Gene: HTR3C

170572
-
5-hydroxytryptamine receptor 3C
protein-coding
3q27.1
Ensembl:ENSG00000178084 MIM:610121 Vega:OTTHUMG00000156862 UniprotKB:Q8WXA8
NG_012749.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.355e-1 (AD)  8.961e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OPN1MW20.602
DEFB1150.599
PLA2G2E0.57
HTR3D0.556
OTOR0.551
FAM83C0.546
PLA2G12B0.534
VN1R30.5
OR7C20.494
TMPRSS90.487

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPATA3-0.211
OR7C1-0.198
NET1-0.194
RAD9B-0.193
OMD-0.191
MRAP-0.183
CYP4B1-0.18
CDNF-0.176
IL12A-0.171
RNASE4-0.171

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget

    There is no CTD record for this GENE !

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI17392525  
GO:0022850serotonin-gated cation-selective channel activity-IDA17392525  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007210serotonin receptor signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22933845Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (2012 Jun)Herman AISubst Abuse Rehabil
20021265Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (2010)Goecke TWActa Obstet Gynecol Scand
Mpgyi