Gene: HTR3C

170572
-
5-hydroxytryptamine receptor 3C
protein-coding
3q27.1
Ensembl:ENSG00000178084 MIM:610121 Vega:OTTHUMG00000156862 UniprotKB:Q8WXA8
NG_012749.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.355e-1 (AD)  8.961e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OPN1MW20.602
DEFB1150.599
PLA2G2E0.57
HTR3D0.556
OTOR0.551
FAM83C0.546
PLA2G12B0.534
VN1R30.5
OR7C20.494
TMPRSS90.487

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPATA3-0.211
OR7C1-0.198
NET1-0.194
RAD9B-0.193
OMD-0.191
MRAP-0.183
CYP4B1-0.18
CDNF-0.176
IL12A-0.171
RNASE4-0.171

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget

    There is no CTD record for this GENE !

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI17392525  
GO:0022850serotonin-gated cation-selective channel activity-IDA17392525  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007210serotonin receptor signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22933845Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (2012 Jun)Herman AISubst Abuse Rehabil
20021265Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (2010)Goecke TWActa Obstet Gynecol Scand