Gene: ADAMTS18

170692
ADAMTS21|KNO2|MMCAT
ADAM metallopeptidase with thrombospondin type 1 motif 18
protein-coding
16q23.1
Ensembl:ENSG00000140873 MIM:607512 Vega:OTTHUMG00000137619 UniprotKB:Q8TE60
NG_031879.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
3.953e-1 (AD)  7.210e-1 (ND)   (Frontal_Cortex)
2.232e-1 (AD)  5.816e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11643269chr16:77343670 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRHL30.657
CHRM50.577
CDH190.567
PPP1R360.544
NHLH20.536
RCAN30.522
CTAG20.522
DTHD10.521
ZNF3670.513
SLC15A50.511

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.363
ADAM33-0.363
LTK-0.325
ASGR1-0.318
TNNT2-0.31
MGAT5B-0.305
ALS2CL-0.304
ATP4A-0.303
NEUROD1-0.3
COL5A1-0.299

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ADAMTS18 mRNA"25614096
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS18 mRNA"27188386
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ADAMTS18 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ADAMTS18 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADAMTS18 mRNA26001963
D004958EstradiolEstradiol affects the expression of ADAMTS18 mRNA23557687
C006780bisphenol Abisphenol A results in decreased methylation of ADAMTS18 promoter27312807
D002994ClofibrateClofibrate results in decreased expression of ADAMTS18 mRNA22300585
C029892cupric chloridecupric chloride results in increased expression of ADAMTS18 mRNA24650576
C061365flusilazoleflusilazole results in decreased expression of ADAMTS18 mRNA22382673
C061365flusilazoleflusilazole results in increased expression of ADAMTS18 mRNA22382673
D008353MannitolMannitol results in increased expression of ADAMTS18 mRNA25270620
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ADAMTS18 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ADAMTS18 mRNA26011545
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS18 mRNA"27188386
D010936Plant ExtractsPlant Extracts results in decreased expression of ADAMTS18 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of ADAMTS18 mRNA24780913
C017947sodium arsenitesodium arsenite results in increased expression of ADAMTS18 mRNA16014739
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADAMTS18 mRNA19465110
D014212TretinoinTretinoin results in increased expression of ADAMTS18 mRNA21934132
C057693troglitazonetroglitazone results in increased expression of ADAMTS18 mRNA28934090
D014635Valproic AcidValproic Acid results in decreased expression of ADAMTS18 mRNA26272509
D014635Valproic AcidValproic Acid results in increased expression of ADAMTS18 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ADAMTS18 gene25487561

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001654eye development-IMP23818446  
GO:0006508proteolysis-IEA-  
GO:0090331negative regulation of platelet aggregation-IDA19218546  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29654602A Genome-Wide Association Study identifies new genes potentially associated with eyelid sagging. (2018 Apr 13)Laville VExp Dermatol