Gene: COX7B2

170712
-
cytochrome c oxidase subunit 7B2
protein-coding
4p12
Ensembl:ENSG00000170516 MIM:609811 Vega:OTTHUMG00000099423 UniprotKB:Q8TF08
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.552e-1 (AD)  3.438e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16859614chr4:46892510 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR7C20.523
OTOR0.515
FCRLA0.501
GDNF0.494
DMBX10.489
RNF170.488
TAS2R600.481
OR51G10.481
EPO0.481
MROH50.481

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR17-0.303
CDH20-0.3
FUT9-0.283
CABLES1-0.25
MARC1-0.245
PURG-0.244
GPR37L1-0.237
ERBB4-0.229
OMG-0.229
RFTN2-0.229

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of COX7B2 mRNA22316170
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of COX7B2 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of COX7B2 mRNA]22185406
D003907DexamethasoneDexamethasone results in decreased expression of COX7B2 mRNA22185406
D002117CalcitriolCalcitriol results in increased expression of COX7B2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of COX7B2 mRNA21592394
D004317DoxorubicinDoxorubicin results in increased expression of COX7B2 mRNA26873546
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of COX7B2 mRNA]22185406
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of COX7B2 mRNA22185406
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of COX7B2 mRNA]22185406
D008070Lipopolysaccharides"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of COX7B2 mRNA]"22185406
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of COX7B2 mRNA]22185406
D011794QuercetinQuercetin results in increased expression of COX7B2 mRNA22185406
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of COX7B2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of COX7B2 mRNA21592394
C082097tocotrienol, delta"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of COX7B2 mRNA]"22185406
C082097tocotrienol, delta"tocotrienol, delta results in decreased expression of COX7B2 mRNA"22185406
D014635Valproic AcidValproic Acid results in decreased methylation of COX7B2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of COX7B2 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of COX7B2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004129cytochrome-c oxidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0022900electron transport chain-IEA-  
GO:1902600proton transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005746mitochondrial respiratory chain-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa04260Cardiac muscle contraction
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal