21
FAM181B-0.209

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4879483-iodothyronamineSLC30A8 mRNA affects the uptake of 3-iodothyronamine19074582
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC30A8 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of SLC30A8 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC30A8 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC30A8 mRNA22316170
C006780bisphenol Abisphenol A affects the expression of SLC30A8 mRNA25181051
D002104CadmiumCadmium affects the expression of SLC30A8 mRNA25294218
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SLC30A8 mRNA28962523
C039353dihydroxyethyldithiocarbamate[Glucose co-treated with dihydroxyethyldithiocarbamate] results in decreased expression of SLC30A819492079
C118739entinostatentinostat results in increased expression of SLC30A8 mRNA27188386
C074031exenatideexenatide inhibits the reaction [LEPR gene mutant form results in decreased expression of SLC30A8 mRNA]21461562
C074031exenatideexenatide inhibits the reaction [LEPR gene mutant form results in decreased expression of SLC30A8 protein]21461562
D005947GlucoseSLC30A8 protein promotes the reaction [Glucose results in increased secretion of INS protein]16984975
D005947GlucoseSLC30A8 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]19450229
D005947Glucose[Glucose co-treated with dihydroxyethyldithiocarbamate] results in decreased expression of SLC30A819492079
D005947GlucoseGlucose results in decreased expression of SLC30A819492079
D005947GlucoseGlucose results in decreased expression of SLC30A8 mRNA23056475
D005947Glucose"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Glucose results in decreased expression of SLC30A8 mRNA]"23056475
D005947GlucoseSLC30A8 protein affects the reaction [Glucose results in increased secretion of INS1 protein]19479076
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Glucose results in decreased expression of SLC30A8 mRNA]"23056475
D011189Potassium ChlorideSLC30A8 protein affects the reaction [Potassium Chloride results in increased secretion of INS1 protein]19479076
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of SLC30A8 gene27618143
D014635Valproic AcidValproic Acid affects the expression of SLC30A8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SLC30A8 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC30A8 gene25560391
D015032ZincSLC30A8 protein affects the localization of Zinc15331542
D015032ZincSLC30A8 protein results in increased abundance of Zinc16984975
D015032ZincSLC30A8 protein results in increased transport of Zinc18326752
D015032ZincSLC30A8 protein results in increased uptake of Zinc16984975
D015032ZincSLC30A8 protein affects the uptake of Zinc19479076
D015032ZincSLC30A8 protein results in increased export of Zinc17126599

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005385zinc ion transmembrane transporter activity-IBA21873635  
GO:0005385zinc ion transmembrane transporter activity-IDA15331542  
GO:0005385zinc ion transmembrane transporter activity-TAS-  
GO:0005515protein binding-IPI24955142  25416956  25910212  
GO:0008270zinc ion binding-IC15331542  
GO:0042803protein homodimerization activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006829zinc ion transport-IDA15331542  
GO:0006882cellular zinc ion homeostasis-ISS-  
GO:0009749response to glucose-IBA21873635  
GO:0009749response to glucose-IMP16984975  
GO:0010043response to zinc ion-IBA21873635  
GO:0030073insulin secretion-IBA21873635  
GO:0030073insulin secretion-IMP16984975  
GO:0032024positive regulation of insulin secretion-ISS-  
GO:0032119sequestering of zinc ion-IDA15331542  
GO:0034341response to interferon-gamma-IEA-  
GO:0042593glucose homeostasisNOTISS-  
GO:0060627regulation of vesicle-mediated transport-ISS-  
GO:0061088regulation of sequestering of zinc ion-IBA21873635  
GO:0061088regulation of sequestering of zinc ion-ISS-  
GO:0070555response to interleukin-1-IEA-  
GO:0071577zinc ion transmembrane transport-IBA21873635  
GO:0071577zinc ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatusNOTIDA15331542  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA15331542  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0030141secretory granule-IDA15331542  
GO:0030658transport vesicle membrane-IEA-  
GO:0030667secretory granule membrane-TAS-  
GO:0031410cytoplasmic vesicle-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-264876Insulin processingTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425410Metal ion SLC transportersTAS
R-HSA-435354Zinc transportersTAS
R-HSA-435368Zinc efflux and compartmentalization by the SLC30 familyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26837367[Association between type 2 diabetes in Uygur and polymorphisms of SLC30A8 and its interaction with smoking]. (2015 Oct)Su YZhonghua Liu Xing Bing Xue Za Zhi
29518490Association of 48 type 2 diabetes susceptibility loci with fasting plasma glucose and lipid levels in Chinese Hans. (2018 May)Liu JDiabetes Res Clin Pract
19020324Clinical risk factors, DNA variants, and the development of type 2 diabetes. (2008 Nov 20)Lyssenko VN Engl J Med