Gene: PSORS1C1

170679
C6orf16|SEEK1
psoriasis susceptibility 1 candidate 1
protein-coding
6p21.33
Ensembl:ENSG00000204540 MIM:613525 Vega:OTTHUMG00000031077 UniprotKB:Q9UIG5
NG_021348.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6917517chr6:31114584 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17598552chr6:31094068PSORS1C1Promoter9.738e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLIPR20.644
CD2260.633
CCR70.614
SYNGR20.614
WIPF10.612
PRAM10.604
DPYD0.599
CACNA2D40.595
SNX200.593
VRK20.59

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
F7-0.374
WIF1-0.355
SLC29A4-0.353
ANK1-0.347
CHRNA2-0.347
POU3F1-0.341
KIT-0.34
KIF21B-0.337
CUX2-0.334
ARSF-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001151ArsenicArsenic affects the methylation of PSORS1C1 gene25304211
D001280AtrazineAtrazine results in increased expression of PSORS1C1 mRNA22378314
D004958EstradiolEstradiol affects the expression of PSORS1C1 mRNA22574217
D010100OxygenOxygen deficiency results in increased expression of PSORS1C1 mRNA26516004
D010936Plant ExtractsPlant Extracts results in decreased expression of PSORS1C1 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PSORS1C1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of PSORS1C1 mRNA25351596
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PSORS1C1 mRNA28065790

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal